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Results for “Retinal Neoplasms”

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At least 1,297 records · Page 72Linked to original sources
PubMed1971

Silent prostatism.

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Adenocarcinoma↗
PubMed1968

Surgical cold.

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Cryosurgery↗
PubMed1981

The Marton Lecture: ultrasound in ophthalmic optics.

A personal tribute to H. B. Marton is given, together with an outline of some of his achievements. The use of ultrasound for visualization through optically opaque areas due to various abnormal ocular conditions is described. Measurement of the eye with its relationship to refraction and the calculation of the power of a lens implant is considered. The help that ultrasonography can offer to the ophthalmic optician is illustrated with A- and B-scan traces.

Adolescent↗
PubMed1997

Molecular studies of loss of heterozygosity in retinoblastoma.

Retinoblastoma (Rb) is a paediatric intraocular tumour in which predisposition can be inherited. Cases of Rb tumours can be divided into three types: familial cases, sporadic bilateral cases and sporadic unilateral cases. Familial and sporadic bilateral cases are usually categorised as hereditary while sporadic unilateral cases as non-hereditary. In both familial and non-familial forms of Rb, loss of heterozygosity of the Rb locus has been reported although its frequency in tumours has not so far been accurately determined. The cloning of the gene responsible for retinoblastoma (Rb1) has facilitated DNA studies and genetic counselling of patients. We have examined forty-five cases of retinoblastoma at five intragenic sites of the Rb1 locus, namely intron 1/BamH1, intron 17/Xba1, intron 24/TthIII1, intron 25/Dra1 and Rb1.20 VNTR. Thirty-six out of the forty-five cases (80%) were informative for these markers. Comparison of results between genomic DNA from peripheral blood and from tumours revealed that loss of heterozygosity of alleles could be detected in 50% of cases studied in which tumour samples were available. Investigation of parental origin of retained alleles showed that in all these cases, the paternal alleles were preferentially retained. The analysis of the genetic origin of mutations predisposing to retinoblastoma can facilitate new approaches for identifying recessive mutant genes that lead to cancer as well as to provide a conceptual basis for accurate prenatal predictions of cancer predisposition.

Genetic Markers↗
PubMed1996

Ophthalmological signs of tuberous sclerosis.

A patient with tuberous sclerosis and retinal astrocytic hamartomas is described. The different types of these astrocytomas are illustrated as well as systemic signs of Bourneville disease. Finally the value of the ophthalmological examination in the diagnostic work-up prior to genetic counselling the patient and/or the family members is discussed.

Adult↗
PubMed1997

[Ultramicroscopic studies in retinoblastoma].

Were examined three cases with undifferentiated retinoblastoma. Were effected cross sections on the samples, remarking tumoral cells with normal aspect interspersed with tumoral necrosis cells. Tumoral cells of the undifferentiated retinoblastoma has low size and a poor cytoplasmic with a big nucleus that occupies nearly the whole cell; the ratio nucleus/cytoplasmic is increased. The cells are uni- or binucleus and the nucleus is monstrous deep invagination of the cover nucleus. Cytoplasmic has poor organelles and mitochondria are swelling following a high degree of hypoxia. Also tumoral cells on remark nontumoral cells (melanocyte).

Cell Nucleus↗