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At least 1,333 records · Page 74Linked to original sources
PubMed2001

The effect of anterior osteophytes and flexural position on thoracic trabecular strain.

STUDY DESIGN: Compressive and shear trabecular strains were evaluated using six cadaveric thoracic spines that included anterior osteophytes. The treatments were divided into three groups: 1) osteophytes intact and the specimen in the neutral position, 2) osteophytes removed and the specimen in the neutral position, and 3) osteophytes removed and the specimen with 5 degrees of additional flexion. OBJECTIVES: To investigate the influence of osteophytes and flexural position on vertebral trabecular strain during axial compression. SUMMARY OF BACKGROUND DATA: In the thoracic spine, the incidence of anterior wedge fractures increases with the severity of kyphosis. It is unclear whether the role of anterior osteophytes in the thoracic spine is to restrict progressive kyphosis, conduct axial load anteriorly, or both. METHODS: Thoracic motion segments, T10-T12, were axially loaded in compression, and the minimum principal and maximum shear strains were measured using texture correlation. RESULTS: No dramatic changes were found in the spatial distribution of the strains following removal of the anterior osteophytes. Conversely, after removal of the osteophytes and orienting the specimen in 5 degrees of additional flexion, the strain distribution shifted anteriorly and the magnitude increased. CONCLUSIONS: This study demonstrated that osteophytes seem to restrict progressive kyphosis rather than conduct axial load anteriorly.

Aged↗
PubMed1983

REM-NREM cycle in the cat may be sleep-dependent.

The periodicity of the rapid eye movement-nonrapid eye movement (REM-NREM) cycle in real time versus compressed sleep was determined by autocorrelation, computed on the sequence of sleep stages in recordings from spontaneously sleeping cats. The resulting autocorrelation function was correlated to damped cosine waves, and the highest squared correlation coefficient (r2) was taken as indicating the most likely periodicity in the data entered for each animal. The periodicity of REM sleep was stronger (significantly higher r2) in the compressed sleep data than in the real-time data, indicating sleep dependency of the REM-NREM cycle. The REM-NREM cycle lengths determined by the autocorrelation technique were not significantly different for the real-time and compressed sleep data. The REM sleep episode interval, defined as the average interval between the start of successive REM sleep episodes, was significantly shorter for real-time sustained sleep than the cycle lengths as determined by the autocorrelation technique. A model is proposed which explains this phenomenon as due to fragmentation of REM sleep within the time periods with high probability for REM sleep. When such fragmentation occurs, the average REM sleep episode interval will not reflect an ultradian REM sleep periodicity.

Animals↗
PubMed1992

Artificial neural network classification of Drosophila courtship song mutants.

Courtship songs produced by Drosophila males--wild-type, plus the cacophony and dissonance behavioral mutants--were examined with the aid of newly developed strategies for adaptive acoustic analysis and classification. This system used several techniques involving artificial neural networks (a.k.a. parallel distributed processing), including learned vector quantization of signals and non-linear adaption (back-propagation) of data analysis. "Pulse" song from several individual wild-type and mutant males were first vector-quantized according to their frequency spectra. The accumulated quantized data of this kind, for a given song, were then used to "teach" or adapt a multiple-layered feedforward artificial neural network, which classified that song according to its original genotype. Results are presented on the performance of the final adapted system when faced with novel test data and on acoustic features the system decides upon for predicting the song-mutant genotype in question. The potential applications and extensions of this new system are discussed, including how it could be used to screen for courtship mutants, search novel behavior patterns or cause-and-effect relationships associated with reproduction, compress these kinds of data for digital storage, and analyze Drosophila behavior beyond the case of courtship song.

Algorithms↗
PubMed2006

Diffusion maps and coarse-graining: A unified framework for dimensionality reduction, graph partitioning, and data set parameterization.

We provide evidence that nonlinear dimensionality reduction, clustering, and data set parameterization can be solved within one and the same framework. The main idea is to define a system of coordinates with an explicit metric that reflects the connectivity of a given data set and that is robust to noise. Our construction, which is based on a Markov random walk on the data, offers a general scheme of simultaneously reorganizing and subsampling graphs and arbitrarily shaped data sets in high dimensions using intrinsic geometry. We show that clustering in embedding spaces is equivalent to compressing operators. The objective of data partitioning and clustering is to coarse-grain the random walk on the data while at the same time preserving a diffusion operator for the intrinsic geometry or connectivity of the data set up to some accuracy. We show that the quantization distortion in diffusion space bounds the error of compression of the operator, thus giving a rigorous justification for k-means clustering in diffusion space and a precise measure of the performance of general clustering algorithms.

Algorithms↗
PubMed1997

Electrical stimulation-induced contraction to reduce blood stasis during arthroplasty.

Deep venous thrombosis and subsequent pulmonary embolism due to venous pooling/stasis commonly occur in patients during hip and/or knee arthroplasty (i.e., replacement). This problem may be alleviated by using techniques to promote lower limb blood flow. Electrical stimulation-induced contractions have been shown to activate the skeletal muscle pump, promote limb blood flow, and may be effective for reducing venous pooling/stasis and edema. Therefore, electrical stimulation may reduce the incidence of deep venous thrombosis (DVT) and pulmonary embolism (PE) during and following surgery. The overall goal of this project was to evaluate the clinical efficacy of sequential electrical stimulation-induced leg muscle contractions on the venous blood flow during surgery. The degree of venous pooling/stasis was monitored via electrical impedance changes in the thorax. The changes in the patient's central hemodynamics were then calculated. Thirty patients were recruited and randomly assigned to either a control group (n = 15, mean age = 66.4 +/- 7.3) or experimental group (n = 15, age = 60.7 +/- 9.7). Both groups received the standard medical treatment for prevention of DVT (i.e., coumadin, heparin, etc.) and compression stockings (TED, Kendall). The control group used the sequential compression device (SCD + TED) and the experimental group used electrical stimulation (ES + TED). Electrical stimulation was applied via surface electrodes to the lower-limb muscles (tibialis anterior and gastrocnemius) and upper limb muscles (quadriceps femoris and hamstrings). These muscles contracted sequentially, using an eight-channel electrical stimulator. Four seconds of calf (contraction/compression) were followed by 7-s of calf and thigh (contraction/compression) interspersed by 60-s rest period during both electrical stimulation or sequential compression device. This cycle continued throughout the surgery (60-75 min) for both groups. At 15 min intervals, venous return was monitored by impedance cardiograph. Physiologic responses including ventricular stroke volume (SV), cardiac output (CO), heart rate (HR), total peripheral resistance (TPR), as well as mean arterial pressure (MAP) were monitored. These responses were statistically analyzed and compared throughout the surgery within each group and between the two groups. The results show stroke volume and cardiac output to be higher throughout surgery in the electrical stimulation group as compared with the sequential compression device group. The heart rate was consistently lower during electrical stimulation for both groups. Total peripheral resistance did not change in the electrical stimulation group; but increased in the sequential compression device group. The data suggest that continuous electrical stimulation-induced contractions could improve lower leg circulation by eliciting the physiologic muscle pump. This will lead to improved venous circulation and reduction of blood stasis during total hip and/or knee surgery. This technique may offer greater protection against DVT and PE during surgery than the commonly used sequential compression device.

Bandages↗
PubMed2006

Interruption of functional recovery by the NMDA glutamate antagonist MK801 after compression of the sensorimotor cortex: implications for treatment of tumors or other mass-related brain injuries.

Glutamate antagonists have recently been shown to limit tumor growth, providing potential new therapeutic targets and strategies against brain tumors. Here, we demonstrate that the glutamate NMDA receptor antagonist MK801, after a delay, adversely reverses functional recovery in rats with compressive mass lesions of the sensorimotor cortex. Our data suggest that the controlled focal cortical compression model may be a valuable pre-clinical tool to screen compounds for the treatment of brain tumors. It may be possible to use this model to develop interventions that maintain anti-cancer effects but with diminished harm to bystander tissue and brain plasticity.

Animals↗
PubMed1998

Pitfalls of artificial neural networks (ANN) modelling technique for data sets containing outlier measurements using a study on mixture properties of a direct compressed dosage form.

An application of the Artificial Neural Networks (ANN) methodology was investigated using experimental data from a mixture properties study and compared to classical modelling technique (i.e. Response Surface Methodology, RSM) both graphically and numerically. The aim of this investigation was to quantitatively describe the achieved degree of data fitting and robustness of the developed models. For comparing the goodness of fit, the R2 coefficient was used, whereas for the robustness of the models an outlier measurement was integrated in the data set. Comparable results were achieved for both ANN- and RSM methodologies for data fitting. The robustness of the models towards outliers was clearly better for the RSM methodology. All determined mixture properties were mainly influenced by the concentration of silica aerogel, whereas the other factors showed very much lower effects. For that reason the physical properties of this excipient (e.g. its specific surface area) are of importance for the behaviour of the mixtures.

Chemistry, Pharmaceutical↗
PubMed2004

The effect of static torsion on the compressive strength of the spine: an in vitro analysis using a porcine spine model.

STUDY DESIGN: Matched porcine cervical spine motion segments were subjected to two main conditions and compared: axial compression and axial compression combined with varying axial torque. OBJECTIVES: To determine the effect of torsion on the acute compressive strength of the spine. SUMMARY OF BACKGROUND DATA: The spine is often subjected to compression together with axial torque as a component of complex loading, yet there is a lack of documentation on its effect on the compressive strength and injury mechanics. METHODS: Matched cohorts of porcine cervical spine (C5-C6) motion segments were compressed to failure at a rate of 3,000 N/s combined with 0 Nm, 5 Nm, 20 Nm, or 30 Nm of axial torque. Three "failure" points were recorded from the stress/strain association: the first "step" (initial microfracture), the initial slope change (yield point or "slow crush" mechanism), and the ultimate failure point (fracture). Furthermore, resultant injuries were documented using planar radiography and visual inspection following dissection of the motion segments. RESULTS: Axial torque affected the failure characteristics during acute compressive loading. The ultimate strength of the motion segments was significantly reduced with increasing static torques. The compressive load at which initial microfracture occurred, indicated by the first "step" in the load-deformation curve, was increased with 5 Nm, 10 Nm, and 20 Nm of applied torsion in comparison to no torque, but this effect was reduced with 30 Nm of torque. The "slow crush" mechanism of failure was not affected by the addition of axial torque. No radiographic gross injuries to the facet joints were observed. Damage appeared to be confined to the endplate and trabecular network of the vertebral body. CONCLUSIONS: Based on this animal model, shown to have similar biomechanical behavior to humans, axial torque appears to significantly reduce the compressive strength of the spine.

Animals↗
PubMed1999

Resin composites for foundation restorations.

This study focused on the compressive properties of two core buildup materials, Ti-Core, (EDS, Inc.) and FluoroCore, (L.D. Caulk). Specimens were 0.6 x 1.2 cm cylinders, Prior to testing, the specimens were aged in a moist environment for one, seven, or 28 day(s). The properties of interest were compressive strength, modulus of elasticity and toughness. The data set for each of the three compressive properties was subjected to a separate two-way analysis of variance. Scheffé F-tests were used to compare means. Whereas the effect of material on each of the three properties was significant (p < 0.002), the effects of specimen age (p > 0.400) and material x specimen age (p > 0.350) were not significant. FluoroCore was stronger and tougher than Ti-Core. On the other hand, Ti-Core displayed the highest stiffness, but ruptured brittley. The moderately low strength of Ti-Core, and the insufficient elastic modulus of FluoroCore, avert favorable recommendations pertaining to the construction of foundation restorations.

Analysis of Variance↗
PubMed2006

Comprehensive quality control utilizing the prehybridization third-dye image leads to accurate gene expression measurements by cDNA microarrays.

BACKGROUND: Gene expression profiling using microarrays has become an important genetic tool. Spotted arrays prepared in academic labs have the advantage of low cost and high design and content flexibility, but are often limited by their susceptibility to quality control (QC) issues. Previously, we have reported a novel 3-color microarray technology that enabled array fabrication QC. In this report we further investigated its advantage in spot-level data QC. RESULTS: We found that inadequate amount of bound probes available for hybridization led to significant, gene-specific compression in ratio measurements, increased data variability, and printing pin dependent heterogeneities. The impact of such problems can be captured through the definition of quality scores, and efficiently controlled through quality-dependent filtering and normalization. We compared gene expression measurements derived using our data processing pipeline with the known input ratios of spiked in control clones, and with the measurements by quantitative real time RT-PCR. In each case, highly linear relationships (R2 > 0.94) were observed, with modest compression in the microarray measurements (correction factor < 1.17). CONCLUSION: Our microarray analytical and technical advancements enabled a better dissection of the sources of data variability and hence a more efficient QC. With that highly accurate gene expression measurements can be achieved using the cDNA microarray technology.

Animals↗
PubMed1977

Time, rate, and temperature factors in the onset of high-pressure convulsions.

An interrupted compression profile technique was used to develop data to separate the effects of time and pressure factors governing increase of high-pressure neurological syndrome (HPNS) convulsion threshold pressures (the compression rate effect) during different compression profiles. A single differential equation fits all data available to date for compression rate effect on convulsion thresholds of CD-1 mice (three distinct types of compression profile; mean compression rates 12-1,000 atm/h). The process leading to increase in HPNS convulsion pressure is initiated at the very beginning of compression, proceeds at increasingly rapid rates as higher pressures are attained, and approaches a limiting upper convulsion pressure. The convulsion threshold pressure in any given experiment is independent of the compression rate prevailing during the time immediately preceding onset of the seizure. The magnitude of the compression rate effect in the CD-1 mouse is independent of chamber temperature over a range of 27-36 degrees C, and rectal temperatures of 29.2-37.5 degrees C. The bearing of these results on the design of optimal compression schedules and on the analysis of the neurological mechanisms underlying the HPNS is discussed.

Animals↗
PubMed2004

Changes in the cross-sectional area of multifidus and psoas in patients with unilateral back pain: the relationship to pain and disability.

STUDY DESIGN: Prospective, cross-sectional observational study. OBJECTIVES: The aim of this study was to determine if there was an association between wasting of psoas and multifidus as observed on MRI scans and the presenting symptoms, reported pathology, pain, or disability of a cohort of patients presenting with unilateral low back pain. SUMMARY OF BACKGROUND DATA: Current physiotherapy practice is often based on localized spine stabilizing muscle exercises; most attention has been focused on transversus abdominus and multifidus with relatively little on psoas. METHOD: Fifty consecutive patients presenting to a back pain triage clinic with unilateral low back pain lasting more than 12 weeks were recruited. The cross-sectional surface area (CSA) of the muscles was measured. Duration of symptoms, rating of pain, self-reported function, and the presence of neural compression were recorded. RESULTS: Data analysis compared the CSA between the symptomatic and asymptomatic sides. There was a statistically significant difference in CSA between the sides (P < 0.001). There was a positive correlation between the percentage decrease in CSA of psoas on the affected side and with the rating of pain (rho = 0.608, P < 0.01), reported nerve root compression (rho = 0.812, P < 0.01), and the duration of symptoms (rho = 0.886, P < 0.01). There was an association between decrease in the CSA of multifidus and duration of symptoms. CONCLUSIONS: Atrophy of multifidus has been used as one of the rationales for spine stabilization exercises. The evidence of coexisting atrophy of psoas and multifidus suggests that a future area for study should be selective exercise training of psoas, which is less commonly used in clinical practice.

Adult↗
PubMed1999

Strain imaging with a deformable mesh.

Ultrasonic strain imaging has drawn much attention recently because of its ability to noninvasively provide information on spatial variation of the elastic properties of soft tissues. Traditionally, local strain is estimated by scaling and cross correlating pre- and postcompression ultrasound echo fields. However, when the motion field generated by compression is more complex, scaling and cross correlation can no longer provide precise displacement estimates because of signal decorrelation. We introduce a new algorithm based on the deformable mesh method. This algorithm can accommodate more general forms of motion, namely, the motion that can be described by bilinear transformations. We applied the new algorithm to three sets of data in order to evaluate its performance. In the first set of data, primitive motions such as shearing and rotation are simulated. The second set of data is collected by compressing a tissue-mimicking phantom with three hard inclusions. The third experiment involves an ex vivo pig kidney embedded in a block of gelatin. The results from all three experiments show improvements with the new algorithm over other methods.

Algorithms↗
PubMed2004

Gridding and compression of microarray images.

With the recent explosion of interest in microarray technology, massive amounts of microarray images are currently being produced. The storage and the transmission of this type of data are becoming increasingly challenging. Here we propose lossless and lossy compression algorithms for microarray images originally digitized at 16 bpp (bits per pixels) that achieve an average of 9.5 - 11.5 bpp (lossless) and 4.6 - 6.7 bpp (lossy, with a PSNR of 63 dB). The lossy compression is applied only on the background of the image, thereby preserving the regions of interest. The methods are based on a completely automatic gridding procedure of the image.

Algorithms↗
PubMed2005

Geometric diffusions for the analysis of data from sensor networks.

Harmonic analysis on manifolds and graphs has recently led to mathematical developments in the field of data analysis. The resulting new tools can be used to compress and analyze large and complex data sets, such as those derived from sensor networks or neuronal activity datasets, obtained in the laboratory or through computer modeling. The nature of the algorithms (based on diffusion maps and connectivity strengths on graphs) possesses a certain analogy with neural information processing, and has the potential to provide inspiration for modeling and understanding biological organization in perception and memory formation.

Algorithms↗
PubMed2006

Compression of interference patterns with application to phase-shifting digital holography.

A compression method of phase-shifting digital holographic data is presented. Three interference patterns are recorded, and holographic information is extracted from them by phase-shifting interferometry. The scheme uses standard baseline Joint Photographic Experts Group (JPEG) or standard JPEG-2000 image compression techniques on the recorded interference patterns to reduce the amount of data to be stored. High compression rates are achieved for good reconstructed object image quality. The utility of the proposed method is experimentally verified with real holographic data. Results for compression rates using JPEG-2000 and JPEG of approximately 27 and 20, respectively, for a normalized root-mean-square error of approximately 0.7 are demonstrated.

Journal Article↗
PubMed2005

Transient cervical nerve root compression in the rat induces bilateral forepaw allodynia and spinal glial activation: mechanical factors in painful neck injuries.

STUDY DESIGN: An in vivo rat model of transient cervical nerve root compression. OBJECTIVES: To investigate the potential for cervical nerve root compression to produce behavioral hypersensitivity and examine its dependence on compression. SUMMARY OF BACKGROUND DATA: Clinically, nerve root injury has been hypothesized as a potential source of neck pain, particularly because cervical nerve roots are at mechanical risk for injury during neck loading. Lumbar radiculopathy models of nerve root ligation show that mechanical allodynia and spinal glial changes depend on nerve root deformation magnitude. However, no investigation has been performed to examine cervical nerve root compression as a cause of pain. METHODS: Two compressive forces (10 and 60 grams force [gf]) were transiently applied to the C7 nerve roots unilaterally using microvascular clips in separate groups (n = 12 each). Sham procedures were also performed in a separate group of rats (n = 12). Bilateral forepaw mechanical allodynia was monitored after surgery for 7 days. On day 7, spinal glial activation was assessed using immunohistochemistry to investigate its dependence on nerve root compressive force, in the context of behavioral hypersensitivity. RESULTS: Bilateral allodynia was observed following injury, which was significantly (P < 0.042) increased over sham and baseline responses. No difference in allodynia was found between the 10 and 60 gf injuries. Astrocytic and microglial activation were observed in the ipsilateral dorsal horn following compression, with only astrocytic activation paralleling allodynia patterns. CONCLUSIONS: Results imply a force threshold exists less than 10 gf for persistent pain symptoms following transient cervical nerve root compression. Findings also suggest that spinal glial activation may be related to behavioral sensitivity and may modulate cervical nerve root mediated pain.

Animals↗
PubMed1995

Relations among compression, suppression, and combination tones in mechanical responses of the basilar membrane: data and MBPNL model.

Recent observations of combination tones and low-frequency suppression in the mechanical response of the basilar membrane have eliminated uncertainty of the existence of these non-linear phenomena at this stage of the cochlea (Robles et al., 1991; Ruggero et al., 1992b; Rhode and Cooper, 1993), and provide the first opportunity to test and extend theoretical understanding of these non-linear responses. This paper reports a systematic study of the new data for the chinchilla with the MBPNL (multiple band-pass non-linearity) non-linear model for rapid compression in cochlear filtering (Goldstein, 1990). The two key findings are that: (1) the large differences in suppression growth rates for low- and high-frequency suppressors are closely predicted by the model, although a statistically significant small bias in the prediction was found; and (2) combination tones of frequency 2f2-f1 were well predicted by the model, while reported levels of 2f1-f2 were underestimated by the model. The most likely explanation of the result for 2f1-f2 is that the model correctly predicts the distributed generation of combination tones, but does not include a propagating medium that allows combination tones to accumulate at their tuned site. Alternative explanations requiring experimental clarification are suggested. The general finding of this study is that the complex level-dependent properties of suppression and combination tones are closely related to the three regions characterizing the tuned response of the basilar membrane, in which linear-like responses at low and high sound levels are joined by a compressive range. The MBPNL model describes this general relationship quantitatively and is a reliable basis for further modeling research.

Acoustic Stimulation↗