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At least 1,279 records · Page 71Linked to original sources
PubMed1972

Studies on the antigenicity of radiation-induced murine osteosarcomata.

The immunogenicities of 15 murine osteosarcomata induced with a bone seeking radioisotope ((90)Sr) in normal and chimaeric CBA mice were studied. Attempts were made to induce tumour-specific immunity in syngeneic mice by treatment with x-irradiated (15,000 rad) tumour or surgical excision of developing subcutaneous tumour grafts. Resistance was evoked against 6 tumours and this was relatively weak. With the remaining tumours, no resistance against the immunizing tumour could be demonstrated, even though the transplantation tests were made highly sensitive by the use of inocula of as few as 2 × 10(3) cells in pre-irradiated (400 rad) hosts. Sera from mice immunized against each of the tumours were tested against viable cells of the immunizing tumour by indirect immunofluorescence. In no instance did tumour antisera give a convincing reaction with tumour cells although alloantisera raised by hyperimmunization of H-2 identical and H-2 different donors with osteosarcomata consistently gave strongly positive reactions. The results are interpreted as illustrating the weak tumour specific antigenicity of radiation-induced murine osteosarcomata. The possibility that antigenic deficiency is a consequence of immunosurveillance in this tumour system is discussed.

Animals↗
PubMed1972

FBJ virus-induced tumours in mice. A histopathological study of FBJ virus tumours and their relevance to murine and human osteosarcoma arising in bone.

Nine of the 15 neonatal CBA mice injected intramuscularly with a Moloney concentrate containing FBJ virus developed tumours: likewise 5 of 7 CBA neonates injected intraperitoneally with a cell-free filtrate derived from a transplanted tumour of the former group.Of soft tissue origin, these FBJ sarcomata have a characteristic histological appearance and are of low grade malignancy. Although occasional islets of cartilage osteoid and bone were noted, these were regarded as indicative of evolutionary metaplasia in the collagenous matrix of pleomorphic fibroblastic sarcoma. No tumour was acceptable as osteosarcoma of conventional type and osseous origin. There were, however, additionally 2 minute spindle cell sarcomata arising in femoral periosteum and non-neoplastic periosteal proliferation was observed. The differences of these FBJ fibroblastic sarcomata from murine osteosarcoma-either spontaneous or induced by Sr 90-are emphasized. Furthermore, their deviation from the structural pattern and behaviour of human osteosarcoma is discussed.

Animals↗
PubMed2005

Enhancement of oxygen surface exchange kinetics of SrTiO(3) by alkaline earth metal oxides.

The oxygen incorporation reaction in undoped SrTiO(3) was investigated by electrical measurements (pressure modulation technique) in the temperature range from 650-920 degrees C and by means of tracer exchange experiments in the temperature range from 458-600 degrees C. The surface of the undoped SrTiO(3) single crystals was modified by alkaline earth metal compounds leading to a tremendous enhancement of the effective surface exchange rate for oxygen incorporation as compared to the uncoated surface.

Kinetics↗