Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Sexual Development”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,279 records · Page 71Linked to original sources

No excuses: televised pornography harms children.

All youngsters are at some risk from exposure to televised pornography, as described above. At particular risk for harm, however, are the most vulnerable children in our society--children in single-parent homes, children with mental and emotional disturbances, mentally challenged children, children who have been physically and/or sexually abused, and children in dysfunctional families. Youngsters for whom television serves as a babysitter or parental surrogate unfortunately are exposed to few competing influences to television viewing. In addition, parents in such homes are least likely to know what their children are viewing and to be able to pass on their own values about sex and sexual behavior. The main possible effects of televised pornography that must concern us as clinicians, educators, and parents are modeling and imitation of language heard and behaviors observed in televised pornography; negative interference with children's normal sexual development; emotional reactions such as nightmares and feelings of anxiety, guilt, confusion, and/or shame; stimulation of premature sexual activity; development of unrealistic, misleading, and/or harmful attitudes toward sex and adult male-female relationships; and undermining of family values with resultant conflict between parents and children. Much more research is clearly needed on this topic. Because of the ethical and procedural problems surrounding research on children exposed to pornography, ideal research designs may never be possible. Nonetheless, we hope that this article will stimulate further discussion and work. To devise public policy that protects children from potentially harmful material while at the same time respecting the media's First Amendment rights, such public discourse and responsible research are essential.

Adolescent↗

Caenorhabditis elegans sex-determining protein FEM-2 is a protein phosphatase that promotes male development and interacts directly with FEM-3.

Male sexual development in the nematode Caenorhabditis elegans requires the genes fem-1, fem-2, and fem-3. The current model of sex determination portrays the FEM proteins as components of a novel signal transduction pathway, but the mechanisms involved in signaling through the pathway are not understood. We report the isolation of fem-2 cDNAs in a yeast two-hybrid screen for clones encoding proteins that interact with FEM-3. Association of FEM-3 and FEM-2 in two independent in vitro binding assays substantiates the interaction detected in the two-hybrid system. FEM-2 is related in sequence to protein serine/threonine phosphatases of Type 2C (PP2C). We demonstrate that FEM-2 exhibits magnesium-dependent casein phosphatase activity, typical of PP2C, in vitro. Point mutations that abolish the casein phosphatase activity of FEM-2 without affecting its FEM-3-binding activity reduce severely its ability to rescue male development in fem-2 mutant nematodes. These results suggest that protein phosphorylation regulates sex determination in C. elegans.

Amino Acid Sequence↗

Sexuality of women with anorexia nervosa.

The sexual development and life of 30 adult women with anorexia nervosa and of 50 control women was investigated using a structured interview and 3 sexological questionnaires. Heterosexual development was found to be normal in the initial stages, but psychosexual adaptation in adulthood was impaired. Primary or secondary insufficiencies of sexual life were found for 80% of the anorectic patients. Biological and psychosocial factors may participate in this unfavourable state. Discussion of sexual problems should be part of the process of treating women with anorexia nervosa.

Adolescent↗

Development of a sexual function questionnaire for clinical trials of female sexual dysfunction.

OBJECTIVE: To better evaluate efficacy in clinical trials of drugs as potential treatments for female sexual dysfunctions (FSD), a brief, multidimensional measure of female sexual function was developed. METHODS: Data from semistructured interviews with 82 women with or without FSD, aged 19-65 years, generated a pool of 61 items that addressed aspects of female sexual function. On review by a panel, individual items were selected for face validity and clinical relevance. Thirty-one items were used as a sexual function questionnaire (SFQ-V1) in two multicenter, phase II clinical trials totaling 781 women with FSD. Normative data were generated from a sample of 201 women without FSD. RESULTS: Factor analysis produced seven domains of female sexual function: desire, physical arousal-sensation, physical arousal-lubrication, enjoyment, orgasm, pain, and partner relationship. The internal consistency of the domains ranged from 0.65 to 0.91, and test-retest reliability ranged from 0.21 to 0.71 for Cohen's weighted kappa and 0.42 to 0.78 for Pearson's correlation coefficient. There was a significant difference between the baseline mean SFQ domain scores of patients with FSD compared with those of women without FSD (p < 0.0001). End-of-study SFQ scores were significantly different for women who reported improvement vs. women who reported no improvement (p < 0.001). CONCLUSIONS: The SFQ produced seven domains of female sexual function with excellent internal consistency, moderate to good reliability, excellent discriminant validity, and sensitivity. The results suggest that the SFQ may be a valuable new tool for evaluating and diagnosing subsets of FSD and, ultimately, for evaluating treatments of these disorders.

Adult↗

Natural born killers?: the development of the sexually sadistic serial killer.

Today's society seems enthralled with serial killers in the news and the media. Forensic psychiatrists often interview serial killers after they have been caught. There are retrospective studies and case reports of individuals who have committed sexually sadistic serial murders. However, there exists a dearth of case reports on adolescents who have expressed serious fantasies about becoming serial killer prior to actualizing their fantasy. This article presents nine clinical cases of 14- to 18-year-olds who have clinically significant fantasies of becoming a serial killer. Similarities exist in these adolescent cases when compared with retrospective studies and case reports of serial killers on the role of sexually sadistic fantasies and actual killings. Since it has been established that sexual paraphilias may develop at a young age, one can surmise that sadistic paraphilias may also develop in some adolescents. The question is posed, can we predict which of these adolescents may go on to actually become serial killers? This article focuses on how the sexually sadistic fantasy can eventually be acted out and possible motives for the act to be repeated multiple times. Finally, recommendations are made about assessing and treating a youngster who expresses violent sexually sadistic killing fantasies so that attempts can be made to interrupt the progression to actual killing.

Adolescent↗

[Coital anorgasmia in marriage].

Out of a sample of 2,425 gynecological patients aged 21-40 and married for at least one year, three groups were selected according to the frequency of coital orgasm. The first group contained 1,266 (52.2%) orgastic women, the second group included 172 (7.1%) patients who did not reach orgasm during coitus, and the third group consisted of 55 (2.3%) patients whose absent orgasms were felt by the examinees as distressing. Significant differences were found between the three groups concerning family environment and childhood, level of education and professional standing, sexual development and life, and in the incidence of psychopathological symptoms. It appears that the absent capacity of women to attain orgasm in sexual intercourse is caused by several factors of both biological and psychosocial nature.

Adult↗

Performance and attitudes of occupational therapists regarding sexual habilitation of pediatric patients.

A survey of 70 registered occupational therapists was conducted to determine the therapists' performance of tasks related to the sexual development of disabled children and the therapists' attitudes toward sexual habilitation issues. The questionnaire used in the survey was developed after a review of the literature on sexuality and disability. Respondents indicated which of the nine tasks listed they performed, which they considered important, and for the performance of which they felt adequately prepared. They also designated individuals who, in their opinion, were best suited for the performance of each task. Results showed a discrepancy between respondents' positive attitudes toward tasks of sexual habilitation and the low frequency of reported task performances. No single health professional was clearly identified as appropriate for performing any of the tasks, nor were parents so identified. Therapists who had received information on sexual habilitation and rehabilitation performed significantly more of the tasks than did therapists without this educational experience.

Adolescent↗

Male pseudohermaphroditism due to 17-hydroxylase deficiency.

A 27-year-old phenotypic female presented with primary amenorrhea, severe hypertension, and hypokalemia. At the age of puberty sexual development had not occurred; in particular, sexual hair had not grown. Past history revealed an episode of subarachnoid hemorrhage and several episodes of ventricular tachyarrhythmia. Karyotype was 46, XY. The steroids requiring 17-hydroxylation (cortisol, testosterone, pregnanetriol, 17-ketosteroids, 17-hydroxycorticosteroids) were low, while those not requiring 17-hydroxylation (progesterone, deoxycorticosterone, corticosterone) were high, demonstrating 17-hydroxylase deficiency. The corticosterone/deoxycorticosterone ratio was relatively low, suggesting an associated partial deficiency of 11-hydroxylase.

Adrenal Hyperplasia, Congenital↗

Theoretical perspectives accounting for adolescent homosexuality.

Few topics in sexology elicit such a diversity of opinions and emotions as the question of etiology of homosexuality. Views frequently carry with them implicit or explicit messages concerning the psychologic health of this sexual orientation. Theories of sexual development usually portray adolescence as a critical time in the life course because of changes in: 1) anatomy and physiology; 2) psychologic functioning: the reawakening, renewal, and reliving of previously established sexual relations and drives; and/or 3) social conditions: an increased exposure and adherence to societal messages concerning appropriate and inappropriate social and sexual behaviors and relationships. This paper provides a brief overview of several major theories--evolutionary biology, psychoanalysis, and social processes--as they relate to the development of sexual orientation. In addition, an ethologic perspective that synthesizes various etiologic theories, as they relate to homosexuality during adolescence, is briefly reviewed. In these discussions, the issue of whether homosexuality is a normal or abnormal developmental state during adolescence is also addressed.

Adolescent↗

Ceratopteris richardii: a productive model for revealing secrets of signaling and development.

Ceratopteris richardii is an aquatic fern grown in tropical and subtropical regions of the world. It is proven to be a productive model system for studies in the genetics, biochemistry, and cell biology of basic biologic processes that occur in early gametophytic development. It provides several advantages to biologists, especially those interested in gravitational biology, polarity development, and in the genetics of sexual development. It is easy to culture, has a relatively short life cycle, and offers an array of attractive features that facilitate genetic studies. The germination and early development of large populations of genetically identical spores are easy to synchronize, and both the direction of polarity development and cell-level gravity responses can be measured and readily manipulated within the first 24 h of spore development. Although there is no reliable transformation system available yet in Ceratopteris, recent studies suggest that the technique of RNA interference can be used to block translation of specific genes in a related fern, Marsilea, and current studies will soon reveal the applicability of this approach, as well as of other transformation approaches, in Ceratopteris. A recently completed expressed sequence tag (EST) sequencing project makes available the partial sequence of more than 2000 cDNAs, representing a significant percentage of the genes being expressed during the first 24 h of spore germination, when many developmentally interesting processes are occurring. A microarray of these ESTs is being constructed, so especially for those scientists interested in basic cellular phenomena that occur early in spore germination, the availability of the ESTs and of the microarray will make Ceratopteris an even more attractive model system.

Base Sequence↗

Commitment to gametocytogenesis in Plasmodium falciparum.

To achieve transmission, a subpopulation of asexually dividing bloodstream forms of the human malaria parasite Plasmodium falciparum withdraws from the cell cycle to develop into gametocytes - cells specialized for sexual reproduction and invasion of the mosquito vector. For natural selection to maximize transmission to new hosts, a balance must have evolved between asexual replication and sexual differentiation. Here, Mike Dyer and Karen Day consider observations on the process of commitment to gametocytogenesis and use this information as the framework for a model that begins to explain the control of the dynamics between asexual and sexual development.

Animals↗

Sexual experiences in childhood: young adults' recollections.

Childhood sexuality and children's sexual experiences have become increasingly important to study because our knowledge on the impact of sexually abusive experiences on children's developing sexuality has increased. The main aim of this paper was to study aspects of young adults' recollections of their sexual experiences before the age of 13, solitary and shared, mutual as well as coercive. Anonymous questionnaires were answered by 269 final year, senior high-school students, mean age 18.6 years; 82.9% of the students reported solitary sexual experiences and 82.5% had mutual experiences together with another child. Most of the children had their experiences together with a same-age friend. Girls had more same-sex experiences than boys did. Thirteen percent reported coercive experiences where they had been tricked, bribed, threatened, or physically forced into participation. Some children, 8.2%, had coerced another child into participation in sexual activities. The majority thought of their childhood experiences as normal. There were also 6.3% of the respondents who had had inappropriate sexual experiences with someone at least 5 years older, the majority being girls. Gender differences were evident in several respects: girls were more often coerced, they felt more guilt, and they had far less experience of masturbation, whereas boys were somewhat more active in explorative activities on their own as well as with peers. Some kind of coercive sexual experiences appears to be part of growing up for quite a few children, although in general the years before puberty seem to be years of frequent mutual sexual exploration and experimentation.

Adolescent↗

Neuronal correlates of sex/role change in labrid fishes: LHRH-like immunoreactivity.

Gonadotropins have been implicated in the proximate control of socially induced sex and role change in labrid fishes. Since the release of gonadotropins is controlled by Gonadotropin Releasing Hormones, immunocytochemical techniques were used here to determine the qualitative and quantitative distribution of Luteinizing Hormone Releasing Hormone (LHRH, the primary Gonadotropin Releasing Hormone in mammals) in the brain of a sex-reversing labrid fish, Thalassoma bifasciatum. Fibers showing LHRH-like immunoreactivity were distributed throughout the brain, with densest concentrations in the olfactory bulb, the telencephalic area dorsalis and preoptic area of the forebrain, the medial posterior tuber and nucleus of the saccus vasculosus of the hypothalamus, and the tectum and tegmentum of the midbrain. Somata positive for LHRH were found in the anterior and posterior divisions of the ganglion of the nervus terminalis, the preoptic area, and the periventricular rostral midbrain. There were no qualitative differences in the distribution of LHRH-like immunoreactive cells and fibers among the different sexual phases. However, there were quantitative differences in the number of LHRH-like immunoreactive cells in the preoptic area, a brain region known to be involved both in sexual development and in the control of sexual physiology and behavior in adults. Based on this, and results in other teleosts, it seems likely that central control of sex reversal and expression of alternative reproductive behaviors in labrid fishes is more directly related to quantitative changes in the number and/or biosynthetic activity of LHRH-positive somata and their fiber projections.

Animals↗

Sex differences in psychoanalytic treatment.

Sex sterotypes, clinical observations, and psychoanalytic theory of sex differences are presented. Stereotypes show differences in areas of inhibition and clinical observations, differences related to the phallic and genital phases in psychosexual development. Divergent analytical views on the sexual development of boys and girls are discussed.

Female↗

Differences in dental and bone maturation in regions with or without hemihypertrophy in two patients with Russell-Silver syndrome.

Hemihypertrophy (hemihyperplasia) is defined as asymmetric body overgrowth of one or more body parts. Hemihypertrophy can be isolated or be part of well-defined syndromes, such as Russell-Silver syndrome (RSS). RSS is characterized by severe intrauterine growth retardation, postnatal short stature, asymmetry of the face, body, and limbs, short and incurved fifth fingers, broad forehead, pointed small triangular shaped face, girdle nose, normal psychomotor development, variations in the pattern of sexual development, and dental and oral abnormalities. The aim of this study was to determine whether or not there was any difference in the maturity of bone in left and right hand-wrist radiographs and dental development in the right and left jaws of two patients with RSS. In addition, the clinical features of the syndrome are discussed.

Adolescent↗

Adolescent girls' representations of their genital inner space.

Psychoanalytical theory and research based on Freud's observations have viewed female sexual development mainly in terms of the fantasies and sensations aroused by the external genitals of the child. Other authors refer to the significance of females' inner sexual organs that define the cavity surrounded by body mass, included in the body image. The purpose of this study was to examine the relationship between girls' representative modalities of their genital inner space and their identity formation. Randomly selected adolescent girls (n = 275) aged 11 to 18 years were asked to make a drawing (1) of the inside of their body and (2) of their sexual organs. Analysis of the main qualitative features of the drawings indicates that structuration and integration of genital inner space in the body image is a slow developmental process.

Adolescent↗

Appropriate use of estrogen replacement therapy in adolescents and young adults with Turner syndrome and hypopituitarism in light of the Women's Health Initiative.

Adolescents and young adult females who are hypoestrogenic need gonadal hormone therapy for sexual development, enhancement of growth, and maintenance of reproductive tissues, cyclic menses, and psychosocial health. In addition, prevention of chronic disease, specifically bone loss and possibly early heart disease, needs to be addressed in these patients. The etiology of hypopituitarism should also be considered when evaluating therapeutic options. The issues concerning estrogen replacement therapy (ERT), including the doses used and the length of therapy, are different for young patients than for postmenopausal women. The highly publicized findings of the Women's Health Initiative have identified risks of combined progestin-estrogen therapy; these risks, found in much older women, have raised questions regarding the appropriateness of ERT in adolescents with hypopituitarism and Turner syndrome. It is therefore appropriate to examine the relative risks and benefits of ERT in these populations.

Adolescent↗

Prenatal sex ratios and expression of sexually dimorphic traits in three snake species.

Variation in intrauterine exposure to hormones associated with variation in the sex of litter mates has well-established and far-reaching effects on sexual development in some mammals. Research on this phenomenon in reptiles is scant, but suggests that lizards may follow the mammalian model whereas snakes may be affected differently. We examined sex-specific expression of four sexually dimorphic traits (tail length, head length, ventral scale count, swimming speed) in three species of snakes (Nerodia sipedon, Thamnophis sirtalis, T. sauritus) relative to litter sex ratios. We found little evidence that traits in either sex were masculinized or feminized in response to variation in litter sex ratio. The one significant result appeared best explained as a statistical artifact attributable to a single litter. Our results indicate that snakes are different from the one lizard studied to date. Unlike previous suggestions that prenatal hormonal mechanisms operate differently in snakes and lizards, however, the difference appears to be that development of sexually dimorphic traits in lizards is affected by litter sex ratios whereas in snakes it is not.

Animals↗