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PubMedDate not supplied

Proteoglycans detected by monoclonal antibodies in adenoid cystic carcinoma of salivary glands.

Thirty-two cases of adenoid cystic carcinoma (ACC) of the salivary glands were examined immunohistochemically by monoclonal antibodies to proteoglycans (PG) such as chondroitin 6 sulfate (C6SPG), chondrotin 4 sulfate (C4SPG), dermatan sulfate (DSPG), heparan sulfate (HSPG) and keratan sulfate (KSPG) in conjunction with specific enzymatic digestion. The cribriform structure of ACC consisted of basaloid, myoepithelium-derived, and luminal tumor cells. The myoepithelial tumor cells were positive for PG, whereas luminal tumor cells were unstained. Occasional pseudocysts also gave positive staining for PG. Tubular structures consisting of modified myoepithelial cells indicated a high intensity reaction for C6SPG and C4SPG, and a slight one for DSPG, HSPG, and KSPG. Immunodepositions in solid and cluster structures were comparatively light in terms of PG. Basement membrane in ACC stained strongly for C4SPG, slightly for C6SPG, and very slightly for DSPG, HSPG, and KSPG. In ACC, immunohistochemical staining of PG was regularly positive in myoepithelium-derived tumor cells, but was irregular in other types of tumor cells.

Antibodies, Monoclonal↗
PubMed1990

Familial multiple eccrine spiradenomas with cylindromatous features associated with epithelioma adenoides cysticum of Brooke.

Four cases of rare familial multiple eccrine spiradenomas showing features of dermal cylindromas and associated with epithelioma adenoides cysticum of Brooke are reported. Skin biopsy specimens were obtained from three generations of this family and routine histochemical and immunoperoxidase stains were used. The eldest affected family member had multiple disfiguring facial and scalp tumors, which precipitated episodes of depression. Unlike other cutaneous genetic disorders, such as neurofibromatosis and tuberous sclerosis, the cutaneous adnexal tumors occurring in these patients continue to erupt and grow during their lifetimes.

Adenoma↗
PubMed1990

[A case of pulmonary metastasis from adenoid cystic carcinoma of the trachea].

A 33-year-old woman with adenoid cystic carcinoma of the trachea was treated by resection of the upper and mid-trachea, plus total laryngectomy, subtotal thyroidectomy, partial resection of the cervical esophageal muscle layer and mediastinal tracheostomy. This tumor invaded directly into the thyroid gland, the larynx, the recurrent laryngeal nerve and the cervical esophagus. Three years after the operation, metastases developed in the right lung (S10, S2) and partial resection of the lung was performed. This patient is now free from disease. Aggressive surgical resection is important for the improvement of survival in this condition, although this tumor shows low grade malignancy and is slowly growing.

Adult↗
PubMed1990

Glycosaminoglycans in pleomorphic adenoma and adenoid cystic carcinoma of the salivary gland.

One of the common histopathologic features of pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) of the salivary gland is the abundant accumulation of glycosaminoglycans (GAGs). To study a relationship between the histologic distribution of GAGs and the morphologic pattern of salivary gland tumors, we carried out immunohistochemical and biochemical analyses of GAGs on 16 cases of PA and three cases of ACC. Immunohistochemically, several GAG fractions such as chondroitin-6-sulfate, unsulfated chondroitin sulfate, and keratan sulfate were seen mainly at the plasma membrane of both PA and ACC cells and of myoepithelial cells of normal salivary glands. Most of these GAG-positive cells were distributed in solid and chondromyxoid parts of PA and in the cellular part of ACC. Biochemical GAG analysis of both PA and ACC, separated into nonsulfated and sulfated fractions by two-dimensional electrophoresis, revealed high concentrations of chondroitin sulfate in both neoplasms, but the concentration of hyaluronic acid, was significantly higher in PA than in ACC. The results show that the concentration of hyaluronic acid, a major nonsulfated GAG fraction, was significantly higher in PA than in ACC and, therefore, this difference may be useful in the differentiation of the two neoplasms.

Adenoma, Pleomorphic↗
PubMedDate not supplied

[Adenoid cystic subglottic carcinoma. A case report].

A case of adenoid cystic carcinoma found in the laryngeal region (suglottically), extending as far as the trachea, four years postoperatively, has not yet shown signs of local recurrence nor of metastasis. The unusual features of this case are its site and favourable progress postoperatively. A study was made of the literature of this type of tumour.

Carcinoma, Adenoid Cystic↗
PubMed1979

Adenoid cystic carcinoma of breast with metastasis: a case report and review of the literature.

Adenoid cystic carcinoma of the breast is a rare tumor having a favorable prognosis. At this writing, less than 100 cases have been reported. A review of the literature discloses only six well-documented cases with associated distant metastases. The characteristic biological behavior of this tumor appears to be the development of distant metastasis without prior detectable invasion of axillary lymph nodes.

Breast Neoplasms↗
PubMed1990

[Carcinoma adenoids cysticum--dispensary case].

In the article the dispensary case of carcinoma adenoids cysticum, highly rare disease of the mandibula is discussed. Clinical and an X-ray examinations revealed many similarities of this disease with cystic radicularis. The correct diagnosis could not be set until histopathological findings of the tissue taken at marsupialization were known. 69 years old female patient was further radically treated in the clinical hospital, where the removed mandibula was replaced by the reconstruction plate. In the literature this disease is presented merely as a metastasis. In the conclusion the accurate and complex examination as well as the necessity of the pathohistological examination of each tissue taken at the oral surgery is stressed.

Adenoids↗
PubMed1989

Adenoid cystic carcinoma of the breast: a histologic, cytologic, and immunohistochemical study.

Six cases of adenoid cystic carcinoma (ACC) of the breast were reviewed. Immunohistochemical studies were carried out for actin, S-100 protein, EMA, keratin, CEA, vimentin, NSE, alpha-lactalbumin, and lysozyme. Fine needle aspiration biopsy smears of five patients were also reexamined. Patients were treated by tumorectomy, quadrantectomy, or modified radical mastectomy. Axillary dissection was carried out in five cases, with negative lymph nodes in all. Five patients are alive without evidence of disease from 1 year 10 months to 13 years 4 months following surgery. One patient died 7 1/4 years after mastectomy, without evidence of disease. Histologically, a diagnostic biphasic cellular pattern was seen in all cases. In addition, several unusual features were encountered in some cases: squamous metaplasia, stromal myxoid pseudocartilaginous foci, and well-formed neoplastic ducts. Actin and/or S-100 protein were variably positive in all cases. The reaction was usually present in occasional basaloid cells predominantly at the periphery of neoplastic structures. Keratin, EMA, and CEA immunostaining disclosed ductal type cells in all cases. Vimentin was positive in four cases, usually in many basaloid cells. Aspiration cytology was suspicious in two cases and yielded a definitive diagnosis of ACC in three cases. Cytologic diagnosis was based on cellular morphology and on the presence of characteristic globoid structures. Immunohistochemical results show that in ACC dual myoepithelial-ductal differentiation occurs but is relatively limited. Most of the tumor cells are not differentiated ("indifferent" cells) and often express strong vimentin positivity. Such cells are regarded as precursor cells for either differentiated element. Unusual metaplastic changes in breast ACC suggest a possible relation with pleomorphic adenoma-type tumors, and this might be of prognostic significance.

Actins↗
PubMed1989

Histochemical study of the biphasic cellular pattern of tubular adenoid cystic carcinoma with azophloxine, amidoblack and acid blue.

A tubular adenoid cystic carcinoma of the soft palate was studied histochemically using tannic acid-phosphomolybdic acid-Azophloxine (TPAzf), tannic acid-phosphomolybdic acid-Amidoblack (TPA) and tannic acid-phosphomolybdic acid-Acid Blue techniques. At the periphery of some tumor nests a few spindle cells were noted stained intensely red, blue-green and dark blue with TPAzf, TPA and TPAcB respectively. The apical portion or the whole cytoplasm of the cuboidal, eosinophilic cells that lined the central lumina of most neoplastic nests showed a similar tinctorial behavior. On the basis of their location and staining properties, the spindle cells were recognized as myoepithelial. On the other hand, the tinctorial behavior of eosinophilic cells was attributed to the dye binding by a conspicuous terminal bar-terminal web system or by tonofibrils accumulated in their cytoplasm as a result of squamous metaplasia. An inverse relation between the presence of myoepithelial cells at the periphery of tumor nests and the increasing thickness of terminal bar-terminal web system or the appearance of numerous tonofibrils in the eosinophilic cells was also noted.

Aged↗
PubMed1989

[Adenoid cystic carcinoma presenting as cavernous sinus syndrome: a clinico-pathological study of two cases].

Adenoid cystic carcinoma (ACC), usually arising in the major and minor salivary glands, is well known to otolaryngologists, but is rarely encountered by neurologists or neurosurgeons. We report two ACC patients who presented initially with cavernous sinus syndrome and in whom CT did not demonstrate apparent abnormalities. Case 1 is a 48-year-old man who first developed right cavernous sinus syndrome. The patient came to our hospital four years later. At this time, the only abnormality found on CT was the clouded sphenoid sinus on the left, which was interpreted as sinusitis. Two years later, the repeat CT revealed the enhancing lesions in the area of bilateral cavernous sinuses with bony destruction. The nasolaryngological exploration of the left sphenoid sinus made the diagnosis of ACC. Case 2 is a 43-year-old man who developed unilateral cavernous sinus syndrome over three months. No radiological abnormality was apparent to the neurologist and neurosurgeons, however, the otolaryngologist detected a nasopharyngeal mass diagnosed as ACC. Histological examinations of the biopsy specimen from both cases revealed mixed cribriform, tubular, and solid patterns characteristic of ACC. Electron microscopic study in Case 1 demonstrated microvilli-containing epithelial tumor cells forming true glandular lumens. In these cystic spaces there were cellular debris and crystalloids consisting of hexagonally-arranged tubules with a diameter of 25 nm. Although thick basement membrane was found in the basal portion of the tumor cells facing the connective tissue, there was no so-called pseudocysts lined by replicated basal lamina. It is possible that the specimen examined electron microscopically is limited to a particular epithelial region.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[A case of adenoid cystic carcinoma of the esophagus].

A surgical case of an adenoid cystic carcinoma (ACC) of the esophagus in a 75-year-old man is reported. Histologically, the tumor consisted of an ACC, a squamous cell carcinoma and a small tubular adenocarcinoma. The ACC and the tubular adenocarcinomatous regions in the submucosa and the lamina propria were continuous with the overlying squamous cell carcinoma and atypical squamous epithelium. Immunohistochemically, two types of tumor cells were detected in the ACC. One was found to have EMA-positive epithelial cells whereas the other had actin-positive myoepithelial cells. In the normal esophageal gland, actin-positive cells are found at the periphery of acini and around the layer of epithelial cells in the small duct but they have not been detected in the main duct. These findings suggest that the tumor developed from the small duct and differentiated into two directions: an ACC and a squamous cell carcinoma.

Actins↗
PubMed1989

[Immunocytochemical demonstration of S-100 protein in adenoid cystic carcinoma of the salivary gland].

Immunocytochemical study was performed for the presence of S-100 protein in adenoid cystic carcinoma (ACC) of salivary gland and normal salivary gland tissues with the immunogold-silver staining method (IGSS). Myoepithelial cells, intercalated duct cells and serous acinar cells of normal salivary gland were S-100 positive. In ACC, S-100 protein can be found in component cells of various histological patterns of the tumor. The results suggest, according to the distribution patterns of S-100 protein positive cells in the tumor tissues, that ACC may originate partly from intercalated duct cells and partly from myoepithelial cells.

Carcinoma, Adenoid Cystic↗
PubMedDate not supplied

[Role of viral reactivation in recurrent adenoiditis and tonsillitis in children].

We have been made virus cultures, excepting EBV, in adenoid and palatine tonsil tissue come from adenotonsillectomy. They were practised to eighteen patients between 4 and 17 years old who suffered recurrent infections processes of these organs. The total was 22 specimens to estimate the reactivation function of latent virus in the etiology of this pathology.

Adenoids↗
PubMed1989

[Disorders of pulmonary ventilation in children with adenoid vegetations].

In a group of children aged 4 to 13 years with hypertrophic adenoid vegetation the pulmonary ventilation and mechanics of respiration were examined by global and regional spirography, incl. evaluation of VC, FEV1%, RV, IGV and V-V loops and in six children by whole-body plethysmography. While during global spirography a pathological finding was recorded in 31%, during regional spirographic examination pathological changes of the mentioned functional values were recorded in 86% of the children, which provides evidence that regional spirography combined with the densitographic method can reveal local disorders of pulmonary ventilation which cannot be detected by global spirography. In children under 10 years of age as compared with older children, more marked and more frequent changes of the investigated parameters were observed. Dispensarization of children where a pathological functional funding was present is essential as part of prevention of possible future development of chronic organic lesions of the lower respiratory pathways.

Adenoids↗
PubMed1987

[Results in combined hyperthermia/radiotherapy of adenoid cystic carcinomas compared with conventional treatment].

158 patients with advanced malignancies of the head and neck area were treated by a combined hyperthermia/radiotherapy since 1972. 16 were adenoid cystic carcinoma (ACC). Their treatment results are compared with 28 ACC after radiotherapy alone. All 16 patients with hyperthermia achieved a complete remission. CR in 28 ACC-patients without hyperthermia was 61%. 113 patients with hyperthermia-treated squamous cell carcinomas had a comparatively low CR-rate of 49%. Five-year-survival on the other hand was 50% for ACC after hyperthermia, 57% after a planned postoperative radiation without hyperthermia and 37.5% after a radiotherapy alone in cases of inoperability. The combination of hyperthermia and radiotherapy is indicated in cases of advanced inoperable ACC and leads to a high percentage of local tumour control.

Carcinoma, Adenoid Cystic↗
PubMed1987

[Adenoid cystic carcinoma of the salivary glands. Apropos of 52 cases].

52 cases of adenoid cystic carcinoma of the salivary glands are reported according to the age of the patient, to the localisation near an osseous structure or in soft tissues, to the histologic grade, to the therapeutic management, viz the surgical or radiotherapy treatment, correlated to the survival. It is worthy to notice that the localisations to the palate have a better prognosis than the localisations in soft tissues. Cribriform histologic grade in the same way have a better involvement than basaloid grade, but worse than tubular grade. Effectiveness of radiotherapy does not appear clearly in our study, unlike the observations of some authors.

Adolescent↗
PubMed1988

[Adenoid cystic carcinoma of the larynx].

Adenoid cystic carcinoma of the larynx is rare. Only 7 cases have been treated in our hospital from 1959 to 1986, which comprised 0.7% of all laryngeal malignancies in the same period. Of the 7 cases, there were 5 males and 2 females with the average age of 47. The symptoms at the time of diagnosis varied according to the size and location of the tumor. Three lesions were considered as supraglottic and one as subglottic. Six cases were treated by surgery and one by radiotherapy alone. The most common site of distant metastasis was the lung. The average survival was long even in those with pulmonary metastasis.

Adult↗