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Homosexual, gay, and lesbian: defining the words and sampling the populations.

The lack of both specificity and consensus about definitions for homosexual, homosexuality, gay, and lesbian are first shown to confound comparative research and cumulative understanding because criteria for inclusion within the subject populations are often not consistent. The Description section examines sociolinguistic variables which determine patterns of preferred choice of terminology, and considers how these might impact gay and lesbian studies. Attitudes and style are found to influence word choice. These results are used in the second section to devise recommended definitional limits which would satisfy both communication needs and methodological purposes, especially those of sampling.

Curriculum↗

Human papillomavirus type 16 in a homosexual man. Association with perianal carcinoma in situ and condyloma acuminatum.

BACKGROUND: The association of anal carcinoma with human papillomavirus (HPV) type 16 infection is well documented. Anal carcinoma is also frequently associated with a history of anogenital condylomata. More than 90% of anogenital condylomata contain HPV type 6 or 11. It is rare for a condylomatous lesion to contain HPV 16. We report the unusual case of a homosexual man, testing positively for human immunodeficiency virus, with carcinoma in situ evolving within perianal condylomata infected with HPV 16. OBSERVATIONS: Microscopic examination of tissue specimens from ulcerated verrucous lesions on the perianal mucosa revealed changes of classic condylomata acuminata with contiguous focal squamous cell carcinoma in situ. Testing for HPV DNA by in situ hybridization identified HPV 16 in both the condylomatous and carcinoma in situ areas. CONCLUSIONS: The association of HPV 16-infected condylomata and adjacent carcinoma in situ implies that cutaneous genital condylomata may progress to high-grade lesions. Given that homosexual men are at high risk for perianal carcinomas, HPV typing of perianal condylomata specimens may help identify immunocompromised patients who are at risk for the development of carcinomas.

Adult↗

[AIDS and HIV infection among homosexual and bisexual men in Belém, Pará, Brazil, 1988-1990].

During three years (1988-1990) blood samples from 307 people were taken to test antibodies for Human Immunodeficiency Virus type 1 (HIV-1) in homo and bisexual males living in Belém, being 149 (48.5%) of the former and 158 (51.5%) of the later. All patients requested examinations spontaneously to find out their status. The ages of tested people ranged from 16 to 64 years old. Serologic diagnosis was made using an enzyme immunoassay (Abbott, São Paulo-Brasil) for screening and an indirect immunofluorescence test (FIOCRUZ, Rio de Janeiro-Brasil) for confirmation. If results were conflicting with these tests, western blot (Du Pont CO. Wilmington-USA) was performed to obtain a definitive result. Sixty-eight (22.1%) of all sera were positive. Although, the positivity in the homosexual group (26.2%) was more higher than in the bisexual group (18.3%). The positivity rate in both groups was directly proportional with the increase of age. Of course, people with less than 20 years old had only 3% of positivity, while between 20-29 had 18.1%, 30-39 had 34.5%, 40-49 had 40% and 50-59 had 50%. The projected curve of positivity, is progressive, that is to say, the risk of homo/bisexual males increases with age and is probably related to increased sexual activity. We conclude that more than one quarter of homosexual men are infected with HIV-1 in Belém.

AIDS-Related Opportunistic Infections↗

[Shigellosis, a sexually transmitted disease in homosexual men].

A study of the registered number of Shigella infections in Amsterdam for the period 1997-2001 revealed that in 2001, there was an increase in the number of homosexual patients with oral-anal contacts as source for their infections. All of these infections were caused by subtype Shigella sonnei. The infections were not associated with a specific meeting place for homosexual men. A relationship with an underlying HIV-infection is likely.

Adolescent↗

[The sexual needs of homosexual HIV seropositive men].

A two-step study was conducted to identify the sexual needs of a group of seropositive homosexual men. At first, there was an interview with 30 men which aimed to define their objectives of sexual health. This was followed by a questionnaire distributed among 88 seropositive men and 173 seronegative men, who evaluated the objectives stated in the first step. The statistical analysis of collected data allowed for the identification and narrowing down of four major needs: being in good health, being in love, being sexual and, to a lesser degree, being secure. Results are discussed and point to the role played by the biological, psychological and sociological uneasiness in the context of the difficulties that seropositive homosexual men have in satisfying their sexual needs. This evaluation can prove useful in the planning and the implementation of sexological services for HIV-positive persons.

Adaptation, Psychological↗

What ever happened to ritualized homosexuality? Modern sexual subjects in Melanesia and elsewhere.

In this paper, I examine the legacy of ritualized homosexuality as a behavioral practice and as an analytic category of research in Melanesia since the early 1980s. A case study of striking change among the Gebusi of Papua New Guinea suggests that ritualized homosexuality and insemination of boys have become behaviorally vestigial or moribund and that characterizing sexual practices in these terms has been difficult to begin with (as the original proponent of these terms has himself suggested). Historical change in Melanesia reveals linkage between the contemporary construction of heterosexual norms and desires for locally modern development and progress. A larger issue is how researchers of sexuality may unwittingly accept Western ideologies of sexual choice and freedom while positing historical and non-Western practices as culturally bound rather than being open to individual exploration and interpersonal diversity.

Adolescent↗

Inappropriate lubricant use with condoms by homosexual men.

Use of condoms has been advocated as an important method of reducing the risk of human immunodeficiency virus (HIV) transmission among high-risk groups such as homosexual and bisexual men, prostitutes, intravenous drug users, adolescents, and hemophiliacs. Despite risk-reduction education campaigns directed to gay men since the early 1980s, evidence shows continued deficits in condom-use skills and knowledge among gay men. Because most failures in the use of condoms are attributed to errors in use, increasing knowledge and skills in condom use is important in preventing HIV infection. Two groups of homosexual and bisexual men were sampled, those entering a risk-reduction education program and participants in a Gay Pride event. They were surveyed on their current sex practices and their efforts to reduce their risk of HIV infection. They were asked about their numbers of sex partners, specific sexual behaviors, use of condoms, types of condoms used, and lubricants used for genital-anal sex. The characteristics of those surveyed were similar to those of respondents in other studies of risk reduction among gay men. The use of an oil-based lubricant with condoms has been shown to weaken latex and to increase the likelihood of condom breakage, which use of water-based lubricants does not. Among respondents who reported having genital-anal sex, 60 percent reported use of an oil-based lubricant with a condom at least once during the year before the survey. Gay men in sexually exclusive relationships engaged in less consistent use of condoms for receptive genital-anal sex than did single gay men. The duration of their relationship with a partner was unrelated to the consistency of risk reducing behaviors practiced by men in sexually exclusive relationships. Gay Pride participants engaged in sexual behavior that was relatively more risky for HIV transmission than did the other group. Gay Pride participants used condoms less consistently for genital-anal sex than did the risk-reduction program entrants.The findings indicate the need for better risk reduction education efforts directed to gay men. Continued improvement in these efforts will require assessing the effectiveness and consistency of risk reduction efforts, determining the potential for gay men to relapse into more risky behavior, and identifying gaps in the knowledge of risk-reduction efforts among gay and bisexual men. Risk reduction programs need to emphasize motivational factors, provide basic information on how one determines the content of lubricants, explain why water-based lubricants only should be used, and teach how to use condoms properly. Active outreach is needed to gay and bisexual men who are unlikely to voluntarily enroll in risk-reduction programs.

Adult↗

Zidovudine use in AIDS-free HIV-1-seropositive homosexual men in the Multicenter AIDS Cohort Study (MACS), 1987-1989.

Zidovudine use data were examined in the Multicenter AIDS Cohort Study to determine (i) if the proportion of pre-AIDS participants (i.e., CD4+ cells less than 200/mm3 or AIDS-related complex) taking zidovudine is high enough to explain a slower than expected rise in AIDS incidence in U.S. homosexual men since mid-1987; (ii) which factors are associated with starting zidovudine and clinical trials of zidovudine; and (iii) if pre-AIDS patients, as a group, are being undertreated. Data on zidovudine use, clinical trial participation, and sociodemographic, clinical, and hematologic variables were collected every 6 months from 1,195 AIDS-free HIV-1-seropositive homosexual men from April 1987 to September 1989. Overall prevalence of zidovudine use rose from 3.6% in mid-1987 (visit 7) to 23% in mid-1989 (visit 11). Of those with less than 200 CD4+ lymphocytes/mm3, the prevalence of zidovudine use rose from 23% (24% if those taking zidovudine or placebo as part of a clinical trial are included) at visit 7 to 58% (69%) at visit 11. Of those with ARC, 20% (23%) were using zidovudine at visit 7 and 55% (65%) at visit 11. Although numbers were small, the advanced ARC participants (CD4+ cells less than 200/mm3 and two or more symptoms) reported the highest treatment rates (50, 78, 80, 60, and 74% at visits 7-11, respectively). By September 1989, 42% (31%) of those with CD4+ lymphocyte levels less than 200/mm3 were still not receiving zidovudine, suggesting that many high-risk, pre-AIDS individuals are being undertreated. To explore this finding further, we examined a range of sociodemographic, hematologic, and clinical variables to determine which factors best predicted initiation of zidovudine therapy outside of clinical trials. In multivariate analyses, CD4+ lymphocyte number was the most consistent predictor of initiation of therapy over all four study visits. For each 100 cells/mm3 deficit, the odds ratios were 2.3 (95% C.I. of 1.7-3.1) at visit 7 and 1.7% (95% C.I. of 1.4-2.0) at visit 11. Symptom status and education level were also associated with starting zidovudine, but not at all visits. The relatively low predictive power of the clinical variables raises and the possibility that nonclinical factors not measured in the MACS (drug cost, third-party insurance restrictions, and individual preferences) may play an important role in predicting zidovudine use. Finally, comparisons were made between seropositive participants starting clinical trials of zidovudine and the rest of the study population. No important differences were found in demographic or major clinical variables between clinical trial participants and zidovudine nonusers in this study.

AIDS-Related Complex↗

Human immunodeficiency virus infection does not alter serum transaminases and hepatitis B virus (HBV) DNA in homosexual patients with chronic HBV infection.

The influence of human immunodeficiency virus (HIV) infection on the clinical course of chronic hepatitis B virus (HBV) infection is controversial. We followed a cohort of 64 homosexual men with persistent HBs antigenemia for a median of 24 months in the hepatitis clinic of a large urban public hospital. We divided the patients into three groups according to their immune status. Group 1 (n = 13) consisted of HIV-seropositive men with evidence of immunosuppression; group 2 (n = 17), HIV-positive patients without evidence of immunosuppression; and group 3 (n = 34), HIV-negative patients. We followed serum ALT and HBV DNA determinations. There was no difference in the demographic characteristics of the three groups. Group 1 had significantly lower levels of circulating T4 lymphocytes. We found no differences in the number and severity of episodes of HBV reactivation, serum ALT levels, or HBV DNA scores among the three groups. In each group, the percentage of patients with circulating HBV DNA was the same. We conclude that HIV infection apparently does not influence the markers of liver inflammation or HBV replication in homosexual men.

Adult↗

Human immunodeficiency virus type-1 infection of homosexual men is accompanied by a decrease in circulating B cells.

As part of the multidisciplinary effort to characterize the natural history of human immunodeficiency virus type 1 (HIV-1) infection, the cell-surface phenotypes of lymphocytes from a cohort of homosexual men were analyzed in detail and related to clinical and laboratory parameters associated with HIV-1 infection. The present study represents a cross-sectional analysis of coded specimens from 153 homosexual men, of whom 74 were seronegative and 79 seropositive for HIV-1. Fewer circulating B lymphocytes (CD19+) were found in HIV-1-seropositive subjects relative to a seronegative reference group. HIV seropositivity was not associated with decreased numbers of CD8+ T cells or activated T cells, which suggests that the number of circulating B cells specifically decreased. In addition to CD19, B cells were measured by CD20 and CD21 in a subset of subjects, and decreases in circulating CD20+ and CD21+ B cells were also apparent in HIV-1-seropositive subjects. The decrease in B-cell numbers was present at the earliest stages of HIV-1 infection (asymptomatic, clinically silent) and became more pronounced at more advanced stages of HIV-1 infection. The absolute B-cell numbers correlated with absolute CD4+ cell numbers (r = 0.59, p less than 0.001). These data suggest that HIV-1 infection is associated with progressive, selective decreases in the numbers of circulating CD4+ T cells and B cells.

Antigens, CD↗

Dominance, submissivity (and homosexuality) in general population: testing of evolutionary hypothesis of sadomasochism by Internet-trap-method.

OBJECTIVES: Dominance and submissiveness represent strong sexual arousal stimuli for a considerable part of population. In contrast to men's sexual dominance and women's sexual submissiveness, the opposite preferences represent an evolutionary enigma. Here, we studied prevalence and strength of particular preferences in general population by Internet-trap-method. DESIGN: The subjects who clicked the banner displayed in the web interface of e-mail boxes were allowed to choose icons with homosexual or heterosexual partner of different hierarchical position. RESULTS: Dominant partner was chosen by 13.8% men and 20.5% women, and submissive partner by 36.6% men and 19.8% women. Homosexual partners were chosen by 7.3% men and 12.2% women. The response times for the submissive and dominant stimuli did not differ while for the equal-status stimuli were significantly longer, suggesting that part of subjects with equal-status preferences probably intentionally mask their natural interests. CONCLUSIONS: Large number of people who chose unequal sexual partner suggests that hierarchical status plays important role in human mating system.

Biological Evolution↗

Predictors of relapse in sexual practices among homosexual men.

Selected sociodemographic, psychosocial, and behavioral variables were used to predict maintenance or relapse in sexual practices over a 1-year interval in a cohort of homosexual men in Chicago. Univariate analyses and multivariate logistic regression were used to define predictive models for safer practices separately for insertive and receptive and sex. Demographic and psychosocial variables were not associated with subsequent relapse. Neither was HIV serostatus. Using more rigorous multiple logistic regression, only monogamous relationships, less peer support, and less assertiveness in negotiating safer sex appeared to predict relapse to less safe practices. The importance of interpersonal variables and social norms for future interventions among homosexual men is discussed.

Acquired Immunodeficiency Syndrome↗

Profile of a homosexual in Singapore.

A study was done on 40 homosexual subjects and 47 controls between the ages of 18-19 years, matched for race and age. There was no significant difference in the educational level, and family background of the 2 groups. But homosexuals had a significantly more unhappy childhood than the controls, were more often reprimanded than physically punished and were often teased by their classmates and called names. They were not overprotected or infantilized by their parents and there was no overclose relationship with their mothers. The majority mixed with effeminate boys, admired a senior person in school and about a third had a physical relationship with this person. Almost half had been molested when they were young. Less than a fifth had girlfriends. About three-quarters knew of AIDS and of these less than a fifth felt they would give up their sexual practices because of fear of AIDS. The main problems faced by the subjects were confusion about their identity, their desire to find the right partner, relationship problems and difficulties in controlling their impulses.

Adolescent↗

[Prevalence of the antibody of hepatitis C virus in HBsAg negative patients with chronic liver diseases: children, prostitutes, and homosexuals].

We present the results of the determination of hepatitis C virus antibody, recently discovered on a group of 34 patients with chronic liver disease, divided in: a) 23 patients with cirrhosis. b) 8 with protracted hepatitis. c) 2 with steatosis of unknown origin++. d) One patients with hepatocellular carcinoma. Another group examined was integrated by persons of promiscuous sexual activity (15 prostitutes and 14 homosexuals). Finally we included 20 children chronically infected with VB. In the 23 patients with cirrhosis, the VB markers (HBsAg and anti-core were negative in 18 and 5 were only anti-core positive; anti-HCV was positive in 3 of the 18 VB negative (16.6%) and in one of the 5 with anti-core positive (20%), that represents a total of 4 cases anti-HCV positive (17.3%). 5 of the 8 patients with protracted hepatitis were virus B and A negative and 4 of them were anti-HCV positive (80%), 3 of which had parenteral infection. The 15 prostitutes and the 14 homosexuals were negative for the anti-HCV, as well as the 20 children chronically VB infected. Our result of the determination of anti-HCV in cryptogenetic cirrhosis (17.3%) is similar that reported in USA (> 20%) and very much lower than of the Italian group (80%). Meanwhile we found a high incidence in protracted hepatitis (80%) with parenteral infection.

Adolescent↗

Venereal transmission of enteric pathogens in male homosexuals. Two case reports.

In two cases there was simultaneous or sequential occurrence of amebiasis, shigellosis, and giardiasis in male homosexuals. Enteric pathogens may, under the proper conditions, be venereally transmitted. In particular, the sexual practices of male homosexuals, most significantly, oral-anal contact, appear to provide the necesseary link for transmission. Evidence suggests that this is a growing problem.

Adult↗

Public opinion regarding AIDS policy: fear of contagion and attitude toward homosexual relationships.

This study examines public attitudes toward AIDS issues and tests the extent to which fear of contracting AIDS and attitude toward homosexuality influence opinions regarding the screening of potentially infected persons and the isolation of those already identified as infected. The data for this study are drawn from a 1989 survey of a representative sample of the adult residents of Edmonton, Alberta (n = 443). Stepwise regression analysis reveals that fear of contracting AIDS and attitude toward homosexual relationships independently predict support for AIDS screening and isolation policies. The implications for public health education are discussed.

Acquired Immunodeficiency Syndrome↗

[Depressive reactions and psychological processing of HIV-positive homosexual males].

Interviews and psychotherapeutic treatments performed with HIV-positive males reveal frequent depressive crises in some of the men, whereas others are mentally relatively stable after having gone through a period of mourning over the loss of long-term life perspectives and prospects. The present study examined in 54 HIV-positive male homosexuals not suffering from AIDS, the causes of the depressive management by comparing a depressive and a non-depressive group. The results show: 1. that three well-defined styles of coping can be discerned, namely, "self-confrontation", "avoidance", and "seeking social support"; 2. that the "avoidance" style of coping is particularly pronounced in the depressive group; 3. that in 86% of the depressive but only in 26% of the non-depressives there is a noticeable conflict between socioemotional retreat and seeking social support; 4. that the depressives estimate the changes of any subjective influence on the course, as being very low, whereas the subjective probability of falling ill is correspondingly high, the self-confronting coping style correlating negatively with the subjective disease probability; 5. that in the depressive group the reasons for the infection are seen rather in one's own person, a mental predisposition being held co-responsible. In this context, the lower self-acceptance of one's own homosexuality plays a decisive role in the "subjective infection theory".

Adaptation, Psychological↗

Accelerated aging and male homosexuality: Australian evidence in a continuing debate.

The evidence of research looking at accelerated aging among gay men is contradictory. In this study the issue of accelerated aging is addressed by accounting for the duality of the gay man's lifestyle as he interacts in both the homosexual community and the larger society where heterosexuality is the presumed norm. The onset of middle and old age as self-perceived by gay men and as perceived by other gay men in the homosexual subculture is contrasted. The results indicate that existing contradictions and debates about gay men and accelerated aging are largely a function of their referent perceptual worlds.

Adaptation, Psychological↗