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[Vacuum therapy in dermatology: a review].

Modern wound therapy is developing continuously. Vacuum therapy is an established procedure to treat wounds. Available on the market is, among others, the V.A.C. (Vacuum Assisted Closure) therapy system. Here, we report the various effects of the vacuum therapy on wounds such as reducing the bacterial contamination, improving granulation and microcirculation and focus on the practical use of the V.A.C., possible complications, contraindications and the economic aspects of the therapy. Since V.A.C. therapy allows rapid mobilization of patients especially with postoperative or posttraumatic wounds, infrequent dressing changes and relative analgesia, this treatment modality is well-accepted by patients with acute or chronic wounds. One explanation for the high acceptance on part of the therapists and the widespread use of the method are the excellent clinical results.

Equipment Design↗

Intravenous cannula fixing and dressing--comparison between the use of transparent polyurethane dressing and conventional technique.

A sterile, disposable, polyurethane intravenous catheter dressing (OpSite; Smith & Nephew), was compared with a conventional dressing for both convenience and cost. Despite lack of familiarity, the use of OpSite proved as easy and acceptable as the traditional non-sterile control method. OpSite was also as durable and would appear, on calculation, to be cheaper when intravenous therapy lasts longer than a day. OpSite is therefore recommended as the intravenous dressing of choice. Its use, or that of a similar sterile disposable product, should be considered mandatory for paediatric and other patients in whom sterility is vital, and in situations where intravenous infusion will continue for more than 24 hours.

Antisepsis↗

[Use of Diprivan in burn patients].

The use of propofol should be avoided in the first 48 hours after a burn injury, as a major haemodynamic instability characterizes this period. For excision and/or grafting, propofol is mainly used as an induction agent. Maintenance of anaesthesia requires higher doses, often in the range of 15 mg.kg-1.h-1, and varying with each patient and the stage of the burn. Propofol is most appropriate in anaesthesia for dressing changes, considering the repetition of the procedures, interfering least with enteral nutrition and the quality of recovery, considered as essential. Combined with alfentanil or fentanyl, the dose of propofol is titrated to obtain the desired effect, from a simple sedation with patient co-operation to total anaesthesia.

Anesthesia, Intravenous↗

[Use of Regenkur hydrogel in the local treatment of burns].

In local treatment of patients with II-IIIA degree burns with the area of from 1.5 to 20% of body surface, the use of hydrogel on the basis of a polymeric sorbent Regencur contributed to attenuation of pain, 2-fold reduction in number of dressings, creation of favourable conditions for course of the reparative processes in burn wounds.

Adolescent↗

Are closed dressing of burns in children effective?

Burns are a common home accident world-wide. Sixty-six patients in the Paediatric Department were treated by closed dressing and were followed up for a period of two months. The peak age was between 2-5 years with the causative agent being hot water. The majority of burns were mild to moderate in severity, that is, first and second degree burns. In the majority of cases, a definite dressing was applied within 24 hours of the burn. 60% of patients were discharged home within 15 days of admission. Three patients died from sepsis (one patient) and probable electrolyte imbalances (2 patients). Other complications were few. The result show that closed dressing of burns in our experience definitely has advantages over the traditional open methods and is to be preferred.

Anti-Infective Agents, Local↗

Use of biosynthetic dressings in paraneoplastic pemphigus.

A 77-year-old woman with paraneoplastic pemphigus and non-Hodgkin's lymphoma was treated with supportive therapy and oral prednisone. Biobrane, a biosynthetic dressing, was later applied to the extensive areas of erosion to assist in pain management and to provide a temporary barrier function. She reported an improvement in the pain associated with the areas of erosion. The use of biosynthetic dressings in blistering disorders has not been previously reported. Standard dressings such as silver sulfadiazine are messy and can cause discomfort with frequent changing. We feel that this is an area that warrants further evaluation as it may contribute to the overall treatment and comfort cares of these patients.

Aged↗

Disinfection by antiseptics in management of postoperative surgical wounds in urologic operations.

The objective of this study was to confirm that frequent disinfection by antiseptics is unnecessary on surgical wounds of urologic operations. Patients who received urologic operations were divided into 3 groups that had the same surgical dressings but different frequencies of disinfection and different antiseptics used. Surgical wounds were evaluated clinically and bacteriologically for the period until removal of sutures. Of the 97 patients randomly recruited for the study, 3 developed surgical-site infection (SSI). There was no significant difference in the incidence of SSI among the 3 groups. Bacterial counts of surgical wounds increased over time after operation, to similar extents in the 3 groups. The major isolate was Staphylococcus epidermidis, one of the normal florae on the skin. This strain was found at almost equal frequencies in all groups. In conclusion, our study suggested that covering with the surgical dressing without frequent disinfection by antiseptics was effective for prevention of SSI. Thus, traditional frequent disinfection should be abandoned.

Anti-Infective Agents, Local↗

[Vacuum dressing in septic wound treatment].

During the last 2 years, we used the vacuum-sealing technique in more than 300 patients. We have seen several advantages: clean and sterile wound dressing and safe wound healing. In addition, we have used the technique successfully in infected areas in combination with alloplastic material. The only problem we found is the dependency on operating theatres and a vacuum. We think the technique should be recommended for septic wounds in surgery.

Combined Modality Therapy↗

The vacuum assisted closure device: a method of securing skin grafts and improving graft survival.

HYPOTHESIS: Use of the vacuum assisted closure device (VAC) for securing split-thickness skin grafts (STSGs) is associated with improved wound outcomes compared with bolster dressings. DESIGN: Consecutive case series. PATIENTS AND SETTING: Consecutive patients at a level I trauma center requiring STSG due to traumatic or thermal tissue loss during an 18-month period. MAIN OUTCOME MEASURE: Repeated skin grafting due to failure of the initial graft. Secondary outcome measures included dressing-associated complications, percentage of graft take, and length of hospital stay. RESULTS: Sixty-one patients underwent STSG placement. Indications for STSG were burn injury (n = 32), soft tissue loss (n = 27), and fasciotomy-site coverage (n = 2). Patients were treated with the VAC (n = 34) or the bolster dressing (n = 27). The VAC group required significantly fewer repeated STSGs (1 [3%] vs 5 [19%]; P =.04). Two additional graft failures occurred in the no-VAC group, but repeated STSGs were refused by these patients. No difference was seen between the groups in age, percentage of graft take, or hospital length of stay. The no-VAC group had significantly larger grafts (mean +/- SD, 984 +/- 996 vs 386 +/- 573 cm(2); P =.006). The patients requiring repeated STSGs (n = 6) did not have significantly larger grafts than those not requiring repeated STSGs (mean +/- SD, 617 +/- 717 vs 658 +/- 857 cm(2); P =.62). No dressing-associated complications occurred in the VAC group. CONCLUSIONS: The VAC provides a safe and effective method for securing STSGs and is associated with improved graft survival as measured by a reduction in number of repeated STSGs.

Adult↗

Duoderm application on scalp donor sites in children.

In a search for an invisible skin donor site and a comfortable dressing for the donor site, a study was designed in which the scalp was used as the donor site and Duoderm was applied as the dressing. The study contained 18 children with minor burns. A Duoderm dressing on scalp donor sites showed a normal healing time. In using the scalp as a donor site the patient can be mobilized very quickly after the operation and the scar is hidden and invisible 1 month postoperation.

Bandages, Hydrocolloid↗

Treatment-resistant pain and distress during pediatric burn-dressing changes.

Recent research has suggested some efficacy for the use of hypnosis in the control of pain and distress in a pediatric population undergoing painful medical procedures. Here, we study a sample (N=23) of pediatric subjects undergoing burn-dressing changes and receiving either an imagery-based or control (social-support) treatment. Subjects' levels of distress were assessed with the Observational Scale of Behavioral Distress. Results indicated that distress behaviors in this population can be measured reliably using this scale. However, no support was found for the main hypothesis that imagery treatment would be superior to control treatment in the alleviation of distress, nor were these treatments effective in comparison to baseline conditions. We discuss the formidable problem that burn and dressing-change pain presents, as well as the reasons why this treatment attempt might have failed to have the predicted effects. We also discuss important developmental considerations regarding the adequate assessment of pain and distress.

Burns↗

Effect of dry fibrin sealant dressings versus gauze packing on blood loss in grade V liver injuries in resuscitated swine.

BACKGROUND: We conducted this study to determine whether the dry fibrin sealant dressing (DFSD) would stop bleeding from a grade V liver injury and to evaluate the effects of leaving the absorbable DFSD in survival animals. METHODS: Twenty-four swine (40+/-3.0 kg) received a uniform grade V liver injury and were randomized to one of four 1-hour treatment groups: (1) gauze packing, (2) DFSD, (3) immunoglobulin G placebo dressing, and (4) no treatment. All animals were resuscitated with lactated Ringer's solution. Total blood loss (TBL), mean arterial pressure, resuscitation volume, and laboratory data were monitored for 1 hour after injury. Four swine were treated with the DFSD after grade V injury and allowed to survive for 7 or 14 days. RESULTS: The TBL was 1,104+/-264 mL (mean +/- SEM), 544+/-104 mL, 4,223+/-1,555 mL, and 6,026+/-1,020 mL for groups 1, 2, 3, and 4 respectively. TBL in DFSD animals was less than that in animals treated with gauze packing (p = 0.06). Grade V injuries were uniform among the 1-hour groups, and no evidence of intrahepatic abscess, unusual adhesions, or hepatic vein, vena caval, or pulmonary thromboses were noted in the long-term survival animals. CONCLUSION: In this model of grade V liver injury, blood loss with the DFSD was 51% of that observed with standard gauze packing (not statistically different). Initial survival data revealed no complications attributable to the fibrin dressing. DFSD may provide simple, rapid, and definitive hemorrhage control in life-threatening liver injuries without the need for reoperation.

Animals↗

Aquacel Ag in the management of partial-thickness burns: results of a clinical trial.

Aquacel Hydrofiber is a moisture retentive topical dressing that has been demonstrated to be safe and efficacious for the management of partial-thickness burns, showing parity for most dressing related aspects to cadaver skin for this indication. Recently, 1.2% w/w silver has been added to the Aquacel Hydrofiber, to create Aquacel Ag. This new material releases silver within the dressing for up to two weeks, and it is this duration that differentiates it from other sustained release silver delivery products indicated for burn management. The dressing was tested in a phase II noncomparative trial in superficial, mid dermal, and mixed partial-thickness burns. Percentage and speed of reepithelialization were satisfactory and appear to be similar at least to results noted with silver sulfadiazine, although, no direct comparisons were performed in this study. Pain reduction between baseline and postburn day number three and five was statistically significant. Conformability, general ease of use and other functional dressing properties were rated very positively. Overall, Aquacel Ag combines several properties known to be beneficial for the management of partial-thickness burns and is a very good choice for superficial and mid-thickness burn injuries.

Adult↗

3M Cavilon No Sting Barrier Film in the protection of vulnerable skin.

Skin often becomes vulnerable in incontinent patients or following the use of aggressive adhesive tapes and dressings. Until recently the only products available for use on such skin have been ointments, creams and alcohol-based products. 3M Health Care has launched a range of no sting barrier film applicators that provide skin protection in many scenarios, but in a product that does not sting or cause pain on application.

Humans↗

Clinical evaluation of a polymeric membrane dressing in the treatment of pressure ulcers.

The healing effects of the Ferris polymeric membrane dressing were tested in a 70-day evaluation of 18 ulcers on 13 elderly subjects with Stage I, II, and III pressure ulcers. The mean length of time these ulcers had been present prior to the trial dressing was 144 days with 50% of the ulcers (n = 9) present for 75 days or longer. Over 60% of the ulcers were completely healed and over 94% were improved during the study.

Aged↗

Treatment of dermal depth burn wounds with an antimicrobial agent-releasing silicone gel sheet.

Silicone gel sheets containing 0.02 per cent Ofloxacin were used in the treatment of 24 patients with a total of 27 dermal depth burn wounds. The gel provided a continuing drug delivery system from the dressing to the wound. Clinically the silicone gel sheets did not adhere to the wound and could be removed easily without pain. No infection developed in any of the dermal depth burn wounds treated with the gel sheets. The silicone gel sheets were found to promote prompt epithelialization in 16 burn wounds of superficial dermal depth (mean 8.4 days) compared with ointment-impregnated gauze dressings (mean 14 days, P less than 0.01). There was less pain and discharge by macroscopic observation of the absorbent materials from both dressings. In nine wounds of mixed superficial and deep dermal burn, the silicone gel also provided prompt epithelialization (mean 12 days) compared to the control wounds (mean 22 days, P less than 0.01).

Adolescent↗

Tegaderm transparent dressing (3M) for the treatment of chronic exposure keratopathy.

We report an effective alternative treatment of profound chronic exposure keratopathy in a proptotic eye due to intraorbital extension of basal cell carcinoma. The corneal surface gradually reepithelialized in a 6-week period after the first application of Tegaderm transparent dressing (3M, St. Paul, MN, U.S.A.) with instillation of antibiotic ointment on the ocular surface. The patient has been comfortable with an intact epithelial surface, a vascularized cornea, and nonirritated surrounding skin after changing the Tegaderm dressing daily for 15 months. There was no evidence of recurrent corneal ulceration or infiltrations. We conclude that Tegaderm represents a useful treatment of exposure keratopathy due to chronic proptosis.

Aged↗