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At least 1,333 records · Page 74Linked to original sources
PubMed2000

[Microsomal triglyceride transfer protein and abetalipoproteinemia].

Microsomal triglyceride transfer protein (MTP) is a dimeric protein complex consisting of protein disulfide isomerase and a unique 97 kDa subunit. In vitro, MTP accelerates the transport of triglyceride, cholesteryl ester, and phospholipid between vesicles. It was recently demonstrated that abetalipoproteinemia, a disease characterized as an inability to produce chylomicrons and very low density lipoproteins in the intestine and liver, respectively, is the result of a genetic absence of MTP. Downstream effects resulting from this defect, include very low plasma cholesterol and triglyceride levels, absence of plasma apolipoprotein B and a lipid malabsorption syndrome, leading to lipo-soluble vitamin deficiencies. A low fat diet is instituted to eliminate the diarrhea. In addition, a therapy with vitamins A and E is essential to prevent patients from developing secondary effects such as neuropathy, muscle weakness, and retinopathy.

Abetalipoproteinemia↗
PubMed2000

[Current aspects of the therapy of chronic wounds].

The therapy of chronic lesions is a matter of debate among both physicians and nursing personnel. Often very different therapeutic approaches are conceivable, which contradict each other to some extent, but which must in any case be prescribed by a physician who is responsible for them. However, carrying out the therapy is often the task of the nursing personnel, who therefore stand in need of thorough information concerning the therapeutic considerations in order to realize these adequately. Here, important, but all too often neglected aspects of therapy are to be described in a summarizing manner.

Aged↗
PubMed2000

[Effects of biologically active food additives with different contents of vitamins on the vitamin status in humans].

The comparative study of influence of two biologically active food additives with the different contents of vitamins is carried out: a drink "Zolotoi Shar", the dose of vitamins in which makes 50-90% from recommended daily consumption, and "Vitabalance 2000", the contents of vitamins in which at 2-17 of time exceeds need of organism. The use of both additives within 3 weeks resulted in increase of levels of vitamins C, A, E, B2, B6 and carotenoids in blood serum. However if in case of consumption of a drink an authentic level was reached only for vitamin C and beta-carotene, in a case "Vitabalance 2000" for all investigated vitamins except vitamin A. Thus, if the consumption of a drink has lowered frequency of deficiency of 3-4 vitamins, but has not allowed to liquidate it completely, in case of "Vitabalance 2000" consumption the simultaneous deficiency 3-4 vitamins. The received data allow to believe the biologically active food additives containing vitamins in amounts exceeding recommended consumption, are convenient for fast liquidation of hypovitaminoses, and the preparations containing vitamins in doses making 30-50% from need of organism, are acceptable for daily filling of insufficient consumption of vitamins with a usual diet for a long time.

Adenine↗
PubMed1998

Diet and adolescent behavior: is there a relationship?

Behavioral problems such as hyperactivity, learning disabilities, mental illness, aggressive and antisocial behavior, and juvenile delinquency have been purportedly linked to the potential influence of foods or nutrients. This article examines the scientific evidence of the relationship between food and behavior in children and adolescents. It highlights the implications for practitioners important to consider in the assessment of the relationship between diet and behavior.

Adolescent↗
PubMed2000

Attention deficit/hyperactivity disorder (ADHD) in children: rationale for its integrative management.

Attention Deficit/Hyperactivity Disorder (ADHD) is the most common behavioral disorder in children. ADHD is characterized by attention deficit, impulsivity, and sometimes overactivity ("hyperactivity"). The diagnosis is empirical, with no objective confirmation available to date from laboratory measures. ADHD begins in childhood and often persists into adulthood. The exact etiology is unknown; genetics plays a role, but major etiologic contributors also include adverse responses to food additives, intolerances to foods, sensitivities to environmental chemicals, molds, and fungi, and exposures to neurodevelopmental toxins such as heavy metals and organohalide pollutants. Thyroid hypofunction may be a common denominator linking toxic insults with ADHD symptomatologies. Abnormalities in the frontostriatal brain circuitry and possible hypofunctioning of dopaminergic pathways are apparent in ADHD, and are consistent with the benefits obtained in some instances by the use of methylphenidate (Ritalin) and other potent psychostimulants. Mounting controversy over the widespread use of methylphenidate and possible life-threatening effects from its long-term use make it imperative that alternative modalities be implemented for ADHD management. Nutrient deficiencies are common in ADHD; supplementation with minerals, the B vitamins (added in singly), omega-3 and omega-6 essential fatty acids, flavonoids, and the essential phospholipid phosphatidylserine (PS) can ameliorate ADHD symptoms. When individually managed with supplementation, dietary modification, detoxification, correction of intestinal dysbiosis, and other features of a wholistic/integrative program of management, the ADHD subject can lead a normal and productive life.

Attention Deficit Disorder with Hyperactivity↗
PubMedDate not supplied

[Infectious and metabolic nervous system complications of systemic cancer].

OBJECTIVE: To review the incidence and causes of the infections and metabolic diseases of the nervous system in patients with systemic neoplasias. DEVELOPMENT: Patients with immunodeficiency, particularly those with hematological neoplasias and persons treated with immunosuppressive drugs have a considerable tendency to infection due to opportunist germs. Infections of the nervous system are relatively rare (0.02%-1%) and the commonest neoplasms are lymphomas, especially those of Hodgkin type and lymphosarcomas. The most frequent infections are caused by the herpes virus, meningitis due to Listeria monocytogenes and the meningitis due to fungi (Aspergillus, Candida and Cryptococcus). Cerebral abscesses, although rarer, are relatively common and are caused by gram negative bacteria, fungi and toxoplasmosis. In recent years there has been a notable increase in the number of patients diagnosed as having progressive multifocal leukoencephalopathy due to the possibility of carrying out studies to detect the DNA of the JC virus by polymerase chain reaction techniques. Empirical treatment of patients with neurological infections and systemic cancer should be started following the guidelines for immunodepressed patients. The metabolic complications of these patients are mainly due to hormone overproduction, hydroelectrolytic changes and vitamin deficits, which in general cause alterations of mental function of the confusion state type. CONCLUSION: In all patients with an infection or metabolic complication involving the nervous system, the presence of a systemic neoplasm makes it necessary to vary both the diagnostic approach and the empirical therapeutic measures taken.

Acute Disease↗