Apneusis and electrical activity of the respiratory muscles in the guinea pig.
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Minute dissection was performed in one male adult cadaver in order to elucidate the detailed distribution of muscular branches of intercostal nerves within the lateral abdominal muscles as well as the segmental relationships. In the obliquus internus and transversus abdominis, as well as in the upper half of the obliquus externus, each muscle fascicle receives the nerve of the corresponding segmental attachment to the rib. On the other hand, in the lower half, the obliquus externus abdominis receives a twig from the lower adjacent segmental nerve, because within the muscle the corresponding segmental nerve first runs horizontally and enters the upper adjacent fascicle before descending obliquely, parallel to the fiber direction.
Eight healthy adult grade ponies were studied at rest as well as during maximal exertion carried out with and without adenosine infusion (3 microM X kg-1 X min-1 into the pulmonary artery) on a treadmill to compare levels of blood flow in respiratory muscles with those in other vigorously working muscles and to ascertain whether there remained any unutilized vasodilator reserve in respiratory muscles of maximally exercising ponies. Radionuclide-labeled 15-micron-diam microspheres, injected into the left ventricle, were used to study tissue blood flows. During maximal exertion, there were increases above base-line values in heart rate (336%), mean aortic pressure (41%), cardiac output (722%), and arterial O2 content (56%). The whole-body O2 consumption was 123 +/- 11 ml X min-1 X kg-1, and the stride/respiratory frequency of the galloping ponies was 138 +/- 4/min. With adenosine infusion during maximal exertion, mean aortic pressure decreased (P less than 0.05), but none of the above variables was different from maximal exercise alone. During maximal exertion, blood flow in the adrenal glands, myocardium, respiratory, and limb muscles increased, whereas that in the kidneys decreased and the cerebral perfusion remained unaltered. With adenosine infusion during maximal exercise, renal vasoconstriction intensified, whereas adrenal and coronary beds exhibited further vasodilatation. During maximal exertion, blood flow in the equine diaphragm (265 +/- 36 ml X min-1 X 100 g-1) was not different from that in the gluteus medius (253 +/- 36) and biceps femoris (233 +/- 29); both are principal muscles of propulsion in the equine subjects) or the triceps brachii (227 +/- 26) muscles.(ABSTRACT TRUNCATED AT 250 WORDS)
In normal young men, there is an abrupt fall in ventilation (VE), a rise in upper airway resistance (UAR), and falls in the activities of the diaphragm (Di), intercostals (IC), genioglossus (GG), and tensor palatini (TP) at sleep onset. On waking, there is an abrupt increase in VE and fall in UAR and an increase in the activities of Di, IC, GG, and TP. The aim of this study was to determine whether these changes are age dependent. Nine men aged 20 to 25 yr were compared with nine men aged 42 to 67 yr. Airflow, UAR, Di, and IC surface electromyograms (EMGs) and the intramuscular EMGs of GG and TP were recorded. It was found that the falls in IC, GG, and TP at the transition from alpha to theta electroencephalogram (EEG) activity were significantly greater in the older than in the younger men (P < 0.05) and that the fall in Di was also greater, although this was only marginally significant (P = 0.15). The rise in GG at theta-to-alpha transitions was also greater in the older than in the younger men, and there was a trend for TP to be higher.
Electromyographic studies were performed on 16 patients with intractable low back pain and no antecedent history of malignancy or metastatic disease. In each case, electromyographic evidence of severe segmental denervation limited to the paraspinal muscles innervated by the posterior primary rami was found. Subsequent diagnostic studies in each patient revealed a primary neoplasm or tumor metastasis as the source of pain. Applying current knowledge of neuromuscular physiology, the electromyograph may prove to be a valuable aid to the early detection of remote metastasis to the spine and paraspinal muscle structures.
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