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PubMed2026

Efficacy of an Adhesive Hydrocolloid Bandage on Wound Healing: Findings of a 28-Day, Single-Centre, Randomised, Controlled Study.

This single-centre, randomised, controlled study assessed the wound healing efficacy of adhesive bandages in eligible healthy adults (N = 36) aged 25-55 with Fitzpatrick skin types II and III using a model of laser-induced wounds. Here, we report data for wounds that were randomised to treatment with either a hydrocolloid bandage for multi-day use (BAND-AID Adhesive Bandage Hydroseal), standard of care (SoC) (BAND-AID Adhesive Bandage Tru-Stay Sheer) or an uncovered control. Primary endpoints included the time to complete healing and a composite wound healing score. Hydrocolloid bandage-treated wounds healed twice as fast as the uncovered control or SoC-treated wounds. Median time (days) to complete healing was significantly faster for the hydrocolloid bandage-treated wounds (6.9) versus SoC (11.9) and uncovered control (11.8). Hydrocolloid bandage-treated wounds had significantly better composite wound healing scores versus SoC and versus uncovered control over 2 weeks. At Day 28, cosmesis was better with hydrocolloid bandage treatment (0.3) versus SoC (0.6) and uncovered control (2.1) (change from baseline in a composite scar score; higher score = worse outcome). Multi-day wound occlusion with a hydrocolloid bandage promoted faster healing and improved cosmesis compared with daily SoC dressings or uncovered control.

Humans↗
PubMed1984

Preliminary development of a collagen membrane for use in urological surgery.

A series of experiments have been carried out in-vitro in order to assess the possibility of using a collagen membrane in the repair of various sections of the urinary tract following operative surgery such as the removal of a stone from the ureter. The collagen film has been tested for its compatability with urine, its ability to prevent leakage of fluid in a simulated wound in-vitro and for its ability to withstand any degradative effect of liver and kidney homogenates. The material was not significantly degraded by either urine or by tissue homogenates and was able to prevent leakage of fluid under the experimental conditions employed. Although some slight build-up of calcium and some trace elements took place after incubation in urine over a six-day period this was not significant. On the basis of the results obtained it has been decided to proceed to in-vivo trials on rabbits using the collagen membrane. The possibility of using such a material in partial nephrectomy operations is discussed.

Animals↗
PubMed1989

Design of a new hydrocolloid dressing.

Hydrocolloid dressings composed of dextran, phospholipid, glycerol and sodium lauryl sulphate have been formulated. A ventilated hygrometer system has been used to study the evaporative water loss (EWL) from the excised wound of rats with and without these dressings. A statistical experimental design has been used to locate a formulation which is flexible and semiocclusive in nature. The phospholipid component of the dressing has a significant role in controlling water vapour permeability of the dressing. The EWL from the excised wound covered with the optimized dressing has been compared with that for two commercial products.

Animals↗
PubMed2000

A survey into toxic shock syndrome (TSS) in UK burns units.

Toxic shock syndrome (TSS) is a rare complication of a Staphylococcus aureus infection and is primarily seen in children with small burns. The true incidence of TSS in burns patients is not known and the number of presumptive cases rarely reported. This survey was undertaken to determine if the incidence of TSS in children with burns could be related to the type of dressing used to cover the wound. A questionnaire was compiled and sent to the Senior Nurse in charge of each of the UK burns units. General information on the number of admissions, age of the patient, cause of injury and burn wound management was sought. An 81% response was obtained after two mailshots and follow up telephone calls. Seventy percent (23/33) of units which answered the survey nursed children. Of these, eight units had either not encountered TSS previously or not had a case within the past two years. These units were small, admitting a maximum of 50 patients each year. Of the units where TSS was encountered, approximately 2.5% of children admitted showed symptoms of TSS. Of the units who nursed both adults and children, seven units had seen TSS in burned adult patients which has not been reported in the literature. Of the eight units where TSS had not been recently encountered, four routinely administered prophylactic antibiotics to prevent infection whereas routine administration of antibiotics occurred in only two of the 15 units where TSS was seen. Although wound management procedures differed slightly there were many similarities. These included wound cleaning with normal saline, covering with either silver sulphadiazine (1%) or povidone iodine (10%), depending upon the infection status, and dressing with a paraffin tulle, gauze and crepe bandages. No association between the management of the burn wound and subsequent development of TSS could be established.

Adult↗
PubMedDate not supplied

Long-term results of a new antithrombogenic cardiac wall substitute.

We evaluated the long-term results of a new antithrombogenic cardiac wall substitute which is composed of collagen-coated ultrafine polyester mesh cross-linked by a hydrophilic polyepoxy compound (CUFP), and compared it with glutaraldehyde-treated equine pericardium (GA graft). In an animal study, 20 CUFPs and 18 GA control grafts were implanted as patches in the right ventricular outflow tract in 38 dogs. In the CUFP at 28 days after implantation, a thin neointima, which was almost endothelialized, had been formed. Fibroblasts and vasa vasorum were seen inside both the neointima and the graft wall. At 168 days, transmission electron microscopy revealed smooth muscle-like cells in the neointima, with endothelialization. The CUFP at 486 days had maintained a white, shiny, smooth, thin, and uniform neointima with endothelialization. Neither ulcer nor thrombus formation was seen on the surface, while in the GA graft at 353 days, no endothelialization was noticed in the center and almost no fibroblasts had infiltrated into the graft wall. From these results, the CUFP should be an ideal candidate for cardiac wall substitution.

Animals↗
PubMed1986

Assessment of collagen film for use in urinary tract surgery.

This investigation assessed a biodegradable collagen membrane which can be sutured around the ureter to prevent urine leakage, thus permitting healing to proceed more rapidly while the membrane itself is resorbed. Following an early in vitro investigation in which collagen was assessed, a more comprehensive survey has now been carried out. Tissue compatibility and biodegradation were assessed by implanting the film into the lumbar muscles of rats; it was then used to cover experimental ureterotomies in New Zealand White rabbits. The data obtained from the rabbits confirmed that a collagen membrane can prevent leakage of urine from the ureter during healing while it itself is biodegraded, indicating that a collagen membrane could be used to repair the injured urinary tract.

Animals↗
PubMed1983

Human amnion in the management of chronic ulceration of the lower limb: a clinico-pathologic study.

This study shows that unmodified human amnion can make a useful contribution to the management of venous ulceration. By suppressing infection, and, by providing a healthy granulating surface, it significantly reduces the pre-skin graft preparation time, when compared with a conventional method of treatment. However, it does not seem to significantly influence the prospects of graft take, or of long term graft survival, in this comparison. A reversion towards normal of local vasculature, as characterized by vessel wall thinning and widening of the lumen, appears to be a significant tissue change induced by amnion treatment. Such a change may have considerable relevance in any analysis of the basis of the therapeutic efficacy of amnion.

Aged↗
PubMed1987

Different demand on temporary skin substitutes for different indications.

In the past, the authors centred their attention on the effect of various skin substitutes on dermal burns. In the present study, the effect of various synthetic and biological skin substitutes on full thickness skin defects was studied. Experiments were carried out on laboratory pigs; the effect of various materials was evaluated in excised full thickness burns and in tangentially excised dermal burns. A parallel study was carried out in burned patients. It was concluded that for different indications, different qualities (or properties) of temporary skin substitutes are desirable or preferable. None of the materials available to date has all desirable qualities for all types of skin defects.

Animals↗
PubMed2006

Leg ulcers - causes and management.

BACKGROUND: A leg ulcer is not a disease but the manifestation of an underlying problem that requires a clear diagnosis. OBJECTIVE: This article outlines the assessment and management of patients with leg ulceration. DISCUSSION: The simple tag of 'leg ulcer' is not an adequate diagnosis. A comprehensive assessment of the patient, skin, vascular status, limb, and ulcer is required to determine the aetiology and to formulate an appropriate management plan. Most leg ulcers are caused by venous insufficiency and compression is required to successfully heal venous leg ulcers. Treatment must address oedema, infection and pressure. Managing peripheral oedema using compression bandages is often more important than the topical dressings. Success requires consistent adherence to a care plan designed to address the underlying pathology and contributing factors.

Family Practice↗
PubMed1989

[Mérocel's method in otorhinolaryngology].

Merocel intra-nasal pack are very effective in controlling epistaxis. Different forms of Merocel are very usefull in external otitis and after endonasal and middle ear surgery. They can protect some particular structures during oto-neuro and head and neck surgery.

Bandages↗
PubMed1988

Wound coverage with cultured autologous keratinocytes: use after burn wound excision, including biopsy followup.

Cultured autologous keratinocytes (CAK) have been used in eight patients as part of their definitive treatment for burn wound closure. The CAK grafts were placed on surgically excised wounds rather than mature granulation tissue. This technique guaranteed that permanent skin coverage derived from cultured cells, and not residual epidermal cells from surviving dermis. Graft take was variable, ranging from zero in the case of one of the children to 85%. Long-term assessment noted adequate permanent coverage, confirmed by biopsy. Electron micrographs demonstrated no well formed anchoring fibrils, which may account for the graft fragility which has been reported as much as 1 year postgraft. Advantages of using CAK are that an acceptable permanent wound closure can be achieved without depending on donor site availability. An almost unlimited quantity of skin is available because the original biopsy can be expanded manyfold in the laboratory.

Adult↗
PubMed1983

[Identification of gram-negative nonfermentation bacteria in the air of a surgical hospital].

The method of detecting Gram-negative nonfermentative bacteria in the air of surgical hospitals by means of the -1 apparatus has been developed. 167 strains of nonfermentative bacteria have been isolated and studied; of these, Acinetobacter calcoaceticus constitute 88%. Nonfermentative bacteria occur most frequently in the air of wards for patients with severe burns, as well as in the air of dressing rooms when patients with burns are being bandaged there. The possibility of the spread of nonfermentative bacteria in the hospital by the aerogenic route should be taken into account.

Acinetobacter↗