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Results for “Coombs Test”

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PubMed1986

Antibody-mediated suppression of erythropoiesis in dogs with red blood cell aplasia.

Eight dogs with acquired RBC aplasia were studied. Unfractionated sera and serum immunoglobulin G fractions were examined for the presence of erythroid progenitor cell inhibitors. A serum immunoglobulin G inhibitor directed against precursors of erythroid colony-forming units was detected in 3 of 5 dogs that were direct Coombs' test-negative and in 1 of 3 dogs that were direct Coombs' test-positive. Sera from these dogs were treated with binary ethyleneimine to inactivate any viruses present. The inhibitory effects of the treated serum on erythroid colony-forming units was not ameliorated.

Animals↗
PubMed1975

[Serological activity of incomplete antibodies].

Blood sera containing incomplete antibodies were studied in various serological tests, by the results of Coombs' and the inhibition of complement fixation tests. It was shown that division of antibodies into complete and incomplete by their serological activity was conditioned. Antibodies detected in Coombs' test could fix the complement. The blocking antibodies depressing the complement fixation test could fix the homologous complement. Proceeding from the latter the author suggests the test of the conglutinating complex fixation which proved to be effective in detection of antibodies inactive in the agglutination and complement fixation tests.

Animals↗