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PubMed1996

A case of drug eruption due to simultaneous sensitization with three different kinds of drugs.

We reported a case of drug eruption induced by combined treatment with three different kinds of drugs, amoxapine, mexiletine hydrochloride and cefaclor. A 63-year-old Japanese woman suffering from 11 years of standing reflex sympathetic dystrophy developed multiple erythematous papules on her trunk and extremities after taking 14 kinds of drugs. The provocation challenge produced positive reactions to amoxapine, mexiletine hydrochloride, and cefaclor, but was negative to the other drugs. We discussed the mechanism of simultaneous sensitization to three different kinds of drugs in our case.

Amoxapine↗

PubMed2004

Erythromelia, or Mitchell's syndrome--new names for unexplained signs of inflammation in distal symmetrical neuropathy in diabetes.

BACKGROUND: Two cases are described in which distal symmetrical sensorimotor neuropathy complicating diabetes was associated with episodes of subacute vasodilation of one or other lower limb, and which were otherwise unexplained. The vasodilation was associated with swelling and stiffness, but was painless and self-limiting. INTERPRETATION: It is suggested that this phenomenon results from disordered vasoregulation in diabetic neuropathy, and is linked to the processes which underlie diabetic neuropathic osteoarthropathy (Charcot foot), as well as disorders such as complex regional pain syndrome-1 (CRPS-1, reflex sympathetic dystrophy) and erythromelalgia. CONCLUSIONS: As self-limiting vasodilation may be not uncommon in distal symmetrical neuropathies, but unrecognized because the phenomenon has not been named, the terms 'neuropathic erythromelia' or 'Mitchell's syndrome' are proposed. The adoption of either of these names may lead to earlier diagnosis and prevent inappropriate investigation and treatment.

Adult↗

PubMed2004

Complex regional pain syndrome (CRPS): survey of current practices.

BACKGROUND AND OBJECTIVES: There are numerous treatments for complex regional pain syndrome (CRPS). These treatments are varied in scope and include pain management therapies, psychological therapies, and physiotherapy. Treatment guidelines have been published in the past, but little information exists as to how clinicians utilize these guidelines. Moreover, there has been a paradigm shift from the older "reflex sympathetic dystrophy" (RSD) nomenclature, with largely sympathetic block driven diagnosis and therapy to more recent trends towards more inclusive "CRPS" diagnostic criteria and multidisciplinary treatment. There remains controversy regarding the selection of various techniques, and the timing of advancement through the treatment algorithm to the more aggressive, interventional techniques. We set out to determine current CRPS treatment practices of interventional pain specialists. METHODS: The authors developed a 36-item, 15-20-minute questionnaire. This questionnaire was sent to 453 interventional pain specialists. RESULTS: One-hundred-five surveys were returned, with 100 being complete. Eighty-three percent of our respondents were practicing anesthesiology pain specialists who on average treat 14.9 (SD = 16.8) CRPS patients per month. CONCLUSIONS: Our survey results revealed the use of a treatment algorithm for CRPS that consists of treatment using medical therapies (pharmacologic, blocks, catheters, and implantable devices), psychological therapies, and physiotherapy in a coordinated fashion. The trend among our survey respondents is to utilize increasingly interventional techniques after a failed 2- to 4-week trial of any one particular therapy.

Journal Article↗

PubMed2004

A management of early CRPS I caused by ankle sprain: a case report.

We present a case of a 13-year-old boy who developed signs and symptoms of neuropathic pain/early Complex Regional Pain Syndrome (CRPS) Type I, formerly known as Reflex Sympathetic Dystrophy (RSD), after spraining his ankle while wrestling. Aggressive pain control, using medications and sympatholytic blocks, with physical therapy and rehabilitation, led to the resolution of his painful condition. This prevented the disease from possibly progressing to a full-blown case of CRPS I (RSD) that is very challenging to treat.

Journal Article↗

PubMed2002

Interposition arthroplasty for osteoarthritis of trapezio metacarpal joint: results of a modified incision and technique of interposing with early mobilisation.

Sixty flexor carpi radialis (FCR) tendon interposition arthroplasties were done using a modified incision from Froimson's approach for osteoarthritis (OA) of thumb carpo metacarpal joint (CMCJ) The tendon was made to resemble an anchovy fillet to preserve pillar length (average 7.5 mm). There was no incidence of injury to the superficial branch of the radial nerve. Graded mobilisation was commenced at two weeks. Our average follow-up for five and a half years shows good results, viz. pain relief (100%), power grip (21 kg), pinch grip (4.2 kg), tripod grip (5.5 kg), key grip (6.5 kg), ability to touch base and tip of little finger (91.6%) and (96.6%), respectively. Activities of daily living (ADL) without pain in turning a key (96.7%), opening jar top (100%), bottle top (93.4%), wringing cloth (86.7%), and using scissors (88.4%). None of them suffered reflex sympathetic dystrophy (RSD) and mobility was almost equal to the non-operated hand. Our experience with this modified incision and technique of interposing with early mobilisation has shown good functional outcome with no significant operative or postoperative complications.

Activities of Daily Living↗

PubMed2006

Sympathetic skin response: monitoring of CT-guided lumbar sympathetic blocks.

PURPOSE: To prospectively evaluate accuracy of sympathetic skin response (SSR) for monitoring computed tomography (CT)-guided lumbar sympathetic blocks, with palpable temperature increase in the foot 30 minutes after injection serving as the reference standard. MATERIALS AND METHODS: Institutional review board approval and written informed consent were obtained. Seventy individual lumbar sympathetic blocks were performed in 13 patients (six female, seven male; mean age, 45 years) with reflex sympathetic dystrophy of the foot. A 22-gauge needle was advanced to the sympathetic trunk at midlumbar level with CT fluoroscopic guidance, and 1 mL of iopamidol (200 mg of iodine per milliliter) and 5 mL of 0.5% bupivacaine were injected. SSR was monitored in both feet before and after bupivacaine injection. SSRs were activated with painless low-strength (5-20-mA) electrical stimuli. SSR ratio (SSR in the injected foot versus SSR in the contralateral foot) was calculated before injection and repeatedly at 1-minute intervals thereafter. Needle tip position and distribution of bupivacaine were measured on CT images. Receiver operating characteristic curves for SSR ratio were calculated until 7 minutes after injection. Logistic regression analyses adjusted for clustering were calculated for SSR ratio, injection parameters, needle tip position, and bupivacaine distribution. RESULTS: Thirty minutes after injection, 83% of procedures were considered clinically successful. An SSR cutoff ratio of 1:10 was used, and sensitivity, specificity, and accuracy of SSR for prediction of clinical success were 84%, 92%, and 86%, respectively, 4 minutes after injection and 95%, 92%, and 94%, respectively, 7 minutes after injection. Needle tip position (P = .19), medial and lateral borders of bupivacaine distribution (P = .11 and .056), and distance between bupivacaine distribution and the vertebral body (P = .41) were not significantly different between successful and unsuccessful injections. CONCLUSION: SSR can be used to correctly identify needle tip position in lumbar sympathetic blocks 6 and 7 minutes after injection.

Adolescent↗

PubMed2006

Osteoid osteoma: percutaneous laser ablation and follow-up in 114 patients.

PURPOSE: To retrospectively evaluate the effectiveness of interstitial laser ablation (ILA) as a curative treatment of osteoid osteoma. MATERIALS AND METHODS: Ethical review board approval was obtained for the retrospective study. Informed consent was waived. From June 1994 to June 2004, 114 patients (mean age, 22.3 years) suspected of having osteoid osteoma underwent ILA with a diode laser (805 nm). An optical fiber was introduced into the nidus of the osteoid osteoma, and 400-3000 J of energy was delivered, depending on the size and location of the nidus. Twelve spinal osteoid osteomas were treated; in five of these cases, the nidus was located fewer than 8 mm from the adjacent nerve roots, and slow epidural or periradicular infusion of normal saline was used to avoid thermal damage to neurologic structures. Pain was evaluated with a visual analog scale (VAS) and medication. ILA was considered successful (score, 0) when complete pain relief was achieved (VAS score, <1) without medication. RESULTS: One week after ILA, 112 patients had a score of 0. One week after ILA, one patient had pain that persisted for 2 months because of reflex sympathetic dystrophy. At follow-up (mean, 58.5 months; range, 13-130 months), six patients had recurrence of pain from 6 weeks to 27 months after the initial ILA. These recurrences were treated successfully with a second ILA. Only one unsuccessful treatment was encountered. CONCLUSION: Percutaneous ILA is an effective treatment for osteoid osteoma.

Adolescent↗

PubMed2004

Complex regional pain syndrome: diagnostic controversies, psychological dysfunction, and emerging concepts.

Complex regional pain syndromes (CRPS) types I and II are neuropathic pain disorders that involve dysfunction of the peripheral and central nervous system. CRPS type I and type II were known formerly as reflex sympathetic dystrophy and causalgia, respectively. Most experts believe that a multidisciplinary approach including pharmacotherapy, physiotherapy, and psychotherapy is warranted. Historically, there has been considerable controversy regarding this disease entity. In particular, the precise mechanism of the sympathetic dysfunction as well as the nature of the psychological dysfunction commonly observed in patients with CRPS has been the subject of considerable debate. Current strides in our understanding of the pathophysiology of this disease have improved treatment options.

Autonomic Nervous System Diseases↗

PubMed1994

Italian multicentric study on pain treatment with epidural spinal cord stimulation.

A multicentric study on the treatment of nonmalignant chronic pain with epidural spinal cord stimulation (SCS) has been carried out in 32 Italian centers devoted to pain therapy. Neurosurgical and anesthesiology units participated in this retrospective study. 410 of the eligible patients were enrolled in the protocol: 48% were male, 52% female. All patients underwent a screening test period (average 21 days) and 74% underwent the definitive implant. The diagnosis was failed back surgery syndrome in 45%, reflex sympathetic dystrophy in 15%, phantom limb pain in 14%, postherpetic neuralgia in 8%, peripheral nerve injury in 5%, others 13%. 84% received noninvasive unsuccessful treatment (10 tensor acupuncture). All had previous pharmacological therapy which was not always discontinued when SCS took place. Pain assessment had been done with the visual analog scale and verbal scale both subjectively and by the physician and nurses. Neuropsychological profile with minimal mental test or MMPI was obtained in 68% of the patients. These results were favorable (i.e. excellent or good; more than 50% reduction of pain) in 87% of the patients at the 3-month follow-up, 75% at the 6-month follow-up, 69% at the 1-year follow-up, and 58% at the 2-year follow-up. Complication rate was: dislocation of the electrocatheter 4%, technical problems 3%, infections of the system 2%. The results will be discussed in correlation with the different etiologies of the nonmalignant chronic pain syndrome.

Adolescent↗

PubMed1989

Spinal cord stimulation in deafferentation pain.

Spinal cord stimulation (SCS) was used in 49 cases to control resistant deafferentation pain resulting from causalgia, phantom limb, plexus and nerve root avulsion, postherpetic neuralgia, reflex sympathetic dystrophy and amputation. In all cases, one or two standard percutaneous leads were introduced into the epidural space and manipulated until the spinal segment at which external stimulation provoked paresthesic sensation in the painful area. Two weeks of external stimulation trial was used to determine the efficiency of the system. Pulse width of 0.1-0.2 ms, a rate of 80-120 cps and amplitude to low paresthesia threshold were programmed as electric parameters. In 36 out of the 49 tested cases showing a positive response to percutaneous SCS, the device was permanently implanted. After a mean follow-up of 5.5 years, 57% of patients had satisfactory pain relief (over 75%). Side effects were limited to dislodgement of the electrode in 1 case and wire extrusion in another, both requiring replacement of the stimulator.

Chronic Disease↗

PubMed1993

Experience with 509 plate electrodes implanted epidurally from C1 to L1.

This article summarizes the experience gained with implantation of 509 plate electrodes performed by a single neurosurgeon. 350 patients were subjected to implantation of plate electrodes in the dorsal epidural space. 227 patients were implanted for chronic pain management (reflex sympathetic dystrophy, failed back syndrome/arachnoiditis, pain following spinal cord injury, nerve injury pain and other miscellaneous pain conditions), 105 patients for motor disorders (spasms/spasticity following spinal cord or head injury, cerebral palsy, multiple sclerosis, spasmodic torticollis and other miscellaneous conditions) and 18 patients for both. A total of 509 electrodes were implanted in the dorsal epidural space. The electrodes types were: 442 Medtronic Resume, 39 Medtronic Resume-TL and 25 Neuromed Lamitrode. 378 electrodes were implanted for chronic pain management, 106 for motor disorders and 25 in patients presenting with both pain and motor disorders. 192 electrodes were implanted in the cervical area and 317 in the thoracic area. 3.7% of the implanted electrodes became infected and had to be surgically removed. Electrode migration occurred in 1.1% of the patients and electrode breakage in 4 patients. 288 (70%) of the implanted electrodes are still being used. Technical factors relevant to the surgical implantation of plate electrodes at various levels in the spine are presented and discussed.

Adolescent↗

PubMed1991

Topical capsaicin in dermatologic and peripheral pain disorders.

Topical capsaicin has been introduced in the U.S. and Canada as a cream indicated for temporary relief of neuralgia following episodes of herpes zoster infections and in the treatment of diabetic neuropathy. Although capsaicin is clinically used as an external analgesic for temporary relief of neuralgia, it has also been widely used as a research tool to study peripheral pain. Capsaicin apparently works to release substance P from sensory nerve fibers and after repeated applications, depletes neurons of substance P. Clinical investigations of topical capsaicin include trials in chronic pain syndromes such as postherpetic neuralgia, postmastectomy neuroma, reflex sympathetic dystrophy syndrome, diabetic neuropathy, rheumatoid arthritis, psoriasis, hemodialysis-associated itching, and vulvar vestibulitis. In addition, therapeutic benefits of capsaicin cream on apocrine chromhidrosis have been described. Further clinical studies are warranted in several of these conditions to establish the efficacy of topical capsaicin. Serious or unexpected adverse reactions from clinical use have not been reported to date. Considering the paucity of safe and effective treatments for the conditions mentioned above, capsaicin cream appears to warrant further clinical investigations to establish its efficacy in a variety of chronic pain syndromes.

Administration, Topical↗

PubMed2000

Subtalar arthrodesis for complications of intra-articular calcaneal fractures.

Eighty six subtalar arthrodeses performed between 1985 and 1996 for complications associated with intra-articular calcaneal fractures were retrospectively evaluated. Patients were divided into three Groups: (I) 59 patients with calcaneal malunions (II) 13 patients with failed open reduction and internal fixation, and (III) eight patients undergoing open reductions and primary fusion for highly comminuted fractures. In each scenario, internal fixation was achieved with cancellous lag screws. Bone graft material consisted of either autogenous iliac crest graft, local graft obtained from the lateral wall exostectomy of the malunion, or freeze-dried cancellous allograft. Fusions in Groups II and III were performed in situ. Fusions in Group I were performed either in situ or utilizing a variety of reconstructive procedures depending upon the type of malunion encountered. Eighty three of the 86 fusion attempts were successful following the initial operations for a union rate of 96%. Fusion rates were similar regardless of the graft material used. Complications included four varus malunions, four cases of osteomyelitis, and two cases of reflex sympathetic dystrophy. A statistically significant shorter hospital stay was found for patients not undergoing iliac crest bone graft procedures. Eighty patients with at least two year follow up achieved a mean American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score of 75.0. Scores were similar for all three groups and for the various types of reconstructive procedures used. No correlation was found between postoperative talar declination angle and the AOFAS ankle-hindfoot score. Worker's compensation patients tended to have a poorer clinical outcome.

Adult↗

PubMed2005

Arthroscopic treatment of soft-tissue impingement lesions of the ankle in adolescents.

BACKGROUND: Ankle sprains are common injuries in adolescents. Most are treated conservatively with rest, ice, antiinflammatory medication, and rehabilitation. A small percentage of patients develop chronic pain and functional instability secondary to intraarticular soft-tissue impingement. This study evaluated the effectiveness of ankle arthroscopy for the treatment of functional instability of the ankle with pain specifically in adolescents between the ages of 13 and 19 years. METHODS: We evaluated 11 patients at an average of 25 (range 15 to 38) months after arthroscopic debridement. The American Orthopaedic Foot and Ankle Society (AOFAS) ankle and hindfoot score was used to evaluate outcomes. In addition, four questions were asked: 1) Are you satisfied with the outcome of your surgery? 2) Would you have the procedure again? 3) Would you recommend it to a friend? 4) Have you returned to your preinjury level of activity. RESULTS: The average postoperative AOFAS score was 95 (range 75 to 100). We found that 10 of 11 patients had good to excellent results with arthroscopic debridement of soft-tissue, intraarticular impingement lesions. All but one patient was satisfied with the procedure and all stated that they would have the procedure again. Two patients had repeat injuries and one subsequently developed reflex sympathetic dystrophy. These two patients had not yet returned to their preinjury level of activity at last followup. CONCLUSIONS: We found ankle arthroscopy to be a safe and effective means of treatment in adolescents with functional instability from soft-tissue ankle impingement.

Adolescent↗

PubMed2005

"Smile" incision: an approach for open reduction and internal fixation of calcaneal fractures.

MATERIALS: A consecutive group of 73 patients (77 calcaneal fractures) treated with open reduction and internal fixation through a smile-shaped lateral approach to the hindfoot were reviewed retrospectively. Inclusion criteria were a closed displaced intra-articular fracture of the calcaneus, no compartment syndrome, and adequate followup. Followup ranged from 4 months to 4 years. RESULTS: One patient had a deep wound infection that required removal of hardware and intravenous antibiotics. No deep dehiscence or flap necrosis occurred. Superficial dehiscence occurred in three patients (4%) and superficial necrosis was seen in nine patients (12%); all resolved with continued casting to protect the wound. Six patients (8%) complained of numbness or pain in the sural nerve distribution. No symptomatic neuromas were seen. Reflex sympathetic dystrophy occurred in three patients (4%); all resolved with sympathetic blocks. Only one patient required an additional procedure for treatment of a wound-related problem or infection. CONCLUSION: The "smile" incision provides good fracture exposure for reduction without added morbidity.

Calcaneus↗

PubMed1986

Dowel arthrodesis for degenerative arthritis of the tarsometatarsal (Lisfranc) joints.

A late complication of fracture with dislocation involving the tarsometatarsal joints of the foot (Lisfranc fracture) is progressive degenerative arthritis and pain. A dowel-graft arthrodesis technique is described that uses percutaneous bone graft from the iliac crest supplemented by crossed-wire fixation. The cases of 15 patients who underwent surgery between 1979 and 1982 in which this technique was used were reviewed retrospectively. These patients suffered from painful posttraumatic degenerative arthritis after tarsometatarsal joint fracture-dislocation. Follow-up evaluation (mean, 37 months) of 13 of the 15 patients demonstrated satisfactory pain relief in 11 patients, whereas 2 were dissatisfied. Complications included three instances of nonunion and one postsurgical reflex sympathetic dystrophy syndrome.

Adolescent↗

PubMed1988

New Jersey low contact stress total ankle replacement: biomechanical rationale and review of 23 cementless cases.

A congruent contact, unconstrained, multiaxial ankle replacement has been developed for use without cement. A talar onlay component with a trochlear surface and central fixation fin uses a cylindrical articulating axis that reproduces the lateral talar curvature. A tibial inlay component with a 7 degree anteriorly inclined short fixation stem uses a flat loading plate, recessed anatomically into the distal tibia to distribute tibial loads to the ankle joint. For both components, made of cast cobalt-chromium-molybdenum, a 275-micron pore-size, sintered-bead, porous coating is used to allow tissue ingrowth stabilization. A congruent ultra-high molecular weight polyethylene bearing is inserted between the metallic implants. Its upper surface is flat, whereas its lower surface conforms to the trochlear surface, thereby providing unconstrained, sliding cylindrical motion with low contact stress on the bearing surfaces. Contact pressure and collateral ligaments maintain ankle stability during both static and dynamic loading conditions. Clinically, 23 total ankle arthroplasties were performed in 21 patients. The follow-up period ranged from 24 months to 64 months with a mean of 35.3 months. Diagnoses included rheumatoid arthritis, 6 patients (26.1%); osteoarthritis, 4 patients (17.4%); post-traumatic arthritis, 10 patients (43.5%); avascular necrosis of the talus, 2 patients (8.7%), and painful ankle fusion, 1 patient (4.3%). Pain was the primary reason for surgery in all cases. Postoperatively, 87% of ankles had no pain or, at most, mild pain. Postoperative complications included poor wound healing in four ankles, reflex sympathetic dystrophy in two ankles, deep infection in one ankle, and one bearing subluxation. No ankle replacements were removed and no fusions were performed for failed implants, although one bearing was exchanged without disrupting the metallic elements. In this report, the suggestion is made that total ankle arthroplasty may have an improved application in various arthritis disorders when used with biologic fixation and unconstrained mobile bearings.

Adult↗

PubMed1992

Ankle arthroscopy: review and long-term results.

Ankle arthroscopy has evolved over the past decade as a diagnostic and an operative modality. Forty ankle arthroscopies were performed by the senior author (G.J.S.) for osteochondral fractures, chronic sprains unresponsive to conservative treatment, posttraumatic osteoarthritis, adhesions, locking, instability, synovitis, and ankle disability of undetermined cause. Thirty cases with at least 24 months of follow-up were reviewed. Complications occurred in two patients: reflex sympathetic dystrophy and a fibular fracture. Postoperatively, the patients were rated clinically as having 13% excellent, 60% good, 17% fair, and 10% poor results. However, 95% of the patients stated that they would undergo the same operation again if needed. Results were significantly better in those patients who had chondral or osteochondral defects as the diagnosis, and in noncompensation cases.

Adolescent↗