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At least 1,315 records · Page 73Linked to original sources
PubMed2003

Burning mouth syndrome. A retrospective analysis of clinical characteristics and treatment outcomes.

Burning mouth syndrome is a condition characterized by burning sensations of the oral cavity in the absence of physical abnormalities of the mucosa or a detectable underlying medical disorder. It is a multifactorial disorder with unclear etiology, affecting predominatly middle-aged women. Multiple approaches to treatment have been described in the literature, with few controlled clinical trials regarding their efficacy. The objectives of this retrospective study were to: 1. determine the epidemiologic characteristics of BMS patients referred to an oral medicine practice; 2. determine if BMS classification correlates with response to treatment; 3. determine the efficacy of a variety of known therapies for BMS. A database was constructed from the charts of 150 consecutive patients diagnosed with BMS; and these charts were reviewed. Patients were classified according to previously published criteria for BMS. Presumed etiologies were grouped into depression/anxiety-associated; hematinic deficiencies, including iron, folate and vitamin B complex; oral habits: and idiopathic BMS. Treatment approaches were divided into seven categories: soft desensitizing appliance; tricyclic antidepressants (TCA); benzodiazepines (BZD); topical analgesics; hematinic supplements; habit awareness counseling; and multi-modal therapy (combining two or more of the above). Improvement was recorded using a zero to 100% VAS scale and classified as no relief (0%); mild (0-40%); meaningful/moderate (41-80%); and profound relief (81-100%). Burning mouth syndrome without any identifiable cause (idiopathic) was diagnosed in 33 patients (46.6%). Patients were followed up at one month (4 weeks) after the initial visit. Nine patients (12.7%) reported profound relief; 17 patients (23.9%) reported meaningful relief; 39 patients (54.9%) reported mild relief. This retrospective review showed no significant correlation between classification of BMS and response to therapy. The most effective treatment modalities were habit awareness, followed by TCAs.

Adult↗
PubMed2003

[Effect of millimeter therapy in burning mouth syndrome].

OBJECTIVE: To observe the millimeter wave therapy responses in patients with burning mouth syndrome. METHODS: Eighty patients were randomized divided into 4 groups. The first group was treated with both millimeter wave irradiation and routine medication, the second group with millimeter wave irradiation, the third with pretending millimeter wave irradiation and routine medication and the fourth with routine medication. Pain, extravasated blood level and autonomic nerve system condition were double-blindly evaluated either before or after the treatment. RESULTS: Statistically significant difference (P < 0.05) was found as the degree of pain was compared before and after treatment of all the 4 groups. The first and second group, which were affected by the millimeter wave irradiation, had obvious improvements in the extravasated blood level and autonomic nerve system condition (P < 0.05). When the 4 groups were compared with each other, there were significant differences (P < 0.05) between the first and the fourth groups, and the second and the fourth groups regarding the reduction of pain. According to extravasated blood level, significant differences (P < 0.05) were found in the first and third or fourth groups, the second and third or fourth groups. CONCLUSIONS: The irradiation of holographic point by millimeter wave can improve the patients' pain, extravasated blood level and autonomic nerve system condition. It might provide a new treatment method for burning mouth syndrome.

Acupuncture Points↗
PubMed2003

Clinical characteristics of an outbreak of hand, foot and mouth disease in Singapore.

BACKGROUND: We experienced a hand, foot and mouth disease (HFMD) outbreak in late year 2000 in Singapore. Between 14 September 2000 and 14 November 2000, a total of 3526 cases of HFMD were notified. There were 652 patients clinically suspected to have HFMD, who were seen at the Children's Emergency department of KK Women's and Children's Hospital of Singapore. OBJECTIVE OF THE STUDY: To study the clinical profile and virologic isolates of children admitted with HFMD during the outbreak. STUDY DESIGN: A prospective observational study. METHODS: Analysis of clinical features and virologic studies of 129 selected cases of HFMD and herpangina. RESULTS: The median age was 25 months with a range of between 4 months and 11 years. The majority were less than 5 years old (87%). The male-to-female ratio was 1.3:1. The median numbers of day of illness to presentation to the hospital was 3 days. Poor feeding and loss of appetite accounted for 76.7% of the admissions. Symptoms of vomiting were present in 37.2% of the cases. Oral ulcers were found in 96.1%, rashes over hands in 87.6%, over feet in 86.8% and over buttocks in 54.3%. Only 4.7% exhibited no rashes other than oral ulcers and were labelled as herpangina. The median duration of fever was 3 days, ranging from 2 to 7 days. An intravenous drip was required in 68.2% due to poor feeding. Viral cultures were sent in 89.1% of patients of whom 61.7% of patients were positive for viruses. Of the positive cultures, types of viruses isolated were EV71 (enterovirus 71) in 59/71 (83%), Coxsackievirus (A16, A24, A2 B3, B4) in 6/71 (8.4%), EV Untypable in 4/71 (5.6%) and mixed [EV71, echo25, cytomegalovirus (CMV)] in 2/71 (2.8%). EV71 was isolated mostly from stool samples followed by vesicle fluid culture and throat swabs. Two siblings aged 14 months and 2.5 years died during this period at day 5 of illness, their post-mortem examinations showed interstitial pneumonitis of the lungs. EV71 was isolated from the brain, heart, tonsils, intestines, throat and rectal swabs. A raised total white cell count of 14,000/L versus 12,000/L was significantly associated with complicated HFMD (P = 0.04). There was no difference in clinical characteristics of EV71 versus non-EV71 infections. Other viral illnesses, e.g. measles and CMV, may be mistaken for HFMD in the outbreak setting. CONCLUSIONS: HFMD tends to occur in younger children less than 5 years old due to low herd immunity. Poor feeding due to mouth ulcers accounts for admission to hospital requiring intravenous drip. EV71 accounted for the majority (75%) of the positive isolations, followed by coxsackievirus and untypable EV, mixed infection of echovirus or CMV. The yield of virus isolation was highest from stool, followed by vesicles and throat swabs. There is no difference in clinical characteristics of EV71 and non-EV71 virus infections. Enterovirus can cause mild symptoms to fatal death. Two infants died of interstitial pneumonitis and encephalitis.

Child↗
PubMed1992

A pathogenesis study of foot-and-mouth disease in cattle, using in situ hybridization.

Eight calves were exposed in an aerosol chamber to nebulized foot-and-mouth disease virus. Two control animals were exposed in a similar manner to cell culture media only. Animals were euthanized at intervals and various tissues examined by in situ hybridization using a biotinylated RNA probe corresponding to a portion of the viral gene coding for the polymerase enzyme. By this technique large amounts of viral nucleic acid were found in coronary band, interdigital cleft and tongue as early as six hours postexposure, indicating a very rapid delivery from the portal of entry to the predilection sites for lesion development. This occurred well before the onset of viremia which by virus isolation was not detectable until 30 hours postexposure. The in situ hybridization signal in these tissues decreased in intensity and extent with time to focally positive areas, occasionally surrounding a vesicle. Other epidermal sites not normally thought of as sites for foot-and-mouth lesion development, such as carpus and eyelid, also had some viral nucleic acid detectable at various time intervals. In the lung by in situ hybridization, alveolar septa had viral nucleic acid early in infection (6-18 h postexposure) while later (36-96 h postexposure), the in situ hybridization signal was prominent in alveolar macrophages.

Animals↗
PubMedDate not supplied

Quantitative measurement of ventilation at the mouth and nose with heat sensors.

Airflow at the nose and mouth is routinely measured during polysomnography for the evaluation of respiratory disturbances during sleep. The usual monitoring device is a small thermocouple placed in front of the nose and mouth that qualitatively detects airflows in or out. A more accurate pneumotachometer on a tight-fitting mask is less frequently used because of the discomfort that is introduced and its potential interference with sleep. The authors tested ten heat-sensing devices modified to increase accuracy without increasing discomfort. The designs of these ventilation monitors differed in choices of specific heat detector, techniques of mounting on the face, and types of heat-trapping covers employed. The goal was to find a comfortable oronasal monitor and to define a procedure that could identify those units that generate signals approaching quantitative ventilatory flow. The signal from each device was compared with a "standard" signal derived from respiratory belts during contrived respiratory maneuvers that assessed specific potential sensing problems. The devices behaved differently, and design perturbations could be controlled to construct flow detectors to closely match actual flow. The more accurate devices could be as comfortable as commonly used monitors that do not have the enhanced accuracy. The principles and techniques described for improving the measurement of oronasal ventilation by heat sensor can be invoked to develop monitors that can closely measure actual quantitative ventilatory flow.

Computer Graphics↗
PubMed2003

Burning mouth (syndrome) disorder.

Burning mouth disorder (BMD) is a chronic, oral pain condition associated with burning sensations of the tongue, lips, and mucosal regions of the mouth. Diagnosis of the condition is complicated by the fact that a variety of systemic and local factors can be contributory. Treatment goals are to reduce symptoms by eliminating identifiable abnormalities. Secondary lines of therapy include pharmacotherapeutic approaches that target neuropathologic mechanisms that appear to be active.

Burning Mouth Syndrome↗
PubMed2003

An index for the measurement of normal maximum mouth opening.

PURPOSE: The aim of this study was to evaluate the relationship between the width of 3 or 4 fingers of one hand and maximum mouth opening (MMO) in healthy subjects. METHODS: One hundred and forty dental students (age 21 to 42 years, mean 27.4 years) participated in the study. The ability of each subject to position 3 or 4 fingers, vertically aligned, between the upper and lower central incisors up to the first distal interphalangeal folds, was documented. Measurements of MMO and the width of 3 fingers (index, middle and ring fingers) and 4 fingers (index, middle, ring and little fingers) were recorded. RESULTS: All subjects were able to position 3 fingers (of both the right and left hands) between the upper and lower central incisors. Only 12 subjects were able to position 4 fingers (both right and left) in this way. There were no significant differences among the measurements of MMO (mean 48.8 mm), 3 fingers of the right hand (mean 47.3 mm) and 3 fingers of the left hand (mean 47.0 mm) (p > 0.05). However, MMO was significantly different from the width of 4 fingers of the right hand (mean 58.1 mm) and 4 fingers of the left hand (mean 57.5 mm) (p < 0.001). Moreover, there was a strong positive correlation between MMO and the 3-finger measurements (p < 0.0001). CONCLUSIONS: These findings strongly suggest that the ability to position 3 fingers in the mouth during dental examination is a convenient index for assessing normal MMO.

Adult↗
PubMed2004

Foot-and-mouth disease control using vaccination: South African experience.

South Africa has zoned status from the Office International des Epizooties (OIE) with the largest part of the country being foot-and-mouth disease (FMD)-free without vaccination. Outbreaks in this zone are handled differently from outbreaks in the control zones, which do not affect the export status of the country. However, the different socio-economic groupings need to be considered when reaching control decisions and in this regard, the country has been challenged with unique foot-and-mouth disease (FMD) control options. Vaccination has been shown to be effective both in ensuring that disease does not spread from the endemic to the free zone, as well as controlling outbreaks in the free zone. New adjuvants that claim to illicit longer lasting immunity have been tested with antigens derived from the SAT serotypes and animals were challenged one year post vaccination to determine the level of protection. However, even with vaccines that provide immunity for more than a year, an annual vaccination campaign will most probably not be acceptable in the buffer zone where calving occurs throughout the year.

Animals↗
PubMed2004

Strategy for the control of foot-and-mouth disease in Southeast Asia (SEAFMD).

The OIE Southeast Asia Foot-and-Mouth Disease Campaign (SEAFMD) involves the coordinated control of foot-and-mouth disease by eight of the ASEAN countries. A long term vision for SEAFMD has been developed and the core element is a progressive zoning approach to the control and eradication of FMD in the region. This paper describes the current status of FMD in Southeast Asia and progress towards achievement of OIE free zone status for FMD in parts of the Philippines and Malaysia and the initiation of the Malaysia-Thailand-Myanmar (MTM) Peninsular Campaign for FMD Freedom. In mainland Southeast Asia, the progressive zoning approach involves several sub-regional groups working in parallel to oversee the epidemiological and economic studies required to determine the feasibility of the approach. Areas involved include the Lower Mekong Basin, Upper Mekong Basin, parts of Myanmar and the Red River Delta of Vietnam. The paper describes the current usage of vaccines for FMD in Southeast Asia and provides recommendations for their supply and use in the new regional initiatives.

Animals↗
PubMed1992

Rejuvenation of the aging mouth.

Viewing the face as a series of three concentric rings, we can successfully rejuvenate the outer ring with the usual face lift, blepharoplasty, and brow lift. Insufficient attention has been paid to the middle and inner rings. The middle ring can be made to look more youthful by correcting the long upper lip with a lip lift, elevating the downturned corners with corner lifts, excising the deep nasolabial furrows, placing a chin implant to correct both the lateral chin-jowl indentations (the fleur-de-lis look) and the drooping chin, and dermabrading the wrinkles. The inner ring can be youthened by creating fuller lips either by the surgical augmentation techniques of inner flaps or vermilion advancements or by injection enhancement with a filler material. Our experience with 1300 procedures indicates that the successful rejuvenation of the middle and inner rings adds a great deal to appearance and satisfaction, the patient often appearing 10 to 15 years younger. Unknowingly altering a locus of identity in the mouth area can lead to significant patient upset and should be avoided. Guiding principles for cosmetic surgery around the mouth have been suggested.

Adult↗
PubMed2004

["Burning mouth syndrome"--is not a symptom of gastro-oesophageal reflux disease].

Burning mouth syndrome (BMS) is a predominantly oral condition characterized by the occurrence of a chronic burning that commonly involves the anterior tongue, painful sensation, dryness and taste alterations. The syndrome is reported more often in women, usually without any oral mucosal signs and laboratory abnormalities. Its etiopathogenesis remains poorly understood, and there is no consensus on diagnostic criteria and treatment strategies. Tongue burning is though to be also one of a non-oesophageal symptom of gastro-oesophageal reflux disease. As reported below, although this symptom may well be diagnostically misleading, careful diagnosis based on clinical signs may distinguish patients with BMS from those with reflux disease, and successful management of burning mouth is often enables.

Burning Mouth Syndrome↗
PubMed1991

[Protection from foot-and-mouth disease virus in naturally-susceptible animals by a linear polymer of a synthetic peptide].

Linear polymer of a peptide corresponding to the fragment 142-155 of the foot-and-mouth disease virus A22(550) protein (VP1) was synthesized. Whereas the monomeric peptide was only slightly immunogenic, the polymer induced virus-neutralizing antibodies in rabbits and protected 100% guinea pigs. Sheep vaccinated once and cattle vaccinated twice were stable against infection with the homologous virulent foot-and-mouth disease virus.

Amino Acid Sequence↗
PubMed2006

[The relationship between mouth pressure or tracheal pressure and esophagus pressure and diaphragmatic pressure].

OBJECTIVE: To investigate the relationship between mouth pressure (Pmo) or tracheal pressure (Ptr) and esophagus pressure (Pes) or transdiaphragmatic pressure. METHODS: Seventeen patients were involved in the study. Maximal inspiratory pressure (MIP), maximal transdiaphragmatic pressure (Pdi(max)), maximal esophagus pressure (Pes(max)), twitch mouth pressure (TwPmo), twitch transdiaphragmatic pressure (TwPdi) and twitch esophagus pressure (TwPes) were measured before narcotization as a normal procedure for the abdominal operation and twitch tracheal pressure (TwPtr(nar)), twitch esophagus pressure (TwPes(nar)) and twitch transdiaphragmatic pressure (TwPdi(nar)) were dynamically monitored during narcotization. RESULTS: (1) The correlation coefficient (r) values between Pdi(max) and MIP, TwPdi and TwPmo, TwPdi(nar) and TwPtr(nar), Pes(max) and MIP, TwPes and TwPmo, TwPes(nar) and TwPtr(nar) were 0.976 +/- 0.030, 0.816 +/- 0.155, 0.923 +/- 0.446, 0.981 +/- 0.185, 0.829 +/- 0.168 and 0.955 +/- 0.292, respectively. (2) The coefficient variation (CV) of MIP, Pes(max), Pdi(max), TwPmo, TwPes and TwPdi were (14.2 +/- 4.7)%, (15.2 +/- 4.3)%, (15.5 +/- 4.1)%, (30.4 +/- 15.9)%, (10.8 +/- 5.1)% and (9.9 +/- 4.0)%, respectively. The CV of TwPmo was the highest (compare with others, all P < 0.05) and that of TwPes and TwPdi was the lowest (compare with others, all P < 0.05). There was no significant difference among MIP, Pes(max) and Pdi(max) (P > 0.05). (3) The r value between the changing values of TwPtr(nar) and TwPdi(nar) or TwPes(nar) during narcotization were 0.839 or 0.894 (P = 0.000, respectively). CONCLUSION: The measurement of MIP and TwPmo should be repeated and the highest value should be chosen in order to reduce the possibility of underestimating the function of diaphragm, which could be dynamically monitored by TwPtr(nar).

Abdomen↗
PubMed2001

Host--protozoans--bacteria--fungi interrelations in the mouths of patients with systemic illnesses.

The aim of this work was to study clinical changes and microorganisms in mouths of three patient groups: with congenital disorders (Cd), dialyzed (D) and control (C). Fifty five patients, 20 to 62 years old were assessed. Swabs and samples of periodontal tissue were used for microscopical study to detect of protozoans and for bacterial and fungal cultures. E. gingivalis and T. tenax were found in all groups. Three out of Cd patients were infected with Acanthamoeba sp.. Fecal bacteria were more often found in D than Cd. In all 30-40 years old D patients, fecal bacteria and various strains of C. albicans occurred. We found that systemic diseases favour instabilities in mouths changing interrelations between protozoa, bacteria and fungi. It may increase risk of clinical complications.

Adult↗
PubMed1990

[Speech intelligibility in tongue and mouth-floor cancer patients who received surgical excisions after induction therapy].

Speech intelligibility has been investigated in 40 patients who had received a glossotomy because of tongue and/or mouth floor carcinomas after preoperative induction therapy. The results are summarized below. 1. Speech was clearer and better understood in intelligibility tests than by tests of single sounds. 2. Speech intelligibility was impaired in 12 patients. The impairment degree was mild (slight difficulty in understanding the spoken content) in 9 cases, where as the speech in the remaining patients was moderately or severely impaired. 3. Hardly any speech impairment resulted when the tongue resection was limited to the ipsilateral 1/3 of the tongue, where as the impairment was greater in cases who received a glossotomy over that limit. 4. Tongue mobility was related to speech intelligibility, and conservation of the tongue tip appeared important. 5. Aggressive induction therapy made limited surgical extirpation possible, and many patients speech functions were well preserved by conservative surgery. Together with good local control, aggressive induction therapy seemed to be beneficial for tongue and mouth-floor carcinomas.

Adult↗
PubMed2006

[Fusion expression of O type foot-and-mouth diseases virus VP1 gene and HSP70 gene and induction of immune responses in mice].

Vp1 gene of O type foot-and-mouth diseases virus and M. tuberculosis HSP70 were expressed in methylotrophic yeast Pichia pastoris expression system. The results of cellular immune responses and humoral immune response were examined after BALB/c mice were immunized with fusion protein expressed in methylotrophic yeast Pichia pastoris. The genes was cloned into the vector pPICZalpha-A by routine molecular technique. The plasmid fusion (pPICZalphaA-vp1-HSP70) was created that HSP70 located downstream of VP1 gene of O type foot-and-mouth disease virus. Vp1 was expressed by fusing to the amino terminus of M. tuberculosis hsp70 in yeast Pichia pastoris. The recombined fusion plasmid was transformed into methylotrophic yeast Pichia pastoris X-33 by electrophoration. The recombinant transformants were selected by Zeocin and induced by the addition of methanol every 24h. The expressived product analyzed by SDS-PAGE and Western blotting. The result indicated that the fusion protein(vp1-HSP70) has specific antigenicity. Mice were inoculated transcutaneous three times at a two-weeks interval with fusion protein, PBS and conventional inactivated vaccines. To evaluate the prophylaxtic efficacy of fusion protein, Titers of antibodies was detected by ELISA and proliferation of lymphocytes were determined by MTT. The results indicated that fusion protein could elicit specific humoral immune and cellular immune responses. Compared with conventional inactivated vaccines, fusion protein elicited slightly lower FMDV antibody level but stronger T cell proliferation.

Animals↗
PubMed1991

[Orthodontic consequences of mouth-breathing].

Mouth breathing habits are frequently associated with orthodontic problems. In the nasal area, the lack of ventilation leads to an underdevelopment of the maxilla: lateral and sometimes anterior cross bites appear. In the buccal area, the want of maintaining the mouth opened induces a new postural position of the mandible which alters the pattern of growth of the mandible ("long face"). The functional context of the buccal praxis is also altered: low or protruded tongue, deviant swallowing, troubles of speech.... The treatment of this pathological context needs a pluridisciplinary approach where the otorhinolaryngologist, the dentist, the orthodontist and the speech pathologist have to play an important role. In the orthodontic fields, we have to carry out an orthopedic treatment (rapid maxillary expansion, facial masks,...) to normalize the growth of the maxilla before the orthodontic treatment.

Child↗