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Three years' experience with esophageal stapling device.

The authors report their experience with forty patients undergoing resection of middle and lower thirds carcinomas of the esophagus or proximal stomach, with esophagogastric or esophagojejunal anastomosis using an end-to-end anastomosis (EEA) stapler. A fatal anastomotic leak occurred in the first two patients and seven other patients died in the early postoperative period from respiratory and cardiovascular complications. Four other patients developed fibrotic strictures between 6 and 24 months after their operation. The strictures were easily dilated and did not recur. The use of an EEA stapler is recommended because it reduces the operating time, the incidence of anastomotic leaks, and probably the blood loss. The majority of anastomoses can be accomplished exclusively through the left chest by using the stapler.

Adenocarcinoma↗

The intramucosal cysts of the stomach. II. Late glandular changes after partial gastrectomy.

Micrometric determinations of the diameter of the gastric glands, of the linear distance between those glands, and of the number of chronic inflammatory cells were performed on gastric biopsies from 71 patients. Forty of the patients had been operated on with a Billroth II and 12 with a Billroth I gastrectomy 5-45 years previously. The mean diameter of the gastric glands was significantly larger for patients with a Billroth II gastrectomy than for those of the Billroth I group or for non-operated control patients with chronic gastritis. The difference was marked for Billroth II patients operated on 26 or more years previously. Contrariwise, the linear distance between glands was significantly smaller in Billroth II patients than in the other two groups. The number of inflammatory cells was somewhat lower in biopsies from operated patients than in controls. The significance and pathogenesis of dilated gastric glands in long-time Billroth-II-gastrectomized patients (a high-risk group for cancer development in the gastric stump) is discussed.

Biopsy↗

Gastritis cystica polyposa.

Gastritis cystica polyposa was diagnosed in five patients between ages 29 and 61 years. All five had been operated on for peptic ulcer disease three to 26 years earlier, when gastroenteric anastomoses had been made. The presenting complaint was abdominal pain, nausea and vomiting, or gastrointestinal bleeding. The lesions, located on the gastric side of the anastomosis, consisted of polypoid mucosal changes associated with hyperplasia and cystic dilatation of glands. Radiologic and endoscopic findings were often nondiagnostic, and surgical intervention was necessary to relieve obstruction and to rule out carcinoma. Resection of the gastrojejunostomy site and choosing anastomotic techniques to minimize bile reflux into the stomach appear to be the preferred methods of treatment.

Adult↗

Internal hernia presenting as obstructive jaundice and acute pancreatitis.

We report the first case of obstructive jaundice and acute pancreatitis caused by herniation of the small bowel through the foramen of Winslow in a 45-year-old man. Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) revealed dilated small-bowel loops positioned in the gastrohepatic space, dilatation of the gallbladder and both intrahepatic bile ducts, and mild swelling of the pancreas. A small-bowel series revealed a cluster of small-bowel loops in the mid-upper abdomen, with displacement of the stomach to the left. At laparotomy, there was an internal herniation of jejunal loop through the defect of gastrocolic ligament into the lesser sac and finally passing through the foramen of Winslow. The common bile duct was compressed externally by the herniated bowel and the pancreas was mildly swollen. To the best of our knowledge, these complications of internal hernia have not been reported previously.

Acute Disease↗

The renin-angiotensin system modulates the peripheral vascular effects of the calcium antagonist isradipine in anesthetized rabbits.

Dihydropyridine calcium antagonists such as isradipine (PN200-110) selectively increase blood flow to the heart, brain, and skeletal muscle. The role of the renin-angiotensin system in bringing about this pattern of selectivity was investigated in two groups of eight barbiturate-anesthetized rabbits. One group was and the other one was not pretreated with 1 mg/kg i.v. of the angiotensin converting enzyme inhibitor, spirapril. In the group with the intact renin-angiotensin system, isradipine (3 and 10 micrograms/kg i.v.) elicited the typical systemic and regional (measured with 15 micron tracer microspheres) hemodynamic effects of a noncardiodepressant dihydropyridine derivative. Inhibition of the angiotensin converting enzyme blunted the effects of isradipine on central venous pressure, cardiac output, and flow to the heart, brain, and skeletal muscle. The isradipine-induced decrease of hepatic arterial and pancreatic blood flow was prevented and a similar tendency was observed in the spleen, stomach, small intestine, cecum, and arteriovenous shunt flow, indicating that the renin-angiotensin system was totally (liver, pancreas) or partially responsible for the effects of isradipine on these vessels. The renin-angiotensin system thus counteracts the dilator effect of calcium antagonists in angiotensin II sensitive vascular beds and participates in bringing about the typical pattern of regional vasodilation of these agents.

Anesthesia↗

Histological and histochemical studies on the fundic mucosa of the camel's stomach (Camelus dromedarius).

The one-humped camel, like our domestic ruminants, has a capacious compartmentalized stomach and is a ruminating animal. In our studies wer followed the currently predominant opinion that the camel stomach consists of three compartments (Vallenas, cummings, Munnel 1971). The third one of it is considered as the tubular portion following the second compartment or reticulum and extends till to the pylorus. The Tunica mucosa in the terminal dilated part (distal one-fifth) of this third compartment bears at its greater curvature very thick folds enclosing flat furrows which divide the mucosa into nearly regular areas (gastric areas). This portion of the third compartment contains the proper gastric glands (fundic glands) which differ somewhat from those in the advanced ruminants, especially in the arrangement of the parietal cells and the behaviour of the chief cells which can store mucosubstance during fastening or diminishing of the food in the camel.

Animals↗

Clinicopathologic consideration of protein-losing enteropathy due to lymphangiectasia of the intestine.

The pathogenesis of intestinal lymphangiectasia and mechanism of enteric loss of serum protein has been discussed from the pathologic and roentgenologic viewpoints of the two patients with this disease. Enteric loss of serum protein was attributed to exudation of lymph from ruptured lymphatic vessels, resulting from non-specific multiple ulcers of the small intestine in one patient and malrotation of the gut in another.

Adult↗

[Experimental studies on the development of residual stomach cancer--comparison of Billroth I and Billroth II].

The effects of duodenogastric reflex on the development of residual stomach cancer and cell proliferation kinetics were investigated in Wistar rats. Billroth II resection (B-II group) was performed on 24 rats and Billroth I resection (B-I group) was performed on 22 rats. The incidence of cancer in the B-II group was 20.8%, though no cancer was noted in the B-I group. The incidences of the pseudopyloric gland, dilated gland and gastritis cystica profunda in the B-II group were significantly higher than those in the B-I group. The degree of mucosal atrophy was greater in the B-II group than in the B-I group. The stomal area in the B-II group had expansion of proliferative zone as well as increased S-phase duration and turn over time, compared with those in the B-I group. The sequence of histological and proliferative events associated with duodenogastric reflux suggests that the residual stomach in the B-II group is susceptible to the development of cancer.

Animals↗

[A case of systemic lupus erythematosus overlapping with progressive systemic sclerosis accompanied by deposition of AA amyloid in the stomach].

A 52-year-old woman was admitted to our department because of fever and dysphasia in November 1994. She had noticed Raynaud's phenomenon, arthralgia, and stiffness in the skin for the past 20 years without receiving specific treatment. A diagnosis of progressive systemic sclerosis (PSS) was made based on the presence of sclerosis of the skin, sclerodactyly, pulmonary fibrosis, and the dilatation of the lower esophagus. It was also confirmed that systemic lupus erythematosus (SLE) overlapped based on the presence of an oral ulcer, polyarthralgia, leukocytopenia, renal dysfunction, positive tests for antinuclear antibodies and anti-DNA antibodies. A gastric biopsy specimen revealed amyloid deposits which showed green birefrigence by Congo red staining under polarized light microscopy. The disappearance of the green birefrigence after potassium permanganate treatment indicated that the deposits consisted of AA amyloid. No amyloid deposits were detected in the rectum or the kidney. The average of the SAA level in active SLE patients is 174 micrograms/ml in our department and the SAA level in the present case was 280 micrograms/ml. Although AA amyloidosis is rarely associated with SLE and PSS, a long-term elevation of SAA level could cause the development of amyloidosis even in the cases of SLE and PSS.

Amyloidosis↗

Modified ultrasound-guided percutaneous transgastric drainage of pancreatic pseudocysts.

We describe a modified ultrasound-guided transgastric drainage technique for pancreatic pseudocysts. Using a water-filled stomach to improve visualization, we have successfully drained pseudocysts in ten patients. This report also describes the use of a stiffening cannula to assist transgastric catheter placement. We emphasize the value of constant real-time tracking of the dilator and guidewire to ensure correct positioning of the drainage catheter.

Adolescent↗

Percutaneous enterostomy with the Cope suture anchor.

Eighty-two percutaneous enterostomies were performed at three institutions with the Cope suture anchor for stomach or jejunal wall stabilization during alimentation tube placement. The anchors were successfully placed into the stomach or jejunum in 81 cases. Early in the series, two anchors were misplaced, with no sequelae. There were no other complications at the time of placement. In all successful cases, excellent immobilization of the viscus was achieved. Tract dilation and tube placement were easily performed, and there were no guidewire or tube dislodgments.

Adult↗