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Inhibition of peptide release from invertebrate neurons by the protein kinase inhibitor H-7.

The protein kinase inhibitor H-7 has been shown to prevent the potentiation of action potentials that normally accompanies an afterdischarge in the bag cell neurons of Aplysia. We have now shown that H-7 attenuates the release of ELH from these neurons during an afterdischarge without influencing the firing frequency or length of the afterdischarge.

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine↗