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Geographic and climatic factors and multiple sclerosis in some districts of Bulgaria.

The multiple sclerosis (MS) prevalence rates in five districts of Bulgaria were compared with some geographic and climatic factors. In Bulgaria the latitude seems not to be a factor influencing the MS distribution. As to the climatic factors, a negative correlation was obtained between MS prevalence and mean annual sunshine hours as well as between MS prevalence and mean annual temperature. When comparing MS prevalence and mean annual precipitation, the correlation was positive.

Bulgaria↗

Environmental temperature and stroke in a subtropical climate.

The effect of environmental temperature on stroke occurrence in a subtropical climate was studied over a 1-year period by documenting the number of strokes (subdivided into cerebral infarct and intracerebral hemorrhage) admitted into a district hospital in Hong Kong at different temperatures. There was no significant correlation between the number of strokes (or its subtypes) per day per temperature category and the environmental minimum or maximum temperature. However, an association was present between the occurrence of cerebral infarcts and maximum temperature on the day of onset in elderly patients aged 70 years and above. Environmental temperature is not a strong risk factor for the occurrence of stroke in a subtropical climate.

Age Factors↗

Climatic and racial factors related to the aetiology of secretory otitis media.

This paper studied the incidence of secretory and chronic otitis among a random group of 5,950 children, aged from 4 to 9, coming from four different climatic regions of Spain, and including a group of Gypsy children. Each of the children was given a questionnaire regarding socio-economic and environmental situation and pathological antecedents; the results for sick and normal children were then statistically analysed. The most significant aetiological factors to emerge were: low economic level, prior respiratory infection, climatic conditions, cases of rhinosinusitis and acute otitis, and family history. Among Gypsy children a much greater incidence was observed, due not to racial origin but to the greater incidence of the factors cited above.

Age Factors↗

Modelling entomological-climatic interactions of Plasmodium falciparum malaria transmission in two Colombian endemic-regions: contributions to a National Malaria Early Warning System.

BACKGROUND: Malaria has recently re-emerged as a public health burden in Colombia. Although the problem seems to be climate-driven, there remain significant gaps of knowledge in the understanding of the complexity of malaria transmission, which have motivated attempts to develop a comprehensive model. METHODS: The mathematical tool was applied to represent Plasmodium falciparum malaria transmission in two endemic-areas. Entomological exogenous variables were estimated through field campaigns and laboratory experiments. Availability of breeding places was included towards representing fluctuations in vector densities. Diverse scenarios, sensitivity analyses and instabilities cases were considered during experimentation-validation process. RESULTS: Correlation coefficients and mean square errors between observed and modelled incidences reached 0.897-0.668 (P > 0.95) and 0.0002-0.0005, respectively. Temperature became the most relevant climatic parameter driving the final incidence. Accordingly, malaria outbreaks are possible during the favourable epochs following the onset of El Niño warm events. Sporogonic and gonotrophic cycles showed to be the entomological key-variables controlling the transmission potential of mosquitoes' population. Simulation results also showed that seasonality of vector density becomes an important factor towards understanding disease transmission. CONCLUSION: The model constitutes a promising tool to deepen the understanding of the multiple interactions related to malaria transmission conducive to outbreaks. In the foreseeable future it could be implemented as a tool to diagnose possible dynamical patterns of malaria incidence under several scenarios, as well as a decision-making tool for the early detection and control of outbreaks. The model will be also able to be merged with forecasts of El Niño events to provide a National Malaria Early Warning System.

Animals↗

Next-generation phylogeography reveals unanticipated population history and climate and human impacts on the endangered floodplain bitterling (Acheilognathus longipinnis).

BACKGROUND: Floodplains harbor highly biodiverse ecosystems, which have been strongly affected by both past climate change and by recent human activities, resulting in a high prevalence of many endangered species in these habitats. Understanding the history of floodplain species over a wide range of timescales can contribute to effective conservation planning. We reconstructed the population formation history of the Itasenpara bitterling Acheilognathus longipinnis, an endangered floodplain fish species in Japan, over a broad timescale based on phylogenetic analysis, demographic modeling, and historical demographic analysis using mitogenome and whole-genome sequences. A genome sequence was newly assembled as a reference for the resequencing analysis. This bitterling is distributed in three plains separated by high mountain ranges and exhibits ecological characteristics well adapted to floodplain environments. RESULTS: Our analyses revealed an unexpected population branching pattern, gene flow, and timing of the differentiation that occurred within a few hundred thousand years, i.e., long after the mountain uplift that was assumed to be the primary geological cause of the population differentiation. The analyses also showed that all local populations experienced a severe decline during the last glacial and post-glacial periods. CONCLUSIONS: Our results suggest that the floodplain bitterling was able to disperse through unknown routes after mountain uplift and that its populations were strongly influenced by climatic and geographic changes in glacial-interglacial cycles and subsequent human activities, probably related to its floodplain-dependent ecology. The genomic data highlight the unanticipated distribution process of this species and the magnitude of the impact of human activities, with important implications for its conservation.

Endangered Species↗

Climatic conditions and gastrointestinal nematode egg production: observations in breeding sheep and goats.

Parasitic egg production was studied in sheep and goats affected by parasitic gastroenteritis. The herds studied were located at different altitudes and in different climatic conditions. Samples were taken every month and the number of eggs per grams of feces was calculated. Observation of preliminary data shows that the maximum peak of egg production was during the winter period, whereas in other countries winter is a period of hypobiosis. This study shows that understanding peak time of infection related to different climatic and environmental conditions will help improve anthelminthic treatments and animal health strategies.

Animals↗

Impact of climatic change on the northern latitude limit and population density of the disease-transmitting European tick Ixodes ricinus.

We examined whether a reported northward expansion of the geographic distribution limit of the disease-transmitting tick Ixodes ricinus and an increased tick density between the early 1980s and mid-1990s in Sweden was related to climatic changes. The annual number of days with minimum temperatures above vital bioclimatic thresholds for the tick's life-cycle dynamics were related to tick density in both the early 1980s and the mid-1990s in 20 districts in central and northern Sweden. The winters were markedly milder in all of the study areas in the 1990s as compared to the 1980s. Our results indicate that the reported northern shift in the distribution limit of ticks is related to fewer days during the winter seasons with low minimum temperatures, i.e., below -12 degrees C. At high latitudes, low winter temperatures had the clearest impact on tick distribution. Further south, a combination of mild winters (fewer days with minimum temperatures below -7 degrees C) and extended spring and autumn seasons (more days with minimum temperatures from 5 to 8 degrees C) was related to increases in tick density. We conclude that the relatively mild climate of the 1990s in Sweden is probably one of the primary reasons for the observed increase of density and geographic range of I. ricinus ticks.

Animals↗

Climate variation and incidence of Ross river virus in Cairns, Australia: a time-series analysis.

In this study we assessed the impact of climate variability on the Ross River virus (RRv) transmission and validated an epidemic-forecasting model in Cairns, Australia. Data on the RRv cases recorded between 1985 and 1996 were obtained from the Queensland Department of Health. Climate and population data were supplied by the Australian Bureau of Meteorology and the Australian Bureau of Statistics, respectively. The cross-correlation function (CCF) showed that maximum temperature in the current month and rainfall and relative humidity at a lag of 2 months were positively and significantly associated with the monthly incidence of RRv, whereas relative humidity at a lag of 5 months was inversely associated with the RRv transmission. We developed autoregressive integrated moving average (ARIMA) models on the data collected between 1985 to 1994, and then validated the models using the data collected between 1995 and 1996. The results show that the relative humidity at a lag of 5 months (p < 0.001) and the rainfall at a lag of 2 months (p < 0.05) appeared to play significant roles in the transmission of RRv disease in Cairns. Furthermore, the regressive forecast curves were consistent with the pattern of actual values.

Alphavirus Infections↗

Mercury, food webs, and marine mammals: implications of diet and climate change for human health.

We modeled the flow of methyl mercury, a toxic global pollutant, in the Faroe Islands marine ecosystem and compared average human methyl mercury exposure from consumption of pilot whale meat and fish (cod, Gadus morhua) with current tolerable weekly intake (TWI) levels. Under present conditions and climate change scenarios, methyl mercury increased in the ecosystem, translating into increased human exposure over time. However, we saw greater changes as a result of changing fishing mortalities. A large portion of the general human population exceed the TWI levels set by the World Health Organization [WHO; 1.6 microg/kg body weight (bw)], and they all exceed the reference dose (RfD) of 0.1 microg/kg bw/day set by the U.S. Environmental Protection Agency (EPA; equivalent to a TWI of 0.7 microg/kg bw). As a result of an independent study documenting that Faroese children exposed prenatally to methyl mercury had reduced cognitive abilities, pregnant women have decreased their intake of whale meat and were below the TWI levels set by the WHO and the U.S. EPA. Cod had approximately 95% lower methyl mercury concentrations than did pilot whale. Thus, the high and harmful levels of methyl mercury in the diet of Faroe Islanders are driven by whale meat consumption, and the increasing impact of climate change is likely to exacerbate this situation. Significantly, base inflow rates of mercury into the environment would need to be reduced by approximately 50% to ensure levels of intake below the WHO TWI levels, given current levels of whale consumption.

Adolescent↗

Endocrine-disrupting chemicals and climate change: A worst-case combination for arctic marine mammals and seabirds?

The effects of global change on biodiversity and ecosystem functioning encompass multiple complex dynamic processes. Climate change and exposure to endocrine-disrupting chemicals (EDCs) are currently regarded as two of the most serious anthropogenic threats to biodiversity and ecosystems. We should, therefore, be especially concerned about the possible effects of EDCs on the ability of Arctic marine mammals and seabirds to adapt to environmental alterations caused by climate change. Relationships between various organochlorine compounds, necessary such as polychlorinated biphenyls, dichlorophenyldichloroethylene, hexachlorobenzene, and oxychlordane, and hormones in Arctic mammals and seabirds imply that these chemicals pose a threat to endocrine systems of these animals. The most pronounced relationships have been reported with the thyroid hormone system, but effects are also seen in sex steroid hormones and cortisol. Even though behavioral and morphological effects of persistent organic pollutants are consistent with endocrine disruption, no direct evidence exists for such relationships. Because different endocrine systems are important for enabling animals to respond adequately to environmental stress, EDCs may interfere with adaptations to increased stress situations. Such interacting effects are likely related to adaptive responses regulated by the thyroid, sex steroid, and glucocorticosteroid systems.

Animals↗

Biological diversity, ecology, and global climate change.

Worldwide climate change and loss of biodiversity are issues of global scope and importance that have recently become subjects of considerable public concern. Unlike classical public health issues and many environmental issues, their perceived threat lies in their potential to disrupt ecological functioning and stability rather than from any direct threat that may pose to human health. Over the last 5 years, the international scientific community and the general public have become aware of the implications that atmospheric warming might have for world climate patterns and the resulting changes in the persistence, location, and composition of ecosystems worldwide. At the same time, awareness of the magnitude of current and impending losses of the world's biological diversity has increased. Human activities are currently responsible for a species loss rate that is the most extreme in millions of years, and an alarmingly increasing rate of transformation and fragmentation of natural landscapes. We are just beginning to grasp the meaning of this loss in terms of opportunity costs to human society and the less quantifiable losses associated with simplification of natural ecosystems. In the case of both global warming and reduction of biological diversity, man is affecting nature in an unprecedented fashion, on a global scale, and with unpredictable and frequently irreversible results.

Animal Population Groups↗

Maize adaptation to temperate climate: relationship between population structure and polymorphism in the Dwarf8 gene.

To investigate the genetic basis of maize adaptation to temperate climate, collections of 375 inbred lines and 275 landraces, representative of American and European diversity, were evaluated for flowering time under short- and long-day conditions. The inbred line collection was genotyped for 55 genomewide simple sequence repeat (SSR) markers. Comparison of inbred line population structure with that of landraces, as determined with 24 SSR loci, underlined strong effects of both historical and modern selection on population structure and a clear relationship with geographical origins. The late tropical groups and the early "Northern Flint" group from the northern United States and northern Europe exhibited different flowering times. Both collections were genotyped for a 6-bp insertion/deletion in the Dwarf8 (D8idp) gene, previously reported to be potentially involved in flowering time variation in a 102 American inbred panel. Among-group D8idp differentiation was much higher than that for any SSR marker, suggesting diversifying selection. Correcting for population structure, D8idp was associated with flowering time under long-day conditions, the deletion allele showing an average earlier flowering of 29 degree days for inbreds and 145 degree days for landraces. Additionally, the deletion allele occurred at a high frequency (>80%) in Northern Flint while being almost absent (<5%) in tropical materials. Altogether, these results indicate that Dwarf8 could be involved in maize climatic adaptation through diversifying selection for flowering time.

Alleles↗

Permafrost and changing climate: the Russian perspective.

The permafrost regions occupy about 25% of the Northern Hemisphere's terrestrial surface, and more than 60% of that of Russia. Warming, thawing, and degradation of permafrost have been observed in many locations in recent decades and are likely to accelerate in the future as a result of climatic change. Changes of permafrost have important implications for natural systems, humans, and the economy of the northern lands. Results from mathematical modeling indicate that by the mid-21st century, near-surface permafrost in the Northern Hemisphere may shrink by 15%-30%, leading to complete thawing of the frozen ground in the upper few meters, while elsewhere the depth of seasonal thawing may increase on average by 15%-25%, and by 50% or more in the northernmost locations. Such changes may shift the balance between the uptake and release of carbon in tundra and facilitate emission of greenhouse gases from the carbon-rich Arctic wetlands. Serious public concerns are associated with the effects that thawing permafrost may have on the infrastructure constructed on it. Climate-induced changes of permafrost properties are potentially detrimental to almost all structures in northern lands, and may render many of them unusable. Degradation of permafrost and ground settlement due to thermokarst may lead to dramatic distortions of terrain and to changes in hydrology and vegetation, and may lead ultimately to transformation of existing landforms. Recent studies indicate that nonclimatic factors, such as changes in vegetation and hydrology, may largely govern the response of permafrost to global warming. More studies are needed to better understand and quantify the effects of multiple factors in the changing northern environment.

Animals↗

20th century climate warming and tree-limit rise in the southern Scandes of Sweden.

Climate warming by ca. 0.8 degree C between the late-19th and late-20th century, although with some fluctuations, has forced multispecies elevational tree-limit advance by > 100 m for the principal tree species in the Swedish part of the Scandinavian mountain range. Predominantly, these processes imply growth in height of old-established individuals and less frequently upslope migration of new individuals. After a slight retardation during some cooler decades after 1940, a new active phase of tree-limit advance has occurred with a series of exceptionally mild winters and some warm summers during the 1990s. The magnitude of total 20th century tree-limit rise varies with topoclimate and is mainly confined to wind-sheltered and snow-rich segments of the landscape. Thickening of birch tree stands in the "advance belt" has profoundly altered the general character of the subalpine/low alpine landscape and provides a positive feedback loop for further progressive change and resilience to short-term cooling episodes. All upslope tree-limit shifts and associated landscape transformations during the 20th century have occurred without appreciable time lags, which constitutes knowledge fundamental to the generation of realistic models concerning vegetation responses to potential future warming. The new and elevated pine tree-limit may be the highest during the past 4000 14C years. Thus, it is tentatively inferred that the 20th century climate is unusually warm in a late-Holocene perspective.

Climate↗

Anthropological and thermoregulatory changes induced by a survival sojourn in a tropical climate.

OBJECTIVE: A survival sojourn in a tropical climate exposes subjects to 2 main constraints: food restriction and tropical climatic conditions. We hypothesized that such a sojourn could modify anthropological characteristics and thermoregulatory responses to heat and cold on return. METHODS: Eight European male subjects were submitted to a sweating test (ST) for 90 minutes (dry bulb temperature [Tdb] = 47 degrees C, relative humidity (RH) = 10%, and wind speed = 0.8 m x s(-1)) and to a whole-body cold-air test (Tdb = 1 degrees C, RH = 40%, and wind speed = 0.8 m x s(-1)) for 120 minutes in thermoclimatic chambers both before and after a 4-week survival sojourn in French Guyana. RESULTS: The survival sojourn resulted in a decrease in lean body mass (P < .05) without any significant change in body fat content. Heat thermoregulatory changes studied during the ST were characterized both by a lower mean skin temperature (Tsk) (P < .05) and a higher sweat rate measured after the sojourn than before it (m(sw); P < .05). Cold thermoregulatory changes were characterized by a higher T(sk) value (P < .05) and a decreased onset for continuous shivering without any significant change in internal temperature or metabolic heat production (M). CONCLUSIONS: This study showed that this type of sojourn modifies not only biometrical characteristics of the subjects but also the thermoregulatory responses, inducing an adaptation of the thermoregulatory system to heat and an increase in the sensitivity of the thermoregulatory system to cold. This finding could have practical implications on return after such a sojourn.

Adaptation, Physiological↗

[Association between dengue incidence and climatic factors].

OBJECTIVE: To describe the occurrence of autochthonous dengue cases according to sex, age, suspected infection site and its relation with climatic variables. METHODS: Autochthonous dengue cases reported in São Sebastião, Southern Brazil, from 2001 to 2002 and confirmed in laboratory were studied. Larval density was verified by three indexes: building, recipients and Breteau. The relationship between rainfall, temperature and number of cases was analyzed through Spearman's correlation using time lag. RESULTS: The annual incidence coefficients for 2001 and 2002 were 80.3 and 211.1 per 10,000 inhabitants, respectively. Most dengue cases (n=1,091; 65%) were reported in the district's central area. Females (n=969; 60%) and the age groups 20 to 29 and 30 to 39 years old of both sexes were mostly affected. Significant associations were not observed between climatic variables and the number of dengue cases in the first month; however, this association became evident in the second month throughout the fourth month. CONCLUSIONS: The association between the number of dengue cases and abiotic factors identified the time lag in which rain and temperature favored the occurrence of new cases. These aspects, associated to tourist vulnerability in the coastal area, promoted conditions for dengue occurrence. The urbanization without sanitary infrastructure possibly affected mosquito density and dengue incidence. Such factors may have contributed to mosquito dispersion and dissemination of different dengue serotypes.

Adolescent↗

[Prevalence of varicella-zoster virus antibodies in young adults from different Brazilian climatic regions].

To evaluate the prevalence of varicella-zoster virus infection in young adults from different Brazilian urban regions, 975 serum samples from blood donors aged 20 to 29 years, from tropical climate cities (Salvador and Fortaleza) and from temperate climate cities (S o Paulo, Curitiba and Porto Alegre) were tested by an in-house ELISA for detection of anti-varicella-zoster virus IgG antibodies. The overall prevalence was 94.2%. The lowest rate was observed in Fortaleza (88.7%) and the highest in Curitiba (99.5%). Seroprevalence in tropical regions of Brazil (89.4%) was significantly higher than in temperate regions (97.3%), a similar pattern to that observed in other tropical countries.

Adult↗

Plate tectonics, seaways and climate in the historical biogeography of mammals.

The marsupial and placental mammals originated at a time when the pattern of geographical barriers (oceans, shallow seas and mountains) was very different from that of today, and climates were warmer. The sequence of changes in these barriers, and their effects on the dispersal of the mammal families and on the faunas of mammals in the different continents, are reviewed. The mammal fauna of South America changed greatly in the Pliocene/Pleistocene, when the newly-complete Panama Isthmus allowed the North American fauna to enter the continent and replace most of the former South American mammal families. Marsupial, but not placental, mammals reached Australia via Antarctica before Australia became isolated, while rats and bats are the only placentals that dispersed naturally from Asia to Australia in the late Cenozoic. Little is known of the early history of the mammal fauna of India. A few mammal families reached Madagascar from Africa in the early Cenozoic over a chain of islands. Africa was isolated for much of the early Cenozoic, though some groups did succeed in entering from Europe. Before the climate cooled in the mid-Cenozoic, the mammal faunas of the Northern Hemisphere were much richer than those of today.

Animals↗