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At least 1,333 records · Page 74Linked to original sources
PubMed2004

Short-term effects of gastric bypass surgery on circulating ghrelin levels.

OBJECTIVE: To prospectively evaluate the short-term effects of Roux-en-Y gastric bypass (RYGBP) on ghrelin secretion and its relevance on food intake and body weight changes. RESEARCH METHODS AND PROCEDURES: Ghrelin response to a standardized test meal was evaluated in eight obese patients (BMI, 43.5 to 59.1 kg/m2) before and 6 weeks after RYGBP. Ghrelin response was compared with that of an age-matched group of six normal weight individuals (BMI, 19.6 to 24.9 kg/m2). RESULTS: Fasting serum ghrelin levels were lower in obese subjects compared with controls (p < 0.05). Meal ingestion significantly suppressed ghrelin concentration in controls (p < 0.05) and obese subjects (p < 0.05), albeit to a lesser degree in the latter group (p < 0.05). Despite a 10.3 +/- 1.5% weight loss, fasting serum ghrelin levels were paradoxically further decreased in obese subjects 6 weeks after RYGBP (p < 0.05). Moreover, at this time-point, food intake did not elicit a significant ghrelin suppression. The changes in ghrelin secretion after RYGBP correlated with changes in insulin sensitivity (p < 0.05) and caloric intake (p < 0.05). DISCUSSION: This study showed that the adaptive response of ghrelin to body weight loss was already impaired 6 weeks after RYGBP. Our study provides circumstantial evidence for the potential role of ghrelin in the negative energy balance in RYGBP-operated patients.

Adult↗
PubMedDate not supplied

Short-term follow-up of the nutritional status of children undergoing autologous peripheral blood stem cell transplantation.

A prospective longitudinal study was conducted to analyze the evolution of the nutritional status of 34 children (12 girls and 22 boys), aged 1.5-15.8 years (median age 9.06), undergoing autologous peripheral blood stem cell transplantation (PBSCT). The nutritional status was evaluated at baseline, days +1 and +7, discharge, and day +30 by dietary or parenteral intake, anthropometric and laboratory measurements, and nitrogen balance. At baseline, changes in anthropometric (53%) and biochemical measurements (83%) are frequent but mild. The mean caloric intake was normal. Children with normal values for the anthropometric parameters all had an intake > 80% (p < .01). No correlation was found between the anthropometric and biochemical parameters. During transplantation, significant changes (p < .001) were found for energy intake, albumin, transferrin, and nitrogen balance. Fibronectin, prealbumin, and retinol-binding protein showed only a few changes. All but prealbumin recovered on day +30. No correlation was found between the nutritional status and toxicity or infection in children undergoing autologus PBSCT. The changes in the nutritional status observed at the start of transplantation correlated with the nutrional intake. Anthropometric and biochemical changes are complementary. The results may be ascribable to the fact that the patients in this series had mild malnutrition.

Adolescent↗
PubMed1998

Factors of weight loss in patients with HIV and chronic diarrhea.

Weight loss is significant in patients with HIV and chronic diarrhea. The aim of our study was to test for the links between weight loss, the level of food intake, and the severity of diarrhea and nutrient malabsorption. One hundred and sixteen patients with HIV and chronic diarrhea underwent a standardized gastrointestinal and nutritional evaluation, which included a questionnaire on diarrhea, a prospective estimation of food intake, a measurement of blood parameters and fecal lipid and nitrogen outputs, a stool examination for bacteria and parasites, and upper and lower digestive tract endoscopy. Diarrhea resulted from an infection by Cryptosporidia, Microsporida, or other pathogens in 22%, 20%, and 13% of the patients, respectively. Diarrhea appeared idiopathic in 45% of the patients. A significant negative correlation existed between the severity of weight loss and the levels of nutrient intake (p < .005), and a significant positive correlation between the severity of weight loss and stool frequency (p < .01). Multiple linear regression identified low caloric intake and high stool frequency as predictive of weight loss. No significant correlation was found between weight loss and the parameters of malabsorption, either by bivariate study or multiple regression. These results suggest that, in patients with HIV and chronic diarrhea, the degree of wasting is significantly related to the levels of dietary intake and the clinical severity of diarrhea, but not to the extent of nutrient malabsorption.

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

Multiorgan dysfunction syndrome: how water might contribute to its progression.

Multiorgan dysfunction syndrome (MODS) is one of the most frequent conditions encountered in intensive-care medicine. MODS is defined as total or partial loss of two or more organs with vital functions. The development of acute renal failure (ARF) in MODS leads to an additional aggravation with considerably higher hospital mortality than in other ICU patients with MODS. Whereas dissolved substances involved in the regulation of regional blood flow, endothelial cell injury, microvascular permeability, oxygenation, and nutrition of cells are at the focus of interest in MODS, hardly any scientific attention is paid to their main solvent water. An impaired renal water excretion and an increased metabolic water volume requiring excretion interfere with diffusive and convective oxygen transport through the different fluid compartments. It will be shown first that the ratio of U(osm)/ P(osm) appears to be a reliable tool to assess overhydration in ARF. Secondly, the limits of urinary output in response to water intake will be considered. Furthermore, the metabolic water formation by an enhanced degradation of endogenous protein and fat will be discussed. Finally, the daily caloric intake is questioned with respect to energy expenditure and metabolic water formation.

Aged↗
PubMed1975

Food habits and nutrient intakes of Filipino women in Los Angeles.

Food habits, dietary changes, and nutrient intakes of forty-seven college-educated, empolyed Filpino women who have moveed from the Philippines to Los Angeles were studied. One-third started drinking mikk in the United STAtes. They said that they were eating more meat, vegetables, frit and less starchy food since they left the Philippines. Eighy per cent continued to eat ricedaily, and seafood was eaten frequently. Daily intakes of protein, niacin, and thiaminment 100 per cent of the 1974 u.s. Recommended Dietary Allowances for almost all subjects, but intakes of calcium and vitamin A were less than two-thrids of the allowances fo 61 and 22 per cent, respectively. The daily caloric intake was higher, with twice as amny calories coming from protein and three times as many from fat as was reported for diets in Philippines.

Adult↗
PubMed2004

Dietary boron intake and prostate cancer risk.

Boron affects human steroid hormone levels. Circulating testosterone and estradiol levels have been proposed to modify prostate cancer risk. However, the association between dietary boron intake and the risk of prostate cancer has not been evaluated by any epidemiological study. We explored the association between dietary boron intake and the risk of prostate cancer in the USA. Our analysis was based on data from the third National Health and Nutrition Examination Survey (NHANES III). Cross-sectional case-control study design was employed by comparing boron intake of 95 prostate cancer cases with that of 8,720 male controls. After controlling for age, race, education, smoking, body mass index, dietary caloric intake, and alcohol consumption, increased dietary boron intake was associated with a decreased risk of prostate cancer with a dose-response pattern. The adjusted odds ratio was 0.46 (95% confidence interval: 0.21-0.98) for the highest quartile of boron intake comparing to the lowest quartile (P for trend = 0.0525). The observed association should be interpreted with caution because of the small case sample size and the nature of the cross-sectional study design, but deserve further investigation.

Adolescent↗
PubMed1990

The relationship between dietary intake and urinary excretion of sodium, potassium, calcium and magnesium: Belgian Interuniversity Research on Nutrition and Health.

During an epidemiological survey, the dietary intake and urinary excretion of sodium, potassium, calcium and magnesium were measured by means of the 24 h food record method and a 24 h urine collection in 2,112 men and 1,943 women. Significant correlations (P less than 0.001) were found between dietary intake and urinary excretion of the above cations in men and women by univariate analysis and after adjustment for age, height, weight and total caloric intake. Taking into account the difficulty of estimating dietary cation intakes and obtaining complete 24 h urine collections, and the non-coincidence of the 24 h urine collection and the food recording periods, our findings point to a strong positive association between dietary intake and urinary excretion of sodium, potassium, calcium and magnesium. No significant relationship was found between these urinary cations and blood pressure.

Adult↗
PubMed1997

Calorie restriction reduces the incidence of myeloid leukemia induced by a single whole-body radiation in C3H/He mice.

Dietary restriction, especially caloric restriction, is a major modifier in experimental carcinogenesis and is known to decrease significantly the incidence of neoplasms. Gross and Dreyfuss [Gross, L. & Dreyfuss, Y. (1984) Proc. Natl. Acad. Sci. USA 81, 7596-7598; Gross, L. & Dreyfuss, Y. (1986) Proc. Natl. Acad. Sci. USA 83, 7928-7931] reported that a 36% restriction in caloric intake dramatically decreased the radiation-induced solid tumors and/or leukemias. Their protocol predominantly produced lymphatic neoplasms. It is of interest to observe the effect of caloric restriction on radiation-induced myeloid leukemia, because the disease was observed to have been increased in the survivors of the atomic bombs in Hiroshima and Nagasaki. The spontaneous incidence of myeloid leukemia in C3H/He male mice is 1%, and the incidence increased to 23.3% when 3 Gy of whole-body x-ray irradiation was given. However, the incidence of myeloid leukemia was found to be significantly decreased by caloric restriction; it was reduced to 7.9% and 10.7% when restriction was started before (6 weeks old) and after (10 weeks old) irradiation, respectively. In addition, the onset of the myeloid leukemia in both restricted groups was prolonged to a greater extent as compared with the control diet group. Caloric restriction demonstrated a significant prolongation of the life span in the groups on a restricted diet after having been exposed to irradiation, either before or after dietary restriction, in comparison with mice that were only irradiated.

Aging↗
PubMed1977

[Therapy of obesity--effectiveness of calorie-reducing diets with various basic nutritional relations].

Within the research project nutrition and performance on altogether 80 test persons during a three weeks' test period the problem was examined, whether the relations of the basal nutrients have an influence on the effectiveness of a diet with an only moderate reduction of calories. The relations of the nutrients were tested in four variants. The daily caloric intake orients at the optimum weight of the test person: 30 kcal/kg optimum weight a day. It was shown that the so-called optimum weight caloric diet led to a sufficient continuous decrease of weight without disturbances of the general state of health. The variation of the relations of the basal nutrients had no decisive influence on the effectiveness.

Adult↗
PubMed2005

A systematic evaluation of food textures to decrease packing and increase oral intake in children with pediatric feeding disorders.

This study examined packing (pocketing or holding accepted food in the mouth) in 3 children who were failing to thrive or had inadequate weight gain due to insufficient caloric intake. The results of an analysis of texture indicated that total grams consumed were higher when lower textured foods were presented than when higher textured foods were presented. The gram intake was related directly to levels of packing. That is, high levels of packing were associated with higher textured foods and low gram intake, and low levels of packing were associated with lower textured foods and high gram intake. All participants gained weight when texture of foods was decreased. Packing remained low during follow-up for 2 participants even when the texture of food was increased gradually over time. These data are discussed in relation to avoidance, response effort, and skill deficit.

Behavior Therapy↗
PubMed1998

Enhanced preference for a protein-containing diet in response to dietary protein restriction.

Rats were maintained for 10 days on either a protein-free or a nutritionally complete maintenance diet, and they were also given access to protein-rich and carbohydrate-rich test diets during separate daily 2-h test sessions. In Experiment 1, rats maintained on the protein-free diet gradually and selectively increased their intake of the protein test diet, and eventually derived 16% of their daily energy intake from the protein test diet. Rats maintained on a nutritionally complete diet ate similar amounts of the two test diets even when their total caloric intake was matched to that of rats maintained on the protein-free diet. In Experiment 2, rats that developed a preference for the protein test diet while maintained on a protein-free diet were given Purina Chow for 25 days to allow them to recover from their protein deficiency. When these rats were later returned to the protein-free diet for 10 days, their preference for the protein test diet was immediate and sustained. However, if they were maintained on the nutritionally complete diet after the 25-day recovery period, they initially preferred the protein test diet, but this preference diminished over days. Results of these studies are consistent with other findings showing that rats can learn to compensate for macronutrient deficiencies by using oral-sensory cues. In particular, the rats' diet selection was consistent with their having learned a preference for the cues paired with dietary protein.

Animal Nutritional Physiological Phenomena↗
PubMedDate not supplied

[A nutritional survey of 38 single elderly persons with free choice of food].

The nutritional habits of 38 randomly selected single aged people with free choice of food have been investigated by the precise weighing method. Blood serum levels of the vitamins A, C, and E and of beta-carotene and biotin were analyzed, and the nutritional status with respect to the vitamins B1, B2, and B6 was examined by the transketolase-test, the glutathione-reductase-test, and the glutamic-acid-oxalo-acetic-transaminase-test. In relation to the desirable daily supply of nutrients and other dietary components the food was deficient in the vitamins B1, and B6 and in magnesium. For women an additional calcium-deficiency was demonstrated. The dietary fat content, however, was found to be high (44% of total calorie intake). The results of the blood analyses suggest an insufficient dietary supply of vitamin B1, partly also of the vitamins B6 and C. The total caloric intake was found to be rather low with respect to the age.

Aged↗
PubMed1982

Responses to dietary adulterations in rats with zona incerta lesions.

Large lesions of the rostral zona incerta (ZI) permanently reduced food and water intake and body weight to about 75% of control levels. When quinine hydrochloride was added to the water supply, the experimental animals exhibited a somewhat greater initial decrease in fluid consumption, but otherwise responded much like control rats to quinine adulteration of both food and water. The ZI animals reduced their fluid intake when water was added to the food supply, in the form of wet mash, while the controls showed no compensation for the auxiliary water. When presented with sucrose solutions, the ZI animals increased their fluid intake, but reduced their mash consumption, to a greater degree than control rats. The experimental animals also showed an exaggerated response in both food and caloric intake to the addition of sucrose to the wet mash.

Animals↗
PubMed1997

The challenges of assessing fat intake in cancer research investigations.

Ecologic comparison of the incidence of cancer (eg, largescale differences between countries in the incidence of breast, prostate, and colon cancer) can be explained best by substantial differences in the intake of dietary fat. Additionally, there is a vast amount of animal and mechanistic data that strongly supports the hypothesis that ditary fat, independent of caloric intake, appears to have a major effect on the incidence and mortality rates for cancer. Yet, results from human case and cohort studies are inconsistent in linking carcinogenesis with fat intake. This is due to several factors. Reported intakes may not reflect previous long-term intakes and may be con-founded by several sources of error, including memory and estimates of portion size. Additionally, ongoing media reports of adverse health effects from high-fat diets may impart a social desirability bias to self-reporting of fat intake. These factors may be significant when investigating the relationship between dietary intake and cancer. Studies have shown considerable error in self-reported dietary data, with under-estimations in energy intake ranging from 3% to 18%. Such a wide range likely is due to differences in dietary assessment methodologies, which highlights the need to continue to develop improved techniques of data collection to relate nutrition better to health outcomes. The Women's Intervention Nutrition Study (WINS) is investigating the effect of dietary fat on the incidence of recurrence and survival in women with early-stage breast cancer. WINS is employing the multiple-pass 24-hour telephone recall system along with enhanced quality control measures to assess dietary intake. This dietary assessment method is particularly applicable when comparing two populations when one population is treated by an extensive dietary intervention.

Animals↗
PubMed1983

Nutrition in spinal cord injury patients.

The nutrient intake and some indices of nutritional state were studied in 22 quadriplegic and 15 paraplegic patients. When measured over two 5-day periods, the average caloric intake recommended for comparable healthy men (2,700 kcal/day) was not achieved by 75% of the quadriplegic and 47% of the paraplegic patients. No overt signs of malnutrition or vitamin deficiencies were observed, but the average hematocrit and serum albumin levels were at the lower limits of normal. The reduced energy needs of spinal cord patients should be considered in the development of desirable nutritional norms for this patient population.

Adult↗
PubMed1996

Zinc deficiency in women, infants and children.

Zinc deficiency in humans is widespread and is more prevalent in areas where the population subsists on cereal proteins. Conditioned deficiency of zinc is seen in many diseased states. A mild deficiency of zinc in pregnancy is associated with increased maternal morbidity, abnormal taste sensation, prolonged gestation, inefficient labor, atonic bleeding, and increased risks to the fetus. Among the urban poor in the US, a marginal zinc intake during pregnancy was associated with increased risk of preterm and very preterm delivery. Factors responsible for zinc deficiency in premature infants include high fecal losses of zinc, low body stores of zinc at birth, and increased zinc requirement during rapid growth. Zinc supplemented infants demonstrated improved linear growth velocity and maximum motor development scores. Marginal and moderate growth impairment in children as a consequence of inadequate zinc intake has been reported from many developed and developing countries. In one study from Japan, 21 prepubertal children were diagnosed to have zinc deficiency. The caloric intake, growth velocity, serum zinc, and plasma insulin-like growth factor-1 increased significantly in the zinc supplemented group. The clinical manifestations of zinc deficiency include growth retardation, hypogonadism in males, neurosensory disorders, cell-mediated immunological dysfunctions, and skin changes. Approximately 300 enzymes are known to require zinc for their activities. Zinc is required for DNA synthesis, cell division and protein synthesis. Several hundreds of zinc containing nucleoproteins are probably involved in gene expression of various proteins. A deficiency of zinc also affects proliferation and maturity of lymphocytes adversely.

Adult↗
PubMed1978

Comparative nitrogen balance study between young and aged adults using three levels of protein intake from a combination wheat-soy-milk mixture.

The protein requirement and the efficiency of protein used were studied in young and old adult human subjects. Protein intake levels (N X 6.25) of 0.4, 0.8, and 1.6 g/kg body weight per day from a combination wheat-soy-milk mixture were fed. Caloric intake was held constant at 40 kcal/kg body weight per day throughout the 11-day study of each dietary period. No significant differences were observed in their protein requirement, efficiency of protein use or the ability to adapt to changes of protein intake levels. Protein digestibility was not impaired in the aged. It is concluded that the protein requirement and the efficiency of protein use are not affected by the aging process.

Adaptation, Physiological↗
PubMed1991

Developmental effects of short-term supplementary feeding in nutritionally-at-risk Indonesian infants.

This study assessed the developmental effects of supplementary feeding over 90 consecutive days on infants aged 6-20 mo at six tea plantations in West Java, Indonesia. Every day except Sunday, the infants attended day-care centers distributed throughout the plantations. Twenty centers and 113 infants were selected; the infants in 9 centers received a dietary supplement, while the infants in 11 centers served as control subjects. Supplements were given twice a day providing, on average, 10.66 kJ (400 kcal) and 5 g protein/d. Measurements of body growth, dietary intake, and mental and motor development were made on all infants. Supplementary feeding had significant effects on weight gain and on motor development. Changes in caloric intake were independently associated with changes in weight and in motor test scores. The data suggest that the effects of the supplement may not have followed a simple mechanistic relationship from intake to weight change to motor development, but, rather, intake may have affected both growth and development domains simultaneously.

Anthropometry↗