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Bio-ontologies: current trends and future directions.

In recent years, as a knowledge-based discipline, bioinformatics has been made more computationally amenable. After its beginnings as a technology advocated by computer scientists to overcome problems of heterogeneity, ontology has been taken up by biologists themselves as a means to consistently annotate features from genotype to phenotype. In medical informatics, artifacts called ontologies have been used for a longer period of time to produce controlled lexicons for coding schemes. In this article, we review the current position in ontologies and how they have become institutionalized within biomedicine. As the field has matured, the much older philosophical aspects of ontology have come into play. With this and the institutionalization of ontology has come greater formality. We review this trend and what benefits it might bring to ontologies and their use within biomedicine.

Animals↗

PubMed perspective of family medicine research: where does it stand?

OBJECTIVE: The aim of this study was to obtain a view of family medicine research by analyzing PubMed citations from 1960-2003. METHOD: Family practice (FP) citations in PubMed from 1960 to 2003 were downloaded in MEDLINE format. This was written into relation database using 'PubMed Grabber/Analyzer' software developed at University of Kelaniya, Sri Lanka. Search Query Language (SQL) and online PubMed queries were used for further analysis. RESULTS: There were 50288 FP citations from 80 countries. Of these, 33712 (67%) citations were from 15 FP journals. United Kingdom (18760), United States (13584), Australia (3262), Canada (1848), Germany-west (1340) were the five countries which had the most citations and 22 countries had less than 5 citations. Van Weel C (118), Geyman JP (116), Olesen F (87), Jones R (83) and Knottnerus JA (82) were numerically, the top five authors. Only 921 authors had more than 10 citations and the vast majority of authors had only one citation. Letters (5121), review (2715), editorial (2259), randomized controlled trials-RCT (1585) and Meta-analysis (44) were the top publication types. 40 citations found under 'qualitative research'. Discussion. The relatively few PubMed FP citations (50288) are by a small number of academics in developed countries. Citations showed an upsurge from the mid 1980s to the late 1990's but reached a plateau in the new millennium. Compared to PubMed citations from 1960-2003 in other specialties such as 2737655 for public health, 1151194 for cardiology & cardiovascular diseases and 318538 for medical informatics, the 50288 FP citations were paltry. Paucity of RCT (1585) and meta-analysis (44) was noted. The low 'qualitative research' citations (44) could have been due to the late introduction of the MeSH concept in 2003. CONCLUSIONS: Priority should be given to increase FP research and also to ensure the indexing of FP journals that are not currently indexed in PubMed. Efforts to increase citations in Medline may not give the desired results because of low priority given primary care specialties such as family medicine in the USA. Alternative solution of a separate bibliographic database for FP similar to PsycInfo may be too costly.

Family Practice↗

Introduction.

Explore the source record for details and available documents.

Biomedical Research↗

Building a virtual cancer research organization.

BACKGROUND: The Cancer Research Network (CRN) comprises the National Cancer Institute and 11 nonprofit research centers affiliated with integrated health care delivery systems. The CRN, a public/private partnership, fosters multisite collaborative research on cancer prevention, screening, treatment, survival, and palliation in diverse populations. METHODS: The CRN's success hinges on producing innovative cancer research that likely would not have been developed by scientists working individually, and then translating those findings into clinical practice within multiple population laboratories. The CRN is a collaborative virtual research organization characterized by user-defined sharing among scientists and health care providers of data files as well as direct access to researchers, computers, software, data, research participants, and other resources. The CRN's research management Web site fosters a high-functioning virtual scientific community by publishing standardized data definitions, file specifications, and computer programs to support merging and analyzing data from multiple health care systems. RESULTS: Seven major types of standardized data files developed to date include demographics, health plan eligibility, tumor registry, inpatient and ambulatory utilization, medication dispensing, laboratory tests, and imaging procedures; more will follow. Data standardization avoids rework, increases multisite data integrity, increases data security, generates shorter times from initial proposal concept to submission, and stimulates more frequent collaborations among scientists across multiple institutions. CONCLUSIONS: The CRN research management Web site and associated standardized data files and procedures represent a quasi-public resource, and the CRN stands ready to collaborate with researchers from outside institutions in developing and conducting innovative public domain research.

Biomedical Research↗

The progressive roles of electronic medicine: benefits, concerns, and costs.

Electronic healthcare will significantly alter the way physicians practice medicine. Electronic medical records with specialized software programs can increase the quality of patient care, reduce unnecessary medical tests, and directly connect with pharmacies to transmit prescriptions. Electronic communication can allow physicians to respond to patients' clinical concerns and questions, and Internet access can provide physicians better access to literature. Nevertheless, there is significant physician hesitance toward adopting medical computerization: patient e-mail can potentially overload physicians with extra work, web sites can direct patients to poor medical information, the computerized interface can degrade the patient-physician relationship, and health regulations can create concern over electronic privacy issues. The finances of e-health appear promising, yet conflicting studies create uncertainty. However, if managed appropriately, the potential disadvantages of e-health can be minimized, and the benefits of e-health in clinical practices can be obtained.

Communication↗

Future directions in electronic image handling.

After a relatively slow start compared with the United States and Japan, several projects are now being established in Europe that are aimed at the development of prototype systems for medical image processing and management. Frequently, this includes aspects of multimedia communication, as well as legal, ethical, and economic issues. Consideration is also often given to systems security, reliability, and data protection. All these projects are based on the application of modern computer and communication technologies. The following interesting conclusions can be drawn from these preliminary activities: 1. PACS and IMAC systems should not be regarded as products or devices, but as a means to improve the infrastructure in a given medical care environment. Sometimes this activity is also referred to as knowledge business. Individual components of these systems, for example image acquisition devices, networks, storage facilities, and medical workstations, should be provided with standard interfaces allowing a modular build-up and an easy adaptation to the specific conditions of clinical departments. 2. Digital luminescence radiography will further establish itself as a method for image acquisition and increasingly will replace analog radiologic methods. Consequently, digital processing, archiving, and communication will be a necessity for optimal patient care. 3. New network technologies and magnetic-optical storage media offer the possibility of an improved cost-effectiveness for communication and storage. They should therefore be considered an important factor in future economic considerations regarding health care services. 4. The practice of modern medicine is based on team-work; good communication among the parties concerned is a critical factor.(ABSTRACT TRUNCATED AT 250 WORDS)

Computer Communication Networks↗

Aggressive fibromatosis involving the cranial base in children.

OBJECTIVE: Aggressive fibromatoses are proliferations of fibrous tissue that infiltrate surrounding tissues and tend to recur after surgical resection. We report a series of five children with aggressive fibromatosis involving the cranial base. METHODS: A search of the database maintained by the Medical Informatics Department at The University of Texas M.D. Anderson Cancer Center identified 78 patients with aggressive fibromatosis of the head and neck. Of these patients, five demonstrated involvement of the cranial base. All five were children. A retrospective review of the charts, diagnostic images, and pathological findings for these five patients was performed. RESULTS: Surgery, radiotherapy, chemotherapy, and hormonal therapy were the treatment methods used. Four patients underwent gross total resections, but tumor cells were present at the margins in all cases. Two of these four patients experienced recurrences; one patient was cured of disease by a second surgical resection and radiotherapy, and the other underwent a second gross total resection. The fifth patient underwent a subtotal resection. He has experienced four recurrences and continues to live with residual disease. One transformation to a Grade 2 fibrosarcoma was observed. CONCLUSION: Fibromatoses of the cranial base are rare and seem to be most common in the pediatric age group. Gross total resection, preferably in the first attempt, should be the goal. Radiotherapy and hormonal therapy are useful adjunctive methods for the treatment of aggressive fibromatosis. Fibromatoses that involve the cranial base are most likely to require a multidisciplinary treatment approach.

Adolescent↗

Ethics and information technology: how nurses balance when integrity and trust are at stake.

When we think about ethics in nursing, such things as "Do Not Resuscitate" (DNR) orders and euthanasia come to mind. However, in the information age, there are some often-overlooked ethical issues surrounding information and information systems. This article examines several information technology influences and their impact on the issues of ethics, integrity, and trust.

Codes of Ethics↗

Legal issues in the information age--part 1.

As legal liability issues regarding managed care continue to emerge, almost simultaneously issues related to the age of technology are appearing. In some instances, the confluence of these two new rapidly developing health care trends has led to additional new legal issues for the health care provider.

Confidentiality↗

Evidence-based medicine: an introduction for psychiatrists.

Evidence-based medicine (EBM) has been defined by Sackett as "the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients." Practicing evidence-based medicine requires the ability to apply a knowledge of medical informatics and clinical epidemiology to the treatment of individual patients. This article provides an introduction to the history, philosophy, and methods of evidence-based medicine for psychiatrists and other mental health professionals. The article focuses on a systematic approach to efficiently finding the best evidence to answer clinical questions. Particular emphasis is given to a method for critically appraising papers that emphasizes validity, importance, and clinical applicability. Resources for further learning are provided.

Journal Article↗

A framework for the application of knowledge technology to the management of diseases.

Medical diagnosis and treatment constitute a network of interrelated processes. The conventional method of medical diagnosis and treatment of diseases involves a state space search of the medical knowledge of diseases and patient history, which could be combinatorially explosive. This paper presents a report on the experimental study of an intelligent, interactive, user-friendly, knowledge-based system which performs a stepwise analysis of a patient's complaints, filtering cognitive and emotional elements to be able to make inferences. It applies both forward and backward chaining in making inferences concerning the management of disease. A case study of the system is carried out using some tropical diseases. It is believed that the system will serve as a useful contribution towards tropical medical informatics.

Computer Systems↗