Swine pseudorabies: abortion, clinical disease, and lesions in pregnant gilts infected with pseudorabies virus (Aujeszky's disease).
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Acremonium kiliense was cultured from the placenta and abomasal contents of an aborted bovine foetus; attempts to isolate viruses and bacteria were unsuccessful although the serum of the dam contained antibodies to Leptospira pomona. The fungus was nonpathogenic for mice but was able to survive in murine tissues for at least 13 weeks. The possibility of this case being a foetal infection as a result of insemination with contaminated semen is discussed.
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During an investigation of a late abortion in a Yorkshire terrier minute virus of canines (MVC) antigen could be demonstrated in fetal tissues by immunofluorescence. The bitch had a high specific anti-MVC serum titer when tested about four weeks after the abortion. Those results implicate an etiological role of MVC in this abortion and to our knowledge it presents the first described case of a MVC-associated abortion in Germany.
BACKGROUND: Bacterial vaginosis in pregnant women is an established risk factor for premature labor, rupture of membranes, and preterm delivery, but information on its natural history during pregnancy is limited. METHOD AND MATERIAL: In this study, 635 pregnant women at less than 35 weeks' gestation were screened for bacterial vaginosis. RESULTS: The prevalence of bacterial vaginosis, as assessed by Gram stain examination of vaginal smears, was 19.7% (125/635). Ninety-two women were retested 4 to 8 weeks later, and bacterial vaginosis persisted in 51.1% (47/92). The incidence of preterm delivery was significantly increased in women with bacterial vaginosis at enrollment (RR 3.1, 95% CI: 1.8-5.4). However, the risk of prematurity was similar in women with or without a persistence of bacterial vaginosis. CONCLUSION: These results suggest that the diagnosis of bacterial vaginosis at any point during pregnancy is associated with an increased risk of perinatal complications in spite of spontaneous recovery in subsequent examinations.
Although the safety of allogeneic blood transfusion has increased dramatically in recent decades, some risks remain. Contamination with infectious agents-including viruses, bacteria, spirochetes, and parasites-is still possible, although recent advances in blood screening and testing have decreased the risk. The principal noninfectious complication of blood transfusion is immunomodulation. Clinical manifestations of transfusion-related immunomodulatory activity include hemolytic and allergic reactions, graft-versus-host disease, the possible decreased survival in patients with cancer, as well as increased susceptibility to postoperative infection, activation of latent infection, improvement in organ allograft survival, decreased frequency of spontaneous abortion, and moderation of immune inflammatory disease. The cause of transfusion-related immunosuppression is not yet known, but possible contributing factors are the development of a suppressor cell network, formation of anti-idiotype antibodies, clonal deletion, macrophage paralysis, up-regulation of cells with latent infections, cytokine infusion, and contamination by infectious and noninfectious agents.
Listeria infection during pregnancy can cause the death of both mother and fetus. Previous studies established that immunostimulatory CpG oligodeoxynucleotides (ODN) increase the resistance of healthy adult mice to many infectious pathogens, including Listeria monocytogenes. This study examines whether the innate immune response elicited by CpG ODN can reduce the susceptibility of pregnant mice to lethal listeria challenge. The results indicate that CpG ODN treatment significantly improves maternal survival and reduces pathogen transmission to offspring. CpG ODN administered during pregnancy did not induce abortion, birth defects, or reduce the size or health of litters. These findings suggest that CpG ODN may provide a safe and effective means of improving the health of mothers and fetuses during pregnancy.
The efficacy of prophylactic antibiotic therapy in induced first-trimester abortions was investigated in a double-blind study. Of the 493 women in the study, 254 received doses of 2 million IU of penicillin G intramuscularly one-half hour before and 3 hours after the procedure, followed by 350 mg of pivampicillin three times daily for 4 days, and 239 women received corresponding doses of placebo. The incidence of pelvic infectious complications was 5.5% in the treated group and 10.9% in the control group (p = 0.05). The difference could be attributed to a selective prophylactic effect in women who had earlier suffered from pelvic inflammatory disease (N = 105). The rate of infection in this group was 22.4% among those receiving placebo and 2.1% among those receiving antibiotics (p = 0.006). Prophylactic administration of antibiotics for first-trimester abortions should be used in women who have earlier had pelvic inflammatory disease.