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PubMed2005

PGP4, an ATP binding cassette P-glycoprotein, catalyzes auxin transport in Arabidopsis thaliana roots.

Members of the ABC (for ATP binding cassette) superfamily of integral membrane transporters function in cellular detoxification, cell-to-cell signaling, and channel regulation. More recently, members of the multidrug resistance P-glycoprotein (MDR/PGP) subfamily of ABC transporters have been shown to function in the transport of the phytohormone auxin in both monocots and dicots. Here, we report that the Arabidopsis thaliana MDR/PGP PGP4 functions in the basipetal redirection of auxin from the root tip. Reporter gene studies showed that PGP4 was strongly expressed in root cap and epidermal cells. PGP4 exhibits apolar plasma membrane localization in the root cap and polar localization in tissues above. Root gravitropic bending and elongation as well as lateral root formation were reduced in pgp4 mutants compared with the wild type. pgp4 exhibited reduced basipetal auxin transport in roots and a small decrease in shoot-to-root transport consistent with a partial loss of the redirective auxin sink in the root. Seedlings overexpressing PGP4 exhibited increased shoot-to-root auxin transport. Heterologous expression of PGP4 in mammalian cells resulted in 1-N-naphthylthalamic acid-reversible net uptake of [3H]indole-3-acetic acid. These results indicate that PGP4 functions primarily in the uptake of redirected or newly synthesized auxin in epidermal root cells.

ATP Binding Cassette Transporter, Subfamily B↗
PubMed1989

Management behaviour of one community health nurse supervisor.

Mintzberg's theoretical framework of management, which examines the roles and functions of a manager in relation to effective communication, is used to analyse observational data of managerial conflict within a community health setting. In this setting the manager failed to establish sound interpersonal relations with her peers or with the clinic nurses. This led to a poor information base from which she could make decisions. The result was that the group became stressed and developed signs of disintegration.

Communication↗
PubMed1996

Season of birth and gender effects in children attending moderate learning difficulty schools.

This paper examines the effects of season of birth and gender on academic achievement and cognitive abilities in children attending moderate learning difficulty schools. Given the high preponderance of both boys and children born in summer attending special schools it is important to consider how well these children perform in relation to their peers. A multivariate analysis reveals that both boys and summer born children perform better on tests of intelligence, mathematical ability, and reading comprehension. Summer born children also perform better on a test of communication skills. Discriminant functions analysis reveals that for both gender and season of birth IQ is the major predictor variable followed by reading comprehension, mathematical ability and communication skill. For gender, IQ discriminates more successfully than the other variables, whereas with season of birth the relative sizes of the effects are more comparable. The results of the analysis are discussed in terms of the implications for the identification of children for placement in moderate learning difficulty schools.

Adolescent↗
PubMed2001

Adolescent development.

This chapter identifies the most robust conclusions and ideas about adolescent development and psychological functioning that have emerged since Petersen's 1988 review. We begin with a discussion of topics that have dominated recent research, including adolescent problem behavior, parent-adolescent relations, puberty, the development of the self, and peer relations. We then identify and examine what seem to us to be the most important new directions that have come to the fore in the last decade, including research on diverse populations, contextual influences on development, behavioral genetics, and siblings. We conclude with a series of recommendations for future research on adolescence.

Adolescent↗
PubMedDate not supplied

The socioemotional adjustment of adolescents with LD in the kibbutz during high school transition periods.

This study examined several aspects of the socioemotional experiences (i.e., loneliness, social skills, reciprocal friendship, reciprocal rejection, and social status) of adolescents with and without learning disabilities in an Israeli kibbutz environment during school transition periods. The sample consisted of 106 students with learning disabilities (LD; 74 boys and 32 girls) and 101 students without learning disabilities (NLD; 62 boys and 39 girls) drawn from seventh grade (i.e., early adolescence) and ninth grade (i.e., middle adolescence). The results revealed that seventh- and ninth-grade adolescents with LD received more social peer rejection than did NLD group adolescents, and students with LD were judged by their teachers to exhibit lower social skills and higher behavioral problems than their classmates. No significant group differences were found on loneliness, but an age-related increase in loneliness feelings was noted, which was independent from group membership and gender. Gender differences on self-report, peer ratings, and teachers' ratings on social measures in favor of girls were demonstrated. The discussion focuses on the potential impact of school transitions and of the developmental environment provided in the kibbutz on adolescents' socioemotional functioning and adjustment.

Adaptation, Psychological↗
PubMed1998

The use of clozapine in the treatment of aggressive schizophrenia.

The atypical antipsychotic drug clozapine was introduced to clinical practice in 1972. It is a dibenzodiazepine derivative with, among other known receptor site activities, a relatively high D1/D2 receptor affinity ratio. The serious side effects of bone marrow suppression and agranulocytosis delayed the acceptance of clozapine into common clinical practice but scrupulous application of a monitoring protocol led to adequate protection from these side effects. There is now a broad consensus about the benefits of clozapine which supports the use of clozapine as a first-line treatment of schizophrenia. There is good evidence that relapse and rehospitalization drop to 22% of the incidence in preclozapine treatment patients. The majority of responders are identified within 4 months of treatment. Clozapine has been demonstrated to be an effective treatment for neuroleptic refractory patients. Forty percent of clozapine-treated patients show significant improvement, with 11% of treated patients showing no residual psychosis. This review also describes the results of clozapine on aggressive and violent assault in a patient population characterized by severe functional deficits, typically chronic schizophrenia with severe impairment, chronic brain syndromes, and developmental handicap. Prior to the introduction of clozapine therapy, in a chronically disrupted milieu that precluded adequate psychosocial programming, seriously assaultive behaviour resulting in peer and staff injury was a common occurrence. Evidence suggests that clozapine is an effective medical treatment for the target symptoms of hostile agitation, threatening, and assaultive violence.

Administration, Oral↗
PubMed2001

Recovery from work-related trauma by perioperative nurses: the effects of social and personal resources.

The complexities of the recovery process following a traumatic event suggest a need to provide support resources that sustain or promote positive perceptions of the events. The availability and effectiveness of social support is a function of both its content and its capability of responding appropriately to the influence of the recovery dynamics in a contingent manner. Further, the quality of recovery from work-related trauma is suggested to be a function of the interactive processes of the individuals, the organisational environment they work in, and the social support provided. Using methodological triangulaton, 213 nurses working in rural and metropolitan operating suites were surveyed to assess the types, amount and effectiveness of social and personal resources that were used following exposure to traumatic work experiences. The findings demonstrate the significance of personal and social support resources in assisting perioperative nurses to recover from traumatic experiences. A personal sense of coherence and emotional support received through disclosure to work colleagues and supervisors were the most salutary aspects of support following trauma. The results suggest that opportunities should be made available through peer support programs, educational programs and professional meetings to better prepare nurses for traumatic situations and their aftermath. Furthermore, the work organisation needs to be educated in the need for and process of creating sanctuary and providing a holistic approach to management. This will then allow individuals, such as perioperative nurses, to continue to function at an acceptable level during the mitigation of the traumatic incident.

Adaptation, Psychological↗
PubMed2003

Infant attachment and temperament as predictors of subsequent externalizing problems and cardiac physiology.

BACKGROUND: The primary objective of this study was to examine the extent to which both individual child temperament and parent-child relationship quality independently and/or interactively predicted physiological, psychosocial, and behavioral 'outcomes'. Employing a longitudinal prospective design over three years, statistical associations were found among infant attachment, uninhibited temperament, and 4-year behavioral and physiological functioning that supported a bio-psychosocial model of development. METHOD: Three cohorts totaling 140 children and their mothers visited the laboratory for observational assessments of attachment classification at age 14 months (Strange Situation), behavioral inhibition at 24 months, and social behaviors with unfamiliar peers at age 4 years. Cardiac measures of heart rate and respiratory sinus arrhythmia (RSA) were collected at every time point. At age 4 years maternal ratings of child temperament and behaviors were also obtained. RESULTS: Analyses of variance (ANOVAs) with inhibition group (high, moderate, low) and attachment classification (A, B, C) revealed that the low inhibited group had significantly higher activity level scores and displayed significantly less reticence at 4 years compared to the moderately and highly inhibited groups. Infants who had an avoidant attachment with their mothers had more externalizing problems (aggressive behaviors) at age 4 than either securely or ambivalently attached infants. This predictive relation, however, was qualified by an interaction whereby avoidant attachment and uninhibited temperament together predicted a higher incidence of externalizing behavior problems. Moreover, infants' avoidant attachment was not concurrently but predictively associated with lower heart rate and high RSA at age 4 years. Therefore, an avoidant mother-child relationship in infancy could influence the development of an underaroused autonomic profile in early childhood. CONCLUSIONS: Consistent with bio-psychosocial models of development, these findings support the contention that both early child temperament and parent-child relationship quality contribute to subsequent psychological/behavioral and physiological functioning.

Analysis of Variance↗
PubMed2006

Birthweight-discordance and differences in early parenting relate to monozygotic twin differences in behaviour problems and academic achievement at age 7.

This longitudinal monozygotic (MZ) twin differences study explored associations between birthweight and early family environment and teacher-rated behaviour problems and academic achievement at age 7. MZ differences in anxiety, hyperactivity, conduct problems, peer problems and academic achievement correlated significantly with MZ differences in birthweight and early family environment, showing effect sizes of up to 2%. As predicted by earlier research, associations increased at the extremes of discordance, even in a longitudinal, cross-rater design, with effect sizes reaching as high as 12%. As with previous research some of these non-shared environmental (NSE) relationships appeared to operate partly as a function of SES, family chaos and maternal depression. Higher-risk families generally showed stronger negative associations.

Anxiety Disorders↗
PubMed2000

Parents' ratings of everyday cognitive abilities in very low birth weight children.

Parents' ratings of everyday cognitive functioning in very low birth weight (VLBW) children free of sensorineural impairments and normal birth weight (NBW) children were compared with the children's actual performance on psychometric measures of cognitive and motor skills. Subjects included 19 VLBW children identified at age 3 years as "suspect" for developmental problems, 19 VLBW children identified at age 3 years as "developing normally," and 30 NBW full-term peers. Results indicated that parents of the suspect VLBW group rated their children as having significant impairments in memory, language, cognitive, and motor skills, findings which were consistent with the results of concurrent psychometric assessments. When compared with psychometric test results, parents identified more children as displaying difficulties in memory, language, and cognitive skills, but fewer children with coordination difficulties. These findings suggest that the parents' ratings and the psychometric measures may be assessing somewhat different aspects of the children's functioning.

Adolescent↗
PubMed1995

Another function of erythrocytes: transport of circulating immune complexes.

OBJECTIVE: To review the main characteristics of the 'immune complex (IC) transport system of erythrocytes', and its possible relevance for transfusion medicine. DATA SOURCES: Literature search, and results Of Studies performed in the laboratory of Dr J. Schifferli from 1986 to 1995. SELECTION CRITERIA: Peer review journals and work relevant to the topic. RESULTS: When antigen/antibody IC form in the presence of complement. C3b binds covalently to the complexes. Such opsonized complexes attach to cells bearing complement receptor 1 (CR1), which is mostly found on erythrocytes in the circulation. This allows IC to be transported through the circulation to the fixed macrophage system of the liver and spleen. In addition, C3b bound to the complexes is catabolized by factor 1 (with CR1 as a cofactor) so that the complement-activating properties of the complexes are reduced. CONCLUSIONS: Complement and erythrocyte CR1 contribute to the safe and effective elimination of IC in humans. This physiologic system prevents IC deposition in the vessel walls.

Antigen-Antibody Complex↗
PubMed2000

Peer networks among heavy, regular and infrequent drinkers prior to marriage.

OBJECTIVE: Research has consistently demonstrated that, among adolescents, the characteristics of one's peers are important predictors of substance abuse. The impact of the peer network on adult drinking, however, has received considerably less attention. The purpose of the present study was to examine social network characteristics that are associated with heavy drinking in adulthood prior to marriage. METHOD: Couples were recruited at the time of their first marriage. Husbands and wives were each given identical questionnaire packets to complete at home, independently, as well as a postage-paid envelope for packet return. A broad range of constructs was assessed; included were personality characteristics, relationship functioning, drinking behavior and social network characteristics. Complete data were obtained from 471 husbands and 471 wives. RESULTS: The social networks of heavy-drinking men, compared to men drinking regularly or infrequently, were younger, more likely to be male and unmarried and consisted of friends rather than family or others. For both men and women, "drinking buddies" accounted for nearly 75% of the heavy drinkers' peer networks. The overall ratings of support and conflict created by peers did not differ according to drinking group, for either men or women. CONCLUSIONS: Prior to marriage, the social networks of heavy drinkers differ considerably from the networks of regular or infrequent drinkers with regard to the drinking patterns of their peers. An important finding was that heavy drinkers appear to experience a similar level of emotional, financial and practical support from their peer network compared to regular or infrequent drinkers.

Adult↗
PubMed2004

Social skills of children with neurofibromatosis type 1.

Children with neurofibromatosis type 1 (NF1) have difficulties in forming friendships and are often rejected by their peers. Factors that contribute to these negative social outcomes are poorly understood. This study investigated the social skills of children with NF1 and the influence of comorbid conditions, such as attention-deficit-hyperactivity disorder (ADHD) and specific learning dfficulties. We assessed and analyzed data from 79 children with NF1 (42 males, 37 females; mean age 11 years 6 months, SD 2 years 4 months) and 46 unaffected siblings (19 males, 27 females; mean age 12 years 1 month, SD 2 years 6 months; age range 8 to 16 years). Social skills were measured with the Social Skills Rating System. Children with NF1 had significantly poorer social outcomes than their unaffected siblings, and significantly poorer social skills in comparison with normative data. The presence of ADHD (in 39% of children with NF1) was the major risk factor for poor social functioning. Children with NF1 and ADHD had the poorest social skills and social outcomes when compared with children with NF1 only or children with NF1 and learning difficulties. These findings dispel the previous assumption that NF1 alone is associated with poor social functioning and has major implications for the development of effective interventions.

Adaptation, Psychological↗
PubMed1982

Effects of locus of control on perceived hospital environment.

Re-examined how psychiatric patients' perception by their treatment setting was related to locus of control, unconfounded by variations in treatment setting, differences in pathology, or length of hospitalization. Forty male patients were drawn from the general psychiatric' population of Norwich Hospital. They were administered the Rotter I-E Scale, Ward Atmosphere and Ward Initiative Scales. In contrast to reports found in the literature, the results of the study indicated that internally oriented patients preferred a well-ordered, organized treatment setting in which therapeutic objectives and treatment procedures were defined clearly. A most important determinant of the perception of the treatment setting appeared to be the Internals' personal involvement in the therapeutic functioning of the unit. Externals felt that the level of personal participation in the operation of the unit should be minimal and that treatment plans and procedures should be formulated by professional staff and not by their peers.

Adult↗
PubMed2026

Treatment updates in myotonic disorders.

Myotonia is delayed muscle relaxation after forceful contraction. It is due to hyperexcitability of the skeletal muscle membrane. It can arise from primary skeletal muscle ion channel dysfunction, involving chloride or sodium channels, but is also a prominent clinical feature in myotonic dystrophies where altered RNA splicing leads to secondary ion channel dysregulation amongst other systemic manifestations. Clinically, myotonia can range from delayed eye opening to a disabling symptom causing impaired mobility, functional difficulty and sometimes pain. It can also be a "hidden disability" with many patients feeling socially embarrassed by "looking healthy", yet being unable to do everyday physical tasks or to do them as effortlessly as their peers. It is a symptom that almost always indicates a genetic diagnosis, although it can occur in acquired conditions, including metabolic and drug-induced causes. To experience myotonia without knowing what it is can be baffling. To receive a genetic diagnosis associated with it can be life changing. Although there is no cure, there are many effective and available symptomatic treatments for myotonia and currently we are in an exciting era of clinical trials for new molecular disease-modifying therapies for myotonic dystrophy type 1. In this review, we consider recent developments in the treatment of myotonic disorders and how they may change clinical practice.

Humans↗
PubMed2006

Accumulation of health disorders as a systemic measure of aging: Findings from the NLTCS data.

BACKGROUND: An index of age-associated health/well-being disorders (deficits), called the "frailty index" (FI), appears to be a promising characteristic to capture dynamic variability in aging manifestations among age-peers. In this study we provide further support toward this view focusing on the analysis of the FI age patterns in the participants of the National Long Term Care Survey (NLTCS). METHODS: The NLTCS assessed health and functioning of the U.S. elderly in 1982, 1984, 1989, 1994, and 1999. Detailed information for our sample was assessed from about 26,700 interviews. The individual FI is defined as a proportion of health deficits for a given person. RESULTS: The FI in the NLTCS exhibits accelerated age patterns. The acceleration is larger for elderly who, at younger ages, had a lower FI (low FI group) than for those who showed a higher FI at younger ages (high FI group). Age-patterns for low and high FI groups tend to converge at advanced ages. The rate of deficit accumulation is sex-sensitive. CONCLUSIONS: The accelerated FI age patterns suggest that FI can be considered as a systemic measure of aging process. Convergence of the (sex-specific) FI age patterns for low and high FI groups by extreme ages might reflect the limit of the FI-specific (or systemic) age as well as the limit of adaptation capacity in aging individuals.

Age Distribution↗
PubMed2003

Children's physiological indices of empathy and their socioemotional adjustment: does caregivers' expressivity matter?

Relations of heart rate and skin conductance reactions to mildly evocative empathy-inducing slides with socioemotional functioning were examined for 154 children (mean age = 9 years, 5 months). In addition, maternal expressivity was tested as a moderator of these relations. Parents and teachers rated children's socioemotional functioning, and a behavioral measure of children's regulation was obtained. Boys who exhibited higher skin conductance and higher heart rate to slides depicting negative emotions were better regulated, less emotionally intense, and better adjusted than their peers. Furthermore, boys' regulation and adjustment were positively related to such physiological responding to negative slides if maternal negative expressivity was relatively low or moderate, but not high. Fewer findings were obtained for girls or for positive slides.

Adaptation, Psychological↗