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Results for “Choline Deficiency”

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At least 1,297 records · Page 72Linked to original sources
PubMed1984

Relationship of tyrosine concentration to catecholamine levels in rat brain.

Rats were fed a choline-free low protein diet for 12 or 26 weeks. In the 12-week group, the brain tyrosine concentration did not change. Dopamine levels were low in both the cerebral cortex and striatum. Norepinephrine level was low in the diencephalon. In the 26-week group, the tyrosine concentration was high in the brain. However, the dopamine and norepinephrine levels did not change in the cerebral cortex, striatum and hypothalamus. Furthermore, in another group of rats which were intraperitoneally injected with tyrosine, the brain tyrosine concentration was high, whereas the dopamine and norepinephrine levels in the hypothalamus were not significantly different from control levels.

Animals↗
PubMed1989

Free radicals and lipid peroxidation in liver of rats kept on a diet devoid of choline.

Rodents kept on a choline devoid (CD) diet up to 14 months develop hepatic lesions progressing through two broad stages. The first is characterized by severe steatosis and increase in cell turnover, the second by a gradual clearance of the deposited fat and fibrosis. Hepatocellular carcinomas eventually arise in rats fed for over 12 months, even though the animals aer not exposed to chemical carcinogens. It has been suggested that the diet may trigger generated thereby may be responsible for initiation of liver cancer and promotion. The radicals would lead to DNA damage, and the altered DNA in a proliferating liver would result in initiation of the carcinogenic process. In this communication we present evidence that the diet used in the above studies contained stable fatty acid isomers with conjugated dienes, which are absorbed and deposited in rat liver. This finding cast doubts on whether a CD diet does indeed cause a peroxidation of cellular membrane lipids. Electron spin resonance (ESR) spectroscopy was also used to investigate whether any abnormal pattern of free radicals exists in the liver of rats fed a CD diet. No significant differences were noted in ESR spectra of either transition metal-centered signals, or organic free radicals.

Animals↗
PubMed2006

A long trek down the pathways of cell death in Alzheimer's disease.

The invitation to contribute to the issue marking the 100th anniversary of Alzheimer's disease gave me pause to reflect on the significant milestones in my own research. This brief and personal description of my laboratory's search for the cause of cell dysfunction and death in Alzheimer's disease marks only highlights, and my apologies to those whose work I have passed over.

Alzheimer Disease↗
PubMed1977

Utilization of choline from crude soybean lecithin by chicks. 1. Growth and prevention of perosis.

Data obtained with growing chicks fed a semi-purified diet indicate that choline from crude soybean lecithin is as well utilized as synthetic choline chloride, on the basis of growth, relative liver weight and prevention of perosis. Extrapolation of the results on growth and perosis prevention, obtained between 1 and 3 weeks of age, to performance on practical-type diets yields choline requirements for broiler-type chicks ranging from 800 to 1000 mg./kg. diet (as choline chloride). The requirement seems to decrease with age.

Animals↗
PubMed1980

Choline/methionine nutrition of starting broiler chicks. Three models for estimating the choline requirement with economic considerations.

Experiments were conducted to test the hypothesis that metabolically labile methyl groups and not methionine per se are limiting the growth of starting broiler chicks fed corn-soy-grease diets formulated to meet NRC (1977) recommendations (except for methionine). The basal diet contained approximately 23% protein, 3200 kcal ME/kg. 32% methionine, .42% cystine, and 1300 ppm choline. In the first two experiments the diets were fed to quadruplicate lots of 10 chicks in battery brooders. Average weight gain (g) and feed per unit gain for supplements of methyl group sources were: 1) methionine: 424, 1.48; 2) choline Cl: 406, 1.49; and 3) betaine HCl: 416, 1.48. These values were not significantly different from one another (P greater than .05) but were significantly different (P less than .05) from the values for the basal (362, 1.57) and from the DL-homocystine supplemented groups (376, 1.56). This indicated that methyl group utilization was not impaired by a lack of the carbon skeleton of methionine. Five 3-week assays with five groups of 10 chicks per treatment (1050 chicks) were conducted to determine the choline requirement using the basal diet without supplemental methionine. Results from the five assays were pooled in computing regressions. Significant regressions (P less than .05) were found for broken-line linear (R2 = .630), quadratic (R2 = .556), and saturation kinetic (R2 = .642) models. The requirement was determined to approximately 2130 ppm by the broken-line linear model. The most economic feeding levels were estimated to be 4100 and 1910 ppm by the quadratic and saturation kinetic models, respectively. The economic implications of the three models are discussed.

Animal Nutritional Physiological Phenomena↗