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Follow-up of patients and partners experiencing penile prosthesis malfunction and corrective surgery.

An interview study is reported involving 14 men who had experienced at least one penile prosthesis malfunction and corrective surgery. Six partners were interviewed separately. The results indicated a broad range of coping patterns in terms of fears and disappointments, but an overall outcome of six cases very satisfactory, five satisfactory despite various worries or complaints, and three unsatisfactory. The discussion emphasizes coping, doctor-patient communication, and difficulties in predicting long-term outcome in these cases.

Adaptation, Psychological↗

Social familiarity and communication in Down syndrome.

The communication of eight Down syndrome individuals with strangers and with acquaintances was analysed. The spontaneity of their speech and the communicative demands they made on their audiences were found to be low. Some of them broke rules of conversation by not answering questions. Surprisingly, their speech was not more spontaneous with acquaintances. It was further observed that Down syndrome individuals' conversations were in the main restricted to comments on current actions. However, different postures are adopted and different body mobility exhibited depending on partner familiarity. It is concluded that Down syndrome persons prefer to express intimacy/social distance in non-verbal modalities.

Adolescent↗

Prevention of sympathetic ophthalmia. State of the art 1989.

Ophthalmologists are daily confronted with intraocular inflammation following trauma and/or intraocular surgery. In rare cases, this may lead to the loss of visual function in both eyes, i.e. sympathetic ophthalmia (SO). In order to reduce the scope of responsible action between enucleation of the exciting eye (EE), which still has good vision, and progressive inflammation of the second eye (SE) resulting in blindness if action is delayed, a score system was established based on all SO symptoms which had become known from the literature and personal communications up the end of 1988. The score system developed by HANNE et al. allows causal differentiation between SO or uveitis of other genesis in the partner eye taking into account the prior history and findings in the EE and the occurrence of symptoms after the last accident/operation and findings in the SE. If the last eye is involved, the presence of SO should be assumed in every case where there are signs of intraocular inflammation in order to allow immediate commencement of anti-inflammatory therapy, the more so since it is known that corticosteroids and cytostatics (this also applies to cyclosporin A) can only arrest the immunopathologic processes in the initial phase of the disease.

Blindness↗

Age and gender in the management of HIV-relevant sexual risks: theoretical background and first results of a population survey in the German speaking part of Switzerland.

OBJECTIVES: Health related lifestyles can be seen as resources for preventive behaviour in HIV-relevant situations. A concept was developed to analyse the management of HIV-relevant sexual risks and to uncover patterns of sexual lifestyles. In this paper first descriptive results will be presented focusing on gender and age. METHODS: 2,275 men and women between the ages of 19 and 65 from the German speaking part of Switzerland were interviewed in a computer-assisted telephone survey. Data were collected concerning attitudes, behaviours and resources, situational aspects and communication with regard to health and sexuality. Particularly, respondents were asked whether within the past 24 months they had had either first sexual contacts with new partners or casual sex, two forms of contacts which have special HIV relevance. RESULTS: 527 men and women reported having had first or casual sexual contacts. First results show a substantial lack of condom use among persons of both sexes in the age group older than 45. In general men showed more risk behaviour than women. CONCLUSIONS: For the first time in Switzerland, detailed data were collected from persons older than 45 years regarding sexual risk behaviour. Older, sexually active people are a vulnerable target group which has been neglected thus far in terms of research and preventive measures.

Adult↗

Support groups for patients with genetic disorders and their families.

In conclusion, those working in pediatric clinics owe it to themselves to know about the relatively new team member, the genetic support group. As the human genome becomes less mysterious to professional and patient alike and as its demystification creates an ever-increasing number of ethical and social dilemmas, consumers and professionals, interested perhaps for different reasons in finding treatment and cure, must work together as partners. Availability of medical care for the family who must cope with a genetic disorder is only one part of the total health picture. Access to communication with and compassion of one family with another family, of one child with another child, of one parent with another parent, within a support group of caring persons, proves one of the most meaningful medical tools that pediatricians can offer their patients. Those working within the walls of the pediatric clinic are in a crucial place to address the comprehensive needs of families with genetic disorders and to identify the role of the genetic support group in a treatment plan.

Genetic Diseases, Inborn↗

The gap junction cellular internet: connexin hemichannels enter the signalling limelight.

Cxs (connexins), the protein subunits forming gap junction intercellular communication channels, are transported to the plasma membrane after oligomerizing into hexameric assemblies called connexin hemichannels (CxHcs) or connexons, which dock head-to-head with partner hexameric channels positioned on neighbouring cells. The double membrane channel or gap junction generated directly couples the cytoplasms of interacting cells and underpins the integration and co-ordination of cellular metabolism, signalling and functions, such as secretion or contraction in cell assemblies. In contrast, CxHcs prior to forming gap junctions provide a pathway for the release from cells of ATP, glutamate, NAD+ and prostaglandin E2, which act as paracrine messengers. ATP activates purinergic receptors on neighbouring cells and forms the basis of intercellular Ca2+ signal propagation, complementing that occuring more directly via gap junctions. CxHcs open in response to various types of external changes, including mechanical, shear, ionic and ischaemic stress. In addition, CxHcs are influenced by intracellular signals, such as membrane potential, phosphorylation and redox status, which translate external stresses to CxHc responses. Also, recent studies demonstrate that cytoplasmic Ca2+ changes in the physiological range act to trigger CxHc opening, indicating their involvement under normal non-pathological conditions. CxHcs not only respond to cytoplasmic Ca2+, but also determine cytoplasmic Ca2+, as they are large conductance channels, suggesting a prominent role in cellular Ca2+ homoeostasis and signalling. The functions of gap-junction channels and CxHcs have been difficult to separate, but synthetic peptides that mimic short sequences in the Cx subunit are emerging as promising tools to determine the role of CxHcs in physiology and pathology.

Animals↗

Seropositive individuals willingness to communicate, self-efficacy, and assertiveness prior to HIV infection.

The purpose of this study was to examine possible communication similarities between human immunodeficiency virus (HIV) positive and HIV negative individuals. Forty HIV positive heterosexuals, who were infected through heterosexual sex, completed an on-line questionnaire to assess their safer sexual communication, willingness to communicate, condom self-efficacy, and assertiveness prior to HIV infection. Results indicate that prior to infection, HIV positive heterosexuals reported having similar safer sexual communication behaviors to those not infected with the virus. Participants in this study reported high levels of willingness to engage in safer sex communication, but low levels of actual communication. Further, results reveal that participants who engaged more often in safer sex communication were more likely to use condoms. Additionally, participants reported high levels of condom self-efficacy and moderate levels of assertiveness; both variables positively correlated with condom use. Finally, participants reported that they believed they did not need to discuss using condoms because they were not at risk. Previous safer sexual communication research reveals HIV negative individuals reported engaging in the same behaviors and holding the same beliefs reported by seropositive individuals. Hence, discussion of the importance of safer sexual communication and the utility of personalization to increase the communication of HIV negative individuals is explored.

Adult↗

Concurrent therapies: a model for collaboration between psychoanalysts and other therapists.

Many psychoanalysts treat individuals who are simultaneously in couples therapy or whose partners are in individual therapy. If such cases stall, some analysts may seek consultation from a colleague, though most have accepted the tacit historical prohibition against communication between therapists treating members of the same family. Experience, however, suggests that a certain form of communication between such therapists can have a powerfully enhancing effect on the concurrent therapies. After a review of the literature, the advantages, disadvantages, and impediments to collaborative cross-communication are examined. A model is then presented for use in ongoing discussion between therapists, and is illustrated with two clinical examples. The proposed model centers on the transference-countertransference configurations within the therapeutic field, and serves as an organizer highlighting areas for discussion.

Adult↗

AIDS in rural Africa: a paradigm for HIV-1 prevention.

Networks of concurrent sexual partnerships may be the primary cause of epidemic spread of HIV-1 in parts of sub-Saharan Africa. This pattern of sexual behaviour increases the likelihood that individuals experiencing primary HIV-1 infection transmit the virus to other persons. Networks of concurrent partnerships are likely to be important in both the early ('epidemic') and late ('endemic') phases of HIV-1 transmission. Interventions should aim to break the sexual networks, whatever the stage of the epidemic. However, prevention of transmission in the endemic phase also requires a greater awareness of early clinical manifestations of HIV-1 infection in the general population. Such awareness, coupled with the availability of condoms and access to HIV-1 testing facilities, may reduce transmission in discordant couples.

Acquired Immunodeficiency Syndrome↗

Employing task arrangements and verbal contingencies to promote verbalizations between retarded children.

This study investigated the effects of arranging task events for interdependence, to increase the probability of social responding. During task interdependence, the subjects, participating in dyads and a four-person group, obtained task materials (a puzzle piece) from their partner before completing their task (appropriately placing the puzzle piece). The verbal contingency required a verbal request to precede a subject's receiving a task material from his partner. The verbal contingency yoked with task interdependence made task completion contingent on the appropriate verbalization. The findings from two experiments suggested that task interdependence was sufficient to increase partner-directed verbalizations for three of the four subjects. When the verbal contingency was added, all subjects increased their requests and other verbalizations to partner. Applied to a four-person group, the verbal contingency yoked with varying levels of task interdependence correspondingly affected the pattern and level of group communications. The greater the task interdependence, i.e., the more members each subject depended on to complete his task, the more complex the social network of verbal contacts, and the higher the level of both requests and other verbalizations for the group.

Behavior Therapy↗

Counseling cancer patients about changes in sexual function.

Cancer treatments often cause sexual dysfunctions that remain severe long after therapy is over. Nevertheless, sexual counseling is not routinely provided in most oncology treatment settings. Most patients and their partners can benefit from brief counseling that includes education on the impact of cancer treatment on sexual functioning; suggestions on resuming sex comfortably and improving sexual communication; advice on how to mitigate the effects of physical handicaps, such as having an ostomy, on sexuality; and self-help strategies to overcome specific sexual problems, such as pain with intercourse or loss of sexual desire. Brief counseling can be provided by one of the allied health professionals on the oncology treatment team. A minority of patients will need specialized, intensive medical or psychological treatment for a sexual dysfunction. In a large cancer center, such treatment could be provided as part of a reproductive health clinic serving the special needs of cancer patients. In smaller settings, the oncologist should build a referral network of specialists. Not all managed care organizations reimburse for these services, however.

Female↗

Why American women are not receiving state-of-the-art gynecologic cancer care.

American women are not receiving state-of-the-art gynecologic cancer care. The three most common gynecologic cancers-endometrial, ovarian, and cervical-are quite uncommon in the United States when compared with othermalignancies. Nevertheless, their importance is clearly out of proportion to their incidence since the annual death rate from ovarian cancer alone is about one third that of breast cancer. And cervical cancer is a very common malignancy of women worldwide. The major problem accounting for suboptimal treatment of ovarian and endometrial cancers in the United States is incomplete surgical staging performed by nongynecologic oncologists. In the case of cervical cancer treatment, suboptimal care is attributable to specialty territoriality and the lack of randomized data. Factors influencing substandard gynecologic cancer for American women include the following: (1) the unregulated nature of the American health care system, (2) failure of professional education related to training in surgical principles and techniques and referral practices, (3) inadequate interactions between subspecialists and referring physicians, (4) disincentives for physicians to refer patients out of managed care networks or group practices, (5) disagreements between clinicians representing competing disciplines, and (6) conflicts of interest on the part of academic physicians or cooperative groups. Recommended initiatives include the following: (1) embracingthe quality of patient care as the overarching principle; (2) designing clinical trials that lead to advances in patient outcomes; (3) emphasizing public education (direct consumer information) as well as professional education; (4) partnering with local, state, and national patient advocacy groups to ensure optimal treatment for gynecologic cancers; (5) implementing practice guidelines; (6) developing referral guidelines; (7) improving communication skills of academic physicians in relating to referring physicians; (8) continuing to conduct and publish outcomes studies; and (9) establishing centers of excellence. It is time to make a commitment to substantially improving gynecologic cancer care for American women, and, I believe, the proposed initiatives will begin to accomplish this essential goal.

Delivery of Health Care↗

Incorporating HIV prevention into the medical care of persons living with HIV. Recommendations of CDC, the Health Resources and Services Administration, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America.

Reducing transmission of human immunodeficiency virus (HIV) in the United States requires new strategies, including emphasis on prevention of transmission by HIV-infected persons. Through ongoing attention to prevention, risky sexual and needle-sharing behaviors among persons with HIV infection can be reduced and transmission of HIV infection prevented. Medical care providers can substantially affect HIV transmission by screening their HIV-infected patients for risk behaviors; communicating prevention messages; discussing sexual and drug-use behavior; positively reinforcing changes to safer behavior; referring patients for services such as substance abuse treatment; facilitating partner notification, counseling, and testing; and identifying and treating other sexually transmitted diseases (STDs). To help incorporate HIV prevention into the medical care of HIV-infected persons, CDC, the Health Resources and Services Administration, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America developed these recommendations. The recommendations are general and apply to incorporating HIV prevention into the medical care of all HIV-infected adolescents and adults, regardless of age, sex, or race/ethnicity. They are intended for all persons who provide medical care to HIV-infected persons (e.g., physicians, nurse practitioners, nurses, physician assistants); they might also be useful to those who deliver prevention messages (e.g., case managers, social workers, health educators). The recommendations were developed by using an evidence-based approach. For each recommendation, the strength of the recommendation, the quality of available evidence supporting the recommendation, and the outcome for which the recommendation is rated are provided. The recommendations are categorized into three major components: screening for HIV transmission risk behaviors and STDs, providing brief behavioral risk-reduction interventions in the office setting and referring selected patients for additional prevention interventions and other related services, and facilitating notification and counseling of sex and needle-sharing partners of infected persons.

Adolescent↗

Designing interventions to prevent HIV-1 infection by promoting use of condoms and spermicides among intravenous drug abusers and their sexual partners.

This paper summarizes the results of a 2-day workshop to identify the most effective educational strategies to promote use of condoms and spermicides for preventing heterosexual transmission of HIV-1 virus from intravenous drug abusers (IVDA) to their steady, nonintravenous drug abusing (NIVDA) sexual partners. Representatives from health departments, drug abuse treatment centers, academic institutions, service organizations, and the community discussed issues relating to population characteristics, educational strategies and recruitment techniques. A consensus document that identifies the most effective recruitment and intervention strategies was developed. Recruitment issues include locations, recruitment targets, anticipated difficulties, and ethical considerations. The majority of workshop participants agreed that an intervention should target the couple (both IVDA and NIVDA). Intervention concerns encompass obtaining trust, maintaining participation, and identifying guidelines to maximize program impact.

Acquired Immunodeficiency Syndrome↗

[AIDS prevention in homosexuals in Switzerland: adaptation to risks according to type of partner].

OBJECTIVE: To evaluate the effectiveness of AIDS prevention and modes of adaptation to risk among gay men. Swiss results are presented from an international study conducted in 8 European countries. METHOD: A self-administered questionnaire was published in gay magazines and distributed by gay organizations and clubs. 934 questionnaires were returned in Switzerland. RESULTS: More than 80% of the respondents report no risk behaviours in the last 12 months. Among all respondents three main modes of adaptation to risk were found: avoidance (no partner, no penetration), protection (condom use), non-use of condoms by stable couples (this assumes an agreement between partners). With casual partners 39% avoid penetration, 49% use condoms and 12% do not use them consistently. With stable partners penetration is more frequent; protection and non use of condoms are found with equal frequency. Nevertheless, 10% of those who report always using condoms say that they have been exposed to a risk, while a third of those who do not always use condoms admitted having taken such a risk. CONCLUSIONS: Prevention campaigns must continue and focus especially on factors linked to the non use of condoms in couples in stable relationships (poor communication, exaggerated trust).

Acquired Immunodeficiency Syndrome↗

Outreach to injecting drug users and female sexual partners of drug users on the lower east side of New York City.

In 1984, outreach to injecting drug users and their female sexual partners was initiated as part of HIV behavioral research projects. HIV, health, drug treatment and family planning information and services were provided in addition to recruiting subjects to the research program. Such outreach also poses certain problems--especially potential disruption of neighborhood day-to-day life and clashes with police. This paper discusses an outreach program to injecting drug users and their female sexual partners that was initiated in New York City to provide HIV-related information and services. We examine the successes of the program and problems that were involved in conducting outreach to persons who are typically not accessible through formal institutional channels.

Acquired Immunodeficiency Syndrome↗

[Interactions between the immune and neuroendocrine systems: clinical implications].

The endocrine and immune systems are interrelated via a bidirectional network in which hormones affect immune function and, in turn, immune responses are reflected in neuroendocrine changes. This bidirectional communication is possible because both systems share a common "chemical language" that results from a sharing of common ligands (hormones and cytokines) and their specific receptors. Cytokines are important partners in this crosstalk. They play a role in modulating the hypothalamo-pituitary-adrenal (HPA) axis responses at all three levels: the hypothalamus, the pituitary gland and the adrenals. Acute effects of cytokines are produced at the central nervous system level, particularly the hypothalamus, whereas pituitary and adrenal actions are slower and are probably involved during prolonged exposure to cytokines such as during chronic inflammation or infection. Several mechanisms have been proposed by which peripheral cytokines may gain access to the brain. They include an active transport through the blood-brain barrier, a passage at the circumventricular organ level, as well as a neuronal pathway through the vagal nerve. The immune-neuroendocrine interactions are involved in numerous physiological and pathophysiological conditions and the interactions with the HPA axis may represent a mechanism through which the immune system, by stimulating the production of glucocorticoids, avoids an overshoot of inflammatory response. They may also be involved in the state of hypogonadism, of hypothyroidism and growth inhibition which can occur during inflammatory and infectious diseases. The crosstalk between the immune and endocrine systems is important to homeostasis, since the interactions can produce various appropriate adaptative responses when homeostasis is threatened.

Animals↗

Prophylactic antibiotics for suction curettage abortion: results of a clinical controlled trial.

The prophylactic use of 300 mg doxycycline at the time of an abortion was evaluated in a randomized controlled trial. In the group with negative chlamydia screening results, only two (0.4%) of 502 patients who received prophylactic treatment developed pelvic infection, compared with 15 (3.0%) of 497 patients who received placebos (p = 0.001). The same effectiveness was found in women with positive chlamydia screening results. Vomiting was the major side effect of the medication and could limit its use. A simulation of selective prophylaxis in women with negative chlamydia screening results showed that its selective use in patients with a history of gonorrhea or in nulliparous women with multiple sex partners could be nearly two thirds as effective as general prophylaxis.

Abortion, Induced↗