Use of a questionnaire for the diagnosis of tear film-related ocular surface disease.
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Adult↗
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Results for “Referred Pain”
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Effect of exercise and ischemia on tissue oximetry and cytochrome in normal subjects, patients with chronic limb pain, and patients with mitochondrial mitopathies.
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Adolescent↗
Plasma taurine in liver cirrhosis with painful muscle cramps.
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Administration, Oral↗
Excision of laminal pseudoarthroses in spondylolytic spondylolisthesis. A review of 13 cases.
A conservative operation involving the excision of laminal pseudoarthroses in patients with spondylolytic spondylolisthesis who complained of referred leg pain is described. The spinous process and related ligaments of the affected lamina are preserved, allowing reattachment of the lumbodorsal fascia to the supraspinous ligaments after completion of the decompression procedures. The results obtained with the use of this method in 13 patients are described. The outcome in only one patient was unsatisfactory due to recurring bouts of back pain and lumbar spasm. No significant complications occurred in the series.
Adolescent↗
Diclofenac delays healing of gastroduodenal mucosal lesions. Double-blind, placebo-controlled endoscopic study in healthy volunteers.
The effects of the water-soluble and delayed-release formulations of a nonsteroidal antiinflammatory drug, diclofenac, on the healing of gastroduodenal mucosal lesions were compared in a double-blind, double cross-over, placebo-controlled endoscopic study conducted in 14 healthy volunteers. Severe endoscopic lesions (petechiae, erosions, ulcers, and esophageal candidiasis) were found only in the group taking the soluble formulation of diclofenac (P less than 0.05 vs placebo). The endoscopic healing of biopsies at one week was delayed by both preparations in comparison to placebo (P less than 0.05 vs placebo). Neither formulation produced significantly more histological inflammation or minor endoscopic lesions (erythema, red striae) than placebo. Both formulations were equally well tolerated and produced no more symptoms than placebo. This study suggests that soluble diclofenac acts topically to delay gastroduodenal healing and produce gastroduodenal injury; it thus provides a model for future studies of the production, perpetuation, and healing of peptic lesions.
Adult↗
The innervation of the spinal dura mater: anatomy and clinical implications.
The nerves supplying the spinal dura mater were studied in four human foetuses (16-22 weeks) with the acetylcholinesterase in toto staining method. The ventral spinal dura contains a dense, longitudinally oriented, nerve plexus, which receives its contributions from: (I) the sinuvertebral nerves, (II) the nerve plexus of the posterior longitudinal ligament, (III) the nerve plexus of radicular branches of segmental arteries. Dorsal dural nerves are much smaller in number, do not form an evident plexus and do not reach the medial region of the dorsal dura. The dorsal nerves are derived from the ventral dural plexus at the level of the "intersleeval" parts of the dura mater. The ventral dural nerves may extend up to eight segments, with a great amount of overlap between adjacent nerves. This may provide an anatomical substrate for the understanding of extrasegmentally referred dural pain. The curled bundles of nerve fibres of pathways (I) and (II) provide an adequate adaptation to displacements of the spinal dura mater during flexion and extension. Pathway (III) has not been described before. The described nerve plexuses may be of importance in elucidating the mechanisms of epidural therapies in back pain and peripheral vascular disease.
Acetylcholinesterase↗
An ergonomic study of chronic musculoskeletal pain in schoolchildren.
OBJECTIVE: Schoolchildren developing chronic musculoskeletal pain from carrying heavy backpacks (hereafter referred to as "pain") is a worldwide issue. The present study of two cohorts, consisting of 248 Indian and 103 American schoolchildren aged 9.0 to 20.6 years, using a semi-objective pain criteria, sought to answer the questions: Can pain be correlated with Body Mass Index (BMI), Weight Carried, Strength, Mood or Body Fat? What are the similarities and differences between the Indian and American schoolchildren in the above context? METHODS: After obtaining parental consent, the schoolchildren completed a questionnaire. Then, they were weighed with and without carry-on items and their height as recorded. Isometric arm and shoulder strengths were measured using the Jackson Strength Tester. Using a Skinfold Caliper, skinfold thicknesses at the right triceps and calf was measured. Using the Borg Pain Scale the students assessed the pain experienced from their own backpacks, rated the acute pain experienced while carrying a standard 10 kg. or 7 kg. backpack. RESULT: Half the schoolchildren reported pain located primarily in the shoulders and back (where most students carry their backpacks). Pain did not correlate with study variables (p > 0.05), and the student moods were mostly happy or neutral. Americans are five times as stressed or sad than the Indians, and the average weight carried decreased as the grade increased. The mean of the age, height, arm and shoulder strengths, and BMI for the 5th to 8th grade schoolchildren (younger groups) and the 9th to 12th grade schoolchildren (older groups), in India, was lower than their American counterparts (p < 0.05). In contrast, the weight carried to school by the Indian children was higher (p < 0.05). The mean pain level perceived by both the younger and older groups in both countries, was not statistically different (p > 0.05). CONCLUSION: Musculoskeletal pain in schoolchildren due to carrying heavy backpacks is a significant problem. There are some similarities, but a number of differences between the Indian and American schoolchildren. Implementing the Pain Prevention Screening is expected to minimize pain, if not lead to a pain-free child.
Adolescent↗
An unusual cause of otalgia--an ossified stylohyoid ligament.
Otalgia is often related to pathology in areas of the head and neck apart from the ear. This is due to the rich innervation of the ear via the fifth, seventh, ninth and tenth cranial nerves and the cervical plexus. It is estimated that 50% of ear pain is referred from non-otologic sites. A case is reported where otalgia was due to the presence of a bone in place of a ligament in the neck and was relieved by its removal.
Adult↗
In situ microdialysis in tendon tissue: high levels of glutamate, but not prostaglandin E2 in chronic Achilles tendon pain.
This investigation was to our knowledge the first to use the microdialysis technique to study concentrations of substances in a human tendon. In four patients (mean age 40.7 years) with a painful nodule in the Achilles tendon (chronic Achilles tendinosis) and in five controls (mean age 37.2 years) with normal Achilles tendons (confirmed by ultrasonography) the local concentrations of glutamate and prostaglandin E2 were measured under resting conditions. A standard microdialysis catheter was inserted into the Achilles tendon under local anesthesia. Sampling was performed every 15 min over a 4-h period. The results showed significantly higher concentrations of glutamate in tendons with tendinosis than in normal tendons (196 +/- 59 vs. 48 +/- 27 mumol/l, P < 0.05), and there were no significant changes in glutamate concentration over the period of investigation. There were no significant differences in the mean concentrations of prostaglandin E2 (83 +/- 22 vs. 54 +/- 24 pg/ml) between tendons with tendinosis and normal tendons. In conclusion, in situ microdialysis appears a useful method to study certain metabolic events in tendon tissue. The higher concentrations of the excitatory neurotransmitter glutamate in Achilles tendons with a painful nodule may possibly be involved in the pain mechanism in this chronic condition. Furthermore, there were no signs of inflammation in the tendons with painful nodules, as indicated by the normal prostaglandin E2 levels.
Achilles Tendon↗
Pain and Stroop interference tasks activate separate processing modules in anterior cingulate cortex.
Investigations of pain using functional imaging techniques have revealed an extensive central network associated with nociception. This network includes the thalamus, insula, prefrontal cortex and anterior cingulate cortex (ACC) as well as the somatosensory cortices. Positron emission tomography (PET) of regional cerebral blood flow (rCBF) has demonstrated activation of the ACC during cognitively challenging tasks such as the Stroop interference task and divided attention. One interpretation of this research is that ACC is involved in the general features of attention and that it does not play a specific role in pain processing per se. Three-dimensional PET imaging provides a method for assessments of rCBF in a single individual during multiple tasks. In addition, coregistration of PET and magnetic resonance (MR) images allows for better localisation of the PET signals so that differences in cortical activation sites can be more accurately determined. This approach was used to assess rCBF during the experience of pain by subtracting images collected during heat from those during noxious heat stimulation. Two regions of the ACC had elevated rCBF, one in the perigenual region and one in the mid-rostrocaudal region (i.e. midcingulate cortex). During the execution of the Stroop task, the group result showed the midcingulate region overlapping with the site seen during the experience of pain. This group result, however, was not confirmed in the individual subject analysis, which revealed widespread and independent areas of ACC response to pain and Stroop. It is concluded that the ACC contributes to multiple cognitive procedures. It is inadequate to describe the primary contribution of ACC to pain processing as "attention" because it is unlikely that the multiple small and independent activation sites produced by pain and Stroop subserve attentive processing throughout the brain.
Adult↗
Intraneural hemangioma of digital nerve diagnosed with MR imaging.
Hemangioma may occur at any location. Although the imaging findings of hemangioma are well known, it may be difficult to differentiate this entity from other soft-tissue tumors. Intraneural hemangiomas are extremely rare. We present a girl with a painful swelling in the fourth web space of her right hand. Since it was painful, the referring clinician considered the possibility of a glomus tumor. However, demonstration of dilated feeding or draining vessels suggested the diagnosis of hemangioma. At surgery a hemangioma of the ulnar digital nerve of the ring finger was resected marginally.
Child↗
Hand disability and related variables in patients with rheumatoid arthritis.
OBJECTIVE: To carry out a cross-sectional study of patients with rheumatoid arthritis (RA) for hand disability, articular damage and to define their relation with demographic, laboratory and clinical parameters. METHODS: The study included 105 RA patients with a mean age of 49.4 years. Demographic parameters of the patients were recorded. Clinical parameters including disease duration, duration of morning stiffness, pain assessed by visual analog scale, Ritchie Articular Index, grip strength, lateral, tip and three-fingered pinch, and laboratory parameters comprising C-reactive protein, erythrocyte sedimentation rate and rheumatoid factor were evaluated in all patients. The Rheumatoid Arthritis Articular Damage (RAAD) score was used to assess the irreversible articular damage and deformities of the hand. Hand disability was assessed by the special hand disability index of Standford Health Assessment Questionnaire (HAQ). RESULTS: Hand disabilities of various levels were detected in 81% of the patients. Disease duration, grip strength, pinch measurements, clinical and laboratory activity parameters were strongly correlated with hand disability (p<0.01). Hand disability was more related to disease activity parameters than articular damage (p<0.01 and p<0.05, respectively). Grip strength and pinch measurements were the most related parameters with hand disability. The disability scores were significantly higher in female patients (p<0.01). The RAAD score was correlated with disease duration and grip strength (p<0.01). The clinical and laboratory parameters and seropositivity were not correlated with articular damage assessed by RAAD score (p>0.05). CONCLUSION: Our data suggest that grip strength and pinch measurements seem to be the most related variables with hand disability and articular damage. Therefore, grip strength and pinch measurement should be included in the evaluation and follow-up of the patients with RA in hand rehabilitation units.
Adult↗
Concomitant lower thoracic spine disc disease in lumbar spine MR imaging studies.
Our objective was to study the coexistence of lower thoracic-spine disc changes in patients with low back pain using a large field of view (FOV) in lumbar spine MR imaging. One hundred fifty patients with low back pain were referred to an MR examination. All patients were studied with a large FOV (27 cm), covering from the coccyx to at least the body of T11. Discs were coded as normal, protrusion, and extrusion (either epiphyseal or intervertebral). The relationship between disc disease and level was established with the Pearson chi(2) test. The T11-12 was the most commonly affected level of the lower thoracic spine with 58 disc cases rated as abnormal. Abnormalities of T11-12 and T12-L1 discs were significantly related only to L1-L2 disease ( p=0.001 and p=0.004, respectively) but unrelated to other disc disease, patient's gender, and age. No correlation was found between other discs. Magnetic resonance imaging of the lumbar spine can detect a great amount of lower thoracic disease, although its clinical significance remains unknown. A statistically significant relation was found within the thoracolumbar junctional region (T11-L2), reflecting common pathoanatomical changes. The absence of relation with lower lumbar spine discs is probably due to differences in their pathomechanisms.
Female↗
Camurati-Engelmann disease: a late and sporadic case with metaphyseal involvement.
A 40-year-old white man with a 3-year history of mild to severe right thigh and knee pain was referred for radiographic investigation. Radiographs show a fusiform, bilaterally symmetrical enlargement of the diaphyses and metaphyses of the long bones (femur, tibia, fibula, radius and ulna). A narrowed medullary cavity is illustrated on CT scan of the femur. All bones show periosteal and endosteal bone formation. There is no history of familial involvement, trauma, infection or systemic illness. Blood chemistry could not point out any abnormality. Radiographic findings and clinical history suggest the diagnosis of Camurati-Engelmann disease, also known as progressive diaphyseal dysplasia (PDD). This case is of interest because of its rare metaphyseal involvement, mild form and sporadic presentation.
Adult↗
Femur ostochondroma and secondary pseudoaneurysm of the popliteal artery.
Osteochondroma is the most common skeletal benign tumour. It may present in a solitary form or as part of an autosomal dominant hereditary syndrome affecting several bones simultaneously. It is found most often in the knee region. It is generally asymptomatic although it may cause complications, including vascular disorders. In view of anatomical circumstances, the popliteal artery is most frequently involved in this type of complication. This is a case report of a 9-year-old boy who referred with pain in the distal third of his femur. Osteochondroma was initially diagnosed through plain X-ray. In view of worsening symptoms, an ultrasound and magnetic resonance imaging were performed and the patient was diagnosed with pseudoaneurysm of the popliteal artery.
Aneurysm, False↗
[Pediatric nursing in pain therapy].
KEY POSITION: Pediatric nursing owns a key position in pain therapy, due to its patient centered tasks and special kind of labor repartition between medicine and nursing. However, it is to admit that this key position obtains various forms of appearance in the different settings of pediatric nurses's practice. PAIN QUESTIONNAIRES: The difficulties within the correct assessment of children's pain by nurses refer to the application of valide pain questionnaires and continuous documentation. A prototype of pain prevention in nursing is the 'minimal handling' concept. Effective psychologic measures of pain prevention and relief are not only intrinsic and extrinsic focussing of awareness but also just holding the patient's hand. 'Cutaneous stimulation' and 'counterirritation' should be mentioned as physical techniques. COPING ABILITY: Close contact with friends or parents is one of the most important factors enhancing the patient's coping ability. If confronted with their own child in pain, parents often feel helpless which may result in anxiousness, overprotection, and inadequate support. Thus both parents and children need professional training to face painful procedures and behave in a supportive manner. There are numerous non-medical techniques which either by themselves, or in combination with analgetics, have the potential to substantially add to quality of life of the paediatric patient in pain.
English Abstract↗
Telephone consultation in palliative care for cancer patients: 5 years of experience in The Netherlands.
GOALS OF WORK: To analyze cancer patient-related consultations of a telephone helpdesk (TH) for palliative care over a period of 5 years in the region of Utrecht, The Netherlands. MATERIALS AND METHODS: A descriptive analysis was performed of consultations over a period of 5 years (2001-2006). The discipline and location of requesting professionals, patient characteristics, reasons for calling, symptoms, palliative care problems and needs for support were registered. MAIN RESULTS: A total of 1,794 consultations were analyzed. There was an increasing number of consultations during the study period. Of the patients, 51% were male and their median age was 65 years (range 0-104). Eighty-four percent were treated at home by their general practitioner. Two thirds of the patients had a life expectancy <4 weeks. Most questions referred to pain (49%), delirium (20%), nausea and vomiting (16%) and dyspnea (12%). The median number of symptoms was 1 (0-6). Of the questions, 54% were related to pharmacological problems, 19% to psychological problems and 21% to the organization of care. Of the requesting professionals, 17% asked for support for themselves. Of the consultations, 14% were related to end-of-life issues: palliative sedation (11%) and euthanasia (3%). CONCLUSION: After more than 5 years, the 24-h telephone consultation service fulfills a need for general practitioners dealing with daily dilemmas in palliative care treatment for cancer patients at home during the last period of their life.
Adolescent↗
Management of terminal cancer patients: attitudes and training needs of primary health care doctors and nurses.
The objective of the study was to ascertain the attitudes and training needs of primary health care (PHC) professionals regarding the management of terminal cancer patients. A cross-sectional study involving 30 PHC teams (15 urban and 15 rural) in the health district of Majorca (Spain) was carried out. Out of the 224 doctors and 186 nurses initially included, 157 and 156, respectively, completed a questionnaire designed to elicit the participant's opinions on the role of PHC in palliative care, their needs in terms of training and their management of clinical and psychological symptoms. Forty percent of professionals considered that terminal care should be the responsibility of PHC, whereas 59.5% thought it preferable for such care to be given either in Palliative Care Units or by oncologists. All kinds of relationships between PHC professionals and specialists were highly valued. Seventy-five percent of general practitioners referred to pain control, and 83% of doctors and nurses provided emotional support. Most health professionals felt training in emotional aspects would be the most desirable. One group of professionals considered palliative care to be an asset in PHC, whereas another group thought that patient care should be provided by specialists. The majority of doctors and nurses pinpointed the need for improving co-ordination with specialists. A need for tuition in palliative care was clearly stated. In conclusion, the planning of palliative care should take into account the attitudes and opinions of PHC doctors and nurses.
Attitude of Health Personnel↗