The treatment of tuberculosis in children.
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Three hundred seventy cases of extrapulmonary tuberculosis were reported to the Oklahoma State Department of Health between January 1, 1965 and December 31, 1973. The annual number of cases reported showed no tendency to decrease with time. A greater proportion of cases reported in recent years had bacteriologic confirmation. When compared to the distribution of all newly diagnosed cases of tuberculosis in the population, a greater proportion of newly diagnosed cases of extrapulmonary tuberculosis occurred in nonwhites. This was especially true to tuberculous meningitis, tuberculous lymphadenitis, and miliary tuberculosis. Possible reasons for the failure of the number of newly reported cases of extrapulmonary tuberculosis to decrease in recent years are presented.
Two cases of histamine poisoning after ingestion of tuna fish occurred in tuberculous patients. The symptoms and circumstances leading to the reaction were identical to those previously reported for 2 other varieties of fish, skipjack and Sardinella (Amblygaster) sirm. Isoniazid, which is an invariable constituent of any antituberculous drug regimen, is a potent histamine inhibitor. When tuna fish, which has a high histamine content, is eaten, the histamine concentration in the tissues tends to increase, producing features of histamine intoxication.
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