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PubMed1995

Drinking after intragastric NaCl without increase in systemic plasma osmolality in rats.

Drinking after intragastric hypertonic solutions was examined to determine whether increased plasma osmolality always accompanied initiation of drinking. A 2-ml infusion through a gastric catheter was the beginning of tests in Sprague-Dawley male rats. Latency to drink was shorter and 1-h water intake was greater for increasing concentrations of NaCl (600, 1,200, and 1,800 mosmol/kg) compared with baseline (290 mosmol/kg). Although 600, 900, or 1,200 mosmol/kg NaCl elicited drinking, such infusions failed to change systemic plasma osmolality, and 900 mosmol/kg also failed to change plasma sodium, protein, renin activity, or packed cell volume at the initiation of drinking. Intragastric 900 mosmol/kg sodium bicarbonate, sodium isethionate, potassium chloride, lithium chloride, and mannitol differentially increased water intake. Total subdiaphragmatic vagotomy abolished drinking elicited by intragastric NaCl; selective gastric or hepatic vagotomy attenuated intake under some conditions. These results support the hypothesis of a vagally mediated, gastrointestinal and/or hepatic-portal, osmosensitive mechanism for initiation of drinking in advance of postprandial increases in systemic osmolality.

Animals↗
PubMed1997

Intracerebroventricular losartan inhibits postprandial drinking in sheep.

We investigated the contribution of brain angiotensinergic mechanisms to postprandial drinking in sheep. Sheep in fluid balance were given 0.8 kg chaff for 30 min, and water intake was measured for the next hour. Intracerebroventricular infusion of the AT1 type angiotensin II (ANG II) receptor blocker losartan (1 mg/h) reduced postprandial drinking by approximately 70% (n = 7, P < 0.01) but did not affect food intake. The same losartan dose given intravenously had little or no effect on prandial drinking. Feeding increased Na+ concentrations in plasma and cerebrospinal fluid (CSF; n = 5, P < 0.05). Intracerebroventricular losartan (1 mg/h) inhibited the drinking responses to intracarotid infusion of ANG II (0.8 microg/min for 30 min, n = 4, P < 0.01) and to intracerebroventricular infusion of 0.5 M NaCl (1 ml/h for 1 h, n = 5, P < 0.05) but had no effect on drinking responses to intravenous infusion of 4 M NaCl (1.3 ml/min for 30 min). These findings indicate that a brain ANG II-dependent mechanism is involved in postprandial drinking in sheep. They suggest also that the mechanism by which increasing CSF Na+ causes thirst involves brain ANG II and is different from the mechanism subserving the drinking response to changes in blood Na+.

Angiotensin II↗
PubMed1988

Suppression of AVP release by drinking despite hypertonicity during and after gestation.

Water drinking suppresses arginine vasopressin (AVP) release before changes in tonicity or volume. To further characterize this oropharyngeal neuroendocrine reflex, we took advantage of ongoing studies of osmoregulation in pregnancy as follows: five women studied serially in early (8 +/- 1 wk, mean +/- SD) and late (32 +/- 3 wk) pregnancy and 8-10 wk postpartum were slowly infused with hypertonic saline for 150 min while drinking water to satiety (drinking started at 120 min). Plasma osmolality (Posmol) at 120 min was increased (277 +/- 3 to 291 +/- 2, 280 +/- 6 to 295 +/- 5, and 287 +/- 1 to 307 +/- 1 mosmol/kg in 1st and 3rd trimesters and postpartum; P less than 0.01), accompanied by increments in plasma AVP (PAVP) up to 7 +/- 5, 5 +/- 3, and 8 +/- 3 pg/ml, respectively (P less than 0.01). PAVP declined as soon as drinking began (P less than 0.01 at 5 min), despite maintenance of peak osmolality for another 30 min. Similar events were recorded in three males. Calculation of normal disappearance rates (t1/2) demonstrated that AVP levels decreased more rapidly (P less than 0.01) in the 3rd trimester compared with early pregnancy and postpartum. Two other subjects became nauseated during their 1st trimester and postpartum tests which permitted comparison of nausea and drinking which evoke central reflexes with opposing action on AVP release. PAVP, which had increased markedly (range 17-42 pg/ml; P less than 0.01), was not abolished by drinking. These data demonstrate the potency of the drinking reflex on osmoregulation in pregnant and nonpregnant subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1999

Recent heavy drinking of alcohol and embolic stroke.

BACKGROUND AND PURPOSE: Epidemiological evidence suggests that heavy alcohol consumption increases the risk for ischemic stroke, whereas light-to-moderate alcohol intake decreases the risk, but the role of different drinking patterns has remained unclear. We investigated recent light, moderate, and heavy alcohol drinking and former heavy drinking as risk factors for acute ischemic brain infarction by etiological subtype of stroke. METHODS: We compared 212 consecutive patients aged between 16 and 60 years, who were completely evaluated for the etiology of their ischemic stroke, with 274 control subjects admitted to the emergency unit of the same hospital. ORs, as estimates of multivariate relative risks (RRs), and 95% CIs after adjustment for possible confounding variables were calculated by logistic regression. The ORs were adjusted for age, sex, body mass index, hypertension, diabetes, hyperlipemia, current smoking, and history of migraine. RESULTS: Recent heavy drinking but not former heavy drinking was an independent risk factor for stroke (RR 1.82, 95% CI 1.08 to 3.05). Consumption of 151 to 300 g and >300 g alcohol within the week preceding the onset of stroke significantly increased the risk for cardioembolic and cryptogenic stroke. Consumption of >40 g alcohol within the preceding 24 hours increased the risk for cardiogenic embolism to the brain among those who had a high-risk source (RR 4.75, 95% CI 1.23 to 18.4), the risk for tandem embolism among those who had prominent large-artery atherosclerosis (RR 7.68, 95% CI 1.82 to 32.3), and the risk for cryptogenic stroke (RR 3.84, 95% CI 1.69 to 8.71). Light drinking did not increase the risk for stroke. CONCLUSIONS: We conclude that acute drinking of intoxicating amounts of alcohol may trigger the onset of embolic stroke among subjects who have a source of thrombus in the heart or the large arteries.

Adolescent↗
PubMed1987

Daily drinking and drunken driving.

In a study of 3,658 drunken drivers, it was found that eight percent reported daily drinking of alcohol, 82% reported no daily drinking, and 10% gave no information about drinking frequency. Measurement of gamma glutamyl-transferase (a biological marker for heavy drinking) in a selection of blood samples from drunken drivers reporting daily drinking, indicated that the majority of these drivers were heavy drinkers. The drunken drivers who reported daily drinking, had higher blood alcohol concentrations, were responsible for a larger number of previously detected drunken driving offences, and were more prone to being arrested for drunken driving during working days and during daylight hours than other drunken drivers. Among the repeating offenders, it was estimated that 13% would report daily drinking, and 74% would not.

Adolescent↗
PubMed2005

Erosive effect of a new sports drink on dental enamel during exercise.

PURPOSE: To compare the potential erosive effect of a prototype carbohydrate-electrolyte drink (PCE) with a neutral control (water) and a commercially available carbohydrate-electrolyte drink (CCE) during exercise. METHODS: : Nineteen healthy adults (male, N = 16; female, N = 3) took part in this single blind, three-way crossover study. Subjects were given each of the three drinks according to a randomization schedule, approximately balanced for first-order carryover effects. At the beginning of each of the three study periods, the volunteers were fitted with an intraoral appliance containing two human enamel blocks. During each study period, volunteers exercised for 75 min.d(-1) (5 repetitions of 15 min of exercise, with 5-min rests between exercise repetitions), 5 d.wk(-1) for 3 wk. Each day, drink aliquots of 200 mL were consumed during a 5-min period before exercise and after every 15-min bout of exercise, followed by a final 400-mL aliquot ingested over a 10-min period: a total of 1400 mL per study day. Dental erosion was measured as tissue loss from the enamel blocks by profilometry at the end of each study period. RESULTS: Water, PCE, and CCE produced 0.138 microm (SD 0.090 microm), 0.138 microm (SD 0.038 microm), and 4.238 microm (SD 3.872 microm) of enamel loss, respectively. A Wilcoxon t statistic showed a significant statistical difference between the PCE and CCE drinks (P < 0.001), whereas no significant difference could be detected between the PCE drink and water (P = 0.740). CONCLUSION: The PCE solution showed minimal erosion compared with the commercially available drink, and was statistically indistinguishable from water under the conditions of this study. Use of CE solutions formulated to minimize erosion during exercise may provide significant dental benefits.

Adult↗
PubMed1996

[A study on the relationship between sources of health information concerning smoking and drinking, and health behavior].

To determine effective measures to popularize knowledge on the health effects of smoking and drinking and to change health behavior, an interview survey of 2000 persons aged 18 or older randomly chosen from national census forms throughout Japan was carried out. The coverage rates of the information concerning smoking and drinking were 97.3% and 92.5%, respectively. Television, newspapers and magazines were the major sources of health information concerning smoking and drinking. In addition, men who gave up or controlled smoking or drinking usually obtained health information from doctors, while those who had never controlled smoking usually obtained health information from their friends and families. Men who could not control drinking effectively usually obtained health information from the health examination consultant at the workplace. However, according to the answers from men who gave up or controlled drinking, the health information useful in changing health behavior was obtained from the health examination consultant at the workplace and from persons who had a disease history. Women who gave up or controlled drinking answered that the health information from their friends and families was helpful to change the health behavior.

Adolescent↗
PubMed2005

Encouraging responsible drinking among underage drinkers.

Public Service Announcements tailored to specific college drinking rituals (Treise, Wolburg and Otnes 1999) were tested on 133 underage undergraduate drinkers. More significant reductions in drinking intentions were found when using appeals focusing on drinking rituals pertaining to Maturity/Order (older students drink moderately: "Don't drink like a freshman.") than to Transformation (desired personality and mood changes), Community (social bonding and camaraderie), or a no-message Control. Gender did not moderate this effect. Underage drinkers may drink, in part, to feel more "grown up." Emphasizing that more senior students actually drink responsibly may diminish this belief and result in reduced alcohol consumption among underage students.

Adolescent↗
PubMed1989

Coordination of eating, drinking and breathing in adults.

The coordination of breathing and swallowing was studied in seven normal males at rest, as well as during eating and drinking. Ventilation was monitored using respiratory inductive plethysmography and swallowing was recorded by submental electromyogram. Swallowing occurred almost exclusively in expiration. Two hundred and seventy-one swallows were seen and only two occurred in inspiration. The mean expiratory duration (Te) of breaths containing a swallow was significantly greater than the mean Te of all breaths during the same period. There was no change in mean tidal volume (VT), inspiratory duration (Ti), expiratory duration (Te), mean inspiratory flow (VT/Ti) or minute ventilation (VE) between the periods of normal breathing, eating and drinking. However, breathing became more irregular during eating and drinking. The mean coefficient of variation of VT, Te, and VT/Ti was significantly greater during eating and drinking than at rest. The coefficient of variation for VT was 22 + 3 percent, 36 +/- 5 percent, and 41 +/- 5 percent during the initial period of resting breathing, eating and drinking. For VT/Ti it was 24 +/- 6 percent, 43 +/- 14 percent and 44 +/- 8 percent during resting breathing, eating and drinking. We conclude that swallowing is almost exclusively an expiratory activity. This may play a protective role in preventing aspiration. Although the level of ventilation is maintained constant during eating and drinking, the pattern of breathing becomes increasingly irregular. This may contribute to dyspnea during meals in some patients with lung disease.

Adult↗
PubMed1984

Drinking and occupational status in New Zealand men.

The self-reported alcohol consumption of various occupational groups in New Zealand is examined. A sample of 10,000, representative of the general adult population, was questioned in 1978-1979. Only data on men (N = 5000) are considered in the present study. Various occupations and groups of occupations are ranked on several variables of frequency and quantity of drinking. The interrelationships of these variables and the working conditions related to them are discussed. There is an association between drinking pattern and general social class, but 61% of the specific occupational groups form a cluster in the range of 25-60 ml of absolute alcohol consumed on one or two occasions per week. The extreme positions on drinking variables of specific occupational groups is examined in terms of job characteristics. Most of the correlations are very low; drinking at work is the highest. The relationships can best be described in terms of the social class of the occupational groups and the frequency vs quantity dichotomy. The distribution of the social classes in terms of drinking intensity is discussed. Employment in the lower classes is related to lower frequency and higher quantity of drinking, and higher cirrhosis mortality. Overall, social class appears to be a more important indicator than occupational group or drinking pattern.

Adolescent↗
PubMed1984

Factors related to problem-drinking rates.

Intercorrelation and regression analyses of data obtained from a drinking-related behavior and attitude household survey (N = 1127) of adults (age 18+) in Iowa are reported. The consumption variables were based on the 30 days prior to interview and included total ounces of absolute alcohol consumed; number of days the subject drank beer, wine and distilled spirits separately; typical quantity of each beverage consumed on drinking days; and the number of days drank five or more drinks within a couple of hours. The drinking attitude variables included level of tolerance (approve, indifferent, disapprove) of others' (men, women, spouse, son and daughter) drinking, getting high and getting intoxicated; a balance score of the proportion of positive and negative definitions of alcoholic beverages endorsed; an level of concern (not worried, somewhat worried and very worried) for eight possible consequences of heavy drinking. The drinking context variables used were the number of past 30 days that respondents drank at a bar or tavern, restaurant or club, home, others' homes, sports event and outdoor recreation; and number past 30 days drank alone, with relatives, work associates and close friends who are not work associates. The family environment variables included the respondent's report of whether any blood-related relatives had experienced alcohol-related problems, and of whether beverage alcohol was used in their childhood home.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1987

Psychosocial factors in adolescent drinking contexts.

A number of environmental and personality characteristics of adolescent students and their relationship to types of drinking contexts were examined using a series of canonical correlation analyses. The strongest relationship was defined by the perceived normative support for drinking, which accounted for 55% of the variance in the drinking context items for males (58% among females). Positive functions of drinking, personal attitudes and values, and environmental contexts were also associated with drinking context items but accounted for smaller proportions of the variance. The contribution of important environmental, personality and drinking context variables to each canonical relationship is discussed. Consistency of studies relevant to the major finding is reviewed and possible bases for discrepancies are explored. Further studies relating to antecedent networks of access to various drinking contexts are identified as areas deserving more intensive and extensive research efforts.

Adolescent↗
PubMed1988

Male Chinese drinking behavior in Los Angeles.

The purpose of this research was to identify the characteristics that distinguish male Chinese drinkers from abstainers and to clarify differences between Chinese men who drink limited amounts of alcohol and those who drink more heavily. A random sample of 218 adult Chinese men was interviewed using a schedule based on a national study of drinking behavior. The stereotype of Chinese as limited drinkers was partially supported by the data. Approximately 22% of the sample were abstainers whereas only 14% were heavy drinkers. Light drinkers were the modal category. A logistic regression model was used to evaluate the relative importance of the significant characteristics of drinkers and abstainers. Parents' drinking behavior influenced respondent's drinking behavior, and drinkers tended to like to go to parties. Chinese men with higher education were more apt to be drinkers. A second logistic regression model was used to identify the predictive variables related to the level of drinking. Chinese men who go to bars and who have friends who drink were the most likely to be heavy drinkers.

Adult↗
PubMed1990

Familial transmission of alcohol use: II. Imitation of and aversion to parent drinking (1960) by adult offspring (1977)--Tecumseh, Michigan.

The "fall-off" effect, when offspring respond to parental high-volume levels by moderating their own drinking, appears highly predictable across generations and is mediated both by subsequent parent drinking level and offspring's perception of problematic intake by their parents. This fall off by adult offspring appears to follow community norms; it occurs, on the average, at the level of daily drinking by fathers, and when the mother approaches daily-drinking levels. An aversion effect holds more to cross-sex parents with problems; thus, both sons and daughters show a nonimitation and fall off to their cross-sex parents who are high-volume problem drinkers. Conversely, however, daughters often imitate a high-drinking father with no problems. For high-drinking mothers, without problems or with problems (numbers are small), daughters' drinking appears "polarized": most (60%) are abstemious, but a higher number than expected (about 35%) show high volume thus imitating the mother's volume, compared to about 17% of the total sample of daughters who were high-volume drinkers. Maximal offspring imitation is strongest for abstemious parents, especially for abstaining parents, and stronger for fathers abstaining than for mothers.

Adult↗
PubMed1992

The effect of acculturation on drinking attitudes among Japanese in Japan and Japanese Americans in Hawaii and California.

Data from a joint Japan-U.S. collaborative study were examined to determine the relationship of acculturation to drinking attitudes among Japanese in Japan and Japanese Americans in Hawaii and California. Drinking attitudes (i.e., self-reported acceptable or appropriate levels of drinking) among ethnic groups differed significantly for the nine situations studied: (1) at a bar with friends, (2) at a party at someone else's house, (3) as a parent, spending time with small children, (4) during working hours, (5) visiting in-laws, (6) with friends at home, (7) with friends after work, (8) with people at sports events and (9) before driving a car. Factor analysis was used to determine the differences in drinking attitudes among these ethnic groups. Japanese and Japanese Americans differentiated drinking situations into different categories. The major difference between the two groups was that the Japanese associated spending time with small children with a situation appropriate for drinking, such as being with friends at home, whereas Japanese Americans associated spending time with small children with a situation inappropriate for drinking, such as before driving.

Acculturation↗
PubMed1992

Measuring quantity and frequency of drinking in a general population survey: a comparison of five indices.

This article compares five indices of alcohol consumption in a general population survey conducted in 1985 in the Netherlands. Self-reports of consumption were obtained with a prospective diary, a retrospective 7-day recall method, and three summary measures, such as a quantity-frequency index. The coverage of sales data appeared highest for the diary (67%), which suggests a higher validity. Special attention was given to comparisons of quantity and frequency of drinking between the diary, on the one hand, and the weekly recall and summary measures, on the other. It was found that underreporting, relative to the diary reports, was generally higher in the frequency than in the quantity domain. This result, together with the finding from longitudinal studies that intraindividual variation is also higher for drinking frequency, leads to the conclusion that forgetting is a potent source of undercoverage in surveys and to the hypothesis that large differences in overall drinking pattern between populations (e.g., in regularity of drinking) may account for the large differences in coverage rates of sales data. Furthermore, the subjectively assessed probability of drinking by means of a "usual" frequency question appeared a poor predictor of (diary) drinking frequency for respondents reporting a low or moderate frequency. For subjects claiming a high "usual" drinking frequency, a reasonable correspondence between diary and summary measures was found. This mitigates the fear often expressed that heavy drinkers particularly underreport their consumption.

Adult↗
PubMed1992

Self-control concerns and drinking loss of control in general and clinical populations.

In popular conceptions, loss of control over drinking involves a double loss of control, over one's life as well as over one's drinking. A measure of "control worries," concerning the experience of difficulties in controlling one's life, was developed. The relationships between measures of control worries, loss of control over drinking and heavy-drinking behavior were examined in samples both of alcohol treatment clients and of the general population in a California county. Alcohol treatment clients reported greater control worries and loss of control over drinking than members of the general population. Although control worries were only slightly correlated with drinking loss of control, this relationship tended to be conditional in the general population. The findings suggest that concerns about personal control in general may be a useful construct to consider in conjunction with the drinking loss of control concept.

Adult↗
PubMed1993

Young adult drinking-driving: behavioral and psychosocial correlates.

Behavioral and psychosocial correlates of drinking and driving were examined in two independent samples of licensed drivers aged 18 to 25 selected from the Colorado Division of Motor Vehicles database. Mail questionnaires were returned by 2,300 young adults (1,196 in Sample 1; 1,104 in Sample 2). Structural equation modeling was used to examine the relation of a latent-variable measure of drinking-driving to latent-variable measures of other driving behaviors, problem behaviors and psychosocial variables. Drinking-driving, drug-driving and risky driving were found to comprise a more general, second-order factor of problem driving behavior. Drinking-driving was also found to constitute one aspect of a larger second-order latent variable that included problem drinking, marijuana use, other illicit drug use and delinquent-type behavior. In combination, the variables of problem driving, other problem behaviors, psychosocial unconventionality, risk-taking and hostility/aggression accounted for 57% of the variance in young adult drinking-driving. All of these Sample 1 findings were buttressed by confirmatory analyses in the independent Sample 2 data. The conclusion can be drawn that drinking-driving is part of a more general lifestyle involving behavior and psychosocial unconventionality.

Adolescent↗