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PubMed1977

Increased incidence of gram-negative neonatal sepsis with intramuscula iron administration.

During a five-year period the incidence of neonatal sepsis was 20 times higher in Polynesian newborns compared with European newborns (11 per 1,000 vs. 0.6 per 1,000 total births). This high incidence in Polynesians was confined to a period when the infants were being given intramuscular iron dextran. When the iron administration was stopped the incidence of disease in Polynesians decreased from 17 per 1,000 to 2.7 per 1,000 total births. An analysis of the Polynesian iron-treated and non-iron-treated groups showed a statistically significant difference in the incidence of sepsis, the type of causative organism, and mortality. The data suggest that the iron dextran injections have impaired the immunity of the treated infants, making them more susceptible to Escherichia coli sepsis.

Bacterial Infections↗
PubMed1977

[Eosinophilic meningitis (author's transl)].

Eosinophilic meningitis, also named human nervous angiostrongyliasis, results from the infestation of the Nervous System by larvae of Angyostrongylus Cantonensis realizing there a parasitic deadlock. The Authors studied 54 patients whose main complaints were severe and lasting headache, and paresthesias. A meningitic syndrome is not always encountered and a facial paralysis of the lower motor neuron type has been noted in a few patients. Study of the Cerebrospinal fluid shows pleiocytosis with a variable percentage of eosinophiles. Complete recovery is usual after a couple of weeks and the prognosis can be given as excellent despite of the fact that no specific therapy is known at the present time.

Eosinophilia↗