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The human incisal suture and premaxillary area studied on archaeologic material.

The purpose of this study was to investigate the extent of the incisal suture, the size of the premaxillary area, and the developmental status of the dentition. Sixty-three medieval crania were examined: 30 from children and 33 from adults, including 5 cases with tooth deviations. All crania were photographed at a 1:1 scale. From the photographs the size of the premaxilla and the length of the incisal suture were measured. In addition, the spatial conditions in the anterior region were recorded. The study showed that the main closure of the suture takes place shortly after the crowns of the permanent incisors have attained their final width size. The mean size of the premaxillary area was larger in individuals with interincisal spacing and smaller in individuals with crowding when comparing with normal spatial conditions. In the cases of tooth agenesis the premaxillary areas were markedly reduced.

Adult↗

Prevalence of malocclusion in 6-year-old Icelandic children.

The prevalence of different malocclusion features was investigated in 396 6-year-old Icelandic children, using the epidemiologic registration method described by Björk et al. in 1964. Girls were ahead of boys with regard to dental stage (P < 0.01). One or more permanent teeth were congenitally missing in 5% of the children. Postnormal occlusion was found in 27% of the boys and in 31% of the girls, and prenormal occlusion was found in 6% and 5%, respectively. Straight terminal plane at the second deciduous molars was found in individuals with either normal or postnormal occlusion. Thus, it can be misleading to use the relation of the terminal planes as a measurement of the sagittal relation between the jaws. The prevalence of hypodontia was much lower than has been reported previously for Icelandic children.

Age Determination by Teeth↗

The control of ingress of albumin into developing enamel from adjacent dentine of the rat incisor.

The present study used an immunohistochemical approach to map the distribution of albumin within the dentine adjacent to the developing enamel of both impeded and unimpeded rat incisors to determine if the dentine could be a possible route of entry for this protein into the developing enamel matrix. In dentine adjacent to the secretory and transition stages of the developing enamel, the dentinal tubules were labelled only over approximately the pulpal quarter of their length. The bulk of the dentine showed no labelling. However, labelling within the dentine appeared at the ADJ at a position approximately 2.5 mm occlusal to the distal root of the first molar, adjacent to enamel with no visible residual matrix. The results of this study suggest that adventitious ingress of albumin into enamel from the dentine is restricted during enamel secretion and can only potentially occur once enamel maturation has been initiated.

Albumins↗

Developmental, neuro and immunotoxic effects of perinatal diazepam treatment in rats.

In utero exposure of rats to low dosages of diazepam (1.0-2.0 mg/kg) has been found to result in depression of the cellular and humoral immune responses during adulthood. Behavioral dysfunctions were also reported in infants from mothers with high benzodiazepine (BDZ) intake during pregnancy. The present experiment was undertaken to reconsider the potential action of diazepam during ontogeny in order to obtain further information about developmental processes using a refined methodology. Time-pregnant rats were treated subcutaneously with diazepam (2.0 mg/kg/day,: group E1) or with diazepam vehicle (group C1) from gestational day 14 to 20. Other dams (group E2) received the same BDZ dose from the 1st to the 21st day of lactation (weaning) or were not treated, remaining undisturbed in their home cages (group C2). The following results were obtained for animals perinatally treated with diazepam compared to groups C1 and C2: 1--increased time for testis descent and decreased time for vaginal opening (group E2); 2--no changes in the dates for ear end eye opening, or incisor tooth eruption (groups E1 and E2); 3--increased locomotor activity in the open-field (group E2) and/or in the plus maze (groups E1 and E2); 4--decreased levels of anxiety measured in the plus maze (groups E1 and E2); 5--decreased macrophage spreading and phagocytosis (groups E1 and E2). These results, which occurred in the absence of overt signs of maternal or fetal toxicity, demonstrate developmental, neuro- and immunotoxic effects of perinatal diazepam treatment in rats.

Animals↗

Medically induced gingival hyperplasia.

Gingival hyperplasia or gingival overgrowth is a common occurrence in patients taking phenytoin, cyclosporine, or calcium channel blockers. Speech, mastication, tooth eruption, and aesthetics may be altered. Controlling the inflammatory component through an appropriate oral hygiene program may benefit the patient by limiting the severity of the gingival overgrowth. In patients in whom gingival overgrowth is present or may be anticipated, recognition of this condition and referral to a general dentist or periodontist are appropriate steps to management. The physician's awareness of the potential for development of overgrowth and the dental practitioner's role in attempting to prevent or minimize this problem are important aspects. In this article, we discuss the medications associated with gingival hyperplasia and describe appropriate recommendations.

Anticonvulsants↗

[Mechanism of action of fluorides in local/topical application].

The marked caries reduction in many countries over the last two decades is thought to be mainly the result of the widespread and frequent use of low concentrations of fluorides mainly via toothpastes. This article gives a review on fluoride sources in the oral cavity and discusses the physiochemical mechanisms by which fluoride interacts with enamel during the caries process and its reversal. From this review it becomes clear that fluoride incorporated into the enamel mineral during tooth development has little effect on the caries process. It is the fluoride incorporated posteruptively and in the aqueous phase during the caries challenge that is of primary importance. The most effective caries preventive fluoride regimen, both from a theoretical perspective and as proved clinically, is the frequent (daily) low concentration application of fluoride from toothpastes and/or mouthrinses. High concentrations, however, used at intervals of months or years and administered by the dentist, work initially not only on both de- and remineralisation, but also by providing fluoride as calcium-fluoride or absorbed in early lesions which is subsequently available over prolonged periods.

Calcium Fluoride↗

Natural remedies recommended for the management of oral health.

This paper discusses various practices recommended by homeopaths, herbalists, spiritual and natural healers for the management and maintenance of oral health. It is intended as a partial guide to educate the dental professional on self-administered, over-the-counter remedies that are easily available to the general population. Since few if any clinical studies exist assessing the efficacy or side effects of these ingested products, little is known about the beneficial or potentially harmful course these remedies may take on the human body.

Adult↗

A case of supernumerary teeth in the premaxilla, maxillary cuspid, and mandibular premolar regions.

A case of several developing supernumerary teeth is reported. A seven-year-old African-American boy presented with retained primary maxillary central incisors, two impacted mesiodens, and unerupted permanent maxillary central incisors. A dentigerous cyst was removed at the time of surgical removal of the mesiodens. Approximately fourteen months post-extraction, a new panoramic radiograph showed the presence of six previously unidentified developing and unerupted supernumerary teeth, one on each of the maxillary cuspid areas and two on the mandibular premolar regions bilaterally. Practitioners should be aware that supernumerary teeth may develop late. Thus, periodic reevaluation with appropriate radiographs is indicated, especially in patients who have presented with supernumerary teeth.

Child, Preschool↗