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At least 1,333 records · Page 74Linked to original sources
PubMed1987

A new permanent exteriorized epidural catheter for narcotic self-administration to control cancer pain.

The lack of an available exteriorized permanent epidural catheter led to the application of the Broviac catheter technology to the development of an epidural catheter. The resulting three-piece silicone-rubber catheter system allows specific spinal-level location of the catheter tip from a lumbar entry site, and exteriorization for ease of self-administration. Fifty-five cancer patients with metastatic disease and intractable pain received 58 catheters. No catheter infections were found during 3891 catheter-days of use, and only 18 minor side effects were noted, with no respiratory depression observed. Hospitalizations for pain control was decreased by 90% after catheter placement. Therefore, the authors recommend early placement of this silicone-rubber epidural catheter to control pain unrelieved by oral analgesics.

Catheterization↗
PubMed1988

Narcotic alkylating agents: synthesis, structure and biological activities.

The synthesis, structure and biological activities of a series of derivatives of normorphine, noracetylmethadol (IV a), 6-amino-4,4-diphenyl-3-heptanol acetate (V a), and norpropoxyphene (VI a), in which the corresponding nitrogen supports an alkylating group (chloroethyl or fumaroyl) are reported. Structural identification was achieved spectroscopically. 13C Nuclear Magnetic Resonance proved the most useful tool in this task. N-Chloroethylnoracetylmethadol (IV c), acted as a potent long-lasting analgesic. Although some compounds (IV c), (V c) and (V d) showed substantial cytostatic activity, no antineoplastic activity in mice with P388 leukaemia was detected in the series.

Alkylating Agents↗
PubMed1980

Clinical effects of parenteral narcotics in hospitalized medical patients.

Of 38,221 hospitalized medical patients monitored by a drug surveillance program, 1821 (4.8 per cent) received morphine, 504 (1.3 per cent) received codeine, 493 (1.3 per cent) received papaveretum, 115 (0.3 per cent) received hydromorphone, and 101 (0.3 per cent) received methadone parenterally. Hydromorphone had an unusually high adverse reaction rate (18 per cent); therefore, it probably should not be used since other equally effective strong analgesics are available. Adverse reactions occurred in 2 per cent of papaveretum recipients, in 4 per cent of methadone and codeine recipients, and in 6 per cent of morphine recipients. Gastrointestinal reactions (primarily nausea, vomiting, and constipation) were most common. Central nervous system disturbances (primarily respiratory depression, drowsiness, and confusion) were second most common. Adverse reactions occurred more often with higher doses of morphine and codeine; the dose-response relationship could not be evaluated for the other three drugs. Life-threatening adverse reactions were reported in 28 patients. Respiratory depression was the most common life-threatening reaction. Most patients with these reactions were seriously ill, and many received other drugs that may have contributed to the event.

Codeine↗