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PubMed1999

Learning-induced plasticity of N-methyl-D-aspartate receptors is task and region specific.

Changes in binding of [3H]dizocilpine maleate to N-methyl-D-aspartate-sensitive ion channel receptors were evaluated after learning in order to specify brain regions which might be involved in memory formation. Rats were trained in a five-trial session of 40 min, to discriminate among three odours to obtain food reinforcement. Another group was trained in an eight-arm maze to choose always the same three arms to obtain food reinforcement (nine trials over 150 min). In rats killed 30 min after odour discrimination learning, dizocilpine maleate binding was significantly reduced in hippocampal sub-regions CA3, CA1 and fascia dentata and in frontal cortex. After spatial learning, changes in binding were limited to the amygdala, where a decrease was also observed. These results indicate that functional changes occur in specific brain regions after learning and suggest anatomical loci for further study of synaptic changes at a morphological level, after spatial learning or odour discrimination.

Amygdala↗
PubMed2000

Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans.

Much evidence suggests that lesions of the prefrontal cortex (PFC) produce marked impairments in the ability of subjects to shift cognitive set, as exemplified by performance of the Wisconsin Card Sorting Test (WCST). However, studies with humans and experimental primates have suggested that damage to different regions of PFC induce dissociable impairments in two forms of shift learning implicit in the WCST (that is, extradimensional (ED) shift learning and reversal shift learning), with similar deficits also being apparent after damage to basal ganglia structures, especially the caudate nucleus. In this study, we used the same visual discrimination learning paradigm over multidimensional stimuli, and the H215O positron emission tomography (PET) technique, to examine regional cerebral blood flow (rCBF) changes associated with these subcomponent processes of the WCST. In three conditions, subjects were scanned while acquiring visual discriminations involving either (i) the same stimulus dimension as preceding discriminations (intradimensional (ID) shifts); (ii) different stimulus dimensions from previous discriminations (ED shifts) or (iii) reversed stimulus-reward contingencies (reversal shifts). Additionally, subjects were scanned while responding to already learnt discriminations ('performance baseline'). ED shift learning, relative to ID shift learning, produced activations in prefrontal regions, including left anterior PFC and right dorsolateral PFC (BA 10 and 9⁄46). By contrast, reversal learning, relative to ID shift learning, produced activations of the left caudate nucleus. Additionally, compared to reversal and ID shift learning, ED shift learning was associated with relative deactivations in occipito-temporal pathways (for example, BA 17 and 37). These results confirm that, in the context of visual discrimination learning over multidimensional stimuli, the control of an acquired attentional bias or'set', and the control of previously acquired stimulus-reinforcement associations, activate distinct cortical and subcortical neural stations. Moreover, we propose that the PFC may contribute to the control of attentional-set by modulating attentional processes mediated by occipito-temporal pathways.

Adult↗
PubMed1989

Hemicholinium-3 impairs spatial learning and the deficit is reversed by cholinomimetics.

The effects of hemicholinium-3 (HC-3) on spatial discrimination learning were studied. Rats were equipped with indwelling cannulae in the right lateral ventricle and, following recovery, were trained on a two platform spatial discrimination task in a water maze. In this task a visible escape platform remains in a fixed position in the pool during a single training session, whilst the location of an identical "float" (which affords no escape) is randomly varied. For each session the location of the fixed escape platform was changed and the rats were retrained to criterion following pretreatment either with artificial cerebrospinal fluid (CSF) or HC-3 (2.5, 5.0 micrograms/rat/ICV) 1 h before training. Each rat received every treatment according to a latin square design. The results showed that spatial learning was dose dependently impaired by HC-3, choice accuracy being reduced to chance levels by the higher dose. There was no evidence of motoric difficulty, as choice latencies were not significantly increased. Experiments were then conducted to test for reversal of the deficit using a range of psychotropic drugs. Rats were treated with CSF or HC-3 (5 micrograms/rat ICV) 60 min prior to testing and test drugs were injected 15 min before testing. Some doses of physostigmine (46-460 micrograms/kg/SC) and tetrahydroaminoacridine (THA) (2.2-10 mg/kg/SC) reversed the spatial learning deficit. The muscarinic agonists arecoline (0.046-1 mg/kg/SC), aceclidine (1-10 mg/kg/SC), oxotremorine (30-100 micrograms/kg/SC) and RS-86 (0.46, 1.0 microgram/kg/SC) were also effective. Pilocarpine (0.22-2.2 mg/kg/SC) showed marginal activity and isoarecoline (4.6-10 mg/kg/SC) was inactive. Nicotine (0.32, 1, 3.2 mg/kg/SC) and piracetam (10, 30, 100 mg/kg IP) were also inactive. The alpha 2 agonist, clonidine (46, 100 micrograms/kg SC) and the antagonist idazoxan (32, 100 micrograms/kg SC) were also inactive. Learning deficits were not reversed by haloperidol (20, 60 micrograms/kg), amphetamine (0.1, 0.46 mg/kg), the selective 5-HT1A agonist 8-OH-DPAT (30, 100 micrograms/kg) or by the benzodiazapine antagonist ZK-93426 (1, 3.2, 10 mg/kg). The results show that forebrain Ach depletion by HC-3 impairs spatial discrimination learning and these deficits are reversed by cholinesterase inhibitors and some muscarinic receptor agonists. Some degree of pharmacological selectivity is indicated by the failure of a range of other drugs to reverse the impairments.

8-Hydroxy-2-(di-n-propylamino)tetralin↗
PubMed1976

Genetic and environmental correlations between brain weight and maze learning in inbred strains of mice and their F1 hybrids.

The relationships among body weight, cerebellum weight, cerebrum weight, maze-learning ability in a double T-maze, and discrimination learning in a Y-maze were studied in six inbred strains of mice and some of their F1 hybrids. The subjects were 131 male albino mice from 14 genotypic groups: five inbred groups and nine groups of crossbred offspring. Intra- and intergroup correlations were computed between all possible pairs of the anatomical and behavioral traits. A significant difference between the intragroup and intergroup correlations for any pair of variables was taken to indicate the presence of a genetic correlation between the two variables. On this basis, positive genetic correlations were indicated between T-maze learning ability and Y-maze learning ability, between body weight and T-maze learning ability, and possibility between body weight and both cerebellum and cerebrum weight and between cerebrum weight and T-maze learning ability. Negative genetic correlations were indicated between cerebellum weight and running time in both mazes and between total number of successes in the Y-maze and Y-maze running time.

Animals↗
PubMedDate not supplied

Temporally graded retrograde amnesia following separate and combined lesions of the perirhinal cortex and fornix in the rat.

The involvement of the perirhinal cortex and the fornix in retrograde and anterograde amnesia in the rat was investigated in this experiment. Male Sprague-Dawley rats were trained on a series of five visual discrimination problems at distinct time intervals prior to receiving bilateral, electrolytic lesions of the perirhinal cortex or the fornix, combined lesions of both these structures, or sham operations. Following recovery from surgery, rats were retested on the preoperatively learned discrimination problems, as well as learning a new discrimination and discrimination reversal. Results indicated that all animals with lesions exhibited temporally graded retrograde amnesia, whereby memories acquired in the recent past (1-3 weeks) were impaired, and memories acquired in the remote past (6-8 weeks) were spared. There was no difference in the magnitude of retrograde amnesia between the three lesion groups. Animals in the perirhinal, fornix, and combined lesion groups were able to learn a new discrimination problem at a rate comparable to control rats; however, the animals with lesions were impaired at learning the discrimination reversal. The perirhinal, fornix, and combined lesion animals also exhibited a significantly faster forgetting rate over a 2-week retention interval than control rats. These results suggest that medial temporal structures including the perirhinal cortex and the fornix are involved in the consolidation of mnemonic information and that their involvement in this process occurs over a discrete period of time.

Amnesia↗
PubMed2001

Configural learning without configural training.

Rats learned discriminations in which 2 familiar compound visual stimuli AB and CD were nonreinforced, whereas less-familiar compounds (EF, GH, IJ...) were reinforced (constant-negative paradigm). Such discriminations can in principle be acquired through elemental (nonconfigural) learning. Three different types of compound--object/object, object/position, and shape/fill-pattern--were used, and the number of familiar compounds extended to 3 or 4. In all cases, when rats were tested for the first time with previously unseen recombinations of the familiar elements--for example, AC, BD--they preferred these to the familiar compounds, implying that they had encoded configural information during the original training. Moreover, preference remained constant despite extended exposure to configural training in the test phase. The findings extend the evidence that configural representations are formed independently of explicit configural training.

Animals↗
PubMed1993

Comparative effects of excitotoxic lesions of the hippocampus and septum/diagonal band on conditional visual discrimination and spatial learning.

Several experiments compared the effects of excitotoxic lesions of the septal/vertical limb nuclei of the diagonal band of Broca (VDB) complex with those of the hippocampus (sparing the subiculum) on different forms of visual discrimination learning. The septal/VDB lesions, which produced significant reductions in choline acetyltransferase activity in the hippocampus and the cingulate cortex, impaired acquisition of a conditional visual discrimination in an operant chamber, while the hippocampal lesion had no effect, unless there was a delay interposed between the discriminative stimulus and the response. Neither lesion affected simple visual or spatial discrimination or reversal learning, also carried out in operant chambers, but both significantly impaired the acquisition and retention of a spatial navigation task (Morris water maze), with the septal/VDB lesions again producing greater deficits than the hippocampal lesions. Possible explanations for this surprising result are discussed and it is concluded that; (1) additional cholinergic de-afferentation of the cingulate cortex produced by the septal/VDB lesion is of functional significance; (2) this may lead to deficits in conditional rule learning, which can contribute to spatial navigation performance under certain circumstances; and (3) the contribution of septal-hippocampal cholinergic projections to spatial learning is in need of re-appraisal.

Animals↗
PubMed2004

The evolution of learning.

Most processes or forms of learning have been treated almost as special creations, each as an independent process unrelated to others. This review offers an evolutionary cladogram linking nearly one hundred forms of learning and showing the paths through which they evolved. Many processes have multiple forms. There are at least five imprinting processes, eleven varieties of Pavlovian conditioning, ten of instrumental conditioning, and eight forms of mimicry and imitation. Song learning evolved independently in at least six groups of animals, and movement imitation in three (great apes, cetaceans and psittacine birds). The cladogram also involves at least eight new processes: abstract concept formation, percussive mimicry, cross-modal imitation, apo-conditioning, hybrid conditioning, proto-pantomime, prosodic mimicry, and image-mediated learning. At least eight of the processes evolved from more than one source. Multiple sources are of course consistent with modern evolutionary theory, as seen in some obligate symbionts, and gene-swapping organisms. Song learning is believed to have evolved from two processes: auditory imprinting and skill learning. Many single words evolved from three sources: vocal mimicry, discrimination learning, and abstract concept formation.

Animals↗
PubMed1979

[The effect of the distribution of practice on the learning and forgetting in Carassius auratus auratus Linné].

The significance of massed and distributed practice in discrimination learning to criterion by goldfish was studied. All animals were trained to discriminate between 6 horizontal black and white stripes (positive stimulus) and 2 vertical black and white stripes (negative stimulus). 5 groups of animals, 12 Ss each, got different training programs. Groups varied in number of trials per day (30, 10, 5 successive trials) and in distribution of trials over the day (30 trials given in blocks of 5 with ITI of 1 h or 5 trials, each spaced by an ITI of 1 h). In general animals with a small number of massed trials/day were superior in early acquisition period. When trials/day were spaced the method proved to be more efficient. The training method showed no effect concerning retention.

Animals↗
PubMed2003

Learning of tactile frequency discrimination in humans.

Learning is based on the remodeling of neural connections in the brain. The purpose of the present study was to examine the extent to which training-induced improvements in tactile frequency discrimination in humans are correlated with an increase of cortical representations in the primary somatosensory cortex. Healthy male subjects (n = 16) were trained in a tactile frequency discrimination task of the left ring finger. During the first 15 days of training, there was a steep improvement in frequency discrimination, which generalized from the trained finger to its homologue on the opposite hand, and to a lesser extent, to the other fingers on both hands. During the following 15 days of training, there was only a minor improvement in tactile frequency discrimination. Retention of improved performance in frequency discrimination 30 days after training was demonstrated for all digits. Cortical finger representation in the primary somatosensory cortex, as measured by magnetic source imaging, did not change during training. Because of the generalized training effect and the lack of detectable increase in the cortical field evoked from the trained finger, we assume that skill improvement was mediated predominantly by regions outside the primary somatosensory cortex.

Adult↗
PubMed1985

Cue significance and response regulation in 3- to 6-year-old children's learning of multiple choice discrimination tasks.

The learning of multiple choice discrimination tasks of 3-, 4-, 5-, and 6-year-old children was compared using the components of learning of cue significance and response regulation. No significant differences between age groups were found in the occurrence of cue significance learning, although the younger children's cue significance responses were less accurately related to task solution. On the two easier tasks, the component of response regulation improved significantly over the age range of 3-5 years. On the two more difficult tasks 6-year-olds' response regulation was significantly better than that of 4- and 5-year-olds. In a second experiment involving two different training procedures, 5-year-olds performed better than 4-year-olds. Only for 5-year-olds was performance with the procedure emphasizing response regulation superior to performance with the procedure emphasizing cue significance. These results are discussed in terms of an association between development of response regulation and maturation of hippocampal-prefrontal cortex systems.

Child↗
PubMed1994

The relationship between learning performance and dopamine in the prefrontal cortex of the rat.

To clarify the relationship between dopamine (DA) release in the prefrontal cortex and learning performance, extracellular DA was measured by an in vivo microdialysis method during a discrimination learning task. Rats were trained to discriminate between lamp-on and -off states under an operant-type learning procedure. After stable discriminative behavior was established, a microdialysis experiment was conducted. Inverse relationships were seen between the relative ratio of DA after the beginning of a learning session to the basal level and the responses (total, correct and error responses) during a session. The results indicate that the degree of DA release in the prefrontal cortex is involve in the inhibitory mechanism of the response during discrimination learning performance.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1978

Inferior temporal lesions do not impair discrimination of rotated patterns in monkeys.

Ablation of inferior temporal cortex in the rhesus monkey produces a visual discrimination learning deficit. The severity of this deficit has often been found to be a function of task difficulty. This report concerns a type of visual discrimination problem that, although difficult, is not sensitive to inferior temporal lesions. Monkeys with anterior, posterior, and complete inferior temporal lesions were repeatedly unimpaired or only slightly impaired in learning to discriminate a pattern from the same pattern rotated 90 degrees or 180 degrees; yet they were very severely impaired in learning equally or more difficult discriminations of two different patterns. This demonstration that discrimination of orientation of patterns is relatively spared after inferior temporal lesions helps specify the pattern-recognition processes that require inferior temporal cortex.

Animals↗
PubMed2004

Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingency.

The orbital prefrontal cortex (PFo) operates as part of a network involved in reward-based learning and goal-directed behavior. To test whether the PFo is necessary for guiding behavior based on the value of expected reward outcomes, we compared four rhesus monkeys with two-stage bilateral PFo removals and six unoperated controls for their responses to reinforcer devaluation, a task that assesses the monkeys' abilities to alter choices of objects when the value of the underlying food has changed. For comparison, the same monkeys were tested on a standard test of flexible stimulus-reward learning, namely object reversal learning. Relative to controls, monkeys with bilateral PFo removals showed a significant attenuation of reinforcer devaluation effects on each of two separate assessments, one performed shortly after surgery and the other approximately 19 months after surgery; the operated monkeys were also impaired on object reversal learning. The same monkeys, however, were unimpaired in acquisition of object discrimination learning problems and responded like controls when allowed to choose foods alone, either on a food preference test among six different foods or after selective satiation. Thus, satiety mechanisms and the ability to assign value to familiar foods appear to be intact in monkeys with PFo lesions. The pattern of results suggests that the PFo is critical for response selection based on predicted reward outcomes, regardless of whether the value of the outcome is predicted by affective signals (reinforcer devaluation) or by visual signals conveying reward contingency (object reversal learning).

Animals↗
PubMed2006

Language discrimination by Java sparrows.

Java sparrows (Padda oryzivora) were trained to discriminate English from Chinese spoken by a bilingual speaker. They could learn discrimination and showed generalization to new sentences spoken by the same speaker and those spoken by a new speaker. Thus, the birds distinguished between English and Chinese. Although auditory cues for the discrimination were not specified, this is the first evidence that non-mammalian species can discriminate human languages.

Animal Communication↗
PubMed1982

Learning, memory, and transfer in profoundly, severely, and moderately mentally retarded persons.

Discrimination learning, memory, and transfer capacity were assessed in representative samples of institutionalized retarded persons in order to provide information on trainability. The 56 subjects were selected from moderately, severely, and two levels of profoundly retarded adults. They learned and relearned three successive two-choice discrimination problems. Generally, the higher functioning subjects, defined by IQ and adaptive behavior learned more rapidly than did the lower functioning subjects. Forgetting was related to IQ/adaptive behavior level. Interproblem transfer was negligible at all levels of retardation, but ceiling effects may have obscured positive transfer in the higher functioning groups. Backward learning curves revealed large differences between lower and higher functioning persons in the presolution trials, but once learning began even profoundly retarded subjects solved these problems as rapidly as did the moderately retarded subjects. Ten of the 56 subjects failed to learn all three problems.

Adult↗
PubMed1984

The hippocampus, context, and information processing.

Two experiments are described in which groups of rats with bilateral hippocampal lesions, cortical lesions, and operated controls are compared on tests of discrimination learning, retention, and reversal learning. Experiment 1 examined the effects of varying prior training and context on new learning. Experiment 2 used a transfer paradigm to compare extent of original learning by hippocampal and control groups in a discrimination task involving multiple discriminanada . The major findings were that rats with hippocampal damage were less efficient at processing information and were more constrained by contextual influences than control rats.

Animals↗
PubMed1999

Changes of cingulothalamic topographic excitation patterns and avoidance response incubation over time following initial discriminative conditioning in rabbits.

Neurons in particular layers of cingulate cortex and in limbic thalamic nuclei exhibit peak firing rates in response to a positive conditional stimulus (CS+) in particular stages of discriminative learning. A given area is maximally activated by the CS+ in the initial, an intermediate, or a late stage of behavioral acquisition, and activation in all of the areas diminishes as training continues after the peak of activation occurs. Thus, the topographic distribution of activation in these areas depends on the stage of behavioral acquisition. The present study determined whether the acquisition-related changes of the topographic distributions of peak firing rates in CS-elicited activity are driven exclusively by the repetition of conditioning trials (i.e., practice) or may occur as well with the passage of time, similar to putative processes of memory consolidation. Multiunit activity was recorded in cingulate cortex and in the anterior dorsal (AD), anterior ventral (AV), and medial dorsal (MD) thalamic nuclei as rabbits learned to step in response to a warning tone (CS+) to prevent a scheduled foot-shock, and to ignore a different tone (CS-) not predictive of foot-shock. The rabbits received two training sessions, S1 and S2. S2 followed S1 immediately in one group of rabbits and after 48 h in a different group. Significant neuronal discharge increments occurred from S1 to S2 in the 48-h group but not in the 0-h group, for the areas (posterior cingulate cortex, AV thalamic nucleus) that previously showed only late-stage activation. Significant discharge increments occurred from S1 to S2 in the 0-h group but not in the 48-h group in areas (anterior cingulate cortex, the AD, and MD thalamic nuclei) that previously exhibited early stage activation. These results indicate that the trial-driven topographic distribution changes also occur with the passage of time after limited initial training. It is suggested that the trial-driven and time-related changes may have a common functional relevance concerning memory consolidation.

Animals↗