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At least 1,297 records · Page 72Linked to original sources
PubMed1986

[Current status of detection and treatment of malignant nasal and paranasal sinus tumors. 1. Pathology, diagnosis and staging of nasal and paranasal sinus tumors].

Malignant tumours of the nasal cavity and paranasal sinuses are uncommon amounting to 0.3-1% of all tumours and 3%-5% of carcinomas of the upper respiratory tract. Modern diagnostic techniques include endoscopy and computer tomography. Prognosis and therapy depend on the histological type, site of origin and extent of the tumour. The variety of possible treatment modalities demands individual therapy planning. A combined surgical and radiotherapeutic approach, possibly supplemented by small volume intracavitary brachytherapy or polychemotherapy in some defined histological tumour types, has been generally accepted, enabling a five year survival rate of 35%-45% to be achieved. The causes for failure are firstly local persistence of tumour (18%) or a local recurrence (37%). The cumulative recurrence rate after one and two years was 76% and 95% respectively. Late recurrences occur in 2.5% of cases. The complication rate with combined-modality therapy reaches 27% with minor complications occurring in 12% and major complications in 15% especially affecting the irradiated homolateral eye. The present statistical results show a number of weak points that cast doubt on their validity. We recommend a controlled, prospective, randomised, multi-centre and multi-disciplinary study to define the prognostic parameters for tumours of the paranasal sinuses and to choose the most effective, individually tailored therapy.

Adenocarcinoma↗
PubMed1986

Esthesioneuroblastoma: cerebrospinal fluid rhinorrhea and widespread metastasis.

Esthesioneuroblastoma, a tumor of neural crest origin arising in the nasal cavity, is uncommon, may be difficult to diagnose, and frequently is not cured. We report a case that was originally diagnosed as an inflammatory polyp and recurred with extension into the anterior cranial fossa. Surgery and radiotherapy were followed by local recurrence and cerebrospinal fluid rhinorrhea. Despite initial negative results of investigation for metastases, recurrence appeared in cervical nodes and was followed by widespread bone, soft tissue, and cerebral metastasis. There was no response to multiple-agent chemotherapy. The results of surgery, radiation, and chemotherapy in this rare and lethal tumor are reviewed.

Adult↗
PubMed1986

Lateral rhinotomy for intranasal tumors: a review of 22 cases.

Lateral rhinotomy is a surgical approach not employed often enough for evaluation, diagnosis and removal of intranasal neoplasms. This paper reviews 22 patients with intranasal tumors requiring 28 rhinotomies between 1973 and 1984. Our experience indicates that lateral rhinotomy is a safe, repeatable and cosmetically sound procedure that provides and excellent surgical approach to the nasal cavity and sinuses. Determination of the site of origin and adequate surgical removal of intranasal tumors, concomitant surgery to the sinuses and intranasal skin grafting are possible with the procedure.

Carcinoma, Squamous Cell↗
PubMed1986

Esthesioneuroblastoma: the University of Virginia experience 1960-1985.

Twenty-six cases of esthesioneuroblastoma were treated by the Department of Otolaryngology-Head and Neck Surgery from 1960 to 1985. This period was divided into the precraniofacial period (1960 to 1975) and the craniofacial period (1976 to 1985) to denote the transition to a more aggressive combined therapeutic approach. Of the eight patients in the precraniofacial group (group I), only 37.5% are alive without disease. In group II (the craniofacial group), 82% of the patients are alive without disease with an average follow-up of 4 years. This latter survival rate compares favorably with the survival rate of group I and the cure rate of 10% to 67% as stated in other studies.

Adult↗
PubMed1986

[Radiotherapy of olfactory neuroblastoma--report of 5 patients].

Olfactory neuroblastoma is a rare tumor arising from the olfactory mucosal epithelium. 5 patients with this tumor were treated in our hospital from 1978 to 1982. The youngest patient was 3 years old and the eldest was 66. The clinical symptoms were nasal stuffiness, rhinorrhea, epistaxis and vascular polypoid mass in the nasal cavity. According to the staging system proposed by Kadish et al, the five patients in this series were 3 stage A and 2 stage C patients. Treatment consisted of radiotherapy, surgery or combination of radiotherapy and surgery. Our data indicate that the olfactory neuroblastoma is a radiosensitive tumor with the prognosis favorable in the stages A and B patients as treated by these three modalities. Two stage A patients are alive for more than 5 years. One of them was treated by radiotherapy alone, the other by combination of surgery and radiation. The third stage A patient as treated by radiotherapy alone has survived more than 3 years. One stage C patient, treated by combination of radiation and surgery, is still alive for more than 3 years. The other stage C patient, treated by radiotherapy alone, had survived for only 7 months after the treatment. The radiation dose varies with the extent of invasion. In stages A and B lesions, a dose of 4,500-5,500 rad in 5 weeks may be reasonable but in stage C, a dose of 6,000-6,500 rad in 7 weeks should be given. The authors agree to the prognostic equation proposed by Homzie et al. It may be possible to predict the tumor control or recurrence after a period of 3 years which gives an accuracy rate of 87%.

Adult↗
PubMed1986

Chronic syndrome of inappropriate antidiuretic hormone secretion and hypertension in a patient with olfactory neuroblastoma. Evidence of ectopic production of arginine vasopressin by the tumor.

A 28-year-old man with the chronic syndrome of Inappropriate antidiuretic hormone secretion and hypertension was found to have an olfactory neuroblastoma. We demonstrated evidence of elevated circulating arginine vasopressin levels, significantly elevated arginine vasopressin and vasopressin neurophysin levels in the tumor extract, and immunohistochemical staining for arginine vasopressin and vasopressin neurophysin in the tumor cells. The patient's clinical syndrome, including hypertension, resolved following subtotal removal of the tumor and radiation therapy. This study identified olfactory neuroblastoma as a definite cause of ectopic arginine vasopressin secretion causing the syndrome of inappropriate antidiuretic hormone secretion.

Adult↗
PubMed1986

[Olfactory neuroblastoma. Clinical course, light microscopic and ultrastructural findings in 3 cases].

Olfactory neuroblastomas are considered to be a clinicopathological entity, but they may show variable histologic pictures. The light and electron microscopic features of 3 cases as examples for the possible range of morphological findings are presented. This report is also aimed at defining essential diagnostic features, at discussing the differential diagnosis and finally at making pathologists more familiar with these rare tumors. The clinical appearance of the three cases was more or less typical for olfactory neuroblastomas. The leading symptom in all patients was a nasal obstruction. Light microscopically, the neuroblast-like tumor cells were arranged in sheaths or nests. Only in case 1 there were some Flexner rosettes, and especially in case 2 numerous Homer-Wright pseudo-rosettes could be found. Somewhat spindled cells with resemblance to Schwann cells were recognized in case 1 and 3. Neither argyrophilia nor argentaffinity could be demonstrated. Neuroblast-like tumor cells in case 2 contained glycogen intracytoplasmically. The diagnostically essential electron microscopic characteristics were neurite-like cellular processes and neurosecretory granules within the cytoplasm. Corresponding to light microscopic findings in cases 1 and 3, cells with features of Schwann cells could be identified. From the literature and the results presented here the conclusion can be drawn, that in nearly all cases a definite diagnosis is possible if besides the histologic picture also clinical data and, if necessary, ultrastructural and immunohistochemical findings are considered. The most important light microscopic criteria are a fine-fibrillary intercellular substance and the occurrence of Homer-Wright pseudo-rosettes. The differential diagnosis of olfactory neuroblastomas with special regard to electron microscopic findings is discussed and some remarks on the clinical behaviour are added.

Adult↗
PubMed1986

Neuroepithelioma in a middle-aged dog.

Paresis progressing to paralysis was caused by a neuroepithelioma located at the level of the L1-L2 interspace in a 7 1/2-year-old Golden Retriever. This tumor has never been reported in a dog more than 3 years old. The possibility of a neuroepithelioma should be considered in the differential diagnosis of paresis/paralysis in older dogs.

Animals↗
PubMedDate not supplied

Acute renal failure due to cisplatin.

A case of acute renal failure associated with cisplatin therapy for a stage IV neuroepitelioma of the chest wall is described. This case was associated with a normal magnesium concentration and with presence of fibrinogen in the Tubular Basement Membrane and of IgG in the interstitial infiltrates. Immunological activation was evidentiated by fine needle aspiration biopsy (FNAB) at the time of renal biopsy.

Acute Kidney Injury↗
PubMed1986

[Olfactory neuroblastoma. 3 case reports as a contribution to the clinical aspects, morphology and prognosis].

The leading symptom in all patients was a nasal obstruction. At first all three cases of olfactory neuroblastoma were mistaken for polyposis nasi. The tumour can be diagnosed solely by histologic examination. The light microscopic as well as the ultrastructural findings demonstrated the great morphological variability of this carcinoma. In nearly all cases a definite diagnosis is possible if besides the light microscopic picture also clinical data, ultrastructural and, if necessary, immunohistochemical findings are considered. At the time of diagnosis one tumour was Kadish-stage A and two were stage C. Lokal and metastatic tumour extension, recurrence of disease after treatment, patient age and radical tumour resection at initial presentation, are prognostic important criteria. The discriminant function by Homzie and Elkon permits the oncologist to predict the patient's outcome accurately.

Adult↗
PubMed1986

[Neurosurgical aspects of the treatment of esthesioneuroblastoma].

On the basis of the example of two observations by the author the diagnostic and therapeutical problems of the esthesioneuroblastoma are discussed. Neurosurgical problems result from the growing of the tumor into the inner space of the skull or the destruction of the anterior base of the skull with subsequent inflammatory consequences.

Adult↗