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Large chest wall reconstruction using titanium micromesh and a pedicled latissimus dorsi musculocutaneous flap: report of a case.

The patient was a 54-year-old woman with a dermatopleural fistula and necrosis of the third to the fifth anterior ribs after postoperative adjuvant radiation for right breast cancer. After resection of the chest wall and combined partial resection of the right upper and middle lobes of the lung, the thoracic cage defect was stabilized by titanium micromesh and the soft tissue defect was covered by an ipsilateral pedicled latissimus dorsi musculocutaneous flap. The dorsal skin defect was covered by split-thickness skin grafts 3 weeks later. The advantages of titanium micromesh lie not only in its good biocompatibility and mechanical strength, but also in its light weight and low radiological interference. No paradoxical movement or other prosthesis-related complications occurred during the follow-up period. Thus, we consider that titanium micromesh is a suitable material to use in the reconstruction of a large chest wall defect.

Breast Neoplasms↗

Unstable burst fractures of the thoraco-lumbar junction: treatment by posterior bisegmental correction/fixation and staged anterior corpectomy and titanium cage implantation.

BACKGROUND: Controversy exists about the best treatment of unstable thoraco-lumbar (TL) burst fractures. Kyphosis correction and canal decompression in case of a neurological deficit are recognized treatment objectives, and various conservative and surgical strategies have been proposed. This prospective observational study evaluates the benefits and risks of a posterior bisegmental transpedicular correction/fixation and staged anterior corpectomy and titanium cage implantation in unstable TL junction burst fractures. METHOD: 20 consecutive patients with a single-level traumatic unstable burst fracture at the TL junction were operated on by a bisegmental posterior correction/fixation, followed by anterior corpectomy and titanium cage implantation 7-10 days later. The radiological and clinical course is documented over a period of 24 months. FINDINGS: The mean posttraumatic loss of anterior vertebral body height was 58% (45-70%). The posttraumatic mean regional kyphosis was 16 degrees and could be corrected by the posterior approach to a mean lordosis of 2 degrees. Mean secondary loss of the kyphosis correction was 3 degrees over 24 months. No hardware failure occurred, and construct stability was observed in all 20 patients. One surgical complication occurred during the posterior approach, and three transient surgical complications by the anterior approach. 12 of the 14 patients with an initial neurological deficit recovered an average of 1.5 grades on the ASIA scale. At 24 months postoperatively, the mean regional TL back pain on a VAS (0-10) was 1.6, and the mean pain at the anterior approach site was 1.2. CONCLUSION: Posterior bisegmental transpedicular correction/fixation and staged anterior corpectomy and titanium cage implantation is a safe and reliable surgical treatment option in unstable TL junction burst fractures. The advantages of this technique are a complete kyphosis correction, immediate stability, maintenance of kyphosis correction, and complete spinal canal decompression in case of a neurological deficit. However, these advantages have to be carefully weighed against the double approach morbidity.

Adult↗

Clinical safety and performance of Sugita titanium aneurysm clips.

BACKGROUND: In spite of advantages for neuro-imaging, titanium aneurysm clips are not yet chosen for routine use for clipping of intracranial aneurysms, probably because their reliability has not been demonstrated in large numbers of cases. We assess reliability and safety of Sugita titanium aneurysm clips for routine clinical use in a large number of operated cases. METHOD: Intra-operative performance and safety of Sugita titanium aneurysm clips were evaluated in 347 patients in our institutions. Aneurysms in 261 patients had ruptured: 86 patients had unruptured aneurysms. RESULTS: A total of 441 clips of 52 different types were used. No early or delayed complications occurred in relation to the titianium clips, such as deformity or slippage of a clip. Patient outcome according to the Glasgow Outcome Scale was similar to that when conventional cobalt-based aneurysm clips were used. INTERPRETATION: Reliability and safety of Sugita aneurysm clips were demonstrated in a large number of patients. The clips are suitable for routine use in aneurysm surgery.

Adult↗

Rationale for interbody fusion with threaded titanium cages at cervical and lumbar levels. Results on 357 cases.

STUDY DESIGN: Retrospective analysis of 357 cases of degenerative disc disease treated by interbody fusion with threaded titanium cages. OBJECTIVE: To determine the safety and efficiency of cervical and lumbar interbody fusions using threaded titanium cages and autogenous bone. SUMMARY OF BACKGROUND DATA: Stabilizing the anterior column by interbody fusion, though reported over 50 years ago, is less commonly done than posterior fusions. The recent development of rigid cages housing autogenous bone simplifies the technique of interbody fusion. This report shows our combined results using this technique. MATERIALS AND METHODS: One hundred thirty-five patients had cervical fusions at 175 levels between C3 and C7. Two hundred twenty-two patients had lumbar fusion at 243 levels between L2 and S1. All surgeries involved one or two disc spaces except for one three level cervical fusion. We implanted all disc spaces with threaded cages containing autogenous bone. RESULTS: In the cervical area, 95% of the radiculopathic patients had a good to excellent result, but only 50% of the myelopathic patients did so. At lumbar level, 80% of the patients were classified as good to excellent, 15% improved but remained disabled, 5% had minimal or no improvement. The cervical fusion rate was 90% at 6 months and 100% at one year. Lumbar fusion rate was 91% at one year and 96% at 2 years. No late breakage or cage displacement occurred. CONCLUSIONS: Cervical and lumbar interbody fusions with threaded titanium cages appear to be efficacious with few complications. Long term follow-up (4 years cervical, 7 years lumbar) confirms that impression.

Adult↗

Evaluation of different bonded investments for dental titanium casting.

The properties of several different investments were investigated including phosphate bonded, magnesia bonded, and alumina cement investments. Measurements included the setting expansion, thermal expansion, and compressive strength of investments, as well as the tensile strength, elongation, Vickers hardness (VHN) and surface roughness of titanium castings. For phosphate bonded investment, the setting expansion after being mixed with its own mixing solution was 2.10%, which was larger than the other investments; the thermal expansion was -0.25% at 200 degrees C, the compressive strength 14 and 5 MPa after heating. For titanium cast in phosphate bonded investment, the hardness on its top surface was 655 Hv, the tensile strength was 379 MPa, the elongation was 19.4%, and the surface roughness was 2.29 microm. Although the thermal expansion of phosphate bonded investment is small, the setting expansion is large enough to compensate for the shrinkage of titanium castings. As its thermal expansion at T > or = 600 degrees C was constant and its heating-cooling cycle was almost reversible, these two properties can reduce the thermal shock and thus avoid cracking of the investment.

Aluminum Oxide↗

Clinical results of titanium retinal tacks with pneumatic insertion.

We used titanium retinal tacks inserted with a pneumatic instrument for retinal fixation in 11 operative procedures in ten eyes with complicated retinal detachments. Titanium was selected for permanent implantation because of its documented biologic tolerance. No intraoperative or postoperative complications related to the tacks were encountered. Three tacks, one 0.7 mm in length and two 1.6 mm in length, became dislodged postoperatively; 50 permanently implanted tacks, each 1.6 mm in length, remained in place after a mean follow-up of five months. Retinal reattachment at the end of the follow-up period was achieved in eight eyes and useful visual function was obtained in three eyes. Titanium retinal tacks are useful when immediate retinal fixation is required either temporarily or permanently to prevent retraction and detachment of the retina until adjunctive diathermy, cryopexy, or photocoagulation becomes effective.

Adult↗

The reduction of hydroxamic acids with titanium(III) chloride: a tool for the characterization of siderophores.

Hydroxamic acid siderophores were observed to be inactivated by exposure to titanium(III) chloride. To study the reaction, a series of eight model hydroxamic acids were prepared and reacted with titanium(III) chloride. The products were shown by ir and NMR comparisons with authentic compounds to be the corresponding amides. The reduction was found to require 2 mol of titanium(III) per mol of hydroxamic acid.

Chemical Phenomena↗

The reduction of aliphatic and aromatic N-oxides to the corresponding amines with titanium(III) chloride.

Amine N-oxides have been observed to be reduced by titanium(III) chloride. To study this reaction, 24 model amine N-oxides were reacted with titanium(III) chloride. The products of these reactions were shown by melting (boiling) points, mixed melting points, derivatives, refractive indices, infrared, and NMR comparisons with authentic compounds to be the corresponding amines. The reductions were found to require 2 moles of titanium(III) per mole of amine N-oxide.

Amines↗

Irritancy and anti-inflammatory activity of bis(eta 5-cyclopentadienyl)titanium(IV) complexes in rats.

Dichloro-bis(eta 5-cyclopentadienyl)titanium(IV) and some related complexes were compared with cis-dichlorodiammineplatinum(II) in rats for acute anti-inflammatory activity against carrageenan paw oedema, anti-arthritic activity against developing and established adjuvant-induced polyarthritis, immunosuppressant activity in a local graft-vs. host assay, irritant effects at sites of administration (paw, skin, peritoneum) and nephro- and gastro-toxicities. These titanium complexes, like cisplatin and its hydrolysis products, in vivo exhibited both anti-inflammatory and anti-arthritic activity as well as immunosuppressant effects. Nephro- and gastro-toxicity were much less severe than in rats given platinum complexes. In vitro they selectively inhibited [3H]thymidine incorporation by isolated thymocytes and prevented the germination of radish seeds. When given intraperitoneally, the anti-inflammatory activity may partly be due to a counter-irritant phenomenon since the titanium derivatives elicited an acute peritoneal effusion if they were injected towards the omentum. However, when injected subcutaneously or applied in dimethylformamide or dimethylsulfoxide to the skin, they manifested both anti-inflammatory and anti-arthritic activity without irritancy or much local skin damage. They might therefore have the potential of being useful drugs, especially if released slowly.

Animals↗

Ultrastructural study of the attachment of human gingiva to titanium in vivo.

A study was conducted to determine if the behavior of epithelium in vitro is similar to its attachment behavior in vivo by the use of small sections of titanium-coated implants that could be inserted in human gingiva. The size of the implants allowed their insertion in a limited region and enabled the fixation and embedding procedures that are necessary for electron microscopy to be effective. Examination of the thin sections obtained from this material demonstrated that the epithelial cells attached to titanium in a manner similar to that observed in vitro and similar to the way that epithelium attaches to the tooth in vivo (Fig. 2). That is, there was a formation of hemidesmosomes and basal lamina. Because the ability of the oral epithelium to form such an attachment with an implant may be a crucial factor in the determination of clinical success or failure, this study provides further evidence that one reason for the apparent clinical success of titanium dental implants may lie in the firm attachment of epithelial cells to this material.

Adult↗

The advantages of coated titanium implants prepared by radiofrequency sputtering from hydroxyapatite.

The method used to apply hydroxyapatite to implant surfaces may affect the thickness and ultimately the physical properties of the coating. This study investigated and compared the healing rates of bone around commercially pure titanium implants and titanium implants sputter-coated from a hydroxyapatite target. Forty-five sputter-coated implants and an equal number of noncoated titanium implants were placed into 15 partially edentulated dog mandibles. The implants were removed at three time periods and were evaluated mechanically and histologically. A multiple analysis of variance indicated that the interface bond strength was statistically greater (p less than 0.01) for the sputter-coated implants. Histologic analysis of the bone-implant interface demonstrated that coated implants had nearly twice the percentage of direct bone contact compared with noncoated implants. The results indicate that implants sputter-coated from a hydroxyapatite target will accelerate the healing of bone at the implant interface.

Animals↗

The effects of cold treatment on the physical properties of stainless steel and titanium alloy endodontic posts and instruments.

This study determined whether cold treatment at -96 degrees C affected the mechanical properties of different compositions and sizes of Flexi-Post systems, various sizes of dental reamers, and external wrenches. The experiment was divided into eight groups. The four control groups were untreated and consisted of (1) 50 stainless steel posts, (2) 40 titanium posts, (3) 50 stainless steel reamers, and (4) 10 stainless steel external wrenches. The four experimental groups were cold treated once and twice and included (1) 100 stainless steel posts, (2) 80 titanium posts, (3) 100 stainless steel reamers, and (4) 20 stainless steel external wrenches. The bending or breaking forces were tested on a universal testing machine. Stainless steel Flexi-Post dowels, stainless steel reamers, and external wrenches all showed a significant (ANOVA) (p < 0.05) increase in strength as a result of the single and double cold treatment. Titanium posts showed no strength increase following a single cold treatment, while they were weakened by a double cold treatment.

Analysis of Variance↗

Effect of hygiene instrumentation on titanium abutments: a scanning electron microscopy study.

Implant abutments can be exposed to a variety of oral prophylaxis procedures. In this in vitro study, titanium abutments were subjected to five oral prophylaxis treatment modalities; a metal scaler, a plastic scaler, a rubber cup, a rubber cup with tin oxide, and an air-powder abrasive. The abutment surfaces were then examined under both light and scanning electron microscopes. The metal scaler was seen to roughen the titanium surface. All other modalities tested appeared to smooth the titanium surface by removing surface debris and rounding off the sharp machined grooves present on the untreated abutment surface.

Air↗

The effect of cold treatment on the physical properties of stainless steel and titanium alloy endodontic posts.

This study determined whether cold treatment at -96 degrees C affected the mechanical properties of various compositions and sizes of the Flexi-Post system. The experiment was divided into four groups of posts. The two control groups were made up of untreated stainless steel (50 posts) and titanium alloy (40 posts). The two remaining cold-treated groups were made up of stainless steel (50 posts) and titanium alloy (40 posts). In each instance the bending or breaking forces were tested on a universal testing machine. Stainless steel Flexi-Post samples showed a significant (p less than 0.05) increase in strength, whereas titanium alloy posts showed no significant increase in strength as a consequence of the cold treatment.

Alloys↗

Properties of test metal ceramic titanium alloys.

Four test alloys were prepared using a high frequency centrifugal casting machine and a ceramic crucible for the development of titanium bonding alloys that can be cast in the ordinary atmosphere. Of these alloys, 10.06% Ti, 78.79% Ni, 9.02% Pd, 1.77% Sn and 9.91% Ti, 78.56% Ni, 9.07% Pd, 1.86% Sn, 0.65% Ir could be cast by the conventional high frequency centrifugal method; however, 89.18% Ti, 8.75% Ni, 1.03% Pd, 0.28% Sn and 89.81% Ti, 8.15% Ni, 1.01% Pd, 0.18% Sn, 0.67% Ir could be cast only by the argon are melting method. The alloys 10.06% Ti, 78.95% Ni, 9.02% Pd, 1.77% Sn and 9.91% Ti, 78.56% Ni, 9.07% Pd, 1.86% Sn, 0.65% Ir showed excellent physical and mechanical properties and bonding strengths, surpassing those of the commercial alloys TPW and Unimetal. Concerning the elution of component elements, the amounts of titanium eluted from these alloys were far smaller than those from pure titanium or a Ti-6Al-4V alloy, and nickel elution, which has become an issue in relation to metal allergy, was almost nil in contrast to Unimetal (Ni-Cr alloy). The alloy 9.91% Ti, 78.56% Ni, 9.07% Pd, 1.86% Sn, 0.65% Ir showed properties that indicated its favorable use as an alloy for the bonding of dental porcelain.

Adhesiveness↗

Retentive properties of threaded split-shaft posts with titanium-reinforced composite cement.

The retention of posts in tooth roots is vital to the success of the restoration. This study compared the retention of posts of various sizes and diameters cemented with a titanium-reinforced composite cement with that of posts previously reported cemented with zinc phosphate cement. Four groups made up of 10 samples each were used and retention values were compared using a universal testing machine. Two-way analysis of variance and the Newman-Keuls multiple range comparison test were performed. Larger diameter posts cemented with titanium cement had better retention than similar posts cemented with zinc phosphate cement. The statistical increase in retention for the larger size posts is probably the result of the deeper channels (threads) in the dentin and the higher cohesive strength for the titanium-reinforced composite resin.

Composite Resins↗

Titanium lymph node pigmentation in the reconstruction plate system of a mandibular bone defect.

A case of titanium pigmentation that involved a submandibular lymph node is reported. A 41-year old man had been treated for ameloblastoma by partial resection of the mandible followed by reconstruction with the use of a titanium plate to bridge the mandibular defect. Titanium pigmentation occurred in the surrounding soft tissue adjacent to the plate and within a submandibular lymph node 2 years after reconstruction.

Adult↗