The ten major problems of aging skin.
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A case of acne on the legs of a 55-year-old white woman is reported. The drugs and chemicals that are known to cause acneiform eruptions are reviewed. No clues to the localization of the disease in this patient were detected.
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A case of Perforating Folliculitis is observed, and its clinical and histological aspects are commented upon. Its differential diagnosis and relation to other dermatosis with transepidermal elimination are discussed. Of particular interest, is the extremely chronic aspect of our case.
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An extraordinary case: large cutaneous tumors, intense "endocrine" exophthalmos, macroglossia, acropachie, prétibial mucinosis, diffuse myxodermia, symptoms of systemic involvement.
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A biopsied specimen of a pink lesion on the knee of a 21-year-old woman showed histologic features of subepidermal vesicular dermatitis. Further studies disclosed diagnostic features of malignant melanoma in situ, and additional clinical data corroborated the diagnosis.
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Erythema annulare centrifugum (EAC), a chronic figurate eruption, occurred in a 28-year-old male physician several months following the onset of recurrent abdominal pain. Two months after the manifestation of EAC, another episode of abdominal pain culminated in appendectomy for perforated appendicitis. During his convalescence, the skin lesions faded and did not reappear. We propose that recurrent appendiceal inflammation caused both the episodic pain and the skin eruptions. Additionally EAC may be a sign of chronic infection, internal malignancy, or food allergy. Although truly chronic appendicitis is a disputed entity, recurrent, spontaneously resolving episodes of appendicitis occasionally do precede surgical appendicitis. The presence of EAC in a patient having recurrent abdominal pain should discourage a precipitant diagnosis of functional illness and prompt further investigation.
This paper reviews the clinical, endocrine and lymphatic status of 6 patients with pretibial myxoedema. The lymphatics were studied to determine whether they were involved in the pathogenesis of the disease. The main lymph trunks were normal although there was occasionally some collateral flow and some of the lymph nodes had small irregular filling defects. These changes suggest compression of the lymphatics by the myxomatous material and the deposition of mucinous material in the lymph nodes. There was no evidence of a primary lymphatic abnormality.
Survival data for over 500 adult frogs (393 Rana pipiens, 35 Rana clamitans , and 97 Rana temporaria) obtained from commercial suppliers were accumulated. Frogs which developed signs of red-leg disease while being kept in 0.15% saline were cured by addition of appropriate antibiotics to the saline. The appropriate antibiotic was determined by sensitivity testing of bacteria isolated from the sick frogs. When many frogs in a shipment were sick, prophylactic treatment of the entire shipment improved the overall survival in the shipment.
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