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The dogged physical examination in the era of the C.A.T.

In attempting to evaluate the usefulness of the screening physical examination, it is necessary to remember that these recommendations are for asymptomatic individuals. When specific symptoms are present they need to be evaluated using physical examination and laboratory techniques that are appropriate to diagnosis. Although some of the same examination techniques are applicable for diagnostic evaluation, the goals, techniques, and interpretation of results are frequently different. One must also be aware of the past history of the patient, which may suggest specific risk factors even in the absence of current symptoms. A past history of breast cancer, for instance, might increase the intensity and scope of the physical examination. A history of alcohol consumption might turn an optimal mouth and throat examination into a diligent search. Additional elements of the physical examination may be pertinent to special high-risk groups. For instance, a mental status examination might be part of the routine examination for the elderly. Finally, it is important to remember that the findings on routine physical examination may themselves alter what should be done during the rest of the examination. For example, the finding of high blood pressure requires a search for arterial narrowing, coarctation, and renal bruits. Positive findings on a screening physical examination must always be supplemented by physical examination techniques designed for specific diagnosis. The recommended elements for a screening physical examination are an attempt to assemble reasonable conclusions based on current clinical use. They do not deal with the question of how frequently routine screening should be done. These recommendations need to be adjusted to the needs and views of each individual physician. One cannot help but be impressed by the medical, social, economic, and technical advantages of the physical examination. Although not a perfect technology, it serves important clinical functions in diagnosis and screening for the 1980s. The physical examination, like the human memory, will not be displaced easily even in this era of the C.A.T. scan, the radioimmunoassay, or the nuclear angiogram.

Humans↗

Physical fitness of obese school children in Hat Yai, southern Thailand.

259 primary school children (average age 9.2 years) were randomly selected from three groups of children whose weights-for-height were 90-110% (normal 111), > 110-120% (over weight 25), and > 120% (obesity 123) of reference values for Bangkok children. They underwent physical fitness tests which included measurement of speed (50 meters run), flexibility (sit-reach), abdominal strength and endurance (30 seconds sit-up), vital capacity (spirometer), and indirect maximum oxygen uptake (VO2 max-submaximal bicycle ergometer). The results showed that all physical fitness tests were statistically significantly different (p < 0.05) between groups, except for flexibility in boys. But for the girls, only 50 meters run, sit-up and VO2 max showed statistically significant differences (p < 0.05). In the comparison of physical fitness tests between sexes, normal weight boys did better than girls (p < 0.05) for all tests except flexibility. There were no statistically significant differences between sexes in overweight and obese children. This study demonstrated that physical fitness of obese children was worse than that of normal children in both sexes, especially as measured by 50 meters run, sit-up and VO2 max tests. Thus, promotion of exercise in obese children should be stimulated to develop better physical fitness and weight reduction. In comparison of physical fitness between the sexes, boys had better physical fitness than girls, significant in the normal weight group only. There is no definite explanation as to why increase in weight results in no difference of physical fitness between sexes. Lifestyle, physical skills, and genetic determinants should be considered for interpretation of physical fitness.

Analysis of Variance↗

Habitual physical activity is not associated with knee osteoarthritis: the Framingham Study.

We evaluated the potential risk factor by examining levels of habitual physical activity during middle age, and knee osteoarthritis (OA) in later years in the Framingham Cohort. Weight-bearing knee radiographs were obtained during the 18th biennial examination (1983-85), when the 1,415 subjects had a mean age of 73 years. Cohort members had been asked at 1954-57 and 1971-73 about the number of hours spent daily at various levels of physical activity, ranging from sedentary to heavy activity. Physical capacity measures, such as forced expiratory volume in one second and resting pulse rate, were also examined for association with OA. In the cohort, 97/589 men and 154/826 women had OA. We found no association between habitual physical activity and knee OA after adjusting for age, body mass index, knee injury, smoking and education. In the highest quartile of habitual physical activity compared to the least active, the aOR for men was 1.34 (95% CI: 0.66, 2.74) and for women was 1.09 (95% CI: 0.63, 1.90). There was no increase in the risk of knee OA with increasing physical activity in either men or women. Physical capacity measures were also unassociated with OA. Of interest, men with high levels of habitual physical activity had significantly elevated rates of asymptomatic osteophytes, [aOR = 2.14, (95% CI: 1.01, 4.54)], suggesting that habitual physical activity may influence development of osteophytes but not of more severe or symptomatic knee OA. In sum, habitual physical activity does not increase the risk of knee OA for men or women.

Aged↗

Physical activity among persons with disabilities--a public health perspective.

Regular physical activity, sports participation, and active recreation are essential behaviors for the prevention of disease, promotion of health, and maintenance of functional independence. This health behavior is essential for persons with and without disabilities. Population-based surveys have consistently demonstrated that persons with disabilities are less likely to be physically active, compared to persons without such limitations. However, these observations are based on relatively few surveys and are dependent on physical activity assessment methods that may not be sensitive and specific enough for persons with disabilities. Studies clearly demonstrate that many persons, representing a variety of selected disabilities, can adapt to increased levels of physical activity, as evidenced by alterations in various components of physical fitness. More importantly, other studies consistently provide evidence that participation in regular physical activity among persons with selected impairments and disabilities results in improved functional status and quality of life. Further efforts are critically needed in the area of the development of physical activity assessment methodology for persons with disabilities. Methods need to be developed that will provide survey researchers and those in public health the capacity to measure and monitor activity patterns of persons with disabilities. This information is important not only for public health officials but also health policy analysts, service providers, and disability advocacy groups. Further understanding of the role of physical activity in the maintenance of function and independence among persons with disabilities is needed. The understanding of environmental and social barriers to physical activity among persons with disabilities needs further exploration. Finally, physical activity determinants research among persons with disabilities, including the role of assistive technology as well as maximizing the intrinsic capacity of functional anatomy and physiology, needs to be addressed.

Adolescent↗

Physical inactivity in New Zealanders aged 60 years and older.

AIMS: To determine the prevalence of physical inactivity among older New Zealanders (> or = 60 years) and to examine the patterns of physical inactivity by sex, age, residential and cognitive status. METHODS: Information on housework-related and leisure-time physical activities obtained from the 910 controls in the Auckland Hip Fracture Study, was used to determine the prevalence of inactivity. Direct standardisation was used to extrapolate the inactivity prevalence figures from the study population to the general Auckland population. Logistic regression analyses were undertaken to examine the patterns of physical inactivity by sex, age, residential and cognitive status. RESULTS: Of the study participants 48.7% did not undertake any leisure-time physical activities and 15.6% did not undertake any physical activity. Extrapolation of these data to the Auckland population indicated that 38.9% of older people do not participate in any leisure time activity and 6.1% do not partake in any physical activity. Non-participation in physical activities was shown to be greater for women (odds ratio = 1.92; 95% confidence interval: 0.98-4.07); those in the older age groups (> or = 90 years, 7.00; 1.88-45.60); those living in institutions (6.52; 4.01-10.64); and for those who were cognitively impaired (13.96; 7.06-28.92). CONCLUSION: Policies and programmes should focus on encouraging and supporting older people to become physically more active, by engaging in activities in which they enjoy participating; by educating older people as to the feasibility and benefits of physical activities, including maintenance of an independent active life; and by encouraging residents in institutions to continue their involvement in housework-related activities, such as gardening, home maintenance and general housework.

Aged↗

Evaluation of physical activity measured via accelerometry in rural fourth-grade children.

Interest in the benefits of exercise has prompted increased research examining the relationship between physical activity and health status in adults. More recently, considerable research effort has been directed toward the role of physical activity in young children as a precursor to adult physical fitness. The purpose of this study was to estimate the relationship between physical activity measured via accelerometry and body mass index, body mass, body composition, and physical fitness in fourth-grade boys and girls during physical education lessons. 54 fourth-grade students in rural Pennsylvania (28 girls, M age 9.6, SD = .56; 26 boys, M age 9.5, SD = .51) were subjects. Girls were significantly less active during all lessons measured (p < .001). The results of linear regression analyses indicated that physical activity was negatively associated with body mass index, body mass, and body fat percentage (p < .05), and positively associated with physical fitness (VO2max) (p < .01). These data indicate the need for curricular intervention to motivate girls to increase their activity during structured physical education lessons and demonstrate the efficacy of the body mass index as a screening tool within the schools.

Adipose Tissue↗

Physical activity and functional status in community-dwelling older women: a 14-year prospective study.

BACKGROUND: Short-term prospective studies have shown physical activity to be related to functional status. To our knowledge, the association between physical activity levels and functional status over a longer period has not been established. METHODS: Two hundred twenty-nine older women (mean age, 74.2 years) who were involved in a randomized controlled walking intervention from 1982 to 1985 were subsequently followed up until December 1999. Physical activity was assessed in 1985, 1995, and 1999 using a physical activity questionnaire and a physical activity monitor. In 1999, functional status was assessed by self-report and performance-based measures. RESULTS: Subjective and objective measures of physical activity in 1985 independently predicted gait speed in 1999 after controlling for age, chronic conditions, and activity limitation (subjective model-adjusted R2 = 0.09 [P=.03]; and objective model-adjusted R2 = 0.13 [P=.008]). The consistency of physical activity participation from 1985 to 1995 was also related to functional status in 1999. Women who were always active had the best functional status and women who were always inactive had the worst functional status. For difficulty with activities of daily living: those always active, 17 (37.8%) of 45 women; those inconsistently active, 24 (40.0%) of 60 women; and those always inactive, 39 (59.1%) of 66 women (chi2 for trend P=.02). For score on the Physical Performance Test: those always active, 24.9; those inconsistently active, 24.5; and those always inactive, 23.8 (analysis of variance with linear contrasts P=.04). For gait speed: those always active, 1.17 m/s; those inconsistently active, 1.15 m/s; and those always inactive, 1.03 m/s (analysis of variance with linear contrasts P=.002). CONCLUSION: We demonstrated a significant relation between physical activity during a 14-year period and current functional status in older women, thus suggesting that physical activity plays a role in maintaining functional ability later in life.

Activities of Daily Living↗

Psychosocial correlates of physical activity in healthy children.

BACKGROUND: Understanding the determinants of physical activity in children is critical for the treatment and prevention of childhood obesity. Social-cognitive theory has been used to understand behavioral patterns in children. OBJECTIVES: To explore the relationship between health beliefs, self-efficacy, social support, and sedentary activities and physical activity levels in children and to examine the relationship between physical activity and children's self-esteem. METHODS: Ninety-two children aged 10 to 16 years completed the study. Physical activity was monitored for 1 week with a motion detector (Actitrac; IM Systems, Baltimore, Md). Moderate-level activity and high-level activity were defined based on the results of treadmill testing. Health beliefs, self-efficacy, social influences, and time spent in sedentary behaviors were determined through questionnaires. Self-esteem was measured using the Piers-Harris Children's Self-Concept Scale. Chronic anxiety was measured with the Revised Children's Manifest Anxiety Scale. RESULTS: There was a significant decline in physical activity levels between ages 10 and 16 years, particularly in girls. Preteen girls spent approximately 35% more time in low- and high-level activity than did teenage girls (P<.001). Overall, children spent 75.5% of the day inactive, with a mean +/- SD of 5.2 +/- 1.8 hours watching television, sitting at the computer, and doing homework. In contrast, only 1.4% of the day (12.6 +/- 12.2 minutes) was spent in vigorous activity. Time spent in sedentary behaviors was inversely correlated with the amount of moderate-level activity (P<.001) but not high-level activity. In contrast, time spent in high-level activity correlated with self-efficacy scores (P<.001) and social influences scores (P<.005). High-level physical activity was also associated with improved self-esteem (P<.05). Higher health beliefs scores were not correlated with physical activity levels. CONCLUSIONS: Children and adolescents are largely sedentary. Correlates of high- and low-level physical activity are different. Time spent on sedentary activities is inversely correlated with moderate-level activity, while self-efficacy and social influences are positively correlated with more intense physical activity. In addition, increased high-level physical activity is an important component in the development of self-esteem in children.

Adolescent↗

Diet, physical activity, and sedentary behaviors as risk factors for overweight in adolescence.

BACKGROUND: The proportion of overweight adolescents has increased, but the behavioral risk factors for overweight youth are not well understood. OBJECTIVE: To examine how diet, physical activity, and sedentary behaviors relate to overweight status in adolescents. DESIGN AND SETTING: Baseline data from the Patient-Centered Assessment and Counseling for Exercise Plus Nutrition Project, a randomized controlled trial of adolescents to determine the effects of a clinic-based intervention on physical activity and dietary behaviors. PARTICIPANTS: A total of 878 adolescents aged 11 to 15 years, 42% of whom were from minority backgrounds. MAIN OUTCOME MEASURE: Centers for Disease Control and Prevention body mass index-for-age percentiles divided into 2 categories: normal weight (<85th percentile) and at risk for overweight plus overweight (AR + O) (>or=85th percentile). RESULTS: Overall, 45.7% of the sample was classified as AR + O with a body mass index for age at the 85th percentile or higher. More girls from minority backgrounds (54.8%) were AR + O compared with non-Hispanic white girls (42%) (chi(2)(1) = 7.6; P =.006). Bivariate analyses indicated that girls and boys in the AR + O group did fewer minutes per day of vigorous physical activity, consumed fewer total kilojoules per day, and had fewer total grams of fiber per day than those in the normal-weight group. Boys in the AR + O group also did fewer minutes per day of moderate physical activity and watched more minutes per day of television on nonschool days than normal-weight boys. Final multivariate models indicated that independent of socioeconomic status (as assessed by household education level), girls had a greater risk of being AR + O if they were Hispanic or from another minority background (odds ratio [OR] = 1.65; 95% confidence interval [CI], 1.09-2.49) and a reduced risk of being AR + O as minutes per day of vigorous physical activity increased (OR = 0.93; 95% CI, 0.89-0.97). A low level of vigorous physical activity was the only significant risk factor for boys being AR + O (OR = 0.92; 95% CI, 0.89-0.95). Analyses based on meeting behavioral guidelines supported these findings and showed that failing to meet the 60 min/d moderate to vigorous physical activity guideline was associated with overweight status for both girls and boys. In addition, boys who failed to meet sedentary behavior and dietary fiber guidelines were more likely to be overweight. CONCLUSIONS: Of the 7 dietary and physical activity variables examined in this cross-sectional study, insufficient vigorous physical activity was the only risk factor for higher body mass index for adolescent boys and girls. Prospective studies are needed to clarify the relative importance of dietary and physical activity behaviors on overweight in adolescence.

Adolescent↗

Impact of adolescent mental disorders and physical illnesses on quality of life 17 years later.

OBJECTIVE: To investigate associations of mental disorders and physical illnesses during adolescence with quality of life (QOL) 17 years later. DESIGN: The Children in the Community Study, a prospective longitudinal investigation. SETTING: Upstate New York. PARTICIPANTS: A community-based sample of mothers and their offspring were interviewed. MAIN OUTCOME MEASURES: Axis I disorders and Axis II personality disorders and physical illnesses were assessed by self-report and mother report in 1985-1986. Outcome indicators of QOL were assessed in 2001-2004. RESULTS: Compared with participants without adolescent illness or disorder, those with a history of physical illness reported poorer physical health (mean difference [MD], -4.8); those with a history of an Axis I disorder reported poorer physical health (MD, -8.0) and more problematic social relationships (MD, -4.5); and those with a history of personality disorder reported poorer physical health (MD, -8.2), more problematic social relationships (MD, -5.0), lower psychological well-being (MD, -3.6), and more adversity within their environmental context (MD, -4.6) in adulthood. Comorbid physical illness and mental disorder were associated with all 5 QOL domains (MD, -3.1 to -11.9). After adjusting for all demographic variables and comorbidity, associations remained between physical illness and poor physical health (effect size [ES], -0.33); an Axis I disorder and problematic social relationships (ES, -0.37); and personality disorder and problematic social relationships (ES, -0.36), low psychological well-being (ES, -0.23), impaired role function (ES, -0.24), and an adverse environmental context (ES, -0.50). CONCLUSIONS: Mental disorders may have more adverse long-term associations with QOL than do physical illnesses. Adolescent personality disorders may have a more adverse impact on adult QOL than do adolescent Axis I disorders.

Adolescent↗

Objectively measured physical activity in sixth-grade girls.

OBJECTIVES: To describe the objectively measured physical activity characteristics of a diverse sample of sixth-grade girls, to examine influences on physical activity, and to report compliance with physical activity guidelines. DESIGN: Cross-sectional study. SETTING: Six locations across the United States. PARTICIPANTS: A total of 1578 sixth-grade girls. Accelerometers were worn for 7 days, and data for 6 days were included in the analyses. Main Exposures Race/ethnicity, free or reduced-price lunch, and geographic region. MAIN OUTCOME MEASURES: Six operational definitions of adequate activity (60 or 30 minutes of daily moderate to vigorous physical activity at or above 4.6, 3.8, or 3.0 metabolic equivalents) were used to examine whether girls met physical activity guidelines. RESULTS: Average times spent in sedentary, light, moderate, and vigorous activities were 460, 342, 18, and 6 min/d, respectively. White girls were more active than girls in other race/ethnic groups, and girls who did not receive free or reduced-price lunch were more active than girls who did. Girls in western states were most active. Percentages of girls in compliance with the 6 thresholds for adequate activity varied widely and ranged from 0.6% to 100.0%. CONCLUSIONS: When physical activity is measured objectively and a 4.6-metabolic equivalents cut point for moderate to vigorous physical activity is used, most sixth-grade girls do not meet guidelines for adequate physical activity. One notable finding was the effect of different accelerometer scoring protocols on estimates of compliance. Conceptual and empirical work is needed to define appropriate physical activity for youth using objective physical activity measures.

Child↗

Physical abuse among high school students. Prevalence and correlation with other health behaviors.

OBJECTIVE: To better understand the epidemiology of physical abuse among adolescents. DESIGN: School-based survey of students in grades 9 through 12. SETTING: Twenty-five schools throughout Oregon in 1993. MAIN OUTCOME MEASURES: Prevalence of ever being physically abused, prevalence of most recent occurrence of physical abuse, and correlation of physical abuse with high-risk health behaviors. RESULTS: Of the 1957 respondents, 31.5% reported having ever been physically abused, with female subjects (34.6%) more likely than male subjects (28.0%) to have ever been abused. Overall, 3.7% of students had been physically abused in the past week, 7.8% in the past month, and 16.3% in the past year. Based on multivariate models, students physically abused in the past year were more likely than students who had never been physically abused to engage in a variety of high-risk behaviors; these included weapon carrying (odds ratio, 1.9), suicidal ideation (odds ratio, 2.1), cigarette smoking (odds ratio, 1.8), cocaine use (odds ratio, 3.2), or multiple sexual partners (odds ratio, 1.9). CONCLUSIONS: Physical abuse, an important problem among high school students, is correlated with many high-risk behaviors. Using consistent definitions, periodic surveys of children about physical abuse and other types of violent behavior are needed to provide better estimates of the extent of these problems.

Adolescent↗

Using internet technology to deliver a home-based physical activity intervention for patients with rheumatoid arthritis: A randomized controlled trial.

OBJECTIVE: To compare the effectiveness of 2 Internet-based physical activity interventions for patients with rheumatoid arthritis (RA). METHODS: A total of 160 physically inactive patients with RA who had a computer with Internet access were randomly assigned to an Internet-based physical activity program with individual guidance, a bicycle ergometer, and group contacts (individualized training [IT] group; n = 82) or to an Internet-based program providing only general information on exercises and physical activity (general training [GT] group; n = 78). Outcome measures included quantity of physical activity (questionnaire and activity monitor), functional ability, quality of life, and disease activity (baseline, 3, 6, 9, and 12 months). RESULTS: The proportion of physically active patients was significantly greater in the IT than in the GT group at 6 (38% versus 22%) and 9 months (35% versus 11%; both P < 0.05) regarding a moderate intensity level for 30 minutes in succession on at least 5 days a week, and at 6 (35% versus 13%), 9 (40% versus 14%), and 12 months (34% versus 10%; all P < 0.005) regarding a vigorous intensity level for 20 minutes in succession on at least 3 days a week. In general, there were no statistically significant differences regarding changes in physical activity as measured with an activity monitor, functional ability, quality of life, or disease activity. CONCLUSION: An Internet-based physical activity intervention with individually tailored supervision, exercise equipment, and group contacts is more effective with respect to the proportion of patients who report meeting physical activity recommendations than an Internet-based program without these additional elements in patients with RA. No differences were found regarding the total amount of physical activity measured with an activity monitor.

Activities of Daily Living↗

Blood coagulability and fibrinolytic activity before and after physical training during the recovery phase of acute myocardial infarction.

The effects of physical training on hemostatic parameters were evaluated in 56 postmyocardial infarction (MI) patients before and after one month of systematic physical training and in 30 control post-MI patients, who did not undergo such training. There were no significant changes in prothrombin time (PT) and alpha 1-antitrypsin (alpha 1AT) at the beginning and end of the study in either group. Levels of fibrinogen, Factor VIII: C (VIII:C) and von Wildebrand antigen (vWf:Ag), and activities of ATIII and plasminogen (Plg) were significantly decreased in the group with physical training (p less than 0.05), while values were unchanged in the control group. Hematocrit, platelet counts, and alpha 2-plasmin inhibitor (alpha 2PI) activities also decreased in the physical training group (p less than 0.05). In contrast, these variables increased in the control group (p less than 0.05). Activated partial thromboplastin time (aPTT) tended to be prolonged in the group with physical training, while it was shortened in the control group. In a subset of 20 patients with physical training, resting levels of plasmin-alpha 2PI complex (PIC), thrombin-antithrombin III complex (TAT), protein-C (P-C:Ag), plasminogen activator inhibitor-1 (PAI-1), VII:C, and P-C activities had significantly decreased after one month of physical training (p less than 0.05), although tissue plasminogen activator activities remained unchanged. Physical training appeared to suppress coagulability as indicated by the decrease in fibrinogen, VIII:C, vWf:Ag, VII:C, and TAT, and prolongation of aPTT. The decrease in plasminogen, t-PA:Ag, alpha 2PI, PAI-1, and PIC after physical training may result from the decreased coagulability. In conclusion, physical training appears to induce a suppression of the coagulation system in patients in the recovery phase of MI.

Adult↗

Childhood conduct problems, stages of Alzheimer's disease, and physical aggression against caregivers.

OBJECTIVE: To assess the prevalence of physical aggression against caregivers by Alzheimer's patients. METHOD: One hundred and ninety-eight individuals with dementia, primarily Alzheimer's disease (AD) were evaluated with the Cohen-Mansfield Agitation Inventory, the Mini Mental Status Examination, two measures of Activities of Daily Living, portions of the Conflict Tactics Scale to measure physical aggression against partner, questions about conduct problems during childhood/adolescence of the patients, and chart records of delusion and paranoia. RESULTS: 25% of the patients engaged in physical aggression against their caregivers in the past year, and 33% of the patients engaged in some act of physical aggression against any individual in the past two weeks. Physical aggression against a caregiver was more likely in the middle (34%) than the early stage of AD (4%). Physical aggression against a partner and agitation were more likely if the patient had a history of symptoms of conduct disorder. Delusions and paranoia were both associated with general physical aggression and general verbal aggression but not physical aggression against a caretaker. CONCLUSIONS: 25% of Alzheimer's disease and Multi-Infarct dementia patients engaged in acts of physical aggression against their caregivers. The rate of aggression seen in this clinical sample was much higher than the rate of physical aggression in a community sample of the elderly.

Activities of Daily Living↗

Physical activity and the risk of colon cancer among women: a prospective cohort study (United States).

Physical activity has frequently been reported to decrease the risk of colon cancer in men, but data on the relation of physical activity to colon cancer risk in women have generally been less consistent. To further investigate the relationship of physical activity with colon cancer risk in women, we studied a cohort of 31,783 US women participating in the Breast Cancer Detection Demonstration Project Follow-up Study. Information on daily physical activity over the past year was ascertained using a self-administered questionnaire at study baseline. The Cox proportional hazards model was used to estimate relative risks (RRs) relating physical activity to the risk of incident colon cancer. During 270,325 person-years of follow-up, 243 colon cancer cases were identified. No association was observed between physical activity and the subsequent risk of colon cancer. The multivariable RRs of colon cancer across increasing quintiles of total physical activity were 1.0, 1.45, 1.16, 1.27 and 1.15 (95% CI: 0.76, 1.75; p(trend) = 0.77). The multivariable RRs comparing women at the extremes of moderate and vigorous physical activity, respectively, were 1.07 (95% CI: 0.70, 1.62) and 1.10 (95% CI: 0.78, 1.55). The relationship between physical activity and colon cancer risk did not vary by anatomic subsite or across subgroups defined by age, body mass, dietary fiber intake, menopausal status, menopausal hormone use or aspirin use. The results of this large prospective cohort study among women do not support the hypothesis that physical activity is related to a lower incidence of colon cancer.

Adult↗

The association between recreational physical activity and mammographic density.

Physical activity has been associated with a reduced risk of breast cancer. However, little is known about the association between recreational physical activity and mammographic density. We examined the association between recreational physical activity and mammographic density using mammograms from 375 white and African American women without breast cancer who served as controls in the Los Angeles component of the Women's Contraceptive and Reproductive Experiences Study. We used data from 5 time periods of activity in the statistical analysis: from menarche to mammogram screening, the first 3 and 10 years after menarche, the most recent 10 years and the 3 years prior to mammogram screening. Lifetime history of recreational physical activity was obtained through interviews using a structured questionnaire. We used multiple linear regression to estimate least-squared mean values of absolute and percent mammographic density within categories of physical activity. Overall, we found no statistically significant evidence that physical activity reduced absolute or percent mammographic density. We observed a modest positive association between lifetime physical activity and percent mammographic density (p for trend = 0.04) among younger women, and between recent physical activity and percent density among both younger (<50 years, p for trend = 0.09) and older (> or =50 years, p for trend = 0.06) women, but these associations diminished after additionally adjusting for body mass index (BMI) (all p > or = 0.10). However, among women younger than 50 years, we found some evidence for a protective effect of "strenuous" physical activity in the first 3 years after menarche, with a nonstatistically significant inverse association with both absolute (p for trend = 0.07) and percent (p for trend = 0.08) mammographic density after adjustment for BMI. Our results suggest that physical activity is not a strong predictor of mammographic density.

Adult↗

Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition Cohort.

Research conducted predominantly in male populations on physical activity and lung cancer has yielded inconsistent results. We examined this relationship among 416,277 men and women from the European Prospective Investigation into Cancer and Nutrition (EPIC). Detailed information on recent recreational, household and occupational physical activity, smoking habits and diet was assessed at baseline between 1992 and 2000. Relative risks (RR) were estimated using Cox regression. During 6.3 years of follow-up we identified 607 men and 476 women with incident lung cancer. We did not observe an inverse association between recent occupational, recreational or household physical activity and lung cancer risk in either males or females. However, we found some reduction in lung cancer risk associated with sports in males (adjusted RR = 0.71; 95% confidence interval 0.50-0.98; highest tertile vs. inactive group), cycling (RR = 0.73; 0.54-0.99) in females and non-occupational vigorous physical activity. For occupational physical activity, lung cancer risk was increased for unemployed men (adjusted RR = 1.57; 1.20-2.05) and men with standing occupations (RR = 1.35; 1.02-1.79) compared with sitting professions. There was no evidence of heterogeneity of physical activity associations across countries, or across any of the considered cofactors. For some histologic subtypes suggestive sex-specific reductions, limited by subgroup sizes, were observed, especially with vigorous physical activity. In total, our study shows no consistent protective associations of physical activity with lung cancer risk. It can be assumed that the elevated risks found for occupational physical activity are not produced mechanistically by physical activity itself but rather reflect exposure to occupation-related lung cancer risk factors.

Adult↗