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PubMed1998

From French vocabulary to the Unified Medical Language System: a preliminary study.

The Unified Medical Language System (UMLS) is an extensive source of biomedical knowledge developed and maintained by the U.S. National Library of Medicine (NLM). The UMLS began to include biomedical terms in other languages a few years ago. However, providing foreign terms for existing concepts is only the first step for the UMLS to become international. The current limits of the use of the UMLS in French are analyzed (partial translation, unique source of the translated concepts, improper character set, and absence of lexical resources for lexical matching tools). Some suggestions are given for French to be better integrated into the UMLS, especially for adapting the lexical resources to French. Once completed, our present work is expected to give the UMLS the capability to be effectively queried in French.

France↗
PubMed1995

Development of nursing CAI in the administration: nursing daily hospital problems.

Since the nurse emerged as a qualified professional to attend human beings, the role which always characterized his/her action was assistance. Already since the foundation of the first nursing school, teaching aimed at developing the student to dispense nursing care necessary for the patient's assistance. When the nurse started to perform their activities in nosocomial and community institutions, the need for someone who would be responsible for the organization, coordination and control of nursing personnel and the Nursing Unit itself, in short, someone who would head the services became apparent. At present, the professional role of the nurse is changing regarding his/her overall assistance to the patient, caring directly, determining and/or carrying out nursing assistance necessary for the patient's health, maintenance or recovery. In this manner, it is necessary for nurses to use tools of administration science such as planning, decision making, and planned changes in order to be able to provide the nursing assistance with quality. Thus, this study aims at helping the development of the nurse's interest in computer during the teaching-learning process, motivating the search for knowledge in computerized sources. We intended to offer the opportunity for discussion and reflection on problems of nosocomial nursing practice, favoring interchange of theory and practice. The system is being developing using ToolBook Live Software to be run in Windows environment. The content of the subject allow the user (student or professional nursing) to choose the most correct answers to questions in the knowledge area. In this case, to discuss nursing administration issues through the study of practical situations is possible, such as the opportunity the verify the performance in tests.

Brazil↗
PubMed2005

Knowledge, attitude and practice of modern contraception among single women in a rural and urban community in southeast Nigeria.

The contraceptive information and services offered to single women in most developing countries is compromised by stigma attached to premarital sex. This study was to ascertain the knowledge, attitude and practice of contraception among single women in a rural and urban community in southeast Nigeria, using a cross-sectional survey of 279 and 295 single women in Ngwo (rural) and Enugu (urban) community. The mean age of the population was 21.3 years. Contraceptive awareness was more among the urban than rural respondents (90.2% vs 34.1%). The major sources of contraceptive knowledge were mass media (68%) and peer groups (86.3%) for the urban and rural respondents, respectively. Most respondents in both groups had positive attitude towards contraception. More urban than rural respondents (68.3% vs 12.5%) began sexual activity during adolescence and the level of contraceptive use during first coitus were 48.4% and 13.7%, respectively. Of the currently sexually active respondents, 32.5% (rural) and 59.7% (urban) were using a form of modern contraception. Condoms, followed by oral pills were the most popular contraceptive method because they can easily procure them over the counter. Poor contraceptive information, highly critical behavior of family planning providers towards unmarried women seeking contraception and attitude of male partners militate against contraceptive practice. There is need to promote information and education on contraception among single women, their male partners and family planning providers.

Adolescent↗
PubMedDate not supplied

Dissemination of relevant information on hypertension.

The timely dissemination of new medical information to the practicing physician has been identified as a problem. To examine the magnitude of this problem and useful strategies for correction, we surveyed primary care physicians to determine their knowledge of the Hypertension Detection and Follow-up Program, a recent clinical trial with important treatment implications. Forty percent of family physicians (44/110) were aware of the study within two months of publication, and 63% of internists (114/182) learned of it within six months. Eighty percent of the family physicians and 50% of the internists listed medicine journals as the source of their knowledge, while 40% of the internists learned of it from continuing medical education (CME) courses. These findings indicate that rapid dissemination of new information can occur when relevant journals are used and that CME courses also provide a timely and effective means of dissemination.

Adult↗
PubMed1998

Automatic extraction of linguistic knowledge from an international classification.

Automatic extraction of knowledge from large corpus of texts is an essential step toward linguistic knowledge acquisition in the medical domain. The current situation shows a lack of computer-readable large medical lexicons, with a partial exception for the English language. Moreover, multilingual lexicons with versatility for multiple languages applications are far from reach as long as only manual extraction is considered. Computer-assisted linguistic knowledge acquisition is a must. A multilingual lexicon differs from a monolingual one by the necessity to bridge the words in different languages. A kind of interlingua has to be built under the form of concepts to which the specific entries are attached. In the present approach, the authors have developed an intelligent rule-based tool in order to focus on a multilingual source of medical knowledge, like the International Classification of Disease (ICD) which contains a vocabulary of some 20,000 words, translated in numerous languages.

Disease↗
PubMed2005

Family members' experiences, information needs and information seeking in relation to living with a patient with oesophageal cancer.

A qualitative study was conducted with the aim to describe family members' experiences, information needs and information seeking in relation to living with a patient suffering from oesophageal cancer. Data were collected by means of semi-structured interviews with nine family members. A content analysis was used in order to organize data. It was found that family members were not aware of the severe diagnosis and the illness caused intrusions on the family. The time following diagnosis family members' information seeking was low. They used interpersonal as well as mass media sources to obtain knowledge about and handle the uncertainty related to the illness. Some family members did not actively seek information. In conclusion, healthcare professionals are expected to improve quality of cancer care. These improvements are unlikely to occur without an understanding of family members' needs. This study shows that the family members were unprepared of receiving a diagnosis of oesophageal cancer. They emphasized the importance of including the children in the care given. Moreover, the whole family was faced with uncertainty, which led to intrusion on everyday life. Therefore, family members used different strategies for managing the uncertainty, whereof one was searching for information. The primary source of information was the physician.

Adult↗
PubMed1997

Yes, but how do we know it's true? Knowledge claims in massage and aromatherapy.

While there is evidence that both massage and aromatherapy can be of benefit, practitioners make a great number of claims about the clinical effects of their treatments. These are presented in literature as simple statements of fact, often with no attempt to explain the basis upon which the claim is made. Though authors do occasionally make reference to the scientific literature, they often do so inadequately and in many cases the cited papers do not support the claims being made. Some authors have been explicit in giving personal experience as the source of their knowledge. However, there are several reasons why it can be difficult to make general statements based on individual experience. The many inconsistencies found in massage and aromatherapy literature--such as different properties being given to the same oil--provide further evidence that the knowledge base of these therapies is unreliable. Practitioners need to develop a critical discourse by which they can evaluate knowledge claims.

Aromatherapy↗
PubMed2005

The nature of memory errors for verbally quantified information.

A variety of theoretical proposals claim that memory is not a faithful reproduction of what was encountered but a blend of what was encountered and knowledge from other sources. We showed participants simple pairings of a person's name and a height or weight or a food name and a calorie count at study. Once veridical responses were removed, there was little evidence that the remaining responses were influenced by the specific value of the studied stimulus. These results suggest that the appearance of memory blends for verbally quantified information may be induced by averaging over different knowledge states.

Female↗
PubMed1989

Information source utilization and teachers' attributes in physical education: a preliminary test of a rational paradigm.

This study sought to provide empirical evidence concerning physical education information-seeking patterns of elementary teachers at the primary level. It also investigated the relationship between information use patterns and teachers' attributes. A model based on simple utilitarian concepts explaining information use patterns was developed and tested. The basic assumption of the model was that the use of information sources would increase as the perceived benefits of the information derived increased, and the costs of retrieving and using the information decreased. Subjects for the study were elementary school teachers from the Vancouver school system in British Columbia, Canada (N = 86). Simultaneous equation procedures employing limited information likelihood estimators were used to test the model. The results of the study indicated that sources of information internal to the school system dominated utilization patterns. Among these, curriculum support material and discussion with colleagues were highly favored, suggesting that teachers at these grade levels rely heavily upon the experience of others in the same system and the support of very specific resource materials about physical education activities. The research also showed that those who felt they knew more and claimed to enjoy teaching actively sought to acquire more knowledge from more sources than those who knew less. Finally, the study demonstrated that models based on simple assumptions of rationality can predict decisions concerning information utilization.

British Columbia↗
PubMed1982

Knowledge of nutrition among housewives in three South African ethnic groups.

Studies on housewives and other groups in Western populations have revealed: (i) a generally high level of claimed or "perceived' knowledge of nutrition; (ii) a much lower level of accurate knowledge; and (iii) an often unsatisfactory application of correct knowledge. Since little is known of knowledge of nutrition in South African populations. White, Indian and Coloured housewives were questioned by use of a questionnaire similar to that used overseas. While the local populations had a fair knowledge of the identity of most nutritional components, their knowledge about good sources of these components and of foods commendable for body building, energy, and slimming, or of those which promote fattening, was only moderately satisfactory. Misconceptions were similar to those reported elsewhere. Factors having a bearing on inadequate or incorrect information are discussed, as is the extent to which this may affect health and disease patterns in Third World and Western populations. Factors detrimental to progress are differences of opinion among nutrition experts and insufficient knowledge on the health/ill-health patterns of those who are knowledgeable of nutrition compared with those who are less knowledgeable.

Black or African American↗
PubMed2001

Use of audiovisual information in speech perception by prelingually deaf children with cochlear implants: a first report.

OBJECTIVE: Although there has been a great deal of recent empirical work and new theoretical interest in audiovisual speech perception in both normal-hearing and hearing-impaired adults, relatively little is known about the development of these abilities and skills in deaf children with cochlear implants. This study examined how prelingually deafened children combine visual information available in the talker's face with auditory speech cues provided by their cochlear implants to enhance spoken language comprehension. DESIGN: Twenty-seven hearing-impaired children who use cochlear implants identified spoken sentences presented under auditory-alone and audiovisual conditions. Five additional measures of spoken word recognition performance were used to assess auditory-alone speech perception skills. A measure of speech intelligibility was also obtained to assess the speech production abilities of these children. RESULTS: A measure of audiovisual gain, "Ra," was computed using sentence recognition scores in auditory-alone and audiovisual conditions. Another measure of audiovisual gain, "Rv," was computed using scores in visual-alone and audiovisual conditions. The results indicated that children who were better at recognizing isolated spoken words through listening alone were also better at combining the complementary sensory information about speech articulation available under audiovisual stimulation. In addition, we found that children who received more benefit from audiovisual presentation also produced more intelligible speech, suggesting a close link between speech perception and production and a common underlying linguistic basis for audiovisual enhancement effects. Finally, an examination of the distribution of children enrolled in Oral Communication (OC) and Total Communication (TC) indicated that OC children tended to score higher on measures of audiovisual gain, spoken word recognition, and speech intelligibility. CONCLUSIONS: The relationships observed between auditory-alone speech perception, audiovisual benefit, and speech intelligibility indicate that these abilities are not based on independent language skills, but instead reflect a common source of linguistic knowledge, used in both perception and production, that is based on the dynamic, articulatory motions of the vocal tract. The effects of communication mode demonstrate the important contribution of early sensory experience to perceptual development, specifically, language acquisition and the use of phonological processing skills. Intervention and treatment programs that aim to increase receptive and productive spoken language skills, therefore, may wish to emphasize the inherent cross-correlations that exist between auditory and visual sources of information in speech perception.

Acoustic Stimulation↗
PubMed2002

[Impact of of school children's nutrition education program on the knowledge and nutritional behavior of their parents].

The aim of the work was to present the analysis of the influence of school children's nutrition education program on the knowledge and nutritional behavior of their parents (110 persons). The program was realized during 10 lessons. The interview with the parents concerning their knowledge and nutritional behavior was carried before and after realization of educational program at school. One can state that changes of parents nutritional behavior was connected with the educational materials getting by children, for example higher consumption of vegetables, fruits, milk and its products were observed. An increased level of knowledge especially on sources of selected nutrients: calcium, dietary fiber was found. Education of children and youth can be seen as one of the effective educational method of their parents.

Adolescent↗
PubMed2003

Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture study.

In contrast to batch cultivation, chemostat cultivation allows the identification of carbon source responses without interference by carbon-catabolite repression, accumulation of toxic products, and differences in specific growth rate. This study focuses on the yeast Saccharomyces cerevisiae, grown in aerobic, carbon-limited chemostat cultures. Genome-wide transcript levels and in vivo fluxes were compared for growth on two sugars, glucose and maltose, and for two C2-compounds, ethanol and acetate. In contrast to previous reports on batch cultures, few genes (180 genes) responded to changes of the carbon source by a changed transcript level. Very few transcript levels were changed when glucose as the growth-limiting nutrient was compared with maltose (33 transcripts), or when acetate was compared with ethanol (16 transcripts). Although metabolic flux analysis using a stoichiometric model revealed major changes in the central carbon metabolism, only 117 genes exhibited a significantly different transcript level when sugars and C2-compounds were provided as the growth-limiting nutrient. Despite the extensive knowledge on carbon source regulation in yeast, many of the carbon source-responsive genes encoded proteins with unknown or incompletely characterized biological functions. In silico promoter analysis of carbon source-responsive genes confirmed the involvement of several known transcriptional regulators and suggested the involvement of additional regulators. Transcripts involved in the glyoxylate cycle and gluconeogenesis showed a good correlation with in vivo fluxes. This correlation was, however, not observed for other important pathways, including the pentose-phosphate pathway, tricarboxylic acid cycle, and, in particular, glycolysis. These results indicate that in vivo fluxes in the central carbon metabolism of S. cerevisiae grown in steadystate, carbon-limited chemostat cultures are controlled to a large extent via post-transcriptional mechanisms.

Carbon↗
PubMed1997

Monaural sound localization revisited.

Research reported during the past few decades has revealed the importance for human sound localization of the so-called "monaural spectral cues." These cues are the result of the direction-dependent filtering of incoming sound waves accomplished by the pinnae. One point of view about how these cues are extracted places great emphasis on the spectrum of the received sound at each ear individually. This leads to the suggestion that an effective way of studying the influence of these cues is to measure the ability of listeners to localize sounds when one of their ears is plugged. Numerous studies have appeared using this monaural localization paradigm. Three experiments are described here which are intended to clarify the results of the previous monaural localization studies and provide new data on how monaural spectral cues might be processed. Virtual sound sources are used in the experiments in order to manipulate and control the stimuli independently at the two ears. Two of the experiments deal with the consequences of the incomplete monauralization that may have contaminated previous work. The results suggest that even very low sound levels in the occluded ear provide access to interaural localization cues. The presence of these cues complicates the interpretation of the results of nominally monaural localization studies. The third experiment concerns the role of prior knowledge of the source spectrum, which is required if monaural cues are to be useful. The results of this last experiment demonstrate that extraction of monaural spectral cues can be severely disrupted by trial-to-trial fluctuations in the source spectrum. The general conclusion of the experiments is that, while monaural spectral cues are important, the monaural localization paradigm may not be the most appropriate way to study their role.

Auditory Perception↗
PubMed2004

Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology.

The endothelial generation of reactive oxygen species (ROS) is important both physiologically and in the pathogenesis of many cardiovascular disorders. ROS generated by endothelial cells include superoxide (O2-*), hydrogen peroxide (H2O2), peroxynitrite (ONOO-*), nitric oxide (NO), and hydroxyl (*OH) radicals. The O2-* radical, the focus of the current review, may have several effects either directly or through the generation of other radicals, e.g., H2O2 and ONOO-*. These effects include 1) rapid inactivation of the potent signaling molecule and endothelium-derived relaxing factor NO, leading to endothelial dysfunction; 2) the mediation of signal transduction leading to altered gene transcription and protein and enzyme activities ("redox signaling"); and 3) oxidative damage. Multiple enzymes can generate O2-*, notably xanthine oxidase, uncoupled NO synthase, and mitochondria. Recent studies indicate that a major source of endothelial O2-* involved in redox signaling is a multicomponent phagocyte-type NADPH oxidase that is subject to specific regulation by stimuli such as oscillatory shear stress, hypoxia, angiotensin II, growth factors, cytokines, and hyperlipidemia. Depending on the level of oxidants generated and the relative balance between pro- and antioxidant pathways, ROS may be involved in cell growth, hypertrophy, apoptosis, endothelial activation, and adhesivity, for example, in diabetes, hypertension, atherosclerosis, heart failure, and ischemia-reperfusion. This article reviews our current knowledge regarding the sources of endothelial ROS generation, their regulation, their involvement in redox signaling, and the relevance of enhanced ROS generation and redox signaling to the pathophysiology of cardiovascular disorders where endothelial activation and dysfunction are implicated.

Animals↗
PubMed1999

Survey of the impact of randomised clinical trials on surgical practice in France. French Associations for Research in Surgery (AURC and ACAPEM). Association Universitaire de Recherche en Chirurgie. Association des Chirurgiens de l'Assistance Publique pour l'Evaluation Médicale.

OBJECTIVE: To evaluate the impact of randomised clinical trials (RCT) on decision-making and therapeutic policies among general and gastrointestinal surgeons in France. DESIGN: Telephone questionnaire. SETTING: Multicentre study, France. SUBJECTS: A random sample of 152 surgeons, mean (SD) age 50 (8) years. INTERVENTIONS AND MAIN OUTCOME MEASURE: Surgeons were asked 12 questions about their knowledge of RCT and how trials were conducted; influence of RCT on their treatment policies; means of obtaining information about treatments; how they evaluated their own results; whether they were willing to take part in RCT; and personal details including age, speciality, and type of practice. Surgeons were stratified according to age and type of practice. RESULTS: 148 questionnaires were suitable for analysis. 83 surgeons (56%) were under 50 years old, 38 (26%) were exclusively gastrointestinal surgeons, 82 (56%) worked in private practice, and 36 (24%) worked in teaching and university hospitals. The rest undertook mixed duties. When asked to say where they obtained their knowledge about antibiotics, 91 (61%) referred to RCT; these were mainly hospital-based, gastrointestinal, and younger surgeons. Asked to name a RCT-based policy, 81 (55%) gave medical rather than operative examples. 80 (54%) had already participated in a RCT; 79 (53%) said that they were willing to participate in a RCT that included random allocation of patients (there were no statistically significant differences in answers according to speciality or type of practice, although younger surgeons answered "yes" to both questions). Specialised journals were the main source of information for 115 (78%), and surgeons read a mean of 40 issues/year. 142 (96%) read journals in French and 66 (45%) in English, but this number fell to 10 (15%) of the 65 surgeons aged 50 or more. Personal experience was considered a more important source of therapeutic knowledge by older and specialist surgeons. 109 surgeons (74%) recalled patients during the first month postoperatively to evaluate their results. CONCLUSIONS: French surgeons, particularly those aged 50 or over, are not well informed about the nature, conduct, and value of RCT. Most of their information is acquired through reading and attending scientific meetings and congresses. Surgeons tended to attach more importance to the fame of the author than to the conduct of the study. The overall impact of RCT was weak among the surgeons questioned.

Adult↗
PubMed2006

Teaching complementary and alternative medicine in a reform curriculum.

BACKGROUND: The increasing utilization of complementary and alternative medicine (CAM) contrasts with a lack of CAM in medical school education. Therefore, CAM therapies were introduced to the Charité University Medical School (Berlin, Germany) reform curriculum. METHODS AND RESULTS: Teaching concept: A CAM seminar provides basic knowledge about naturopathy, homeopathy, and Traditional Chinese medicine (TCM), plus their utilization, empirical research, and underlying philosophies. Experiential and dialogical didactic techniques are employed. EVALUATION: Students evaluated one of the seminars using the 'Heidelberg Inventory for Educational EVALUATION' (Heidelberger Inventar zur Lehrveranstaltungs-EVALUATION, HILVE). Student participation and classroom atmosphere were rated as very good. All other categories were rated above average, except workload and excessive demands. Demand for Education: 69% of all 3rd- and 7th-semester students (n = 74) answered a questionnaire about their opinions on CAM, and the extent and sources of their knowledge. Acupuncture and homeopathy were the best-known methods, primarily from courses or seminars. Personal experience with CAM was reported by 44% of the students. Depending on the method 73-96% of the respondents supported the inclusion of CAM therapies into the medical school curriculum. Acknowledged advantages of CAM were its use as an alternative or additional treatment (73-82%), fewer side effects (44%), and cost reduction (37%). DISCUSSION: The presented concept helps medical students develop a reflected opinion on CAM. The students rated the quality of the seminar as above average. The high support for university CAM education reflects the students' desire for more knowledge. Interest in other philosophies of disease and therapy may prepare them for a more integrative and pluralistic approach to medicine.

Adult↗