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Results for “SELF STIMULATION”

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At least 1,315 records · Page 73Linked to original sources
PubMed1982

Contingent self-stimulation for stuttering.

In this investigation, 10 adult stutterers were given time-out contingent on each stuttering. Ten other stutterers administered themselves time-out contingent on each stuttering. Stutterers in both time-out conditions evidenced marked reductions in stuttering compared with spontaneous speaking base rates. Stutterers who presented their own time-outs for stuttering, however, showed significantly less extinction of reduced stuttering following the time-out period, and significantly greater generalization to a telephone speaking situation, than did stutterers who were given time-out by an experimenter.

Adult↗
PubMed2004

Self-stimulated NO reduction and CO oxidation by iron oxide clusters.

It is shown that a bare Fe2O3 cluster can oxidize CO to form CO2 and reduce NO to form N2 by undergoing compositional changes between Fe2O2 and Fe2O3 states. Investigations based on density functional theory reveal that the above reactions occur through an interesting sequence. An initial CO or NO adsorbed on the Fe2O3 weakens one of the O-Fe bonds to create a loosely attached O site. A subsequent CO gets oxidized by this O and transforms the cluster to a reduced Fe2O2 that now reduces NO via multiple oxidation and reduction steps that return the cluster to the oxidized Fe2O3 state. It is shown that the small size allows geometrical rearrangements that eliminate reaction barriers, allowing energetics and not barriers to be the primary motor for catalysis. Detailed reaction paths and the corresponding energetics are presented to illustrate the viability of the proposed mechanisms.

Adsorption↗
PubMed1958

Self-stimulation of the brain; its use to study local effects of hunger, sex, and drugs.

My conclusions are these: (i) The cells which mediate primary rewarding effects are located in a midline system running from the midbrain through the hypothalamus and midline thalamus and into the subcortical and cortical groups of the rhinencephalon. (ii) The cell groups which mediate primary rewarding effects are different from those which mediate primary punishing effects. (iii) Despite this relative independence, there are, undoubtedly, relationships of mutual inhibition existing between these two systems. Rewards do, among other things, tend to reduce sensitivity to pain, and punishments do tend to reduce rewarding effects. (iv) These primary reward systems of the brain are subdivided into specific drive-reward subsystems mediating the specific drives such as hunger and sex. (v) Because there are also subsystems of this set of rewarding structures sensitive to different chemical effects, it is reasonable to hope that eventually it will be possible to control the reward systems pharmacologically in cases where behavior disorders seem to result from deficits or surfeits of positive motivation.

Brain↗
PubMed1961

Slowing of heart rate after septal self-stimulation in rats.

Heart rate, recorded continuously from rats trained to press a bar for intracranial electrical stimulation of their septal areas, fell consistently after brain stimulation. Interpretation of the rewarding effect of septal stimulation had previously been limited by the absence of any data on the autonomic effects of the stimulation. The results of this study suggest that the rewarding effect may possibly be produced by a parasympathetic (quieting) reaction of the autonomic nervous system to septal stimulation.

Animals↗
PubMed2002

A case of trigeminal-vagal neuralgia relieved by peripheral self-stimulation.

A case of simultaneous trigeminal and vagoglossopharyngeal neuralgia is described. No microvascular compression was seen at the trigeminal complex while the origin of vagoglossopharyngeal pain could have been due either to Chiari malformation or microvascular compression of the IX-X nerve complex. Decompressive surgery was ineffective. The patient could completely block his facial painful fits by strongly pinching the anterior axillary fold. This case militates against peripheral theories of facial neuralgias, including microvascular compression and ganglion ignition focus theories, and supports a central origin thereof.

Aged↗
PubMed1988

Molecular interactions in intermediate and transition states in the self-stimulated inhibition of enzymes.

Di-isopropyl fluorophosphate (DFP) and other organophosphorus inhibitors recruit the catalytic power of their target enzymes: the enzyme catalyzes its own irreversible phosphorylation. The magnitude of the catalytic acceleration can approach the factor by which the enzyme catalyzes its own acylation by natural substrates. The reaction of DFP with five serine proteases [chymotrypsin, elastase, dipeptidyl peptidase IV (DP IV), subtilisin and thermitase] exhibits in all cases the same pH dependence as does enzyme acylation by natural substrates. Chymotrypsin and elastase form a "fast" class of enzymes which react about ten-fold faster than the other three "slow" enzymes. All enzymes show k(HOH)/k(DOD) of about 2 but the proton inventory indicates one-proton character for "slow" enzymes and multiproton character for "fast" enzymes. Enthalpies of activation are about 33 kJ/mol (subtilisin, "slow") and 10 kJ/mol (elastase, "fast"). Entropies of activation are about -120 J.T-1.mol-1 (subtilisin, "slow") and -175J.T-1.s-1 (elastase, "fast"; T = temperature in K).

Enzyme Inhibitors↗