Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Predictive testing”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,297 records · Page 72Linked to original sources
PubMed1979

A short-term test to predict acceptable levels of exposure to airborne sensory irritants.

An animal model has been developed using decrease in respiratory rate in mice as an index of sensory irritation. Concentration-response relationships were developed for 11 sensory irritants. The RD50, defined as the concentration associated with a 50% decrease in respiratory rate, has been shown to have a predictable relationship to sensory irritation in man. By extending the accepted toxicological principle that the ratio lethal/toxic/effective/ineffective/acceptable in diet is 10/1/10(-1)/10(-2)/10(-3) dosage units to air concentrations, exposure guidelines can be proposed for TLVs, STELs, etc.

Air Pollutants↗
PubMed1996

Biological activity of recombinant human ZP3 produced in vitro: potential for a sperm function test.

The human zona binding test is the most predictive test of sperm function yet the availability of human zona severely restricts its clinical use. The primary aim of this study was to use a commercially available in-vitro transcription and translation system to produce immobilized recombinant human ZP3 (rhuZP3) on agarose beads. The biological activity of this preparation was examined using sperm binding and the acrosome reaction. Significantly higher levels of sperm binding to rhuZP3 beads (n = 12, P < 0.05) compared with controls were observed and there was a significant induction (n = 12, P < 0.01) in the acrosome reaction after overnight incubation at 37 degrees C in 5% CO2 in air. In conclusion, the in-vitro transcription and translation system can produce sufficient quantities of purified immobilized biologically active rhuZP3. These preliminary experiments will enable further refinements to be made so that a solid-phase sperm function test based on rhuZP3 coated beads is likely to be developed in the near future.

Acrosome↗
PubMed1979

Evaluation of tests for predicting the viability of axial pattern skin flaps in the pig.

The viability of axial pattern skin flaps in pigs was assessed by the use of intravenous fluorescein, intradermal injection of 133Xe in saline, intravenous 51Cr tagged red cells, and angiography. The results were correlated with flap survival at 4 days postoperatively. Intravenous fluorescein provided the most accurate method for prediction of viable tissue at the time of operation. There was no evidence of vascular perfusion in the distal portions of these flaps. These axial pattern flaps differed in their viability from similar flaps in humans, and anastomoses between discrete vascular territories were infrequent in pigskin.

Animals↗
PubMed1998

Bishop score: a poor diagnostic test to predict failed induction versus vaginal delivery.

BACKGROUND: We evaluated the accuracy of the Bishop score in predicting the likelihood of successful labor induction (entry into active phase) in nulliparous and multiparous women. METHODS: During an index year, all patients having induction of labor and a preinduction Bishop score were included in a standard protocol for cervical ripening and use of oxytocin. Receiver-operating characteristic (ROC) curves were constructed for Bishop scores (0 to 11) to predict abdominal delivery for failed induction (final cervical dilation <4 cm) versus vaginal delivery. RESULTS: Parturients who had vaginal delivery (n = 253) and those in whom attempted induction failed (n = 38) did not differ significantly with respect to maternal demographics, length of gestation, Bishop score and its distribution, and infant birth weight. The area under the ROC curve did not differ significantly from the area under the nondiagnostic line. CONCLUSION: The Bishop score appears to be a poor predictor of the outcome of labor induction.

Adult↗