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Parenteral premedication with lorazepam--a dose/response study.

The dose/response characteristics of lorazepam when administered parenterally as a premedicant drug were studied. The parameters studied included its' sedative and amnesic effects as well as effects on the cardiovascular and respiratory systems. Intramuscular and intravenous routes using doses 2 mg, 3 mg and 4 mg were compared. The findings suggest that lorazepam's sedative and amnesic effects were more pronounced with the intravenous route, and that in both routes the incidence and degree of sedation and of amnesia were dose dependant. There were minimal changes in arterial blood pressure, pulse rate or quality of respiration. We recommend that due to local logistic factors, the intravenous route might be more suitable, affording a more rapid onset of sedation before induction of anaesthesia, provided that close nursing observation is available. Furthermore, lorazepam 2 mg intravenously is just as effective as the larger doses with less incidence of nausea and vomiting associated with the larger doses.

Adult↗
PubMed1987

Sociodemographic and premedical school factors related to postgraduate physicians' humanistic performance.

In an extensive survey of postgraduate physicians in two teaching hospitals (N = 141) for their humanistic attitudes, values and behavior, all ratings of physicians' humanistic performance, including physicians' own scores on self-report measures, supervising faculty, nurses and patient ratings, were modestly but significantly correlated with each other. Sex, ethnic or racial background, year of training, marital status, number of children, Alpha-Omega-Alpha membership or number of articles published were unrelated to physicians' humanistic behavior. Several measures of humanism were positively correlated with having taken more courses in the social sciences and humanities, having had more early person-centered work experience and reporting that before medical school others had confided in them or sought their advice more frequently.

Attitude of Health Personnel↗