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At least 1,297 records · Page 72Linked to original sources
PubMed1981

[Neutron activation analysis of human hair--interrelation of hair constituents (author's transl)].

In an attempt to study the availability and limitation of analytical data of human hair as an indicator of environmental pollution and/or of human health effect, concentrations of elements in 202 scalp hair samples collected from local population in the Tokyo Metropolitan area were determined by instrumental neutron activation analysis. The correlation coefficients between concentrations of 13 elements in each sex and in each age group were calculated and discussed. There were significant correlations between some pairs of elements, i.e. Na-K, Br-Cl, Ca-Zn and Ca-Mg, in all five age classes in both of male and female, indicating that the correlations were consistent. Ca was observed to be reversely correlated with Cl. No significant correlation was apparent between Hg and Se, when the correlation coefficient was calculated using logarithmic converted concentration data.

Adolescent↗
PubMed1978

[Thymus implant in a case of DiGeorge syndrome (author's transl)].

A boy with III-IV pharingeal pouch malformative syndrome, hypocalcemia and recurrent infections is presented. The immunological work-up disclosed deficiency in the specific cellular immunity with normal serum immunoglobulin levels. An adult thymus in Millipore diffusion chambers was implanted in the rectus adominalis muscle. One week later clinical and analytical data suggesting immunological reconstitution was recorded. Two years later the patient remains in good health, T and B lymphocyte percentages are normal, being the only immunological abnormality a low serum level of IgG.

DiGeorge Syndrome↗
PubMedDate not supplied

[IgE values in nasal mucus in the diagnosis of perennial allergic rhinitis].

Perennial rhinitis may be caused by an allergic response or by the vasomotor reaction to cholinergic hyperactivity. The differential diagnosis of these etiologic forms poses a difficult problem for the clinicians. The pathophysiology of rhinitis is characterized by vascular ingurgitation and mucous edema, phenomena which may result from such diverse etiologic factors as cholinergic hyperactivity and allergy. In our study, we will evaluate total IgE levels in nasal secretions, irrespective of serum of local origin. Fifty-four patients suffering from perennial rhinitis, aged between 7 and 63 years, were studied. Fourteen presented vasomotor rhinitis, while the remaining 40 were affected with the IgE-dependent form. The following tests were done: blood eosinophil count, mucous eosinophyl count, serum IgE (PRIST), cutaneous tests with house dust, acarus and fungal antigens and nasal provocation tests. IgE levels in mucous were also evaluated. The following results were obtained: 1. No significant differences were found in blood eosinophil counts between the groups studied. 2. No significant differences were found in serum IgE levels between the groups studied. 3. Significant differences were found (P less than 0.001) in the levels of eosinophils in mucous among the groups studied. 4. Mucous IgE levels are significantly greater in the allergic form than in the vasomotor form of rhinitis. The level of IgE in mucous serves as a useful but not pathognomic parameters in the differential diagnosis of the different etiologic forms of rhinitis. As such it should be considered within the context of all clinical and analytic data before a conclusive diagnosis is made.

Adolescent↗
PubMedDate not supplied

[Protein composition of human sperm from oligozoo-, teratozoo-, asthenozoo- and azoospermia].

The amino acid analysis of seminalplasma and spermatozoa shows for the different andrological diagnoses that the predominant amino acids were aspartic--and glutamic acid, serine, glycine and lysine. Analytical data indicate that there were differences between plasma and spermatozoa for a lot of amino acids. No differences in the protein composition of the ejaculates were found between the various groups of andrological diagnoses.

Adult↗
PubMed1980

Pregnant mare serum gonadotropin. Rapid chromatographic procedures for the purification of intact hormone and isolation of subunits.

A method exploiting hydroxylapatite chromatography was developed to purify pregnant mare serum gonadotropin (PMSG or eCG) to high biological activity from partially purified commerical preparations. In addition, an alternative method utilizing chromatography on quaternary aminoethyl (QAE)-Sephadex and Sephadex G-200 is also presented. Both procedures are capable of producing, from commerical material with a potency of approximately 2,500 IU/mg, a product in excess of 12,000 IU/mg. If care is taken in the selection of fractions from the hydroxylapatite chromatography, essentially purified material may be obtained in a single step. The best fraction from the QAE-Sephadex and G-200 chromatography procedure contains a minor impurity. Pregnant mare serum gonadotropin subunits were purified by a single chromatographic step from the foregoing preparations utilizing 6 M guanidine hydrochloride for dissociation, followed by chromatography on Sephadex G-75. Analytical data, including amino acid composition, carbohydrate composition. NH2-terminal amino acid determinations, and electrophoretic behavior of the subunits in sodium dodecyl sulfate polyacrylamide gel electrophoresis are presented.

Amino Acids↗
PubMed1980

The WHO/IAEA research programme on trace elements in cardiovascular diseases.

Heart, kidney, liver, hair, and toenails were analysed for Cd, Cr, Cu, Se and Zn in male subjects who died with myocardial infarction or hypertension, as compared to subjects who died a non-cardiovascular death. Autopsy collection was made according to a WHO protocol using a titanium knife. Tissues were immediately frozen and subsequently shipped by air to the analytical laboratory. Analysis was usually by neutron activation according to an IAEA protocol. Pathology and analytical data were reported according to standard formats. Institutions in many countries, both developed and developing, collaborated in this programme.

Adult↗
PubMed1995

Screening and identification of sumatriptan and its main metabolite by means of thin-layer chromatography, ultraviolet spectroscopy and gas chromatography/mass spectrometry.

Sumatriptan (CAS 103628-46-2, 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide++ +), a substance for treatment of acute migraine attacks, and its main metabolite are investigated by thinlayer chromatography (TLC), ultraviolet spectroscopy, and gas chromatography/mass spectrometry (GC/MS). The resulting analytical data (correlated hRf-values, UV solvent spectra, remission spectra, GC retention indices, and electron impact (EI) mass spectra) including an extraction procedure and different derivatization methods are presented. Their applicability is described for urine analysis.

Biotransformation↗
PubMed1978

Correlations between quality and pigment parameters in young Beaujolais red wines.

The commercial qualities of 15 young Beaujolais red wines from the 1974 and 1975 vintages were scored by experienced tasters in the following summers. Measurements were made of a wine colour and the separate contributions to it by the coloured anthocyanins and the polymeric pigments, b total anthocyanins (coloured plus non-coloured) and c total pigments, i.e. total anthocyanins plus total polymers (coloured and non-coloured). All the tasting and analytical data were subjected to regression analysis. Statistically significant correlations were found in both years: a. Between overall quality and the contents of total pigments, total anthocyanins, coloured anthocyanins and the tasters' mean colour scores; b. Flavour and the contents of total pigments and total anthocyanins. Thus the colour of the acidified wine (total pigment) was the most simple indication of flavour and quality in these young wines of the same variety and age. In other respects there were marked differences between the vintages. In 1974 additional significant correlations were found a between overall quality and wine colour, pH and non-coloured anthocyanins, b between flavour and colour scores and coloured anthocyanins, and c between aroma and total pigments, total anthocyanins, coloured and non-coloured anthocyanins and pH. In 1975, flavour correlated with non-coloured anthocyanins and pH. The results demonstrate the desirable effects of anthocyanins on quality.

Anthocyanins↗
PubMed1995

Model selection for extended quasi-likelihood models in small samples.

We develop a small sample criterion (AICc) for the selection of extended quasi-likelihood models. In contrast to the Akaike information criterion (AIC). AICc provides a more nearly unbiased estimator for the expected Kullback-Leibler information. Consequently, it often selects better models than AIC in small samples. For the logistic regression model, Monte Carlo results show that AICc outperforms AIC, Pregibon's (1979, Data Analytic Methods for Generalized Linear Models. Ph.D. thesis. University of Toronto) Cp*, and the Cp selection criteria of Hosmer et al. (1989, Biometrics 45, 1265-1270). Two examples are presented.

Age Factors↗
PubMed1995

On plotting renovated samples.

In this note we use the Buckley-James method for censored regression in the p sample problem where the samples are subject to right-censoring. The samples are reconstructed so as to remove the effect of censoring, and graphical procedures based on quantiles (such as boxplots) may then be used as a standard data-analytic tool to describe the variable being measured.

Antimetabolites, Antineoplastic↗
PubMed1995

Systematic toxicological analysis using HPLC/DAD.

A high-performance liquid chromatographic method with diode-array detection (HPLC/DAD) for systematic toxicological analysis of human blood or plasma samples is presented. After single-step liquid/liquid extraction at pH 9.5 using chloroform/2-propanol/n-heptane (60:14:26, v/v/v), the drugs elute isocratically from a NovaPak C18 (Waters) 4-micrometers column (300 mm x 3.9 mm, i.d.) at 30 degrees C, with methanol/tetrahydrofuran/pH 2.6 phosphate buffer (65:5:30, v/v/v) as the mobile phase (flow rate 0.8 mL/min). Full UV spectra from 200 to 400 nm (resolution 1.3 nm) are recorded on-line during the 20 min chromatographic run. Solute identification may be automatically performed by comparison of analytical data (retention times and UV spectra) with references of 311 pharmaceuticals, toxicants and drugs of abuse stored in a computerized library. The method is simple, rapid, relatively inexpensive and highly specific. The previously reported applications of HPLC/DAD technology to drug screening are reviewed, and the interests and limitations of the method are discussed in the light of this literature.

Chromatography, High Pressure Liquid↗
PubMedDate not supplied

[Symptomatic primary biliary stenosis without cholestasis].

The case of a 59-years old patient with typical clinical manifestations of primary biliary cirrhosis (PBC): pruritus, asthenia, arthralgias and dry syndrome, with skin pigmentation and AMA positivity, hypergammaglobulinemia and an elevation of IgM is presented. Liver biopsy was compatible with stage II PBC. No analytical data of cholestasis, has been seen over 26 months of follow up with normal transaminases, alkaline phosphatase, gamma-glutamyltranspeptidase and cholesterol. The absence of cholestasis in the presence of symptoms is of interest.

Clinical Enzyme Tests↗
PubMedDate not supplied

[Silent thyroiditis and postpartum thyroiditis].

OBJECTIVE: Six cases of silent thyroiditis are described. Clinical, analytical, therapeutical and prognostical features are reviewed. DESIGN: Descriptive and retrospective study. SETTING: Outpatient endocrinological clinic of a General Hospital PATIENTS OR OTHER PARTICIPANTS: Six women (age 26-41 years) that fulfil clinical and analytical criteria of silent thyroiditis. In 4 patients thyroiditis was diagnosed in the postpartum period and in the remaining 2 there was no relationship with pregnancy. MAIN MEASUREMENTS AND RESULTS: Serum levels of thyroid hormones and thyroglobulin and thyroid peroxidase antibodies were measured in all patients. Follow-up period was between 12 and 41 months. The 2 patients with the sporadic form of silent thyroiditis showed clinical and analytical data of thyrotoxicosis that spontaneously resolved. The remaining 4 patients presented with hypothyroidism. In one of them the hypothyroidism spontaneously resolved, in 2 it became permanent and in a further one it developed to subclinical hypothyroidism. CONCLUSIONS: Silent thyroiditis (sporadic or postpartum) is a frequent disorder, usually benign and transient. It can present in different clinic forms and evolve to resolution of permanent thyroid dysfunction.

Adult↗
PubMed1995

[An investigation on acute flaccid paralysis (AFP) cases in some provinces with high risk of poliomyelitis of China].

In the mid Jun, 1994, a study team organized by MOPH investigated AFP cases in 10 provinces with high prevalence of poliomyelitis (polio). Twenty prefectures and ten counties were selected randomly from each of 10 provinces and relevant prefectures. The team identified 681 AFP cases under 15 years old from 45 hospitals at prefecture level and 13 hospitals at country level based on hospital records from cases occurred during 1991-1994. AFP, Polio, Non-polio AFP and GBS (Guillian-Barre Syndrome) cases aged from 0-14 years scattered around 101 counties (cities) among target population and their average incidences by year were 1.04, 0.48, 0.57 and 0.31 (per 10(5) respectively. Noticingly, the incidence of polio had reduced significantly since 1991, and its proportion among AFP was also reducing from first place yearly since 1991. In addition, over 95% of the polio cases were concentrated in the 4 year olds which indicated that the target population for surveillance and prevention should mainly be focusing on 0-4 year olds. As the incidence of non-polio AFP has been used as a current sensitive index of surveillance system, we noticed that the incidence rates had been significantly different from various regions. According to the analytic data, we recommend that "Rate of non-polio AFP in children 0-14 years of age greater than 1/10(5)" might be a better and more sensitive index for surveillance program in China.

Acute Disease↗
PubMed1995

Psychoanalytic technique and the creation of analysands: on beginning analysis with patients who are reluctant to pay the analyst's fee.

This paper discusses prospective analysands who are able but reluctant to pay analysts' fees. The author presents analytic data in which analysts decided to gratify their reluctant analysands by reducing their fees in order to facilitate the subsequent analysis of their reluctance. These examples are employed to discuss the general question of fee reduction.

Adult↗
PubMed1995

Carotenoids, retinoids, tocopherols and tocotrienols in the diet; the Finnish Mobile Clinic Health Examination Survey.

New analytical data of Finnish foods were utilized in calculating the intakes of 8 different carotenoids, 6 retinoids, 4 tocopherols and tocotrienols in a Finnish population sample (5403 men and 4750 women) forming a basis for prospective studies on the associations of diet and chronic diseases. Data on habitual food consumption referring to the preceding year were collected by a dietary history interview method in 1967-1972. Beta-carotene, lutein and lycopene, mainly provided by different vegetables, were the most abundant carotenoids. Alltrans retinol was a predominant retinoid compound. A major proportion of total vitamin A (85% in men and 74% in women) was attributed to dietary retinoids. Alpha-tocopherol accounted for approximately half of the total tocopherols and tocotrienols of diet, and made up approximately 85% of total vitamin E. Intakes of different tocopherols and tocotrienols were mainly associated with the consumption of cereal products and/or margarine and oils, but alpha-tocopherol and vitamin E had several other food sources. It is suggested that these more specific measures for carotenoids and tocopherols would increase the accuracy of estimating health impacts of antioxidant vitamins in the study population.

Adult↗
PubMed1993

Serum lipids of adults 20-74 years: United States, 1976-80.

This report presents descriptive and analytic data for serum total cholesterol, cholesterol lipoproteins, and triglycerides for adults 20-74 years of age by age, sex, and selected subgroups of the population at risk of developing coronary heart disease. This information is from the second National Health and Nutrition Examination Survey, which was conducted during the years 1976-80.

Adult↗
PubMed1995

[Presentation, diagnosis and treatment of pyogenic liver abscess: analysis of a series of 63 cases].

BACKGROUND: The aim of this study was to know the clinical, etiopathogenic and microbiologic characteristics of pyogenic liver abscesses (PLA). METHODS: A retrospective analysis of the cases of PLA diagnosed from 1978 to 1992 in the Internal Medicine, Infectious Disease, and Gastrointestinal Surgery Departments of the Hospital de Bellvitge in Barcelona, Spain was performed. RESULTS: A total of 63 cases of PLA (43 males and 20 females, mean age 54 +/- 19 years) were analyzed. The most frequent clinical and analytical data included fever (92%), leucocytosis (84%) and abnormal levels of alkaline phosphatase (81%). The PLA were single in 65% and multiple in 35%. Echography was diagnostic in 91% of the cases. A positive culture of the abscess was obtained in 40 cases, being monomicrobial in 27 cases (67.5%). Eleven of the 13 polymicrobial cultures were from single PLA. The most frequent bacteria found were the enterobacteria (44%) followed by the microaerophilic streptococci (28%) and the anaerobes (17%). The PLA was of biliary origin in 31.8%, contiguous in 12.7% and unknown in 38%. Percutaneous drainage was performed in 34 patients (54%). Mortality attributable to the abscess was 3%. CONCLUSIONS: The clinical presentation of pyogenic liver abscess has not varied over time. There has, however, been a change with respect to its epidemiology and therapeutic management. At present, the possibility of rapid diagnosis and image guided percutaneous drainage offers a better prognosis for this disease.

Adolescent↗