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Results for “PANTOTHENIC ACID”

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At least 1,333 records · Page 74Linked to original sources
PubMed1979

Purification and properties of L-Aspartate-alpha-decarboxylase, an enzyme that catalyzes the formation of beta-alanine in Escherichia coli.

L-Aspartate-alpha-decarboxylase, an enzyme that catalyzes the production of beta-alanine, has been purified to apparent homogeneity from Escherichia coli. The properties of the enzyme are: (a) pH optimum of 6.8 to 7.5, (b) temperature optimum of 55 degrees C, (c) Km for L-aspartate of 0.16 mM, and (d) molecular weight of 58,000. The activity of the enzyme is inhibited by reagents (hydroxylamine, phenylhydrazine, and sodium borohydride) that react with carbonyl groups, but no pyridoxal phosphate is present. The compound containing the carbonyl group has been identified as covalently bound pyruvate. Approximately 1 mol of pyruvate was found/mol of enzyme. That the enzyme has a biosynthetic function rather than a catabolic role is indicated by the observations that a mutant (designated as E. coli 99-2) which requires either beta-alanine or pantothenic acid for growth contains only trace amounts of enzyme activity, whereas it is present in substantial amounts in the parent strain (E. coli W) and in a spontaneous revertant of the mutant.

Alanine↗
PubMed1986

Nutrient intake and obesity in a multidisciplinary assessment of osteoarthritis.

The nutritional composition of diets and prevalence of obesity in 77 osteoarthritis patients were assessed biweekly for 12 weeks as part of a multidisciplinary approach to the management of osteoarthritis. Height was measured at the first visit, and weight was measured at each of the seven biweekly follow-up visits. A body mass index was calculated, based on height and weight, to determine obesity. Nutrient information was obtained by use of a 24-hour dietary recall and a food frequency questionnaire. Seventy-nine percent of the patients were obese. Obesity was positively related to pain from osteoarthritis and was more prevalent among these osteoarthritis patients than it is among the general geriatric population. Dietary intakes of vitamin D, folacin, vitamin B6, zinc, and pantothenic acid were below 80% of the recommended dietary allowance. Osteoarthritis patients may benefit from weight loss if they are obese and from eating more foods that supply the nutrients in which they are deficient. In addition to providing nutritional recommendations to avoid dietary deficiencies, a registered dietitian can assist in the multidisciplinary treatment of osteoarthritis by providing weight-control counseling and follow-up.

Adult↗
PubMed1985

Biochemical and clinical study of calcium pantetheine-S-sulfonate.

Calcium pantetheine-S-sulfonate (PaSSO3Ca) is one of the pantothenic acid derivatives. We examined PaSSO3Ca inhibition capacity of tyrosinase activity in vitro. For the safety evaluation when it will be applied to the human skin, we tested PaSSO3Ca creams to the fifty one patients with skin diseases by 48 hours closed patch test method. And clinical evaluation of PaSSO3Ca creams were performed in fifty patients with chloasma by half side method. Results were as follow: 1, PaSSO3Ca was proved to inhibit the tyrosinase activity in vitro. 2, PaSSO3Ca cream was shown to be safe to human skin. 3, 10% PaSSO3Ca cream lightened the skin hyperpigmentation.

Administration, Topical↗
PubMed1985

Footnotes to food tables. 2. The underestimations of intakes of lesser B vitamins by pregnant and lactating women as calculated using the fourth edition of McCance and Widdowson's 'The composition of foods'.

In McCance & Widdowson's 'The composition of foods' many items lack information on the content of the lesser B vitamins, and dietary intakes can therefore be underestimated. The degree of this underestimation was assessed using data from a longitudinal study of the food intake of 63 pregnant and lactating mothers in Cambridge, UK, with a total of 3185 days of weighed diet records. The extra mean daily additional intake of each vitamin contributed by foods eaten by the mothers but lacking data in the food tables was estimated to be: vitamin B12, 0.1 micrograms, (1.5 per cent of total intake); vitamin B6, 0.04 mg (3.3 per cent); total folate, 10 micrograms (5.3 per cent); pantothenic acid, 0.6 mg (11.5 per cent); and biotin, 5 mg (14.3 per cent). Although many items in the tables lack data, most were eaten infrequently and made little contribution to vitamin intake. It was estimated that, if data were added for a limited number of frequently-eaten foods, namely, white toast, baked beans, biscuits, breakfast cereals and 'chicken with skin', then intakes of all five vitamins would be underestimated by less than 4 per cent.

Diet↗