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At least 1,315 records · Page 73Linked to original sources
PubMed2004

Advanced technology permits the provision of advanced hospital care in the patients' homes.

Improvements in disease management and the aging of populations in Western countries are the main factors that have resulted in a disquieting rise in demand for expensive hospital beds. The patient-centred and family-friendly concept "Hospital at Home" has recently appeared on the global scene of health services, promising to offer a solution. This type of service has proved to be very welcome to patients and those they live with. However, Hospital at Home schemes reported in the literature are organized only to provide improved primary care services, usually to patients who are discharged from hospital a few days early and for the rest of their treatment. These services are mainly provided by nurses who perform one or fewer home visits a day and the medical contribution, if any, is limited to telephone consultations when necessary. Whenever something unusual happens the patient is readmitted. Some Hospital at Home settings, which are characterized as "admission avoidance", actually include only patients with conditions so stable that they might have stayed at home anyway, with some good primary care support. Yet Hospital at Home has much more to offer. Incorporated in the administrative structure of a hospital as real wards, manned with doctors, nurses and other health professionals on 24-hour duty in shifts and providing frequent--at least twice a day--regular home visits by doctors and nurses, Hospital at Home can reproduce real hospital conditions in the patients' homes. Portable medical devices enable the performance of a wide range of examinations at home, while information and communication technology neutralizes distances and makes collaboration between the virtual team and other contributors feasible and effective. Almost any patient whose condition neither requires prompt surgical operation nor meets the criteria for admission to an intensive care unit can be safely hospitalised at home, provided that he is attended by a properly organized, properly equipped and highly alert Hospital at Home service.

Computer Communication Networks↗
PubMed2005

Digital cine angiography permits radiation dose reduction without reduction in image quality.

PURPOSE: To investigate how much the radiation dose in digital cine angiography (DCA) systems can be reduced while maintaining an image quality equivalent to that of conventional cine angiography (CCA). MATERIALS AND METHODS: Simulated vessel phantoms were subjected to DCA and CCA. In DCA, the input dose value to the image intensifier built in the system was 0.10, 0.12, 0.14, 0.17, 0.2, and 0.24 microGy. The detectability for simulated vessel phantoms was visually evaluated by five observers. The radiation dose was measured using radiofluorescent glass-rod dosimeters. Doses of digital cine imaging were measured as relative values with the dose of CCA considered as 1.0. RESULTS: The relative DCA/CCA values in DCA, measured by radiofluorescent glass-rod dosimeters, ranged from 0.414 to 0.901 for simulated vessel phantoms CONCLUSION: DCA allows a reduction by 59% of the radiation dose compared with CCA without reduction of image quality.

Analysis of Variance↗
PubMed2005

Low temperature of GroEL/ES overproduction permits growth of Escherichia coli cells lacking trigger factor DnaK.

Escherichia coli trigger factor (TF) and DnaK cooperate in the folding of newly synthesized proteins. The combined deletion of the TF-encoding tig gene and the dnaK gene causes protein aggregation and synthetic lethality at 30 degrees C. Here we show that the synthetic lethality of deltatigdeltadnaK52 cells is abrogated either by growth below 30 degrees C or by overproduction of GroEL/GroES. At 23 degrees C deltatigdeltadnaK52 cells were viable and showed only minor protein aggregation. Overproduction of GroEL/GroES, but not of other chaperones, restored growth of deltatigdeltadnaK52 cells at 30 degrees C and suppressed protein aggregation including proteins >/= 60 kDa, which normally require TF and DnaK for folding. GroEL/GroES thus influences the folding of proteins previously identified as DnaK/TF substrates.

Chaperonin 10↗
PubMedDate not supplied

[The asylum seeking process a breeding ground for apathy among certain children. A negative answer concerning the residence permit is often a triggering factor].

In this study, 124 of 1,299 children from asylum seeking families living in northern Sweden required psychiatric help. Compared to Swedish children a larger proportion seeks psychiatric help. In the last few years more children seeking asylum have had severe generalised losses of functions and need help with activity of daily life. Almost every child's health condition improves when they get permission to stay in Sweden. Children from the former Soviet Union seek help more frequently than children from other countries do.

Adolescent↗
PubMed2006

Pseudotyped viruses permit rapid detection of neutralizing antibodies in human and equine serum against Venezuelan equine encephalitis virus.

Virus envelope proteins are the primary targets of neutralizing antibody responses. The epitopes recognized differ sufficiently between virus subtypes and species to distinguish viruses and provide an important basis for disease diagnosis. Venezuelan equine encephalitis virus (VEEV) causes acute febrile illness in humans and has high mortality in equines. The most specific detection methods for serum antibodies use live virus in neutralization assays or in blocking enzyme linked immunosorbent assays. However, work with Venezuelan equine encephalitis virus requires biosafety level 3 containment and select agent security in the United States. We report two new assays for detection of Venezuelan equine encephalitis virus neutralizing antibody responses, based on virus pseudotypes. The first provides detection by marker gene expression after 20 hours and is particularly suited for high-throughput screening; the second uses a new, rapid virus entry assay to give readouts within 1 hour. Both assays are safe, sensitive, and in general recapitulate neutralizing antibody titers obtained by conventional plaque reduction assays. Each is suitable as a rapid primary screen for detection of neutralizing antibodies against Venezuelan equine encephalitis virus.

Analysis of Variance↗
PubMed1991

[Optimization of the parameters that permit improvement in plate sorption activity for solid-phase immunoenzyme analysis].

The possibility of increasing the sorption activity of polystyrene plates with an initially low capacity for sorption has been shown. The qualitative and quantitative parameters of the process of physical modification have been ascertained. The empirical formula for achieving the highest degree of the sorption activity of plates by their definite exposure to ultraviolet radiation has been obtained.

Adsorption↗