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At least 1,315 records · Page 73Linked to original sources
PubMed2005

Fibroepithelioma of pinkus is a fenestrated trichoblastoma.

Pinkus described "pre-malignant fibroepithelioma" as a proliferation that gave rise to many tiny basal cell carcinomas within each lesion. Later authors have generally considered it to be an unusual variant of basal cell carcinoma (BCC). The delineation of trichoblastoma as the general term for the benign counterpart of BCC raises the possibility that the fibroepithelioma of Pinkus (FEP) would be better classified under that rubric. To address this subject, we examined the records of 114 patients with FEP for body site, age and sex distribution, and sections from 75 lesions. All FEP examined show a blunt interface with the underlying dermis (where one could be seen), differentiation toward follicular bulbs and papillae, and large areas of cellular stroma. FEP has a slight female preponderance in contrast to BCC, which is more common in males. Unlike the common types of BCC, FEP has an overwhelming predilection for the trunk and extremities, and only 5% of tumors are set in a dermis with significant amounts of solar elastosis. Next, FEP, BCC, and FEP with BCC-like areas were stained with MIB-1 (to assess proliferation), p53 (an oncogene product), and CK20 (a Merkel cell marker) antisera. FEP shows a low level of staining for p53 and MIB-1, in contrast to conventional BCCs that over-express these markers. FEP also shows retention of Merkel cells, a characteristic of benign neoplasms with follicular germinative differentiation but not in general of BCC. The BCC-like areas in some FEP tumors reflect these staining tendencies with less striking differences. Given the contrast between FEP and BCC with respect to site of occurrence, relationship to sun damage, histopathologic features, and immunohistochemical studies, it appears that FEP more closely resembles trichoblastoma than BCC.

Adolescent↗
PubMed2004

A procolophonoid reptile with temporal fenestration from the Middle Triassic of Brazil.

The small tetrapod Candelaria barbouri, from the Middle Triassic of southern Brazil, is the first example of an owenettid procolophonoid outside Africa and Madagascar. Candelaria barbouri was originally described as a primitive procolophonid; however, a re-examination of the holotype, as well as new material, reveals that C. barbouri is in fact the youngest member of the Owenettidae, extending the chronological range of the group by more than 10 million years. The recognition of C. barbouri as an owenettid points to a broader diversity and distribution for owenettids than hitherto thought. In addition, C. barbouri is the first member of the Owenettidae to exhibit temporal fenestrae, a discovery that draws attention to the significance of this feature in 'anapsid' reptiles.

Animals↗