The participation of N-acetyl-L-aspartic acid in brain metabolism.
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Male mice of a non-inbred strain "H" were used to verify the effect of a 10-day peroral administration of K and Mg aspartates on haemopoietic functions. The salts were proved to stimulate the proliferation and differentiation processes in the thymus, bone marrow and spleen tissues. Mice exposed to a single whole-body X-irradiation after pretreatment with K, Mg aspartate exhibited a more conspicuous postirradiation regeneration of haemopoietic organs and an increased postirradiation survival. The results suggest the possibility of using K, Mg aspartate for radioprotective purposes.
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The effects of infusing aspartate or glutamate into the third ventricle of unanesthetized female animals was examined. LH levels were significantly enhanced within 5-15 min following aspartate (0.5 and 0.2 micromoles), separated by one hour and twenty-four hours, promoted consecutive increases in plasma LH. Plasma FSH levels, however, were not altered in any of the animals examined. This study further supports the findings that neuroexcitatory amino acids promote LH secretion.