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At least 1,297 records · Page 72Linked to original sources
PubMed1975

Adenoid cystic carcinoma (cylindroma) of the trachea masquerading as asthma.

A 40-year-old woman was admitted with upper airway obstruction; chest roentgenogram with tomograms, laryngoscopy, and bronchoscopy verified the presence of a subglottic tumor. Spirometry disclosed a maximum inspiratory flow rate more reduced than in the maximum expiratory flow rate, suggestive of upper airway obstruction. The pathologic conditions were consistent with cystic adenoid carcinoma (cylindroma) of the trachea. The patient underwent tracheostomy and total laryngectomy with an uneventful recovery. No evidence of local extension or distant metastases were evident at time of surgery.

Adult↗
PubMed2007

Establishment and characterization of a human adenoid cystic carcinoma cell line forming colonies cultured in collagen gel and transplantable in nude mice.

We established a new cell line (ACCNS) from human adenoid cystic carcinoma (AdCC) of the maxilla, using tissue culture techniques and it has been successfully subcultured for more than 100 passages during 2 years. The population doubling time was approximately 39.2 h on a plastic dish. In type I collagen gel culture, the cells formed spherical colonies by day 7 after seeding. The colonies showed tubular and solid structures, and eosinophilic material stained with mucicarmine was revealed in the inner space. Immunohistochemically, ACCNS cells demonstrated expressions of keratin, alpha-smooth muscle actin, vimentin and S-100 protein, similar to those of original AdCC. These findings indicate that ACCNS cells possess the characteristics of AdCC. In addition, inoculation of 4.0x10(6) cells into nude mice developed tumors that were histologically confirmed as undifferentiated carcinoma. Therefore, ACCNS is the first AdCC cell line with tumorigenicity in nude mice. Based on these results, ACCNS provides a useful culture model of AdCC to analyze the biological characteristics and behavior of this tumor.

Animals↗
PubMed1991

[Sensitivity of human squamous and adenoid cystic carcinoma cell lines with cisplatin and it's combined chemotherapy in vitro].

This was a report on the sensitivity of human squamous (Tca-8113) and adenoid cystic carcinoma (Acc-2) cell lines with Cisplatin (DDP) and it's combined chemotherapy (DDP+VCR+PYM, or PVP). DDP could kill both these two cell lines in vitro depending on the concentration of agent in given time. The rate of 3H-TdR incorporation, plating efficiency and DNA synthesis of carcinoma cells were prevented in drug-exposing groups. Tca-8113 cell line was more sensitive to DDP than Acc-2 cell line (P less than 0.01). PVP combined chemotherapy could enhance DDP's anticancer efficiency.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1991

[Adenoid cystic carcinoma of the parotid gland].

The authors report 7 cases of adenoid cystic carcinoma arising in the parotid gland between 1969 and 1990. All patients underwent surgery. Radiotherapy was performed twice following surgery. Local failure, nodal failure and distant metastasis are analyzed. Death appears to be related mainly to local failure. Radiotherapy does not seem to improve the local control obtained by surgery alone. Surgery must then be total and if necessary mutilating. Radiotherapy associated to surgery might be useful in case of extensive tumors for which complete eradication is not possible. A review of the world literature is performed.

Adult↗
PubMed1977

Ectopic ACTH syndrome due to salivary gland adenoid cystic carcinoma.

A 68-year-old woman developed Cushing syndrome associated with a submaxillary salivary gland adenoid cystic carcinoma. High levels of immunoreactive adrenocorticotrophic hormone (ACTH) were found in the tumor and peripheral blood. Urinary 17-hydroxycorticosteroid levels decreased following administration of dexamethasone, suggesting possible suppression of ectopic ACTH production. however, there was no specific in vitro binding of dexamethasone by tumor cytosol. A trial of metyrapone therapy resulted in control of hypokalemia and hyperglycemia. Both plasma cortisol and 11-deoxycortisol levels decreased with metyrapone administration, suggesting that this agent may inhibit not only 11-beta-hydroxylation, but also possibly earlier steps in glucocorticoid synthesis.

Adrenocorticotropic Hormone↗
PubMed1990

[Cystic adenoid carcinoma. Study of 13 cases].

In this study we examine the epidemiology, evolution and treatment of our patients diagnosed and treated for adenoid cystic carcinoma of the salivary glands, the result of which serves, with our experience, to clarity its irregular behavior and propose new guidelines for individualized therapy. We present a total of 13 cases which were diagnosed, treated and intervened by us during the period of 1982 and 1989.

Adult↗
PubMed1990

[A clinical study on the adenoid cystic carcinoma in oral cavity].

Two cases of adenoid cystic carcinoma occurred on the palate are reported. They were female and aged 65 and 69 year. They showed expansile growth in association with the bony destruction of maxillary sinus wall. Histologically the case 1 had cribriform pattern and the case 2 had cribriform and tubular pattern, and exhibited perineural invasion of tumor cells in both cases. The radical surgery were conducted, and there were no lymph node metastasis and recurrence.

Aged↗
PubMedDate not supplied

[Monocentric retrospective study on the prognosis of adenoid cystic carcinoma].

Studies on 26 patients confirm the relevance of the factors tumour size and histological subtype for the prognosis of adenoid cystic carcinoma. For high risk tumours (tumour size over 3 cm, solid or tubular subtype) a postoperative adjuvant radiologic therapy is recommendable. The rate of wrong diagnoses found by reclassification is surprisingly high.

Carcinoma, Adenoid Cystic↗
PubMedDate not supplied

[Maxillofacial adenoid cystic carcinoma. Retrospective clinical study of 51 cases].

The clinical behavior of 51 adenoid cystic carcinomas of the salivary glands demonstrated a protracted and partly insidious course of disease with obstinately recurring tumors and a high tendency for distant metastases. The tumors are mainly localized in the minor salivary glands, invasion and growth along adjoining nerves are characteristic of these tumors. With increasing size of the tumor the prognosis significantly deteriorates. The treatment of choice is radical surgery, possibly combined with irradiation. A treatment of both the primary tumor and the recurrent tumor is of benefit in the presence of distant metastases, because the latter remains clinically symptomless for years. Because of the protraction of the disease the importance of early detection of these tumors is pointed out.

Adult↗
PubMed1978

Adenoid cystic carcinoma of the vulva. Malignant cylindroma.

A case of adenoid cystic carcinoma (cylindroma) of the vulva is presented, reviewing the clinical course and response to therapy over a 5-year period. Only 9 previous cases had been reported by 1963. Several sources of cell origin had been previously suggested. Findings and histology in this case support a relation to a similar tumor occurring in other sites of the upper respiratory tract and salivary gland.

Carcinoma, Adenoid Cystic↗
PubMedDate not supplied

[An assessment of middle ear involvement in children with allergic rhinitis: a comparison with chronic hypertrophic adenoiditis].

The allergic inflammation may contribute to the development of otitis media with effusion (OME). For this reason we have examined two groups of children: the first (group A) formed by 12 children with allergic rhinitis, the second (group B) by 15 children with hypertrophic adenoids. We have found respectively: pathologic otoscopy in 75% and 93% of cases; pathologic tympanometry in 83% and in 90%; pathologic audiometry in 60% and in 83%. This values are not significant according to a statistic analysis. Instead, the degree of compromission has been significant: in fact 16% of the children belonging to group A had a retracted and atelectatic eardrum in comparison with 33% of the children belonging to group B. Also tympanometry has confirmed this aspect: in fact 33% of group A showed type C and B tympanograms in comparison with 77% of group B. Besides, audiometry has confirmed the presence of hearing loss in the subjects with tympanometry of type C and B, belonging to both groups. For this reason the allergic rhinitis, because it may cause OME, must be treated in order to limit the negative effects of allergic nasal obstruction on the functionality of the middle ear.

Adenoids↗
PubMed1977

The effect of radiotherapy in the treatment of adenoid cystic carcinoma of the head and neck arising in minor salivary glands.

Eighteen cases of adenoid cystic carcinoma of the minor salivary glands are reviewed. Noteworthy in the history is the report of pain at the site of the lesion which radiates elsewhere, or of numbers or tingling in its area. Radiation therapy is as able to control the primary as local surgery. Involvement of a much wider field than is required to treat the primary may control the perineural spread common to this tumor and avoid the massive procedures necessary to cure it by surgical means. Metastases to the lung, bone, and brain by venous spread can probably be avoided only by early diagnosis.

Adult↗
PubMed1978

Pericardial reconstruction of the membranous trachea after resection of adenoid cystic carcinoma (cylindroma).

An intraluminal adenoid cystic carcinoma (cylindroma) in the patient reported herein involved just the membranous portion of the distal region of the trachea and extended caudally to include the carina and the membranous portions of both main-stem bronchi--a total linear involvement of 6 cm. The tumor occluded 90% of the airway in its greatest extension. Conservative resection of this extensive tumor was successfully performed by membranous tracheal reconstruction with a pedicled autogenous pericardial patch graft.

Bronchial Neoplasms↗
PubMed1990

Primary adenoid cystic carcinoma masquerading as syringoma of the scalp.

We report a case of primary adenoid cystic carcinoma of the scalp in a 72-year-old man. It consisted of syringomalike papules scattered on an erythematous plaque that showed a loss of hair. Histologically, the papular lesion at first showed numerous tadpole-like tubular structures similar to those found in syringoma. Subsequent histologic studies over 2 years revealed the presence of numerous cribriform tumor masses penetrating into the subcutis, reaching the galea aponeurotica. Immunohistochemically, the neoplastic cells showed no staining with either polyclonal (P) or monoclonal (M) antibodies to carcinoembryonic antigen. M-cytokeratin, M-vimentin, and P-S-100 protein antibodies were positive only focally as were other antibodies, including anti-actin, anti-human lactalbumin, anti-beta 2 microglobulin, and breast cancer--associated antigens. The neoplastic cells showed no binding to lectins that characteristically react with the sweat apparatus, except for concanavalin A (con A) and peanut agglutinin (PNA), although the striking histopathologic resemblance to syringoma suggested its histogenic relation to eccrine glands initially.

Adenoma↗
PubMed1990

Biological characterization of pseudocyst-forming cell lines from human adenoid cystic carcinomas of minor salivary gland origin.

Two cell lines (ACCS and ACCY) were isolated from two individuals with adenoid cystic carcinoma (AdCC) using tissue culture techniques. Both cell lines have similar morphology, i.e., elongated and flattened cells with slender cytoplasmic processes. The two cell lines tend to form pseudocysts, which are a specific architectural feature of AdCC. Coexpression of cytokeratin and vimentin was found in the two cell lines, which occasionally also contained S-100 protein and lactoferrin or lysozyme immunoreactivity. Moreover, ACCS and ACCY displayed potential for the production of a large amount of extracellular matrix including basal lamina components such as fibronectin, laminin, and type IV collagen and glycosaminoglycans which are also part of the basal lamina. These findings suggest that the tumor cells, probably basal or myoepithelial like cells, are responsible for the formation of the peculiar stroma of AdCC consisting of a large amount of collagen-like fibers, basal lamina components, and mucopolysaccharides.

Carcinoma, Adenoid Cystic↗
PubMed1990

[Clinical analysis of 11 cases of primary tracheal adenoid cystic carcinoma and review of literature].

Eleven cases of primary tracheal adenoid cystic carcinoma treated in our hospital from 1968 to 1988 are reported. All were proven by pathology. Seven (64%) had been misdiagnosed and mistreated as chronic bronchitis, bronchial asthma, bronchiectasis etc. for 1-4 years with an average of 2 years before admission. The incidence, pathologic changes, clinical manifestations, X-ray findings, diagnosis and prognosis are discussed with a review of literature. It is indicated that early diagnosis is the key to improve prognosis.

Adult↗
PubMed1990

[A case of primary tracheal adenoid cystic carcinoma performed curative surgical resection].

A 67-year-old woman who was diagnosed as a relative early primary tracheal adenoid cystic carcinoma by preoperative examination underwent surgical resection. The histopathological extension of this carcinoma into the tracheal wall was much greater than was suggested before operation and 6 tracheal rings was curatively resected circumferentially. Median sternotomy and transection of the left brachiocephalic vein facilitated access to the trachea. To resect the extensive segment of the trachea, the right pulmonary ligament and hilum were mobilized. Additionally Dedo's laryngeal release was performed to lessen the tension at the anastomosis. Then the flap of the pleura and adipose tissue with the right internal mammary artery and vein was wrapped around the anastomosis for revascularization and protection of brachiocephalic artery. The postoperative course was not eventful. The postoperative dysphagia by Dedo's laryngeal release was mild and resolved within 7 days after operation. And the postoperative mammary arteriography showed the vessels around the anastomosis. This wrapping procedure is easy and does not need a laparotomy. So we think it is beneficial for prevention against postoperative complications of tracheoplasty.

Aged↗