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PubMed1985

Use of 2,3-dimercaptopropane-1-sulfonate in treatment of lead poisoning in children.

2,3-Dimercaptopropane-1-sulfonate (DMPS) is a water-soluble metal complexing agent. Administration to lead-poisoned children of 5-day courses of 200 or 400 mg of DMPS per m2 surface area per day given p.o. in divided doses resulted in a significant decline in the concentration of lead in blood. DMPS treatment did not significantly alter the concentrations of zinc or copper in plasma. Urinary excretion of lead, zinc and copper was increased by DMPS administration and these increases were sustained throughout the 5-day course of treatment. No significant changes in hepatic, renal or hematological function were found in DMPS-treated children and no side effects attributable to DMPS were noted. It is concluded that a 5-day course of DMPS given p.o. may be safe and effective in the treatment of asymptomatic lead poisoning in children.

Aspartate Aminotransferases↗
PubMedDate not supplied

[Lysosomotropism and anti-inflammatory action of gold salts].

Gold salts have been widely used in the past 70 years in the treatment of various connective tissue diseases and more particularly in rheumatoid arthritis. However their mechanism of action remains poorly understood. Gold salts are transported in the blood linked with several serum proteins including immunoglobulins. Methods of analytical electron microscopy (Castaing probe) have shown that gold is actively concentrated in the lysosomes of various cell types, including the proximal tubular cells of the kidney and certain bone marrow cells. These data, together with those provided by biochemical techniques, suggest that sodium aurothiopropanol sulfonate modifies the stability of lysosome membranes. In the present study it is shown that the stability of kidney lysosomes of treated rats was increased by 42.4 per cent after treatment for 3 days. This protective action was also seen when lysosomes were subjected to lysis by digitonin. The protective effect of gold salts on the lysosomal membrane may be explained by the formation of chemical complexes between gold and sulfhydryl groups present in the membrane, resulting in stable mercaptic bonds. These findings suggest that the increase in stability of lysosomal membranes plays a significant role in the anti-inflammatory action of gold salts.

Animals↗