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PubMed1985

Depression and anxiety in pain clinic patients. Rapid assessment by microcomputer.

Computer administered depression and anxiety rating scales were used in a pilot study to screen patients attending a regional pain relief unit. Patients found the procedure acceptable and helpful. There was a poor correlation between the computer assessments and doctors' ratings, with in general a much greater degree of morbid depression and anxiety revealed by the computer. Computer administered rating scales may be useful as a screening tool in pain clinic patients to identify those at risk of significant psychiatric morbidity.

Anxiety↗
PubMed1987

Evaluation of a microcomputer program (OPT) for parameter optimisation in clinical pharmacokinetics: gentamicin and tobramycin.

1. Several nomograms and computer programs are available to aid in aminoglycoside dosing. 2. Due to the variability in the relationship between dosage and serum drug levels, monitoring through the acquisition of serum drug levels is mandatory. 3. All clinical data, including serum drug levels, are subject to errors. 4. The program we have evaluated, OPT, calculates the most likely set of pharmacokinetic parameter estimates for individual patients by applying Bayes' theorem and the principle of Maximum Likelihood Estimation. Through a feedback process all available data are used, taking possible errors into account. 5. Our study shows that OPT is able to predict serum aminoglycoside levels accurately in the routine clinical setting. It may thus contribute to the quality of aminoglycoside therapy.

Adolescent↗