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PubMedDate not supplied

Effect of antiphlogistic steroids on urinary hydroxyproline excretion in systemic lupus erythematosus.

Total hydroxyproline excretion in 24-hour urine was determined in 20 cases of systemic lupus erythematosus (SLE) before and during treatment. Additionally the excretion of hydroxyproline was determined in 14 patients receiving steroids for various other diseases (endocarditis, thrombocytopenia, acute leukemia, apofocal polyarthritis, ischialgia, spastic bronchitis, pleuritis and Dressler's post-infarction syndrome). The normal hydroxyproline value was established in 40 healthy persons. The normalization of pathologically increased hydroxyproline excretion in patients with SLE during treatment with prednisone in doses from 1.0 to 1.35 mg/kg/daily was associated with remission of clinical symptoms. Large doses of prednisone in pathological processes not primarily affecting connective tissue increased the 24-hour excretion of hydroxyproline and small doses of prednisone had no effect on hydroxyprolinuria.

Adult↗
PubMed1976

[Ayurveda].

The ancient medicine of India (ayurveda) is a broadly conceptualized anthropology embracing the whole human being without the Western body/soul dualism. A symptomatology based on careful observation leads, in conjunction with etiology, pathogenesis and pathology, with constitutional and personality features, to a differentiated nosology. This broad concept is matched by multidimensional therapy embracing pharmacologic, surgical, psychotherapeutic and "paramedical" measures. Ayurveda ("life knowledge") is a combination of religious, philosophical, anthropological, medical and psychological concepts. It is impressive how accurate the knowledge and description of psychiatric diseases already was 2,500 years ago, and how little these phenomena have changed with time. The therapeutic armamentarium (paramedical, psychotherapeutic and pharmacologic) of ayurveda psychiatry has not yet been sufficiently studied by scientific methods.

Humans↗
PubMed1998

Comparison of seroprevalences of human herpesvirus-6 and -7 in healthy blood donors from nine countries.

BACKGROUND AND OBJECTIVES: The purpose of the study was to register antibody prevalences of HHV-7 in various locations of the world in comparison to the closely related HHV-6. MATERIALS AND METHODS: Sera of healthy blood donors from nine countries in five continents were titered by indirect immunofluorescent assays using HHV-6 infected HSB2 and HHV-7 infected SupT1 cells. RESULTS: Antibody prevalence for HHV-7 is high (75-98%) in practically all countries except for Northern Japan (44%), with no simple correlation to elevated HHV-6 antibody titers. There were regions of low, intermediate and high mean antibody titers against HHV-7 such as 78.5-91.3 for Belgium, Israel, Japan, USA and Australia, 175.4-182.6 for Mexico and Cologne/Germany, and 389.2 for South Africa for which geographic characteristics may be responsible. CONCLUSION: HHV-7, similar to HHV-6, is a widespread human herpesvirus with elevated antibody titers in the healthy human population essentially everywhere. The data warrant further studies to evaluate its possible pathologic potential, preferentially in persons with defective immune responses.

Adolescent↗
PubMed2002

Results of screening colonoscopy among persons 40 to 49 years of age.

BACKGROUND: The prevalence of colorectal lesions in persons 40 to 49 years of age, as identified on colonoscopy, has not been determined. METHODS: We reviewed the procedure and pathology reports for 906 consecutive persons 40 to 49 years of age who voluntarily participated in an employer-based screening-colonoscopy program. The histologic features of lesions that were identified and removed on endoscopy were categorized according to those of the most advanced lesion removed proximally (up to the junction of the splenic flexure and the descending colon) and the most advanced lesion removed distally. An advanced lesion was defined as an adenoma at least 1 cm in diameter, a polyp with villous histologic features or severe dysplasia, or a cancer. RESULTS: Among those who underwent colonoscopic screening, 78.9 percent had no detected lesions, 10.0 percent had hyperplastic polyps, 8.7 percent had tubular adenomas, and 3.5 percent had advanced neoplasms, none of which were cancerous (95 percent confidence interval for cancer, 0 to 0.4 percent). Eighteen of 33 advanced neoplasms (55 percent) were located distally and were potentially within reach of a sigmoidoscope. If these results are applicable to the general population, at least 250 persons, and perhaps 1000 or more, would need to be screened to detect one cancer in this age group. CONCLUSIONS: Colonoscopic detection of colorectal cancer is uncommon in asymptomatic persons 40 to 49 years of age. The noncancerous lesions are equally distributed proximally and distally. The low yield of screening colonoscopy in this age group is consistent with current recommendations about the age at which to begin screening in persons at average risk.

Adenoma↗
PubMed1999

Relationship between stress coping and personality in patients with major depressive disorder.

BACKGROUND: Stress coping is defined as a behavioral or cognitive response of an individual to uncomfortable or difficult situations. It has been suggested that coping, like personality, is related to the pathology and course of mental disorders. Accordingly, we here used a clinical sample to investigate the relationships between coping strategies and personality traits. METHODS: Subjects were 60 outpatients who were in remission from major depressive disorder and who completed the Coping Inventory for Stressful Situations (CISS) and the Munich Personality Test (MPT). RESULTS: Task-oriented coping showed a positive correlation with extraversion and frustration tolerance. Emotion-oriented coping was closely associated with neuroticism, esoteric tendencies and isolation tendency. Avoidance-oriented coping was related to extraversion. Principal component analysis indicated three corresponding factors between coping and personality; one was related to psychopathology (loading from the neuroticism, esoteric tendencies and isolation tendency scales of the MPT, and from the emotion-oriented coping scale of the CISS), a second was a social-adaptive ability component (loading from the frustration tolerance and extraversion scales of the MPT, and from the task-oriented coping and avoidance-oriented coping scales of the CISS), and a third was a passive-avoidance coping component (loaded from the emotion-oriented coping and avoidance-oriented coping scales of the CISS only). CONCLUSION: Some personality traits such as extraversion and frustration tolerance are significantly related to task-oriented coping, and psychopathological personality traits such as neuroticism are associated with emotional-oriented coping in major depressive disorder.

Adaptation, Psychological↗
PubMedDate not supplied

[Psychosocial factors in young people with coronary disease].

Psychosocial factors are analyzed for a group of 44 coronary patients, males under 40 years of age and women under 45. The questionnaires describe a group which is predominantly masculine, with a personality inclined toward developing different pathological symptoms, full of stress and anxiety, having previously experienced vital events, on-the-job stress, gastric pathologies and possessing a very limited capability of dealing with problems. Without possessing the behavioural pattern known as a type "A" personality. The data presented tends to confirm the importance of psychosocial factors among young coronary patients and the possibility and suitability of their being evaluated by the general practitioner.

Adult↗
PubMed2004

Short report: Evaluation of hepatic fibrosis in persons co-infected with Schistosoma mansoni and human immunodeficiency virus 1.

To investigate whether infection with human immunodeficiency virus 1 (HIV-1) affects fibrosis development in patients infected with Schistosoma mansoni, we evaluated schistosomiasis-induced pathology in the livers of Kenyan patients co-infected with HIV-1. Compared with persons with schistosomiasis alone (n = 58), there were no significant differences in distribution of ultrasound-detectable pathology in persons with HIV-1 co-infection (n = 23). Similarly, serum aspartate aminotransferase levels were not significantly different in HIV-1+ individuals. Hepatic fibrosis was associated with significantly decreased CD4+ T cell counts, even in the absence of HIV-1 infection. These data suggest that HIV-1 co-infection does not significantly alter the proportion of patients experiencing schistosomiasis-induced fibrosis, but pathology associated with S. mansoni infections leads to CD4+ T cell reductions and thereby may exacerbate the effects of HIV-1 in co-infected individuals.

Adult↗
PubMed1979

[Content of thyroglobulin polyribosomes in normal and pathological thyroid cells].

The content of individual thyreoglobulin (TG) polyribosomes in human thyroid gland was studied in healthy persons and in patients with thyroid pathology. The content of TG polyribosomes makes up to 16.2% in normal thyroid tissue and is found to decrease down to 7.8% and 7% under nodal euthyroid goiter and toxic adenoma, respectively. This content is decreased to 12.5% under diffuse toxic goiter and is intermediate between nodal and diffuse toxic goiter under mixed goiter (9.4%).

Goiter↗
PubMed1991

Electroencephalographic and neuroradiological findings in adults with newly diagnosed unprovoked seizures.

Adult persons, 17 years old or older, with newly diagnosed (incident) epileptic seizures were prospectively identified in a community-based study. Electroencephalographic (EEG) recordings when awake and/or during sleep were performed in 103 persons (96.3%). Epileptiform activity was recorded during wakefulness in 18 of 101 persons (18%) and during sleep in another 11 persons (10.7%) of whom 10 had no epileptiform activity on wake EEGs. Pathological findings on EEGs recorded during sleep or when awake were more common in persons with partial seizures than in those with primary generalized tonic-clonic seizures. EEG recording during sleep significantly increased the proportion of pathological findings in partial seizures compared with other seizure types. 45 persons (42.1%) were neuroradiologically investigated by both computerized tomography (CT) and magnetic resonance imaging (MRI) using a low-field-strength imager (0.02 tesla). 2 persons with normal CT had pathological findings on MRI. 4 persons with normal MRI had pathological findings on CT.

Adolescent↗
PubMed2000

A practical approach to the treatment of patients with borderline personality disorder.

This approach to the treatment of BPD is part of a general framework for treating all forms of personality disorder. The therapeutic model has two components: (1) general strategies to manage core self and interpersonal pathology that characterizes all cases of personality disorder and (2) a specific or tailored component required to treat the problems of individual cases. The general strategies, derived from generic models of therapeutic change and self-psychology, emphasize the therapeutic relationship and the importance of a consistent treatment process, validation, and building motivation. A combination of specific interventions, including medication and psychotherapeutic strategies drawn from treatment approaches, is incorporated into this framework as required. The overall model is not an eclectic approach to treatment but an integrated framework based on an understanding of borderline pathology that emerges from recent research.

Adult↗
PubMed1980

Multiple personalities. A report of 14 cases with implications for Schizophrenia and hysteria.

Evidence exists to support the concept of pathology or diseases of hypnosis. Multiple personalities is such a syndrome, as are many or perhaps all cases of hysteria (Briquet's syndrome). The crux of multiple personalities is the subject's unrecognized abuse of self-hypnosis, by which she creates personalities, beginning at age 4 to 6 years. The process of self-hypnosis allows the delegation of an experience or a function to an alter ago, henceforth relegated to unconsciousness by the amnesia of hypnosis. Most of these patients qualify for the diagnosis of hysteria (Briquet's syndrome), and many are diagnosed incorrectly as being schizophrenic because of their hallucinations, paranoid ideas, and "delusions." Hysteria may owe many of its characteristics to the self-hypnotic induction of conversion and other symptoms.

Adaptation, Psychological↗
PubMed2003

Diagnosis and treatment of pathologic gambling.

Pathologic gambling (PG) is an impulse control disorder characterized by recurrent and maladaptive gambling behaviors that significantly disrupt the patient's functioning in the personal, familial, or vocational spheres. Pathologic gambling is estimated to currently affect 1% to 3.4% of the adult US population and is frequently comorbid with substance abuse or dependence, attention-deficit/hyperactivity disorder (ADHD), and affective disorders. Studies show evidence for the involvement of the serotonergic, noradrenergic, and dopaminergic systems in the etiology of PG. Medication treatment studies performed in PG patients demonstrated the short-term efficacy of various serotonin reuptake inhibitors, opioid antagonists, and mood stabilizers in a subsample of adult pathologic gamblers who seek treatment. This review focuses on recent research examining the neurobiology and treatment of PG.

Adult↗
PubMed2002

[Visceral neuroses: clinical approaches to the problem].

Visceral neuroses are regarded as psychosomatic pathology represented by functional symptom complexes common for both psychic (personality, psychopathologic disorders of anxietyphobic, affective, hypochondriac spectrum) and somatic pathology. Two hundreds fourteen patients: 67 with hyperventilation syndrome (HVS), 77 with Da Costa syndrome (DCS), 70 with irritable bowl syndrome (IBS) have been studied. The study suggest that visceral neuroses represent a group of independent diseases. In contrast to converse neuroses, a topical projection (respiratory, cardiovascular system, gastrointestinal tract, etc.) of visceral neuroses reflects not only a psychosomatic disorder's specificity but also the course and prognosis regularities inherent to them. HVS course is wavy with periodic exacerbations and incomplete remissions, DCS one is phased (remissive), IBS is chronic without distinct phases and intervals. HVS and DCS are comorbid to milder psychic (personality and anxiety phobic disorders) and somatic pathology. IBS is associated with not only more severe mental disorders (overvalued, hypochondriac, affective) but also with chronic somatic diseases (alimentary system).

Adult↗
PubMed1999

The impact of personality on the reporting of unfounded symptoms and illness.

This study examined the role of personality in the reporting of symptoms and illness not supported by underlying pathology. After assessment of the Big Five personality factors, 276 healthy volunteers were inoculated with a common cold virus. On each of the following 5 days, objective indicators of pathology, self-reported symptoms, and self-reported illness onset were assessed. Neuroticism was directly associated with reports of unfounded (without a physiological basis) symptoms in individuals at baseline and postinoculation in those with and without colds. Neuroticism was also indirectly associated with reports of unfounded illness through reports of more symptoms. Openness to Experience was associated with reporting unfounded symptoms in those with verifiable colds, whereas Conscientiousness was associated with reporting unfounded illness in those who were not ill.

Adolescent↗
PubMedDate not supplied

Notes on countertransference in borderline conditions.

"When dealing with borderline or severely regressed patients, as contrasted to those presenting symptomatic neuroses and many character disorders," Kernberg (1975) observed, "the therapist tends to experience rather soon in the treatment, intensive emotional reactions having more to do with the patient's premature, intense and chaotic transference and with the therapist's capacity to withstand psychological stress and anxiety, than with any specific problem in the therapist's past" (pp. 16-17). The argument in the present paper contends that Kernberg's description of countertransference reactions to borderline patients is a caricature that applies only within a limited range of borderline conditions, specifically the most primitive or poorly organized level of borderline functioning or regressive borderline states. The description does not apply to the full range of borderline psychopathology, and in many cases can be misleading. It has generally been recognized that countertransference vicissitudes play an extremely important role in the therapy of borderline patients at one or another phase of the treatment. At critical points in the development of transference (TR) and countertransference (CT) and their interaction, the therapist's recognition of and capacity to deal with CT issues become crucial to the treatment progression. The present paper explores the dimensions of CT experience and provides a tentative model for the understanding of transference-countertransference (TR/CT) interactions. The central points emphasized are: (1) that borderline disorders form a spectrum of character pathology falling between the psychoses on one side and the narcissistic personality disorders on the other; (2) that these conditions reflect varying degrees of pathological disruption and varying levels of personality integration; (3) that, depending on the form of pathological organization, these conditions manifest a variety of types and degrees of intensity of TR involvement and elicit corresponding CT reactions; and, finally (4) that these forms and degrees of TR/CT call for corresponding modifications in therapeutic response.

Aggression↗
PubMed1992

[Study od visual evoked potentials in employees of the Chemical Works in Bydgoszcz].

Examined was a group of 50 persons aged 25-60 years employed in the Chemical Works in Bydgoszcz. The time of professional contact counted from 4 month to 31 years. During this time the workers had contact with the following--at least 2--compounds: chlorine and its derivates, benzene, propylene, katolite, phosgene, isocyanianes, epichlorohydrine and others. In 33 among 50 examinees (66 p.c.) the authors detected a normal record of VEP. A pathological record was observed in 17 persons (34 p.c.). The greatest per cent of pathological records concerned a group of professional practice amounting 20-29 years as well as persons undertaking the work before the 25th year of life. The most frequent pathological record of VEP was a curve with reduced amplitude of the P wave; the least frequently seen was the debasement of the amplitude together with the elongation of the latent time of this wave.

Adult↗
PubMed1996

Cultural factors in the emergence of borderline pathology.

Most of the research and clinical reports concerning borderline personality disorder (BPD) come from highly developed countries. Although BPD can also be diagnosed in developing societies, it is likely that this form of pathology is more prevalent in North America and Europe. However, the personality traits and psychological risk factors underlying borderline personality may also be found in individuals from developing countries. The hypothesis of this paper is that social protective factors suppress the development of these traits into diagnosable personality disorders. This process is illustrated by cases in which borderline pathology emerged only after immigration.

Adult↗
PubMed2002

[Pathologic ophthalmologic changes in prematurity].

The personal author's experiences has been presented, with regards to the early discovering and adequate preventing of ophthalmology diseases at prematurely born children. Thanks to the development of perinatology, almost every organ can be monitored and functionally examined even before the child is born. Despite all problems, the work of ophthalmo-paediatritians is extremely challenging, because that is the only situation in which embryology of the eye can be seen "In Vitro" and in which the physiological development of the eye's function can been monitored. During the period from 1999 to 2002, it was examined 66 children in total, who had an anamnestical data about prematurity, as well as the data about delivery-weight. Out of these 66 children, there were 40 (60.6%) boys and 26 (39.4%) girls, with 1-4 of age. All children were examined by usual, in daily work available, examination methods. The biggest percentage of children (80%) were sent to us by the paediatritian-neonathologist, and 20% war sent from the Primary Health Care centers, or they were sent from other centers. At 52 (78.7%) of children, the certain changes on the eyes were found, while at 10 (15.1%) children no changes at all were found. At 4 (6.2%) cases, we found minor changes, but we monitored those children as well. Ophthalmology changes were found in almost all forms, from the most complicated (ROP, coloboma horioretinae, congenital glaucoma, congenital cataract), to the simpler ones on which are less difficult to treat (refraction changes, amblyopia, strabismus, ptosis etc). Since these changes are still present with prematuruses, it is necessary to intensively monitor this population, as a part of the multidisciplinary team, made of the experts of the different profiles (paediatritian-neonatologist, otologist, logopedist, ophthalmologist, etc), and which would be possible through the Register of Prematurity. Author introduces her own experience of ophthalmologic diseases in children who are categorized as "risky". A team of different specialists does treatment.

Eye Diseases↗