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PubMedDate not supplied

Monocyte, macrophage and foreign body giant cell interactions with molecularly engineered surfaces.

To elucidate the mechanisms involved in monocyte/macrophage adhesion and fusion to form foreign body giant cells on molecularly engineered surfaces, we have utilized our in vitro culture system to examine surface chemistry effects, cytoskeletal reorganization and adhesive structure development, and cell receptor-ligand interactions in in vitro foreign body giant cell formation. Utilizing silane-modified surfaces, monocyte/macrophage adhesion was essentially unaffected by surface chemistry, however the density of foreign body giant cells (FBGCs) was correlated with surface carbon content. An exception to the surface-independent macrophage adhesion were the alkyl-silane modified surfaces which exhibited reduced adhesion and FBGC formation. Utilizing confocal immunofluorescent techniques, cytoskeletal reorganization and adhesive structure development in in vitro FBGC formation was studied. Podosomes were identified as the adhesive structures in macrophages and FBGCs based on the presence of characteristic cytoplasmic proteins and F-actin at the ventral cell surface. Focal adhesion kinase (FAK) and focal adhesions were not identified as the adhesive structures in macrophages and FBGCs. In studying the effect of preadsorbed proteins on FBGC formation, fibronectin or vitronectin do not play major roles in initial monocyte/macrophage adhesion, whereas polystyrene surfaces modified with RGD exhibited significant FBGC formation. These studies identify the potential importance of surface chemistry-dependent conformational alterations which may occur in proteins adsorbed to surfaces and their potential involvement in receptor-ligand interactions. Significantly, preadsorption of alpha2-macroglobulin facilitated macrophage fusion and FBGC formation readily on the RGD surface in the absence of any additional serum proteins. As alpha2-macroglobulin receptors are not found on blood monocytes but are expressed only with macrophage development, these results point to a potential interaction between adsorbed 2-macroglobulin and its receptors on macrophages during macrophage development and fusion. These studies identify important surface independent and dependent effects in foreign body reaction development that may be important in the identification of biological design criteria for molecularly engineered surfaces and tissue engineered devices.

Journal Article↗
PubMed1998

Intraocular mass simulating a retained foreign body.

PURPOSE: To present an unusual case of a preretinal mass that simulated a retained metallic foreign body. METHOD: Case report. RESULTS: A 30-year-old man presented with unilateral iridocyclitis and an ipsilateral preretinal mass with ultrasonographic and computed tomographic characteristics of a metallic foreign body. Histologic examination of the mass disclosed a central concentration of iron-containing hemoglobin breakdown products surrounded by a cocoon of fibrous tissue. CONCLUSION: Blood breakdown products surrounded by a fibrous capsule can present with the characteristics of an intraocular metallic foreign body.

Adult↗
PubMed2006

Non-resolving pneumonia in a young boy--beware of foreign body aspiration.

A 4 1/2-year-old boy presented with recurrent cough and cold of 2 years duration. Chest x-ray revealed collapse consolidation of right lower lobe. Rigid bronchoscopy was done and the nozzle of a pen was extracted from right main bronchus. The radiological improvement took three months after extraction of the foreign body. Undetected foreign body aspiration is one of the causes of nonresolving pneumonia in children.

Airway Obstruction↗
PubMed2002

Pediatric external auditory canal foreign bodies: a review of 698 cases.

OBJECTIVE: The study goal was to determine the relationships between patient management factors and patient outcomes in pediatric patients with external auditory canal foreign bodies. STUDY DESIGN AND SETTING: Retrospective analysis was conducted of 698 consecutive cases of pediatric external auditory canal foreign bodies (n = 605 patients) who presented to a tertiary care pediatric referral center during a 6-year period. RESULTS: Emergency physicians frequently removed foreign bodies under direct visualization while otolaryngologists primarily used otomicroscopy. Both of these methods had high success rates overall (77% and 86%), but attempts under direct visualization had lower success rates with removing spherical objects, objects touching the tympanic membrane, and objects in the canal for more than 24 hours. Failed removal attempts resulted in higher complication rates. CONCLUSION: Certain foreign body and patient characteristics are associated with poor outcomes with removal attempts made under direct visualization. These cases should be referred directly to otolaryngologists for otomicroscopic removal.

Adolescent↗
PubMed2000

Clinical experiences of removing foreign bodies in the airway and esophagus with a rigid endoscope: a series of 3217 cases from 1970 to 1996.

This study examined 11,333 rigid endoscopy procedures performed in the Department of Otolaryngology, National Taiwan University Hospital, during a 27-year period from 1970 to 1996. Among these cases, 3217 were performed to remove foreign bodies from the airway (459 cases, 14.3%) and esophagus (2758 cases, 85.7%). Retrospective analysis of these data revealed that peanuts (217 cases) and animal bones (1184 cases) were the most frequent foreign bodies encountered in the airway and esophagus, respectively. The successful rate of removal of these foreign bodies was 99.9% (3213/3217). The complication rate was only 0.2% (8/3217), and the mortality rate was less than 0.1% (2/3217). On the basis of these results, we conclude that foreign bodies in the airway and esophagus can be removed safely under direct visualization through rigid endoscopy with relatively few complications. A significant finding in this study is the declining trend in the number of cases in recent years. Despite the decline in the number of procedures, endoscopic removal of foreign bodies remains as a vital skill of the aerodigestive tract surgeon.

Adolescent↗
PubMed1993

Visibility of foreign bodies in soft tissue in plain radiographs, computed tomography, magnetic resonance imaging, and ultrasound. An in vitro study.

We compared conventional plain radiography, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound (US) with respect to their suitability for detecting foreign bodies in soft tissue in an in vitro model using a cow tongue to simulate orofacial soft tissues. Four samples of different sizes of fractured tooth crown, pieces of amalgam, glass, asphalt, composite, dry wood, and stone were each embedded under a 2-cm-thick flap on the caudal surface of the tongue. Plain radiographs revealed all the materials except wood, and there was some variation in the subjectively evaluated radiopacity of the materials which indicated the nature of the foreign bodies concerned. MRI proved to be the least suitable imaging method, as particles with a metallic content gave rise to powerful interference artifacts. CT and especially US proved to be suitable imaging methods for foreign-body detection in soft tissue. Amalgam produced a metallic streaking artifact in CT, which visualized wood as gas density, and depicted all the other materials as similar hyperdense masses. Ultrasound was both sensitive and specific in detecting foreign bodies in soft tissue. The particles were better defined in form and size with CT and US than with MRI or plain radiography. We conclude that when plain radiographs, history, and clinical examination fail to reveal the presence of superficial foreign bodies, US or CT can serve as an alternative method.

Animals↗
PubMed1990

[Foreign bodies in the alimentary tract. Surgical treatment].

Gastro-intestinal foreign bodies are a by no means rare event in surgery and in the USA mortality is about 1500 people per annum. The surgical treatment of foreign bodies in the alimentary tract is reported here. Certain cases of voluntary ingestion in mental patients are reported, comparing personal experience with the data reported in the literature.

Adolescent↗
PubMed1992

Vaginal foreign body extraction by forceps: a case report.

Cases in which foreign bodies have been inserted into the vagina are uncommon but do occur. The technique and use of obstetric forceps for the extraction of an orange as a vaginal foreign body is described in this case report. Tucker-McLane forceps are the forceps of choice for this technique in this case.

Adult↗
PubMed2006

[Diagnosis of intraocular foreign bodies in multidetector-CT: influence of acquisition parameters on radiation dose and detectability].

PURPOSE: Determination of the influence of acquisition and reconstruction parameters on radiation dose and detectability of intraocular foreign bodies using multidetector CT (MDCT). MATERIALS AND METHODS: Porcine eyes with intraocular foreign bodies of a 0.3-mm quartz fiber and a 0.1-mm steel wire as well as 0.5 ml of blood in the vitreous were investigated using MDCT. The tube current was 500, 250, 100, and 50 mAs; the collimation was 16 x 0.75 mm and 16 x 1.5 mm; and the pitch was 0.5 and 0.75. Image reconstruction was performed using a soft tissue (H30), a bone algorithm (H60 s), and thin (0.7 and 2 mm, respectively) and thick (2 and 4 mm, respectively) reconstruction increments. The resulting data sets were then used to determine the signal difference to noise ratio (SDNR) between the foreign body and adjacent vitreous. RESULTS: Changes in tube current resulted in a proportional change in the radiation dose but only in the SDNR within a range of 1:2. Reducing the collimation from 1.5 mm to 0.75 mm resulted in a doubling of the SDNR at an approximately identical radiation dose. The series with a lower pitch at the same dose per volume showed a slightly higher SDNR. Reconstruction using a bone algorithm and thin increments resulted in an increase in the mean SDNR by a factor of 1.8 to 2.3. CONCLUSION: When diagnosing small intraocular foreign bodies using MDCT, the following parameters can yield an adequate SDNR while minimizing radiation exposure: tube current 50 mAs, pitch 0.5, collimation 16 x 0.75, bone algorithm, and reconstruction increment 0.7 mm.

Animals↗
PubMed1971

Management of ingested foreign bodies in childhood.

A total of 660 patients with ingested foreign bodies admitted to the general surgical services in two children's hospitals in Liverpool are reviewed. Endoscopic removal (205 cases) is recommended for all foreign objects impacted in the oesophagus, with the exception of rounded or blunt objects in the lower third, which should be observed for a maximum of 12 hours. The indications for laparotomy for removal of a foreign body (43 cases, 6.5%) are the danger of perforation and failure of progression. The ingestion of a long slender object-for example a hair-grip-in a child under 2 years of age, is an absolute indication for prophylactic operative removal owing to the high incidence of impaction and perforation of the duodenum.

Adolescent↗
PubMed2001

A rare foreign body on penis leading to incarceration.

Foreign body on penis is usually put himself or by his female partner by adults for sexual gratification and in children as an innocent childish play. We have managed a 10 years shepherd who put on a bark of tree with successful outcome which is not being reported in literature.

Child↗
PubMed1991

[Cervical esophagostomy in cases of incarcerated foreign bodies].

One thousand and twenty incarcerated foreign bodies of oesophagus were observed in ENT Department in Szczecin in the period 1973-1989. To remove five of them, the external esophagotomy was required. Particular description of these cases as well as the surgical technique and the indications to this operation are discussed in the paper.

Adolescent↗
PubMed2002

Long retained intravaginal foreign body: a case report.

Recurrent vaginal discharge in children may be due to variety of causes. Intravaginal foreign body retained for long duration can be a diagnostic dilemma. This report presents the case of a girl who had an intravaginal foreign body for over four years duration. Recurrent, unremitting, foul-smelling, bloody vaginal discharge in a child should alert the clinician to the possibility of a retained vaginal foreign body.

Child↗
PubMed2004

Unrecognized foreign body ingestion: an unusual cause for abdominal pain in a healthy adult.

An unusual case of a unrecognized foreign body ingestion in a healthy, reliable adult patient is reported. A diagnosis of a foreign body perforation of the stomach was made on computed tomographic imaging of the abdomen that was obtained for evaluation of unremitting pain. This case emphasizes the importance of considering foreign body ingestion in the differential diagnosis for abdominal pain of unknown etiology.

Abdominal Pain↗