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PubMed1985

Regression of lymphosarcoma by treatment with acetylsalicylic acid in rats.

Increased synthesis of prostaglandins (PGs) may be an important promoting factor in the development of lymphosarcoma. Thus, inhibition of PG synthesis may represent a logical way of controlling the growth of lymphosarcomatous cells. In order to verify this hypothesis, two groups of rats with lymphosarcoma have been used: the test-group received acetyl salicylic acid (54 mg/animal/day) and the control-group received the same quantity of physiological saline solution. After 4 days of treatment, the lymph nodes stopped growing in the test-group. Microscopic and electron microscopic examinations of lymph node sections were carried out after 11 days of treatment. These showed for the test-group the disappearance of the characteristics of malignancy.

Animals↗
PubMed1981

Age-associated changes of responses to acetylsalicylic acid.

Aspirin can be an effective antipyretic, analgesic and anti-inflammatory agent, but unfortunately, its use in the elderly is often excessive [43]. In a survey by Gillies and Skyring, the overall prevalence of daily aspirin intake was greater in middle-age and older-age groups than for those of less than 40 years of age [16]. The elderly are susceptible to the advertising of non-prescription drugs and aspirin is frequently self-prescribed [8,31]. Age-related physiological changes modify the response to aspirin in the elderly. A higher incidence of drug reactions and interactions has been evidenced in this age group. The cases cited throughout this report substantiate the need for caution on the part of the geriatric patient and the physician in regard to aspirin therapy for the elderly.

Age Factors↗
PubMed1989

Double-blind evaluation of analgesic efficacy of orally administered diclofenac, nefopam, and acetylsalicylic acid (ASA) plus codeine in chronic cancer pain.

The analgesic efficacy and toxicity of oral diclofenac sodium 50 mg (q.i.d.) vs. nefopam 60 mg (q.i.d.) and a combination of 640 mg ASA and 40 mg codeine (q.i.d.) in cancer patients with moderate to severe chronic pain has been evaluated in a randomized double-blind study. Planned duration of treatment was 10 days. Pain intensity was evaluated by a visual analog scale. The length of patient participation in the trial, the patient's final global evaluation and the incidence of side effects were also evaluated. Ninety-nine patients were enrolled in the study. All treatments produced a statistically significant pain relief (P less than 0.01) without differences among groups but only 26 of 99 patients (26.3%) completed the planned treatment period. Mean time in the study was 4.65 days. Inefficacy and side effects were the main reasons for premature treatment interruption. Patients treated with nefopam had a significantly shorter period in the study than patients treated with the other 2 treatments. Adverse effects were slightly more frequent with the nefopam and ASA + codeine regimens. The 3 therapeutic regimens appear to be similar as to analgesic efficacy, but diclofenac presents the advantage of a slightly better safety profile than nefopam and the ASA + codeine combination.

Administration, Oral↗