There is more to aptitude than cognitive capacities.
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Adolescent↗
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Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
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The relationship between leg power and physical performance in mobility-limited older people.
OBJECTIVES: The purpose of this study was to assess the influence of leg power and leg strength on the physical performance of community-dwelling mobility-limited older people. DESIGN: Cross-sectional analysis of baseline data from a 12-week randomized controlled exercise-intervention study. SETTING: Exercise laboratory within the Department of Health Science of an urban university. PARTICIPANTS: Forty-five community-dwelling mobility-limited people (34 women, 11 men), aged 65 to 83. MEASUREMENTS: Health status, depression, cognition, physical activity, and falls efficacy; physiological measures of lower extremity strength and power; and measures of physical performance. RESULTS: Through bivariate analyses, leg power was significantly associated with physical performance as measured by stair-climb time, chair-stand time, tandem gait, habitual gait, maximal gait, and the short physical performance battery describing between 12% and 45% of the variance (R2). Although leg power and leg strength were greatly correlated (r = .89) in a comparison of bivariate analyses of strength or power with physical performance, leg power modeled up to 8% more of the variance for five of six physical performance measures. Despite limitations in sample size, it appeared that, through quadratic modeling,the influence of leg power on physical performance was curvilinear. Using separate multivariate analyses, partial R2 values for leg power and leg strength were compared, demonstrating that leg power accounted for 2% to 8% more of the variance with all measures of physical performance. CONCLUSION: Leg power is an important factor influencing the physical performance of mobility-limited older people. Although related to strength, it is a separate attribute that may exert a greater influence on physical performance. These findings have important implications for clinicians practicing geriatric rehabilitation.
Age Factors↗
Use of health education and attempted dietary change to modify atherosclerotic risk factors: a controlled trial.
The purpose of this investigation was to determine if nutrition education regarding atherosclerotic risk factors and dietary changes that might reduce these factors, taught in an elementary school setting, would cause children to alter their diets in a way that would produce a significant reduction in risk factor values as compared to a control group. Serum cholesterol, blood pressure, height, weight, and skinfold thickness were the evaluated variables. Sixty-eight children who had been enrolled in the intervention program had complete data at the termination of the 3-year study. The major control group consisted of 23 children from a different school. Additional control groups were formed to provide information regarding general population changes in the risk factors during the time span of the study and to investigate values of children who did not complete the entire program. The results showed no major significant changes for these variables as compared to the control group or the preintervention values of the intervention population. As expected, the population had an initially relatively low risk. Tracking of these variables over 3 years showed results similar to those of other investigations that did not include intervention. It is concluded that, although the education proved effective by cognitive testing, the methodology used in this study was ineffective in reducing significantly the above risk factors of the population investigated.
Arteriosclerosis↗
Cognitive and noncognitive characteristics of medical school applicants.
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Behavior↗
The structure of cardiological revolutions. James B. Herrick Lecture.
Four revolutions are transforming the cardiology of our day. The first is a social revolution. It has resulted in plummeting esteem for the medical profession reflecting disenchantment coupled with the rapid emergence of the recognition that health care is a right rather than a privilege. The second revolution, interventional cardiology, has provided powerful therapeutic tools demanding technical as well as cognitive expertise. The third, the revolution in molecular and cellular biology, is transforming our understanding of mechanisms underlying disease. Because of the seminal importance of progress in basic science to advances in clinical cardiology, features of these three revolutions are being synthesized in a fourth, a revolution transforming cardiology itself. Novel approaches are needed for optimal training of clinicians with diverse areas of interest, investigators in fundamental and clinical research, house staff, and students; for optimal use of clinical and research resources; and for optimal responsiveness to the needs of patients. They must be developed with cognizance of and fidelity to our clinical and scientific heritage.
American Heart Association↗
Stem cell strategies, future and beyond.
The use of stem cells for neuroreplacement therapy is no longer science fiction--it is science fact. We have succeeded in the development of neural and mesenchymal stem cell transplantation to produce neural cells in the brain. We have seen the improvement of cognitive function in a memory-impaired aged animal model following stem cell transplantation. These results may promise a bright future for stem cell strategies. Before we begin to think about clinical applications beyond the present preclinical studies or even consider the pathophysiological environments of individual diseases, we must address and weigh the factors that may affect stem cell biology. Here, we not only show the potential for therapeutic applications for stem cell strategies in neuropathological conditions, but we also discuss the effects on the biology of stem cells of those factors that are altered under disease conditions.
Alzheimer Disease↗
Application of college and flight background questionnaires as supplementary noncognitive measures for use in the selection of student naval aviators.
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Achievement↗
Skilled expert practice: is it 'all in the mind'? A response to English's critique of Benner's novice to expert model.
In a recent critique of the work of Patricia Benner in relation to expertise, skilled intuitive grasp and the Dreyfus model of skill acquisition, English (Journal of Advanced Nursing 1993, vol. 18, pp. 387-393) uses the tenets of positivism and cognitive psychology to criticize Benner's work for lacking objectivity, validity, generalizability and predictive power. In this response to English's critique I show how he has misread, failed to read, and consequently misunderstood her work, and, equally importantly, its philosophical basis. Benner's work is developed from a philosophical foundation grounded in interpretive and Heideggerian phenomenology. This wholly different 'take' on the world and on human behaviour embodies a strong critique of those very same traditional-science worldviews which English uses to damn her work. English's critique is valuable in highlighting the ways in which Benner's work can be misrepresented and this response tries to remedy this misunderstanding by attempting to clarify the fundamental differences between phenomenological and cognitive understandings. These differences are crucial to understanding Dreyfus's and Benner's work. Here, I also attempt to correct some of English's wilder assertions regarding Benner's work. Finally, I try to show how Benner's work has empowered, enthused and challenged, rather than being 'denigrating to the majority of nurses'.
Clinical Competence↗
Relationship between ideology and science.
After defining the characteristics of ideological knowledge and knowledge based on research, the experimental work on illusory correlations, serial effects, difficulties in "grasping counter-examples" and prejudiced pseudo-knowledge is reported. This proves how ideology can develop from the very functioning of the cognitive processes (perception, thought) when it is not kept under critical scrutiny. The difference between ideological and scientific thought reflects the different social conditions behind the production of the two types of knowledge. The production of scientific knowledge is regulated by specific rules such as the logic of the experimental method and empirical references, and is animated by a depressive attitude ("I am responsible for matters within the confines of rules set by the research community") while the propositions of ideology are anti-empirical, shy away from counter-examples, are confusional, and are underpinned by an attitude that is potentially maniacal and omnipotent. The ideological factors that can have an effect on professional research are listed and it is shown how the results of this, once controlled, lose all ties to the ideology they may have been inspired by, to the extent that they constitute another sphere that is completely autonomous and independent.
Philosophy↗
Early language development in children exposed to or infected with human immunodeficiency virus.
OBJECTIVES: To compare language development in infants and young children with human immunodeficiency virus (HIV) infection to language development in children who had been exposed to HIV but were uninfected, and (among subjects with HIV infection) to compare language development with cognitive and neurologic status. DESIGN: Prospective evaluation of language development in infected and in exposed but uninfected infants and young children. SETTING: Pediatric Infectious Disease Clinic, State University of New York-Health Science Center at Syracuse. SUBJECTS: Nine infants and young children infected with HIV and 69 seropositive but uninfected infants and children, age 6 weeks to 45 months. RESULTS: Mean Early Language Milestone Scale, 2nd edition (ELM-2) Global Language scores were significantly lower for subjects with HIV infection, compared with uninfected subjects (89.3 vs 96.2, Mann-Whitney U test). The proportion of subjects scoring >2 SD below the mean on the ELM-2 on at least one occasion also was significantly greater for subjects with HIV infection, compared with uninfected subjects (4 of 9 infected subjects, but only 5 of 69 uninfected subjects; Fisher's exact test). Seven of the 9 subjects with HIV infection manifested deterioration of language function. Four manifested unremitting deterioration; only 1 of these 4 demonstrated unequivocal abnormality on neurologic examination. Three subjects with HIV infection and language deterioration showed improvement in language almost immediately after the initiation of antiretroviral drug treatment. Magnetic resonance imaging or computed tomography of the brain were performed in 6 of 7 infected subjects with language deterioration, and findings were normal in all 6. ELM-2 Global Language scaled scores showed good agreement with the Bayley Mental Developmental Index or the McCarthy Global Cognitive Index (r = 0. 70). Language deterioration, or improvement in language after initiation of drug therapy, coincided with or preceded changes in global cognitive function, at times by intervals of up to 12 months. CONCLUSIONS: Language deterioration occurs commonly in infants and young children with HIV infection, is seen frequently in the absence of abnormalities on neurologic examination or central nervous system imaging, and may precede evidence of deterioration in global cognitive ability. Periodic assessment of language development should be added to the developmental monitoring of infants and young children with HIV infection as a means of monitoring disease progression and the efficacy of drug treatment.
Child, Preschool↗
[Interventional gerontology in German-speaking countries: a social and behavioral science assessment].
This work is aimed at reviewing 20 years of gerontological intervention research within the social and behavioral domain in German speaking countries. Only controlled studies based on adequate measurement instruments are considered. Literature analyses reveal that the issue of cognitive intervention research is well-covered, underlining clear positive training effects in intellectual performance and memory. Also, studies on the limits of mental capacity represent a highlight of German cognitive training research. Another bunch of studies underlines the potential of different intervention to enhance independence in day-to-day function, social activity, and subjective well-being. Positive effects in self-concept, personal control, and attribution style are as well reported. A general discussion of this body of work leads to suggestions for future research priorities.
Adaptation, Psychological↗
Meta-analysis and the science of schizophrenia: variant evidence or evidence of variants?
Quantification (meta-analysis) of the neuroscience evidence on schizophrenia shows very modest average differences between patient and control distributions across a great variety of measures and literatures. The strongest findings involve cognitive and psychophysiological measures. Several possible explanations for this situation are reviewed including technical immaturity, methodological variability, dimensional and multiple illness models and the nature of cognitive measurement. An argument is developed that biological subtypes and endophenotypes within the broad diagnostic category of schizophrenia underpin the meta-analytic evidence. Considerations in the use of this evidence to identify illness variants are described and four candidate subtypes are proposed. Schizophrenia is a disease that will resist biological definition until its variants are isolated and extracted from the generic patient population.
Case-Control Studies↗
An integrated view of pathophysiological models of schizophrenia.
Pathophysiological processes that underlie the profound neuropsychiatric disturbances in schizophrenia are poorly understood. However, the clinical course of the disease, and a number of clinical and basic science observations, provide direction for formulating pathophysiological models that could be empirically tested. For example, repeated psychostimulant administration to healthy subjects can induce psychotic symptoms, and acute stimulant challenge in schizophrenia patients can precipitate psychosis. Also, NMDA antagonists induce positive, negative, and cognitive schizophrenic-like symptoms in healthy volunteers and precipitate thought disorder and delusions in schizophrenia patients. These human studies provide support for the dopamine and NMDA receptor hypofunction hypotheses of schizophrenia. Well-documented effects of NMDA antagonists on dopamine systems provide a basis to integrate the dopamine and NMDA receptor hypofunction hypotheses. Furthermore, it has become apparent that prominent actions of antipsychotic drugs, especially those with 'atypical' properties, involve antagonism of behavioral, electrophysiological and brain metabolic effects produced by administration of NMDA receptor antagonists. A confluence of clinical and basic science data suggests that an early developmental insult, potentially involving reduced NMDA receptor function, could facilitate sensitization of dopamine systems, leading to the formal onset of schizophrenia in late adolescence and early adulthood. Although clearly speculative, this conceptual model is consistent with existing evidence and suggests lines of future experimental investigation.
Animals↗
A conceptual framework for drug treatment process and outcomes.
Evidence from specialized treatment evaluations and large-scale natural studies of treatment effectiveness is organized conceptually into a "treatment model" for summarizing how drug treatment works. Sequential relationships between patient and treatment program attributes, early patient engagement, recovery stages, retention, and favorable outcomes are discussed--along with behavioral, cognitive, and skills training interventions that have been shown to be effective for enhancing specific stages of the patient recovery process. Applications of the treatment model for incorporating science-based innovations into clinical practice for improving early engagement and retention, performance measurements of patient progress, program monitoring and management using aggregated patient records, and organizational functioning and systems change also are addressed.
Evidence-Based Medicine↗
Shine-through: temporal aspects.
If a vernier stimulus precedes a grating for a very short time, the vernier either remains invisible, but may bequeath some of its properties to the grating (feature inheritance), or might shine through keeping its features - depending on the number of grating elements [Herzog, M. H. & Koch, C., 2001. Seeing properties of an invisible element: feature inheritance and shine-through. Proceedings of the National Academy of Science USA 98, 4271-4275]. Feature inheritance and shine-through represent two different states of feature binding [Herzog, M. H., Koch, C., & Fahle, M., Switching binding states. Visual Cognition (in press)], whereas shine-through depends in subtle ways on the spatial layout of the grating [Herzog, M. H., Fahle, M., & Koch, C., (2001). Spatial aspects of object formation revealed by a new illusion, shine-through Vision Research]. Here, we show that also temporal parameters of the grating influence shine-through. For example, a delayed presentation of certain grating elements can deteriorate performance dramatically.
Afterimage↗
Animal-assisted activity and infection control implications in a healthcare setting.
Animal-assisted activity/therapy (AAA/T) is an emerging science using animals to solve human problems. It is an interdisciplinary approach using animals as an adjunct to other conventional therapies. The benefits include improved physical, social, emotional or cognitive functioning. Studies in the past have shown lowering of blood pressure and increased survival in those who own a pet. This may not be effective for all individuals, however, it is essential that a complete assessment be made before implementation of AAA/T. The goals of such a therapy must be defined. Animal bites, allergies and zoonoses are the major animal-associated health hazards. The type of AAA/T and needs of the patients are important issues to be considered. Specific guidelines including suitability of patients, animals and infection control policies need to be formulated before initiation of AAA/T. Such an intervention would also require additional resources and there may be legal implications.
Animals↗
Effects of hyperbaric environment on the P300 component of event-related potentials.
Hyperbaric chamber dives at 19 ATA with helium-oxygen were performed at the Japan Marine Science Technology Center, Yokosuka, from January 31 to February 2 in 1990. During simulated underwater experiments, event-related potentials were recorded in 2 divers for assessment of the cognitive function. Although the P300 amplitude of the potentials did not show any significant change, its latency was clearly prolongated and this prolongation continued to when the decompression reached to 70 m below sea level. These findings indicated that the hyperbaric environment corresponding to 180 m below sea level or less must cause some cognitive dysfunctions and that P300 is useful for early detection of those dysfunctions or HPNS.
Cognition↗
Neuroethics: a guide for the perplexed.
Like filings to a magnet, issues of all shapes, sizes, and degrees of importance are sticking to the idea of neuroethics. Martha Farah, an early thinker in this new field, proposes that, numerous as they are, the problems actually fall into just three categories. She finds that neuroethics has made a quick start sizing up many practical--and some unique--questions swirling up from brain science, but, she writes, watch for challenges that reach beyond these to the metaphysical. Neuroscience may one day explain in terms of neural tissue virtually all aspects of human cognition and emotion--realms traditionally deemed apart from physical law. Thus, we should also expect neuroethics to grapple with our fundamental distinction between persons and mere "things." If mental processes prove to result from purely physical events, this opens to question our notions of consciousness, spirituality, free will, and moral responsibility.
Behavior↗