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PubMed1967

Babinski's sign.

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History, 19th Century↗
PubMed1976

Disulfiram-induced encephalopathy.

Two patients with disulfiram-(Antabuse-)induced encephalopathy exhibited paranoid ideas, disorientation, impaired memory, ataxia, dysarthria, snout and grasp reflexes, and abnormal electroencephalograms. The first patient developed symptoms on two occasions, each time after disulfiram administration. The second patient experienced a generalized seizure followed by fulminant psychosis three weeks after starting disulfiram therapy. Spinal fluid examination in the latter patient revealed a low homovanillic acid (HVA) level. Since disulfiram inhibits dopamine oxidation, disulfiram-induced encephalopathy may be related to excess dopaminergic activity in the central nervous system.

Adult↗
PubMed1977

Reversible subacute peripheral neuropathy induced by phenytoin.

Dysesthesia and sensory and reflex loss in the legs developed in a patient treated for seizures with phenytoin (diphenylhydantoin) for one year. Her serum drug levels had been in the therapeutic range, and no other clinical toxic reactions had been noted. The peripheral neuropathy resolved when phenytoin therapy was discontinued.

Adult↗
PubMed1977

Significance of positive spike burst in Reye syndrome.

We have previously reported a high incidence of 14-and 6-cps positive spike bursts in comatose patients with Reye syndrome. To further demonstrate this association, positive spike bursts were obtained in three additional cases but only in certain stages during the acute phase of illness. They varied in frequency from 7 to 13 cps, presumably reflecting the degree of slowing of the background EEG activity. A loud noise or other stimuli often precipitated the bursts, particularly when high amplitude delta waves were prominant. We believe that the presence of the positive spike bursts in comatose patients may be of diagnostic significance in Reye syndrome and that an undetermined metabolic or biochemical disturbance may be responsible for their appearance.

Acoustic Stimulation↗
PubMed1978

St Louis encephalitis with particular involvement of the brain stem.

We report a case of St Louis encephalitis in a 4-year-old child in which the main clinical features were dominated by brain stem dysfunction. We document an drome and present a review. We also discuss St Louis encephalitis, with special attention to the ocular manifestations.

Brain Stem↗
PubMed1978

Peripheral polyneuropathy associated with primary malignant lymphoma of the brain.

A patient with a primary malignant lymphoma of the brain manifested a peripheral polyneuropathy during his illness that could not be accounted for by the usual causes. The polyneuropathy is considered to be a nonmetastatic complication of the primary brain tumor. A review of the literature did not uncover a similar case.

Brain Neoplasms↗